Ivosidenib

Generic name: Pronounced as (eye"voe sid' e nib)
Brand names
  • Tibsovo®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2021

Ivosidenib may cause a serious or life-threatening group of symptoms called differentiation syndrome. Your doctor will monitor you carefully to see whether you are developing this syndrome. If you experience any of the following symptoms, call your doctor immediately: fever, cough, rash, sudden weight gain, decreased urination, swelling of arms or legs, dizziness or lightheadedness, shortness of breath, or difficulty breathing. These symptoms may occur up to 3 months after starting treatment with ivosidenib. At the first sign that you are developing differentiation syndrome, your doctor will prescribe medications to treat the syndrome, and may tell you to stop taking ivosidenib for some time.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to ivosidenib.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ivosidenib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

Ivosidenib is used to treat a certain type of acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells) that has returned or that has not improved after previous treatment(s). Ivosidenib is also used to treat a certain type of AML in some adults older than 75 years of age as a first treatment. Ivosidenib is also used in adults who have already received previous treatment(s) to treat a certain type of cholangiocarcinoma (bile duct cancer) that has spread to nearby tissues or other parts of the body. Ivosidenib is in a class of medications called IDH1 inhibitors. It works by slowing or stopping the growth of cancer cells.

Ivosidenib comes as a tablet to take by mouth. It is usually taken with or without food once daily. Do not take it with a high fat meal (such as fried foods or fast food). Take ivosidenib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ivosidenib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

If you vomit after taking ivosidenib, do not take another dose. Continue your regular dosing schedule.

Your doctor may reduce your dose or temporarily or permanently stop your treatment with ivosidenib depending on your response to treatment or any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ivosidenib,

  • tell your doctor and pharmacist if you are allergic to ivosidenib, any other medications, or any of the ingredients in ivosidenib tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone), ciprofloxacin (Cipro), disopyramide (Norpace), dofetilide (Tikosyn), fluconazole (Diflucan), gemifloxacin (Factive), granisetron (Sancuso, Sustol), hormonal contraceptives (birth control pills, patches, rings, implants, or injections), itraconazole (Sporanox, Tolsura), ketoconazole, levofloxacin, moxifloxacin, ofloxacin, ondansetron (Zofran), palonosetron (in Akynzeo), posaconazole (Noxafil), procainamide, quinidine (in Nuedexta), rifampin (Rifadin, Rimactane), sotalol (Betapace, Sorine, Sotylize), and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with ivosidenib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death); if you have or have ever had a slow or irregular heartbeat, heart failure, or other heart problems; low blood levels of sodium, potassium, or magnesium; nervous system problems; liver disease, including cirrhosis; or if you are receiving dialysis treatments or if you have or ever had kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant, or are breastfeeding. You should know that ivosidenib may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections) while you are taking this medication. Talk to your doctor about using another form of birth control. If you become pregnant while taking ivosidenib, call your doctor immediately. Ivosidenib may cause fetal harm.

  • tell your doctor if are breastfeeding. Do not breastfeed during your treatment with ivosidenib and for 1 month after your final dose.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

Make sure you drink plenty of water or other fluids every day while you are taking ivosidenib.

If your next dose is due in 12 hours or more, take the missed dose as soon as you remember it. However, if the next dose will be taken in less than 12 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Ivosidenib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • fatigue

    • joint or muscle pain

    • diarrhea

    • constipation

    • vomiting

    • nausea

    • loss of appetite

    • mouth pain and ulcers

    • stomach pain

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

    • dizziness, lightheadedness, or fainting

    • weakness or tingling sensation in legs, arms, or upper body; numbness and pain on one side or both sides of the body; changes in your ability to see, touch, hear, or taste; burning or prickling sensation; or difficulty breathing

    • chest pain

  • Ivosidenib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with ivosidenib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Ivosidenib.
Delavirdine Delavirdine The metabolism of Ivosidenib can be decreased when combined with Delavirdine.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Ivosidenib.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Ivosidenib.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Anagrelide.
Cilostazol Cilostazol The risk or severity of QTc prolongation can be increased when Cilostazol is combined with Ivosidenib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Ivosidenib can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Conjugated estrogens can be decreased when combined with Ivosidenib.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Ivosidenib.
Methylergonovine Methylergonovine The metabolism of Ivosidenib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Ivosidenib.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Acebutolol is combined with Ivosidenib.
Ranitidine Ranitidine The excretion of Ranitidine can be decreased when combined with Ivosidenib.
Reserpine Reserpine The serum concentration of Ivosidenib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The metabolism of Ivosidenib can be increased when combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Ivosidenib.
Triamcinolone Triamcinolone The metabolism of Ivosidenib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Ivosidenib can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Ivosidenib.
Fluconazole Injection Fluconazole Injection The metabolism of Ivosidenib can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Ivosidenib.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Ivosidenib.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Ivosidenib.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Ivosidenib can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Metoclopramide is combined with Ivosidenib.
Metronidazole Injection Metronidazole Injection The metabolism of Ivosidenib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Ivosidenib.
Zidovudine Injection Zidovudine Injection The excretion of Zidovudine can be decreased when combined with Ivosidenib.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Ivosidenib.
Ondansetron Ondansetron The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Ivosidenib.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Ivosidenib.
Olanzapine Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Ivosidenib.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Ivosidenib.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Ivosidenib.
Orlistat Orlistat The metabolism of Ivosidenib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Ivosidenib can be increased when combined with Oxcarbazepine.
Anakinra Anakinra The metabolism of Ivosidenib can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Ivosidenib.
Trimipramine Trimipramine The serum concentration of Ivosidenib can be increased when it is combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Ivosidenib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Ivosidenib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Ivosidenib.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Ivosidenib.
Epinephrine Injection Epinephrine Injection The metabolism of Ivosidenib can be decreased when combined with Epinephrine.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Escitalopram.
Zonisamide Zonisamide The serum concentration of Ivosidenib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Ivosidenib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Ivosidenib.
Atomoxetine Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Ivosidenib.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Ivosidenib.
Mefloquine Mefloquine The metabolism of Ivosidenib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Ivosidenib.
Vardenafil Vardenafil The serum concentration of Ivosidenib can be increased when it is combined with Vardenafil.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Ivosidenib.
Aprepitant Aprepitant The metabolism of Ivosidenib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Ivosidenib.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Ivosidenib.
Progesterone Progesterone The metabolism of Progesterone can be increased when combined with Ivosidenib.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Ivosidenib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Ivosidenib.
Infliximab Injection Infliximab Injection The metabolism of Ivosidenib can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Ivosidenib.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Ivosidenib.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Ivosidenib.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Ivosidenib.
Bosentan Bosentan The metabolism of Ivosidenib can be increased when combined with Bosentan.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Ivosidenib.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Ivosidenib.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Ivosidenib.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Ivosidenib.
Voriconazole Voriconazole The metabolism of Ivosidenib can be decreased when combined with Voriconazole.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Ivosidenib.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Ivosidenib.
Deferasirox Deferasirox The metabolism of Ivosidenib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Ivosidenib can be decreased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Ivosidenib can be increased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Ivosidenib can be increased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Ivosidenib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Ivosidenib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Ivosidenib.
Gefitinib Gefitinib The metabolism of Ivosidenib can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Ivosidenib.
Paliperidone Paliperidone The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Ivosidenib can be increased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The excretion of Clofarabine can be decreased when combined with Ivosidenib.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Ivosidenib.
Posaconazole Posaconazole The metabolism of Ivosidenib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Ivosidenib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Ivosidenib can be increased when it is combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection The excretion of Pemetrexed can be decreased when combined with Ivosidenib.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Ivosidenib.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Ivosidenib.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Ivosidenib.
Sorafenib Sorafenib The metabolism of Ivosidenib can be increased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Ivosidenib can be increased when combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Ivosidenib can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Ivosidenib.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Ivosidenib.
Armodafinil Armodafinil The metabolism of Ivosidenib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Ivosidenib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Ivosidenib.
Nilotinib Nilotinib The metabolism of Nilotinib can be increased when combined with Ivosidenib.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Ivosidenib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Ivosidenib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Ivosidenib can be decreased when combined with Chloramphenicol.
Doripenem Injection Doripenem Injection The excretion of Doripenem can be decreased when combined with Ivosidenib.
Etravirine Etravirine The metabolism of Ivosidenib can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Ivosidenib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Ivosidenib can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Ivosidenib.
Leucovorin Injection Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Ivosidenib.
Pilocarpine Pilocarpine The metabolism of Ivosidenib can be decreased when combined with Pilocarpine.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Flecainide is combined with Ivosidenib.
Certolizumab Injection Certolizumab Injection The metabolism of Ivosidenib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Ivosidenib.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Ivosidenib.
Mitotane Mitotane The metabolism of Ivosidenib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Ivosidenib.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Ivosidenib.
Midazolam Midazolam The metabolism of Ivosidenib can be decreased when combined with Midazolam.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Ivosidenib.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Ivosidenib.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Ivosidenib.
Iloperidone Iloperidone The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Iloperidone.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Ivosidenib.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Ivosidenib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Ivosidenib.
Dronedarone Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Ivosidenib.
Saxagliptin Saxagliptin The excretion of Saxagliptin can be decreased when combined with Ivosidenib.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Telavancin is combined with Ivosidenib.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Ivosidenib.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Ivosidenib.
Golimumab Injection Golimumab Injection The metabolism of Ivosidenib can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Ivosidenib.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Asenapine.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Ivosidenib.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Ivosidenib.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Ivosidenib.
Tocilizumab Injection Tocilizumab Injection The metabolism of Ivosidenib can be increased when combined with Tocilizumab.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Ivosidenib.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Ivosidenib can be increased when it is combined with Cabazitaxel.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Ivosidenib.
Acetaminophen Injection Acetaminophen Injection The metabolism of Ivosidenib can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Ivosidenib can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Ivosidenib.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Ivosidenib.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Ivosidenib.
Linagliptin Linagliptin The metabolism of Ivosidenib can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Ivosidenib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Ivosidenib can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Ivosidenib can be increased when combined with Cyclophosphamide.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Ivosidenib.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Ivosidenib.
Ticagrelor Ticagrelor The metabolism of Ivosidenib can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Ivosidenib.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Ivosidenib.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Ivosidenib.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Ivosidenib.
Vemurafenib Vemurafenib The serum concentration of Ivosidenib can be increased when it is combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Ivosidenib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Ivosidenib.
Crizotinib Crizotinib The metabolism of Ivosidenib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Ivosidenib.
Naloxone Injection Naloxone Injection The metabolism of Ivosidenib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Ivosidenib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Ivosidenib.
Enzalutamide Enzalutamide The metabolism of Ivosidenib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Ivosidenib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Ivosidenib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Ivosidenib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Ivosidenib can be increased when combined with Corticotropin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Ivosidenib.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Bedaquiline is combined with Ivosidenib.
Ponatinib Ponatinib The metabolism of Ivosidenib can be increased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Ivosidenib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Ivosidenib.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Ivosidenib.
Canagliflozin Canagliflozin The serum concentration of Ivosidenib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Ivosidenib.
Trametinib Trametinib The metabolism of Ivosidenib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Ivosidenib.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Ivosidenib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Ivosidenib.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Ivosidenib.
Lomitapide Lomitapide The metabolism of Ivosidenib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Ivosidenib can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Ivosidenib.
Apremilast Apremilast The metabolism of Ivosidenib can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Ivosidenib.
Siltuximab Injection Siltuximab Injection The metabolism of Ivosidenib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Ivosidenib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Ivosidenib.
Idelalisib Idelalisib The metabolism of Ivosidenib can be increased when combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Ivosidenib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Ivosidenib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Ivosidenib can be decreased when combined with Vorapaxar.
Suvorexant Suvorexant The metabolism of Ivosidenib can be decreased when combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Ivosidenib.
Olaparib Olaparib The metabolism of Ivosidenib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Ivosidenib.
Lanreotide Injection Lanreotide Injection The metabolism of Ivosidenib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Ivosidenib.
Secukinumab Injection Secukinumab Injection The metabolism of Ivosidenib can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of QTc prolongation can be increased when Risperidone is combined with Ivosidenib.
Palbociclib Palbociclib The metabolism of Ivosidenib can be increased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Ivosidenib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Ivosidenib.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Ivosidenib.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Haloperidol.
Ivabradine Ivabradine Ivabradine may increase the QTc-prolonging activities of Ivosidenib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Ivosidenib can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Ivosidenib.
Flibanserin Flibanserin The serum concentration of Ivosidenib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Ivosidenib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Ivosidenib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Ivosidenib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Ziprasidone.
Eluxadoline Eluxadoline The excretion of Eluxadoline can be decreased when combined with Ivosidenib.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Ivosidenib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Ivosidenib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Ivosidenib.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Ivosidenib.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Ivosidenib.
Rifapentine Rifapentine The metabolism of Ivosidenib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Ivosidenib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Ivosidenib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Dexamethasone can be increased when combined with Ivosidenib.
Venetoclax Venetoclax The metabolism of Ivosidenib can be increased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Ivosidenib can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Ivosidenib.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Ivosidenib.
Rucaparib Rucaparib The metabolism of Ivosidenib can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Ivosidenib.
Brigatinib Brigatinib The metabolism of Ivosidenib can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ivosidenib.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Deutetrabenazine.
Deflazacort Deflazacort The metabolism of Ivosidenib can be increased when combined with Deflazacort.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Ivosidenib.
Sarilumab Injection Sarilumab Injection The metabolism of Ivosidenib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Ivosidenib can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Ivosidenib can be increased when combined with Neratinib.
Enasidenib Enasidenib The metabolism of Ivosidenib can be increased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Ivosidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Ivosidenib.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Ivosidenib.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Ivosidenib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Ivosidenib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Ivosidenib.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Ivosidenib.
Letermovir Letermovir The metabolism of Ivosidenib can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Ivosidenib.
Buprenorphine Injection Buprenorphine Injection The metabolism of Ivosidenib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Ivosidenib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Ivosidenib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Ivosidenib.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Ivosidenib.
Lofexidine Lofexidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Ivosidenib.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Encorafenib is combined with Ivosidenib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Ivosidenib can be increased when it is combined with Lusutrombopag.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Ivosidenib.
Dacomitinib Dacomitinib The serum concentration of Ivosidenib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Ivosidenib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Ivosidenib.
Sarecycline Sarecycline The serum concentration of Ivosidenib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Ivosidenib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Ivosidenib.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Ivosidenib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Ivosidenib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Ivosidenib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Ivosidenib.
Rifamycin Rifamycin The metabolism of Ivosidenib can be increased when combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Ivosidenib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Ivosidenib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Ivosidenib.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Ivosidenib.
Erdafitinib Erdafitinib The serum concentration of Ivosidenib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Ivosidenib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Ivosidenib.
Triclabendazole Triclabendazole The metabolism of Ivosidenib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Ivosidenib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Ivosidenib.
Istradefylline Istradefylline The serum concentration of Ivosidenib can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Ivosidenib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Ivosidenib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin Ivosidenib may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Ivosidenib.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Ivosidenib.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Ivosidenib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Ivosidenib.
Voxelotor Voxelotor The serum concentration of Ivosidenib can be increased when it is combined with Voxelotor.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Ivosidenib.
Lasmiditan Lasmiditan The serum concentration of Ivosidenib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Ivosidenib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Ivosidenib.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Ivosidenib.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Ivosidenib.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Ivosidenib.
Tucatinib Tucatinib Ivosidenib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Ivosidenib.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Ivosidenib.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Ivosidenib.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Ivosidenib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Ivosidenib.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Ivosidenib.
Octreotide Octreotide The serum concentration of Ivosidenib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Ivosidenib.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Ivosidenib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Ivosidenib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Ivosidenib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Ivosidenib.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Ivosidenib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Ivosidenib.
Indomethacin Indomethacin The excretion of Indomethacin can be decreased when combined with Ivosidenib.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Ivosidenib.
Phenobarbital Phenobarbital The metabolism of Ivosidenib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Ivosidenib.
Primidone Primidone The metabolism of Ivosidenib can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Ivosidenib.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Ivosidenib.
Diazepam Diazepam The metabolism of Ivosidenib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Ivosidenib.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Ivosidenib.
Bromocriptine Bromocriptine The metabolism of Ivosidenib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Ivosidenib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Ivosidenib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Tetracycline can be decreased when combined with Ivosidenib.
Prochlorperazine Prochlorperazine The metabolism of Ivosidenib can be decreased when combined with Prochlorperazine.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Thioridazine.
Methadone Methadone The metabolism of Ivosidenib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Ivosidenib can be decreased when combined with Oxybutynin.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Ivosidenib.
Maprotiline Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Ivosidenib.
Orphenadrine Orphenadrine The metabolism of Ivosidenib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Ivosidenib.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Ivosidenib.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Ivosidenib.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Ivosidenib.
Dactinomycin Dactinomycin The serum concentration of Ivosidenib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Ivosidenib.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Ivosidenib.
Hydralazine Hydralazine The metabolism of Ivosidenib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Ivosidenib.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Ivosidenib.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Ivosidenib.
Loperamide Loperamide The metabolism of Ivosidenib can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of QTc prolongation can be increased when Promethazine is combined with Ivosidenib.
Daunorubicin Daunorubicin The metabolism of Ivosidenib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Ivosidenib can be increased when combined with Griseofulvin.
Digoxin Digoxin Ivosidenib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The serum concentration of Ivosidenib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Ivosidenib.
Quinine Quinine The metabolism of Quinine can be increased when combined with Ivosidenib.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Ivosidenib.
Calcitriol Calcitriol The metabolism of Ivosidenib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Ivosidenib can be increased when combined with Sulfinpyrazone.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Ivosidenib.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Ivosidenib.
Secobarbital Secobarbital The metabolism of Ivosidenib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Ivosidenib can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Ivosidenib.
Imipramine Imipramine The serum concentration of Ivosidenib can be increased when it is combined with Imipramine.
Probenecid Probenecid The metabolism of Ivosidenib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Ivosidenib.
Procainamide Procainamide The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Procainamide.
Isoniazid Isoniazid The metabolism of Ivosidenib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Ivosidenib can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Disopyramide.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Ivosidenib.
Tamoxifen Tamoxifen The metabolism of Ivosidenib can be increased when combined with Tamoxifen.
Methimazole Methimazole The metabolism of Ivosidenib can be decreased when combined with Methimazole.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Ivosidenib.
Niacin Niacin The metabolism of Ivosidenib can be decreased when combined with Niacin.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Ivosidenib.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Ivosidenib.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of QTc prolongation can be increased when Chlorpheniramine is combined with Ivosidenib.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Ivosidenib.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ivosidenib.
Danazol Danazol The metabolism of Ivosidenib can be decreased when combined with Danazol.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Ivosidenib.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Propranolol is combined with Ivosidenib.
Nortriptyline Nortriptyline The serum concentration of Ivosidenib can be increased when it is combined with Nortriptyline.
Amphotericin B Injection Amphotericin B Injection The metabolism of Ivosidenib can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Ivosidenib.
Allopurinol Allopurinol The excretion of Allopurinol can be decreased when combined with Ivosidenib.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Ivosidenib.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Ivosidenib.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Ivosidenib.
Fluorouracil Injection Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Fluorouracil is combined with Ivosidenib.
Colchicine Colchicine The serum concentration of Colchicine can be increased when it is combined with Ivosidenib.
Cefaclor Cefaclor The excretion of Cefaclor can be decreased when combined with Ivosidenib.
Cefazolin Injection Cefazolin Injection The excretion of Cefazolin can be decreased when combined with Ivosidenib.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Ivosidenib.
Acetazolamide Acetazolamide The metabolism of Ivosidenib can be decreased when combined with Acetazolamide.
Ketoconazole Ketoconazole The metabolism of Ivosidenib can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Ivosidenib.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Ivosidenib.
Captopril Captopril The excretion of Captopril can be decreased when combined with Ivosidenib.
Vinblastine Vinblastine The metabolism of Ivosidenib can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Ivosidenib.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Ivosidenib.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Ivosidenib.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Ivosidenib.
Diltiazem Diltiazem The metabolism of Ivosidenib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Ivosidenib can be increased when combined with Nifedipine.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Ivosidenib.
Verapamil Verapamil The metabolism of Ivosidenib can be decreased when combined with Verapamil.
Bumetanide Bumetanide The excretion of Bumetanide can be decreased when combined with Ivosidenib.
Etoposide Etoposide The serum concentration of Ivosidenib can be increased when it is combined with Etoposide.
Glyburide Glyburide The metabolism of Ivosidenib can be decreased when combined with Glyburide.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Ivosidenib.
Dicloxacillin Dicloxacillin The metabolism of Ivosidenib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Ivosidenib can be increased when combined with Nafcillin.
Pentamidine Injection Pentamidine Injection The risk or severity of QTc prolongation can be increased when Pentamidine is combined with Ivosidenib.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Ivosidenib.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Ivosidenib.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Ivosidenib.
Lovastatin Lovastatin The metabolism of Ivosidenib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Ivosidenib can be decreased when combined with Ciprofloxacin.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Ivosidenib.
Clozapine Clozapine The metabolism of Ivosidenib can be increased when combined with Clozapine.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Ivosidenib.
Clarithromycin Clarithromycin The metabolism of Ivosidenib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Ivosidenib can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Ivosidenib.
Quinapril Quinapril The excretion of Quinapril can be decreased when combined with Ivosidenib.
Simvastatin Simvastatin The serum concentration of Ivosidenib can be increased when it is combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Ivosidenib.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Ivosidenib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Ivosidenib.
Itraconazole Itraconazole The metabolism of Ivosidenib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Ivosidenib can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Ivosidenib is combined with Sotalol.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Ivosidenib.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Ivosidenib.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Ivosidenib.
Isradipine Isradipine The metabolism of Ivosidenib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Ivosidenib can be increased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Cisapride is combined with Ivosidenib.
Fluvastatin Fluvastatin The metabolism of Ivosidenib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Ivosidenib.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Ivosidenib.
Fluvoxamine Fluvoxamine The metabolism of Ivosidenib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Ivosidenib can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Ivosidenib.
Losartan Losartan The metabolism of Ivosidenib can be decreased when combined with Losartan.
Valacyclovir Valacyclovir The excretion of Valaciclovir can be decreased when combined with Ivosidenib.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Ivosidenib.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Ivosidenib.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Ivosidenib.
Lansoprazole Lansoprazole The metabolism of Ivosidenib can be increased when combined with Lansoprazole.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Ivosidenib.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Ivosidenib.
Nicardipine Nicardipine The metabolism of Ivosidenib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Ivosidenib.
Saquinavir Saquinavir The metabolism of Ivosidenib can be decreased when combined with Saquinavir.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Ivosidenib.
Ritonavir Ritonavir The serum concentration of Ivosidenib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Ivosidenib.
Clomipramine Clomipramine The metabolism of Ivosidenib can be increased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Ivosidenib.
Mirtazapine Mirtazapine The metabolism of Ivosidenib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Ivosidenib can be increased when combined with Topiramate.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Ivosidenib.
Fexofenadine Fexofenadine The serum concentration of Ivosidenib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Ivosidenib.
Carvedilol Carvedilol The serum concentration of Ivosidenib can be increased when it is combined with Carvedilol.
Bicalutamide Bicalutamide The metabolism of Ivosidenib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Ivosidenib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Ivosidenib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Ivosidenib can be decreased when combined with Irbesartan.
Quetiapine Quetiapine The risk or severity of QTc prolongation can be increased when Quetiapine is combined with Ivosidenib.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Ivosidenib.
Paroxetine Paroxetine The metabolism of Ivosidenib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Citalopram can be decreased when combined with Ivosidenib.
Capecitabine Capecitabine The metabolism of Capecitabine can be increased when combined with Ivosidenib.
Efavirenz Efavirenz The metabolism of Ivosidenib can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Ivosidenib can be increased when it is combined with Sildenafil.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Ivosidenib.
Oseltamivir Oseltamivir The excretion of Oseltamivir can be decreased when combined with Ivosidenib.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Ivosidenib.
Rabeprazole Rabeprazole The metabolism of Ivosidenib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Ivosidenib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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