Alpelisib

Generic name: Pronounced as (al" pe lis' ib)
Brand names
  • Piqray®
  • Vijoice®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2023

Alpelisib (Piqray) is used in combination with fulvestrant (Faslodex) to treat a certain type of breast cancer that has spread to nearby tissues or other parts of the body in women who have already gone through menopause (''change of life,'' end of menstrual periods) or in men, whose cancer got worse during or after certain other treatments. Alpelisib (Vijoice) is used to treat adults and children 2 years of age or older who have certain types of PIK3CA Related Overgrowth Spectrum (PROS; a genetic condition that causes overgrowth and abnormalities in certain body tissues). Alpelisib is in a class of medications called kinase inhibitors. It works to treat cancer by blocking the signals that cause cancer cells to multiply, which helps to stop the spread of cancer cells. It works to treast PROS by blocking the signals that cause overgrowth and abnormalities in certain body tissues, which reduces the size of the overgrowths and improves symptoms.

Alpelisib comes as a tablet to take by mouth. It is usually taken with food once a day for as long as your doctor recommends treatment. Take alpelisib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take alpelisib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. Do not take a tablet that is broken, cracked, or is damaged.

If you are taking alpelisib (Vijoice) for PROS and are unable to swallow the tablets whole, you may dissolve them in water. Place the tablet(s) into a drinking glass that contains 2 to 4 ounces (60 to 120 mL) of water. Wait 5 minutes and then crush the tablets and stir the mixture with a spoon. Drink the mixture immediately. Add another 2 to 3 tablespoons of water to the glass and stir with the same spoon to rinse out any particles that are still in the glass. Drink all of this mixture to be sure that you receive all of the medication and repeat if necessary.

If you vomit after taking alpelisib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose of alpelisib, treat you with other medications, or interrupt or stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with alpelisib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking alpelisib,

  • tell your doctor and pharmacist if you are allergic to alpelisib, any other medications, herbal products, or any of the ingredients in alpelisib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, or nutritional supplements you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have ever had a rash with red sores on the lips, mouth or skin, or shedding, blistering skin; or have or have ever had diabetes or kidney disease.

  • tell your doctor if you or your partner are pregnant, or plan to become pregnant. You or your partner should not become pregnant during your treatment with alpelisib. If you are a female that can become pregnant, you will need to have a pregnancy test before you begin treatment, and you should use effective birth control during your treatment and for 1 week after your final dose. If you are a male with a female partner that can become pregnant, use a condom and effective birth control during your treatment and for 1 week after your final dose. If you or your partner become pregnant while taking alpelisib, call your doctor. Alpelisib may harm the fetus.

  • tell your doctor if you are breast-feeding. Your doctor may tell you not to breast-feed during your treatment and for 1 week after your final dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking alpelisib.

  • you should know that alpelisib may cause an increase in blood glucose. If you have diabetes or high blood sugar, check your blood sugar as often as directed by your doctor. If your blood sugar is higher than usual, call your doctor. Tell your doctor immediately if you have any of the following symptoms while you are taking alpelisib: extreme thirst, frequent urination, extreme hunger, blurred vision, confusion, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar that is not treated can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include dry mouth, upset stomach and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness. Call your doctor if you are unable to eat or drink normally due to nausea, vomiting, or diarrhea while you are taking alpelisib. Your doctor may need to change your diet or medication to help control your blood sugar while you are taking alpelisib.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if more than 9 hours passed since the missed dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Alpelisib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • extreme tiredness

    • decreased appetite

    • change in the way things taste

    • weight loss

    • abdominal pain

    • heartburn

    • hair loss

    • headache

    • itching

    • dry skin

    • dry mouth

    • mouth sores

    • vaginal dryness

    • fever

    • swelling of the arms or legs

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

    • trouble swallowing or breathing; rash; hives; flushing; fever; or fast heartbeat

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • rash; blistering, peeling, or reddened skin; blistering of the lips, eyes, or mouth; fever; flu-like symptoms

    • shortness of breath, cough, chest pain, difficulty breathing

    • severe diarrhea, dry mouth, cramps, weakness, decreased urination, swelling of legs or ankles

    • watery or bloody diarrhea, stomach pain

    • frequent, painful, or urgent urination

  • Alpelisib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • nausea

  • lack of energy

  • rash

  • increased thirst and appetite

  • dry mouth

  • urinating more often or larger amounts

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to alpelisib.

Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with alpelisib (Piqray).

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Alpelisib.
Montelukast Montelukast The serum concentration of Montelukast can be decreased when it is combined with Alpelisib.
Leflunomide Leflunomide The serum concentration of Leflunomide can be decreased when it is combined with Alpelisib.
Delavirdine Delavirdine The metabolism of Alpelisib can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The serum concentration of Alpelisib can be decreased when it is combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Alpelisib.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Alpelisib.
Candesartan Candesartan The serum concentration of Candesartan can be decreased when it is combined with Alpelisib.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Alpelisib.
Clopidogrel Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Alpelisib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Alpelisib can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Alpelisib.
Methylergonovine Methylergonovine The metabolism of Alpelisib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Alpelisib.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Alpelisib.
Triamcinolone Triamcinolone The metabolism of Alpelisib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Alpelisib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Alpelisib can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The serum concentration of Hydromorphone can be decreased when it is combined with Alpelisib.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Alpelisib.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Alpelisib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Alpelisib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Alpelisib.
Zidovudine Injection Zidovudine Injection The serum concentration of Zidovudine can be decreased when it is combined with Alpelisib.
Cyclosporine Cyclosporine The serum concentration of Alpelisib can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The serum concentration of Ondansetron can be decreased when it is combined with Alpelisib.
Torsemide Torsemide The serum concentration of Torasemide can be decreased when it is combined with Alpelisib.
Alosetron Alosetron The serum concentration of Alosetron can be decreased when it is combined with Alpelisib.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Alpelisib.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Alpelisib.
Meloxicam Meloxicam The serum concentration of Meloxicam can be decreased when it is combined with Alpelisib.
Orlistat Orlistat The metabolism of Alpelisib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Alpelisib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The serum concentration of Alpelisib can be increased when it is combined with Pantoprazole.
Telmisartan Telmisartan The serum concentration of Alpelisib can be increased when it is combined with Telmisartan.
Anakinra Anakinra The metabolism of Alpelisib can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be decreased when it is combined with Alpelisib.
Etanercept Injection Etanercept Injection The metabolism of Alpelisib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Alpelisib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Alpelisib.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Alpelisib.
Epinephrine Injection Epinephrine Injection The metabolism of Alpelisib can be decreased when combined with Epinephrine.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Alpelisib.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Alpelisib.
Adalimumab Injection Adalimumab Injection The metabolism of Alpelisib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Alpelisib.
Atazanavir Atazanavir The serum concentration of Atazanavir can be decreased when it is combined with Alpelisib.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Alpelisib.
Eletriptan Eletriptan The serum concentration of Eletriptan can be decreased when it is combined with Alpelisib.
Mefloquine Mefloquine The metabolism of Alpelisib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The serum concentration of Rosuvastatin can be decreased when it is combined with Alpelisib.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Alpelisib.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Alpelisib.
Aprepitant Aprepitant The metabolism of Alpelisib can be decreased when combined with Aprepitant.
Progesterone Progesterone The serum concentration of Alpelisib can be increased when it is combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Alpelisib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Alpelisib.
Infliximab Injection Infliximab Injection The metabolism of Alpelisib can be increased when combined with Infliximab.
Rifaximin Rifaximin The serum concentration of Alpelisib can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The serum concentration of Duloxetine can be decreased when it is combined with Alpelisib.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Alpelisib.
Bosentan Bosentan The serum concentration of Bosentan can be decreased when it is combined with Alpelisib.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Alpelisib.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Alpelisib.
Voriconazole Voriconazole The serum concentration of Voriconazole can be decreased when it is combined with Alpelisib.
Ramelteon Ramelteon The serum concentration of Ramelteon can be decreased when it is combined with Alpelisib.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Alpelisib.
Deferasirox Deferasirox The metabolism of Alpelisib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Alpelisib can be decreased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Alpelisib can be increased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Alpelisib can be increased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Alpelisib can be increased when combined with Abatacept.
Imatinib Imatinib The serum concentration of Alpelisib can be increased when it is combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Alpelisib.
Gefitinib Gefitinib The serum concentration of Alpelisib can be increased when it is combined with Gefitinib.
Bortezomib Bortezomib The serum concentration of Bortezomib can be decreased when it is combined with Alpelisib.
Posaconazole Posaconazole The metabolism of Alpelisib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Alpelisib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Alpelisib can be increased when it is combined with Darunavir.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Alpelisib.
Sorafenib Sorafenib The serum concentration of Alpelisib can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib The serum concentration of Alpelisib can be increased when it is combined with Sunitinib.
Dronabinol Dronabinol The serum concentration of Alpelisib can be increased when it is combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Alpelisib can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The serum concentration of Alpelisib can be increased when it is combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Alpelisib.
Armodafinil Armodafinil The metabolism of Alpelisib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Alpelisib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Alpelisib.
Nilotinib Nilotinib The serum concentration of Alpelisib can be increased when it is combined with Nilotinib.
Bexarotene Bexarotene The serum concentration of Bexarotene can be decreased when it is combined with Alpelisib.
Budesonide Budesonide The metabolism of Alpelisib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Alpelisib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The serum concentration of Etravirine can be decreased when it is combined with Alpelisib.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Alpelisib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Alpelisib can be decreased when combined with Desvenlafaxine.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Alpelisib.
Tretinoin Tretinoin The serum concentration of Tretinoin can be decreased when it is combined with Alpelisib.
Pilocarpine Pilocarpine The metabolism of Alpelisib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Alpelisib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Alpelisib.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Alpelisib.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Alpelisib.
Mitotane Mitotane The serum concentration of Alpelisib can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The metabolism of Alpelisib can be increased when combined with Rufinamide.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Alpelisib.
Eltrombopag Eltrombopag The serum concentration of Alpelisib can be increased when it is combined with Eltrombopag.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Alpelisib.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Alpelisib.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Alpelisib.
Prasugrel Prasugrel The serum concentration of Prasugrel can be decreased when it is combined with Alpelisib.
Lacosamide Lacosamide The serum concentration of Lacosamide can be decreased when it is combined with Alpelisib.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Alpelisib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Alpelisib.
Dronedarone Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Alpelisib.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Alpelisib.
Tapentadol Tapentadol The serum concentration of Tapentadol can be decreased when it is combined with Alpelisib.
Topotecan Topotecan The metabolism of Alpelisib can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Alpelisib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Alpelisib can be decreased when combined with Pazopanib.
Pitavastatin Pitavastatin The serum concentration of Pitavastatin can be decreased when it is combined with Alpelisib.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Alpelisib.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Alpelisib.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Alpelisib.
Tocilizumab Injection Tocilizumab Injection The metabolism of Alpelisib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Alpelisib can be increased when it is combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Alpelisib can be increased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Alpelisib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Alpelisib can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Alpelisib.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Alpelisib.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Alpelisib.
Rilpivirine Rilpivirine The serum concentration of Alpelisib can be increased when it is combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Alpelisib can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The serum concentration of Cyclophosphamide can be decreased when it is combined with Alpelisib.
Ticagrelor Ticagrelor The metabolism of Alpelisib can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Alpelisib can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Alpelisib.
Vandetanib Vandetanib The serum concentration of Alpelisib can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Alpelisib can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Alpelisib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The serum concentration of Alpelisib can be increased when it is combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Alpelisib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Alpelisib.
Crizotinib Crizotinib The metabolism of Alpelisib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Alpelisib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Alpelisib can be decreased when combined with Naloxone.
Enzalutamide Enzalutamide The serum concentration of Alpelisib can be decreased when it is combined with Enzalutamide.
Regorafenib Regorafenib The serum concentration of Alpelisib can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Alpelisib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Alpelisib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The serum concentration of Alpelisib can be increased when it is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The serum concentration of Cabozantinib can be decreased when it is combined with Alpelisib.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Alpelisib.
Ponatinib Ponatinib The serum concentration of Alpelisib can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Alpelisib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Alpelisib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The serum concentration of Apixaban can be decreased when it is combined with Alpelisib.
Dabrafenib Dabrafenib The serum concentration of Alpelisib can be increased when it is combined with Dabrafenib.
Ospemifene Ospemifene The serum concentration of Ospemifene can be decreased when it is combined with Alpelisib.
Trametinib Trametinib The metabolism of Alpelisib can be increased when combined with Trametinib.
Afatinib Afatinib The serum concentration of Alpelisib can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Alpelisib.
Vortioxetine Vortioxetine The serum concentration of Vortioxetine can be decreased when it is combined with Alpelisib.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Alpelisib.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Alpelisib.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Alpelisib.
Ketorolac Injection Ketorolac Injection The serum concentration of Ketorolac can be decreased when it is combined with Alpelisib.
Simeprevir Simeprevir The serum concentration of Alpelisib can be increased when it is combined with Simeprevir.
Dapagliflozin Dapagliflozin The serum concentration of Dapagliflozin can be decreased when it is combined with Alpelisib.
Apremilast Apremilast The metabolism of Alpelisib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Alpelisib.
Siltuximab Injection Siltuximab Injection The metabolism of Alpelisib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Alpelisib can be increased when combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Alpelisib.
Testosterone Injection Testosterone Injection The serum concentration of Testosterone can be decreased when it is combined with Alpelisib.
Oritavancin Injection Oritavancin Injection The metabolism of Alpelisib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Alpelisib.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be increased when combined with Alpelisib.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Alpelisib.
Olaparib Olaparib The serum concentration of Alpelisib can be increased when it is combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Alpelisib.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Alpelisib.
Lanreotide Injection Lanreotide Injection The metabolism of Alpelisib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Alpelisib.
Secukinumab Injection Secukinumab Injection The metabolism of Alpelisib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The serum concentration of Alpelisib can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Alpelisib can be increased when combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Alpelisib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Alpelisib.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Alpelisib can be increased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Alpelisib.
Rolapitant Rolapitant The serum concentration of Alpelisib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Alpelisib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Alpelisib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Alpelisib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Alpelisib.
Trabectedin Injection Trabectedin Injection The serum concentration of Trabectedin can be decreased when it is combined with Alpelisib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Alpelisib.
Alectinib Alectinib The serum concentration of Alpelisib can be increased when it is combined with Alectinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Alpelisib.
Rifapentine Rifapentine The metabolism of Alpelisib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The serum concentration of Lesinurad can be decreased when it is combined with Alpelisib.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Alpelisib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Alpelisib can be decreased when it is combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The serum concentration of Brivaracetam can be decreased when it is combined with Alpelisib.
Venetoclax Venetoclax The serum concentration of Alpelisib can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Alpelisib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Alpelisib.
Diphenhydramine Injection Diphenhydramine Injection The serum concentration of Diphenhydramine can be decreased when it is combined with Alpelisib.
Rucaparib Rucaparib The serum concentration of Alpelisib can be increased when it is combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Alpelisib can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The serum concentration of Alpelisib can be increased when it is combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The serum concentration of Doxepin can be decreased when it is combined with Alpelisib.
Deflazacort Deflazacort The metabolism of Alpelisib can be increased when combined with Deflazacort.
Safinamide Safinamide The serum concentration of Alpelisib can be increased when it is combined with Safinamide.
Sarilumab Injection Sarilumab Injection The metabolism of Alpelisib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Alpelisib can be decreased when it is combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Alpelisib.
Enasidenib Enasidenib The serum concentration of Alpelisib can be increased when it is combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Alpelisib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Alpelisib.
Abemaciclib Abemaciclib The serum concentration of Alpelisib can be increased when it is combined with Abemaciclib.
Acalabrutinib Acalabrutinib The metabolism of Alpelisib can be increased when combined with Acalabrutinib.
Letermovir Letermovir The serum concentration of Alpelisib can be increased when it is combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The serum concentration of Alpelisib can be increased when it is combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Alpelisib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The serum concentration of Alpelisib can be increased when it is combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Alpelisib can be increased when it is combined with Avatrombopag.
Baricitinib Baricitinib The serum concentration of Alpelisib can be increased when it is combined with Baricitinib.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Alpelisib.
Ivosidenib Ivosidenib The metabolism of Alpelisib can be increased when combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Alpelisib.
Cannabidiol Cannabidiol The serum concentration of Alpelisib can be increased when it is combined with Cannabidiol.
Dacomitinib Dacomitinib The serum concentration of Alpelisib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Alpelisib.
Stiripentol Stiripentol The metabolism of Alpelisib can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The serum concentration of Alpelisib can be increased when it is combined with Gilteritinib.
Glasdegib Glasdegib The serum concentration of Alpelisib can be increased when it is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Alpelisib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Alpelisib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Alpelisib.
Rifamycin Rifamycin The serum concentration of Alpelisib can be decreased when it is combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Alpelisib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Alpelisib can be increased when combined with Emapalumab.
Siponimod Siponimod The therapeutic efficacy of Siponimod can be decreased when used in combination with Alpelisib.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Alpelisib.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Alpelisib.
Darolutamide Darolutamide The serum concentration of Alpelisib can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The serum concentration of Triclabendazole can be decreased when it is combined with Alpelisib.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Alpelisib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Alpelisib.
Istradefylline Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Alpelisib.
Pitolisant Pitolisant The serum concentration of Alpelisib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Alpelisib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Alpelisib.
Phenytoin Injection Phenytoin Injection The serum concentration of Alpelisib can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Alpelisib can be decreased when it is combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Alpelisib.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Alpelisib.
Avapritinib Avapritinib The serum concentration of Avapritinib can be decreased when it is combined with Alpelisib.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Alpelisib.
Lasmiditan Lasmiditan The serum concentration of Alpelisib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Alpelisib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Alpelisib.
Cenobamate Cenobamate The serum concentration of Alpelisib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Alpelisib.
Selumetinib Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Alpelisib.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Alpelisib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Alpelisib.
Ripretinib Ripretinib The serum concentration of Alpelisib can be increased when it is combined with Ripretinib.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Alpelisib.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Alpelisib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Alpelisib.
Fostemsavir Fostemsavir The serum concentration of Alpelisib can be increased when it is combined with Fostemsavir.
Octreotide Octreotide The serum concentration of Alpelisib can be increased when it is combined with Octreotide.
Pralsetinib Pralsetinib The serum concentration of Alpelisib can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Alpelisib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Alpelisib.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Alpelisib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Alpelisib.
Indomethacin Indomethacin The serum concentration of Indomethacin can be decreased when it is combined with Alpelisib.
Mefenamic Acid Mefenamic Acid The serum concentration of Mefenamic acid can be decreased when it is combined with Alpelisib.
Naproxen Naproxen The serum concentration of Naproxen can be decreased when it is combined with Alpelisib.
Phenobarbital Phenobarbital The serum concentration of Alpelisib can be decreased when it is combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Alpelisib.
Primidone Primidone The serum concentration of Alpelisib can be decreased when it is combined with Primidone.
Methsuximide Methsuximide The metabolism of Methsuximide can be decreased when combined with Alpelisib.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Alpelisib.
Diazepam Diazepam The serum concentration of Diazepam can be decreased when it is combined with Alpelisib.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Alpelisib.
Bromocriptine Bromocriptine The metabolism of Alpelisib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Alpelisib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Alpelisib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Alpelisib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Alpelisib.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Alpelisib.
Dapsone Dapsone The serum concentration of Dapsone can be decreased when it is combined with Alpelisib.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Alpelisib.
Methadone Methadone The serum concentration of Methadone can be decreased when it is combined with Alpelisib.
Oxybutynin Oxybutynin The metabolism of Alpelisib can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The serum concentration of Ibuprofen can be decreased when it is combined with Alpelisib.
Orphenadrine Orphenadrine The metabolism of Alpelisib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Alpelisib.
Sulfasalazine Sulfasalazine The serum concentration of Alpelisib can be increased when it is combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Alpelisib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Alpelisib can be increased when combined with Doxorubicin.
Carbamazepine Carbamazepine The serum concentration of Alpelisib can be decreased when it is combined with Carbamazepine.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Alpelisib.
Hydralazine Hydralazine The metabolism of Alpelisib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Alpelisib can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be decreased when it is combined with Alpelisib.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Alpelisib.
Loperamide Loperamide The metabolism of Alpelisib can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Promethazine can be increased when combined with Alpelisib.
Daunorubicin Daunorubicin The metabolism of Alpelisib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Alpelisib can be increased when combined with Griseofulvin.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Alpelisib.
Quinine Quinine The serum concentration of Quinine can be decreased when it is combined with Alpelisib.
Calcitriol Calcitriol The metabolism of Alpelisib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Sulfinpyrazone can be increased when combined with Alpelisib.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Alpelisib.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Alpelisib.
Secobarbital Secobarbital The metabolism of Alpelisib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Alpelisib.
Amitriptyline Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Alpelisib.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Alpelisib.
Probenecid Probenecid The metabolism of Alpelisib can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be increased when combined with Alpelisib.
Isoniazid Isoniazid The metabolism of Alpelisib can be decreased when combined with Isoniazid.
Rifampin Rifampin The serum concentration of Alpelisib can be decreased when it is combined with Rifampicin.
Valproic Acid Valproic Acid The serum concentration of Valproic acid can be decreased when it is combined with Alpelisib.
Tamoxifen Tamoxifen The serum concentration of Tamoxifen can be decreased when it is combined with Alpelisib.
Methimazole Methimazole The metabolism of Alpelisib can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The serum concentration of Chlorpropamide can be decreased when it is combined with Alpelisib.
Tolbutamide Tolbutamide The serum concentration of Tolbutamide can be decreased when it is combined with Alpelisib.
Tolazamide Tolazamide The serum concentration of Tolazamide can be decreased when it is combined with Alpelisib.
Dextromethorphan Dextromethorphan The serum concentration of Dextromethorphan can be decreased when it is combined with Alpelisib.
Niacin Niacin The metabolism of Alpelisib can be decreased when combined with Niacin.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be increased when combined with Alpelisib.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Alpelisib.
Danazol Danazol The metabolism of Alpelisib can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Alpelisib.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Alpelisib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Alpelisib can be decreased when combined with Amphotericin B.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Alpelisib.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Alpelisib.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Alpelisib.
Acetazolamide Acetazolamide The metabolism of Alpelisib can be decreased when combined with Acetazolamide.
Ketoconazole Ketoconazole The metabolism of Alpelisib can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Alpelisib.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Alpelisib.
Vinblastine Vinblastine The metabolism of Alpelisib can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Alpelisib.
Aspirin Aspirin The serum concentration of Acetylsalicylic acid can be decreased when it is combined with Alpelisib.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Alpelisib.
Trimethoprim Trimethoprim The serum concentration of Trimethoprim can be decreased when it is combined with Alpelisib.
Diltiazem Diltiazem The serum concentration of Diltiazem can be decreased when it is combined with Alpelisib.
Nifedipine Nifedipine The metabolism of Alpelisib can be increased when combined with Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Alpelisib.
Verapamil Verapamil The serum concentration of Alpelisib can be decreased when it is combined with Verapamil.
Piroxicam Piroxicam The serum concentration of Piroxicam can be decreased when it is combined with Alpelisib.
Etoposide Etoposide The metabolism of Alpelisib can be increased when combined with Etoposide.
Glyburide Glyburide The serum concentration of Glyburide can be decreased when it is combined with Alpelisib.
Glipizide Glipizide The serum concentration of Glipizide can be decreased when it is combined with Alpelisib.
Dicloxacillin Dicloxacillin The metabolism of Alpelisib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Alpelisib can be increased when combined with Nafcillin.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Alpelisib.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Alpelisib.
Flurbiprofen Flurbiprofen The serum concentration of Flurbiprofen can be decreased when it is combined with Alpelisib.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Alpelisib.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Alpelisib.
Ciprofloxacin Ciprofloxacin The metabolism of Alpelisib can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The serum concentration of Diclofenac can be decreased when it is combined with Alpelisib.
Fluoxetine Fluoxetine The serum concentration of Fluoxetine can be decreased when it is combined with Alpelisib.
Clozapine Clozapine The serum concentration of Clozapine can be decreased when it is combined with Alpelisib.
Idarubicin Idarubicin The serum concentration of Idarubicin can be decreased when it is combined with Alpelisib.
Clarithromycin Clarithromycin The metabolism of Alpelisib can be decreased when combined with Clarithromycin.
Etodolac Etodolac The serum concentration of Etodolac can be decreased when it is combined with Alpelisib.
Felodipine Felodipine The metabolism of Alpelisib can be decreased when combined with Felodipine.
Nabumetone Nabumetone The serum concentration of Nabumetone can be decreased when it is combined with Alpelisib.
Pravastatin Pravastatin The serum concentration of Alpelisib can be increased when it is combined with Pravastatin.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Alpelisib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Alpelisib.
Teniposide Injection Teniposide Injection The metabolism of Alpelisib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Alpelisib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Alpelisib can be increased when combined with Rifabutin.
Zolpidem Zolpidem The serum concentration of Zolpidem can be decreased when it is combined with Alpelisib.
Doxazosin Doxazosin The serum concentration of Doxazosin can be decreased when it is combined with Alpelisib.
Isradipine Isradipine The metabolism of Alpelisib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The serum concentration of Alpelisib can be increased when it is combined with Omeprazole.
Cisapride Cisapride The metabolism of Alpelisib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The serum concentration of Fluvastatin can be decreased when it is combined with Alpelisib.
Venlafaxine Venlafaxine The serum concentration of Venlafaxine can be decreased when it is combined with Alpelisib.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Alpelisib.
Fluvoxamine Fluvoxamine The metabolism of Alpelisib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Alpelisib can be decreased when combined with Nefazodone.
Losartan Losartan The serum concentration of Losartan can be decreased when it is combined with Alpelisib.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Alpelisib.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Alpelisib.
Lansoprazole Lansoprazole The serum concentration of Alpelisib can be increased when it is combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Alpelisib.
Nicardipine Nicardipine The metabolism of Nicardipine can be decreased when combined with Alpelisib.
Bupropion Bupropion The serum concentration of Bupropion can be decreased when it is combined with Alpelisib.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Alpelisib.
Saquinavir Saquinavir The serum concentration of Alpelisib can be increased when it is combined with Saquinavir.
Glimepiride Glimepiride The serum concentration of Glimepiride can be decreased when it is combined with Alpelisib.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Alpelisib.
Ritonavir Ritonavir The serum concentration of Alpelisib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Alpelisib can be increased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Alpelisib.
Zafirlukast Zafirlukast The serum concentration of Zafirlukast can be decreased when it is combined with Alpelisib.
Mirtazapine Mirtazapine The metabolism of Alpelisib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Alpelisib can be increased when combined with Topiramate.
Zileuton Zileuton The serum concentration of Zileuton can be decreased when it is combined with Alpelisib.
Valsartan Valsartan The serum concentration of Valsartan can be decreased when it is combined with Alpelisib.
Donepezil Donepezil The serum concentration of Donepezil can be decreased when it is combined with Alpelisib.
Nelfinavir Nelfinavir The serum concentration of Alpelisib can be increased when it is combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Alpelisib.
Carvedilol Carvedilol The serum concentration of Carvedilol can be decreased when it is combined with Alpelisib.
Selegiline Selegiline The serum concentration of Selegiline can be decreased when it is combined with Alpelisib.
Bicalutamide Bicalutamide The metabolism of Alpelisib can be decreased when combined with Bicalutamide.
Sertraline Sertraline The serum concentration of Sertraline can be decreased when it is combined with Alpelisib.
Raloxifene Raloxifene The metabolism of Alpelisib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The serum concentration of Irbesartan can be decreased when it is combined with Alpelisib.
Paroxetine Paroxetine The metabolism of Alpelisib can be decreased when combined with Paroxetine.
Citalopram Citalopram Alpelisib may increase the QTc-prolonging activities of Citalopram.
Capecitabine Capecitabine The metabolism of Capecitabine can be increased when combined with Alpelisib.
Efavirenz Efavirenz The metabolism of Alpelisib can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be decreased when it is combined with Alpelisib.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Alpelisib.
Celecoxib Celecoxib The serum concentration of Celecoxib can be decreased when it is combined with Alpelisib.
Rosiglitazone Rosiglitazone The serum concentration of Rosiglitazone can be decreased when it is combined with Alpelisib.
Tolterodine Tolterodine The serum concentration of Tolterodine can be decreased when it is combined with Alpelisib.
Thalidomide Thalidomide The serum concentration of Thalidomide can be decreased when it is combined with Alpelisib.
Nateglinide Nateglinide The serum concentration of Nateglinide can be decreased when it is combined with Alpelisib.
Rabeprazole Rabeprazole The serum concentration of Alpelisib can be increased when it is combined with Rabeprazole.
Terbinafine Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Alpelisib.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists