Drug & supplement interaction

Humann Superbeets Heart Chews + Mitotane

Mitotane brand name: Lysodren.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Humann Superbeets Heart Chews and Mitotane in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mitotane states a food rule worth keeping to.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Humann Superbeets Heart Chews and Mitotane

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mitotane and Humann Superbeets Heart Chews in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Humann Superbeets Heart Chews safety at a glance

Humann Superbeets... overall Use caution Generally well tolerated for most healthy adults, but check with a clinician if you have cardiovascular conditions.

Pregnancy Avoid Safety has not been established in pregnancy, so it is best avoided unless your doctor approves.

Breastfeeding Avoid There is not enough safety information during breastfeeding, so avoid it unless advised otherwise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mitotane and Humann Superbeets Heart Chews? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Mitotane

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mitotane is filed under a single classification — oral drugs. Humann Superbeets Heart Chews has documented interactions with 4 drug classes — the most serious being antihypertensive drugs (minor), cytochrome p450 2d6 (cyp2d6) substrates (minor) and cytochrome p450 2e1 (cyp2e1) substrates (minor) — and none of Mitotane’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Humann Superbeets Heart Chews Does Interact With Other Medications

Humann Superbeets Heart Chews has 894 minor known drug interactions in our database — Mitotane isn’t one of them. If you take anything else, check it against the full list below.

Minor 894 No known interaction 1,936 (incl. Mitotane)

Taking anything else?

Check Another of Your Medications Against Humann Superbeets Heart Chews

Covers the 2,830 medications we’ve checked against Humann Superbeets Heart Chews. Pick one to open its full report.

What to actually watch for

What Mitotane’s Own FDA Label Lists

This is not an interaction — none of it involves Humann Superbeets Heart Chews. These are the most notable effects listed in the ADVERSE REACTIONS section of Mitotane’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

A change in thyroid levels Worth acting on
Muscle weakness Worth acting on
Unsteadiness Worth acting on
Confusion Worth acting on
A low platelet count Worth acting on
Kidney problems Worth acting on
Anemia Worth acting on
Raised blood pressure Worth acting on
Shortness of breath Worth acting on
A low white blood cell count Worth acting on

Showing the 10 most notable of 29 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Mitotane. Read the label on DailyMed › Humann Superbeets Heart Chews’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Humann Superbeets Heart Chews side to compare — that is a limit of the record, not a statement that Humann Superbeets Heart Chews has no side effects.

How to take them

Some Mitotane Products Have a Food Rule — Humann Superbeets Heart Chews Should Not Break It

At least one FDA label for a product containing Mitotane says to take it with food. If you take Humann Superbeets Heart Chews on an empty stomach out of habit, keep them separate — and take Mitotane with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mitotane products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended initial dose of LYSODREN is 2000 mg to 6000 mg orally, in three or four divided doses per day with food.

From the Dosage and Administration section of the FDA label we read for Mitotane — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Mitotane

This page covers Humann Superbeets Heart Chews only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mitotane page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Mitotane page

“Mitotane (Lysodren) is chemotherapy for adrenal cancer, and doses are adjusted based on blood levels, so a supplement list like this one deserves genuine attention rather than a shrug. All 17 entries work the same basic way, by changing how much mitotane your gut actually takes in.”

Reviewed by 2 · Jul 18, 2026

Open the Mitotane interaction page

How much people look this up

Where Humann Superbeets Heart Chews and Mitotane Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Humann Superbeets Heart Chews

Top half

#634 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Mitotane

Top half

#1,214 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Humann Superbeets Heart Chews is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Humann Superbeets Heart Chews reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Humann Superbeets Heart Chews and Mitotane records this page draws on were last updated June 20, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Humann Superbeets Heart Chews

What is Humann Superbeets Heart Chews?

Heart and cardiovascular support
Healthy blood pressure support
Nitric oxide and blood flow support
Antioxidant support
Energy and circulation

SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric oxide production. Some research on dietary nitrate from beets and on grape seed extract suggests modest cardiovascular benefits, but evidence for this specific product is limited. It is generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have heart problems or take blood pressure medicine.

Beetroot (root) powder and grape seed extract · Chewable tablets (chews)

An interaction check asks whether these two react with each other — it does not ask whether Humann Superbeets Heart Chews is a good idea for someone in your situation. Here is what our Humann Superbeets Heart Chews record says about it on its own.

Humann Superbeets Heart Chews: dosing

There is no official standardized dose for this product or its ingredients. The best approach is to follow the directions on the package label, which typically suggests a set number of chews per day.Do not take more than the label recommends in hopes of stronger effects.

From our Humann Superbeets Heart Chews monograph — the full record covers uses, side effects and every documented interaction.

Read the full Humann Superbeets Heart Chews monograph & all interactions

Medication

About Mitotane

What Is Mitotane Used For?

Brand name: Lysodren

Lysodren (mitotane) tablets are indicated for the treatment of inoperable adrenocortical carcinoma (ACC) — a rare cancer of the adrenal gland's outer layer (the cortex). It can be used whether or not the tumor is actively producing hormones (functional or nonfunctional).

Because the cancer cannot be removed surgically in these patients, Lysodren works to suppress and damage the adrenal tissue itself, helping to control the disease.

See full Mitotane drug information

Keep checking

Other Drugs & Humann Superbeets Heart Chews

Browse every other medication we’ve checked against Humann Superbeets Heart Chews — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

894Minor

1,935No known interaction

894 Minor 1,935 No interaction

Minor

894 interactions

Showing 60 of 894 minor interactions — see all 894 on the Humann Superbeets Heart Chews page.

No interaction 1,935 drugs checked — show the list

We also checked Humann Superbeets Heart Chews against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,935 medications checked with no known interaction — see the full Humann Superbeets Heart Chews list.

See the full Humann Superbeets Heart Chews interactions page

See every supplement checked against Mitotane, ranked by severity

Evidence & sources

Humann Superbeets Heart Chews References

The 2 sources that drive our Humann Superbeets Heart Chews monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Humann Superbeets Heart Chews is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Grape Seed Extract — NIH NCCIH Source
Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Humann Superbeets Heart Chews and Mitotane Together: Common Questions

Is it safe to take Humann Superbeets Heart Chews with Mitotane?

We do not list a known interaction between Humann Superbeets Heart Chews and Mitotane. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Humann Superbeets Heart Chews and Mitotane at the same time of day?

At least one FDA label for a product containing Mitotane says to take it with food. If you take Humann Superbeets Heart Chews on an empty stomach out of habit, keep them separate and take Mitotane with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Mitotane products can differ — so check the directions on your own box. This is about absorption, not an interaction.

How was the Humann Superbeets Heart Chews and Mitotane combination checked?

Interactions in our licensed database are recorded against drug classes. Mitotane is filed under 1 classification, and Humann Superbeets Heart Chews has documented interactions with 4 drug classes — none of Mitotane's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Humann Superbeets Heart Chews interact with any other medications?

Yes. Humann Superbeets Heart Chews has 894 documented drug interactions in our database — Mitotane is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Mitotane interact with any supplements?

Yes. Mitotane has documented interactions with 17 supplements in our database — Humann Superbeets Heart Chews is not one of them. The Mitotane interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Humann Superbeets Heart Chews monograph Uses, safety profile, and every drug interaction in one place Mitotane drug information The full plain-English guide to this medication Mitotane supplement interactions Every supplement checked against Mitotane, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mitotane and Humann Superbeets Heart Chews?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.