Duvelisib
Generic name: Pronounced as (doo" ve lis' ib)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 11/15/2018
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
Duvelisib may cause serious or life-threatening infections. Tell your doctor if you have an infection, or if you have or have ever had cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems). If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, shortness of breath, or other signs of infection.
Duvelisib may cause diarrhea or colitis (swelling of the large intestine). Tell your doctor if you have diarrhea or if you have ever had colitis or other conditions that affect your stomach or intestine. If you experience any of the following symptoms, call your doctor immediately: an increase in the number of bowel movements in a day, blood in your stool, or any stomach cramps or pain.
Duvelisib may cause serious or life-threatening skin reactions. If you experience any of the following symptoms, call your doctor immediately: new or worsening rash, rash with a fever, rash with itching, blisters or peeling skin, or painful sores or ulcers on your skin, lips, or in your mouth.
Duvelisib may cause serious or life-threatening pneumonitis (swelling of the lungs). Tell your doctor if you have lung disease or breathing problems. If you experience any of the following symptoms, call your doctor immediately: new or worsening cough, difficulty breathing, wheezing, or shortness of breath.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to duvelisib.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with duvelisib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Why is this medication prescribed?
Duvelisib is used to treat chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) or small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes) that has returned or is unresponsive to at least two other treatments. It is also used to treat certain types of follicular lymphoma (FL; a type of cancer that begins in the white blood cells) in adults whose cancer that has returned or is unresponsive to at least two other treatments. Duvelisib is in a class of medications called kinase inhibitors. It works by blocking the signals that cause cancer cells to multiply. This helps to stop the spread of cancer cells.
How should this medicine be used?
Duvelisib comes as a capsule to take by mouth. It is usually taken twice daily with or without food. Take duvelisib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take duvelisib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsule whole; do not open, chew, or break them.
Your doctor may decrease your dose of duvelisib or tell you to stop taking the medication for a time or permanently if you experience serious side effects during your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take duvelisib even if you feel well. Do not stop taking duvelisib without talking to your doctor.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking duvelisib,
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tell your doctor and pharmacist if you are allergic to duvelisib, any other medications, or any of the ingredients in duvelisib capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Epitol, Tegretol, Teril, others); clarithromycin (Biaxin); medications used to treat human immunodeficiency virus (HIV) such as efavirenz (Sustiva, in Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), and ritonavir (Norvir, in others); itraconazole (Onmel, Sporanox); ketoconazole, midazolam; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate). Many other medications may also interact with duvelisib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor what herbal products you are taking, especially St. John's wort.
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tell your doctor if you have or have ever had liver disease.
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tell your doctor if you are pregnant or plan to become pregnant. You must have a pregnancy test before you start taking duvelisib. You should not become pregnant during your treatment with duvelisib. If you are female, you should use birth control to prevent pregnancy during your treatment with duvelisib and at least 1 month after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment and for 1 month after your final dose. If you or your partner become pregnant while taking duvelisib, call your doctor immediately. Duvelisib may harm the fetus.
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tell your doctor if you are breastfeeding. You should not breastfeed while you are taking duvelisib and for at least 1 month after your final dose.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
If you miss a dose of duvelisib by less than 6 hours, take the missed dose as soon as you remember it and then take the next dose at the scheduled time. However, if you miss a dose by more than 6 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Duvelisib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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nausea
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vomiting
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constipation
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tiredness
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headache
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muscle or join pain
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Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
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yellow eyes or skin; abdominal pain; unexplained bruising or bleeding; loss of appetite; yellow or brown-colored urine; pale stools; or pain in the upper right part of the stomach
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Duvelisib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Delavirdine | Delavirdine The metabolism of Duvelisib can be decreased when combined with Delavirdine. |
Aminophylline | Aminophylline The metabolism of Aminophylline can be decreased when combined with Duvelisib. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The serum concentration of Duvelisib can be increased when it is combined with Erythromycin. |
Fenofibrate | Fenofibrate The metabolism of Duvelisib can be decreased when combined with Fenofibrate. |
Methylergonovine | Methylergonovine The metabolism of Duvelisib can be decreased when combined with Methylergometrine. |
Paregoric | Paregoric The serum concentration of Duvelisib can be increased when it is combined with Morphine. |
Reserpine | Reserpine The serum concentration of Duvelisib can be increased when it is combined with Reserpine. |
Tacrolimus | Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Duvelisib. |
Triamcinolone | Triamcinolone The metabolism of Duvelisib can be increased when combined with Triamcinolone. |
Doxycycline Injection | Doxycycline Injection The metabolism of Duvelisib can be decreased when combined with Doxycycline. |
Fluconazole Injection | Fluconazole Injection The serum concentration of Duvelisib can be increased when it is combined with Fluconazole. |
Meperidine Injection | Meperidine Injection The metabolism of Duvelisib can be increased when combined with Meperidine. |
Methylprednisolone Injection | Methylprednisolone Injection The metabolism of Duvelisib can be increased when combined with Methylprednisolone. |
Metronidazole Injection | Metronidazole Injection The metabolism of Duvelisib can be decreased when combined with Metronidazole. |
Morphine Injection | Morphine Injection The serum concentration of Duvelisib can be increased when it is combined with Morphine. |
Cyclosporine | Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Duvelisib. |
Dofetilide | Dofetilide The metabolism of Dofetilide can be decreased when combined with Duvelisib. |
Orlistat | Orlistat The metabolism of Duvelisib can be increased when combined with Orlistat. |
Oxcarbazepine | Oxcarbazepine The metabolism of Duvelisib can be increased when combined with Oxcarbazepine. |
Pantoprazole | Pantoprazole Pantoprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Telmisartan | Telmisartan Telmisartan may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Anakinra | Anakinra The metabolism of Duvelisib can be increased when combined with Anakinra. |
Trimipramine | Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Duvelisib. |
Etanercept Injection | Etanercept Injection The metabolism of Duvelisib can be increased when combined with Etanercept. |
Modafinil | Modafinil The metabolism of Duvelisib can be increased when combined with Modafinil. |
Tenofovir | Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Duvelisib. |
Sirolimus | Sirolimus The metabolism of Sirolimus can be decreased when combined with Duvelisib. |
Epinephrine Injection | Epinephrine Injection The metabolism of Duvelisib can be decreased when combined with Epinephrine. |
Zonisamide | Zonisamide The serum concentration of Duvelisib can be increased when it is combined with Zonisamide. |
Adalimumab Injection | Adalimumab Injection The metabolism of Duvelisib can be increased when combined with Adalimumab. |
Atazanavir | Atazanavir The metabolism of Duvelisib can be decreased when combined with Atazanavir. |
Mefloquine | Mefloquine The metabolism of Duvelisib can be decreased when combined with Mefloquine. |
Rosuvastatin | Rosuvastatin The metabolism of Duvelisib can be decreased when combined with Rosuvastatin. |
Vardenafil | Vardenafil The serum concentration of Duvelisib can be increased when it is combined with Vardenafil. |
Aprepitant | Aprepitant The metabolism of Duvelisib can be decreased when combined with Aprepitant. |
Tegaserod | Tegaserod The serum concentration of Duvelisib can be increased when it is combined with Tegaserod. |
Progesterone | Progesterone Progesterone may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Infliximab Injection | Infliximab Injection The metabolism of Duvelisib can be increased when combined with Infliximab. |
Rifaximin | Rifaximin The metabolism of Duvelisib can be increased when combined with Rifaximin. |
Duloxetine | Duloxetine The metabolism of Duvelisib can be decreased when combined with Duloxetine. |
Norethindrone | Norethindrone The metabolism of Duvelisib can be decreased when combined with Norethisterone. |
Bosentan | Bosentan The metabolism of Duvelisib can be increased when combined with Bosentan. |
Erlotinib | Erlotinib The metabolism of Duvelisib can be decreased when combined with Erlotinib. |
Voriconazole | Voriconazole The metabolism of Duvelisib can be decreased when combined with Voriconazole. |
Deferasirox | Deferasirox The metabolism of Duvelisib can be increased when combined with Deferasirox. |
Tipranavir | Tipranavir The metabolism of Tipranavir can be decreased when combined with Duvelisib. |
Felbamate | Felbamate The metabolism of Duvelisib can be increased when combined with Felbamate. |
Ranolazine | Ranolazine The serum concentration of Duvelisib can be increased when it is combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The metabolism of Duvelisib can be increased when combined with Abatacept. |
Imatinib | Imatinib The metabolism of Duvelisib can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin The serum concentration of Duvelisib can be increased when it is combined with Sitagliptin. |
Gefitinib | Gefitinib Gefitinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Paliperidone | Paliperidone The serum concentration of Duvelisib can be increased when it is combined with Paliperidone. |
Bortezomib | Bortezomib The metabolism of Bortezomib can be decreased when combined with Duvelisib. |
Posaconazole | Posaconazole The metabolism of Duvelisib can be decreased when combined with Posaconazole. |
Primaquine | Primaquine The metabolism of Duvelisib can be decreased when combined with Primaquine. |
Darunavir | Darunavir The metabolism of Darunavir can be decreased when combined with Duvelisib. |
Sorafenib | Sorafenib The metabolism of Duvelisib can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Duvelisib can be decreased when combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Lapatinib | Lapatinib The serum concentration of Duvelisib can be increased when it is combined with Lapatinib. |
Dasatinib | Dasatinib The metabolism of Dasatinib can be decreased when combined with Duvelisib. |
Armodafinil | Armodafinil The metabolism of Duvelisib can be increased when combined with Armodafinil. |
Ivermectin | Ivermectin The metabolism of Duvelisib can be increased when combined with Ivermectin. |
Temsirolimus | Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Duvelisib. |
Nilotinib | Nilotinib The metabolism of Duvelisib can be decreased when combined with Nilotinib. |
Toremifene | Toremifene The serum concentration of Duvelisib can be increased when it is combined with Toremifene. |
Bexarotene | Bexarotene The metabolism of Duvelisib can be increased when combined with Bexarotene. |
Budesonide | Budesonide The metabolism of Duvelisib can be increased when combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Duvelisib can be decreased when combined with Chloramphenicol. |
Etravirine | Etravirine The metabolism of Duvelisib can be increased when combined with Etravirine. |
Mitoxantrone Injection | Mitoxantrone Injection The metabolism of Duvelisib can be decreased when combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine The metabolism of Duvelisib can be decreased when combined with Desvenlafaxine. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Duvelisib. |
Pilocarpine | Pilocarpine The metabolism of Duvelisib can be decreased when combined with Pilocarpine. |
Certolizumab Injection | Certolizumab Injection The metabolism of Duvelisib can be increased when combined with Certolizumab pegol. |
Ixabepilone Injection | Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Duvelisib. |
Irinotecan Injection | Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Duvelisib. |
Mitotane | Mitotane The metabolism of Duvelisib can be increased when combined with Mitotane. |
Rufinamide | Rufinamide The metabolism of Duvelisib can be increased when combined with Rufinamide. |
Silodosin | Silodosin The serum concentration of Duvelisib can be increased when it is combined with Silodosin. |
Midazolam | Midazolam The metabolism of Duvelisib can be decreased when combined with Midazolam. |
Eltrombopag | Eltrombopag Eltrombopag may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Milnacipran | Milnacipran The metabolism of Duvelisib can be decreased when combined with Milnacipran. |
Lacosamide | Lacosamide The metabolism of Duvelisib can be decreased when combined with Lacosamide. |
Everolimus | Everolimus The metabolism of Everolimus can be decreased when combined with Duvelisib. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The metabolism of Duvelisib can be decreased when combined with Tolvaptan. |
Dronedarone | Dronedarone The metabolism of Dronedarone can be decreased when combined with Duvelisib. |
Romidepsin Injection | Romidepsin Injection The metabolism of Duvelisib can be decreased when combined with Romidepsin. |
Topotecan | Topotecan The metabolism of Duvelisib can be decreased when combined with Topotecan. |
Golimumab Injection | Golimumab Injection The metabolism of Duvelisib can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The metabolism of Duvelisib can be decreased when combined with Pazopanib. |
Albendazole | Albendazole The metabolism of Duvelisib can be decreased when combined with Albendazole. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Duvelisib can be increased when combined with Tocilizumab. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Duvelisib can be decreased when combined with Cabazitaxel. |
Acetaminophen Injection | Acetaminophen Injection The metabolism of Duvelisib can be increased when combined with Acetaminophen. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The metabolism of Duvelisib can be decreased when combined with Aldesleukin. |
Busulfan Injection | Busulfan Injection The metabolism of Busulfan can be decreased when combined with Duvelisib. |
Roflumilast | Roflumilast The metabolism of Duvelisib can be decreased when combined with Roflumilast. |
Linagliptin | Linagliptin The serum concentration of Duvelisib can be increased when it is combined with Linagliptin. |
Rilpivirine | Rilpivirine Rilpivirine may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Telaprevir | Telaprevir The serum concentration of Duvelisib can be increased when it is combined with Glecaprevir. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Duvelisib can be decreased when combined with Cyclophosphamide. |
Rivaroxaban | Rivaroxaban The serum concentration of Duvelisib can be increased when it is combined with Rivaroxaban. |
Ticagrelor | Ticagrelor The serum concentration of Duvelisib can be increased when it is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The metabolism of Duvelisib can be decreased when combined with Brentuximab vedotin. |
Ruxolitinib | Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Duvelisib. |
Vandetanib | Vandetanib The metabolism of Duvelisib can be decreased when combined with Vandetanib. |
Clobazam | Clobazam The serum concentration of Duvelisib can be increased when it is combined with Clobazam. |
Vemurafenib | Vemurafenib The serum concentration of Duvelisib can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib Vismodegib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Ivacaftor | Ivacaftor The serum concentration of Duvelisib can be increased when it is combined with Ivacaftor. |
Axitinib | Axitinib The metabolism of Axitinib can be decreased when combined with Duvelisib. |
Crizotinib | Crizotinib The metabolism of Duvelisib can be decreased when combined with Crizotinib. |
Cabergoline | Cabergoline The metabolism of Duvelisib can be decreased when combined with Cabergoline. |
Naloxone Injection | Naloxone Injection The metabolism of Duvelisib can be decreased when combined with Naloxone. |
Ambrisentan | Ambrisentan The serum concentration of Duvelisib can be increased when it is combined with Ambrisentan. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Duvelisib can be increased when it is combined with Carfilzomib. |
Enzalutamide | Enzalutamide The metabolism of Duvelisib can be increased when combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Duvelisib can be increased when it is combined with Mirabegron. |
Regorafenib | Regorafenib The metabolism of Duvelisib can be decreased when combined with Regorafenib. |
Bosutinib | Bosutinib The metabolism of Duvelisib can be decreased when combined with Bosutinib. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The metabolism of Duvelisib can be increased when combined with Corticotropin. |
Teriflunomide | Teriflunomide Teriflunomide may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Ponatinib | Ponatinib The metabolism of Duvelisib can be decreased when combined with Ponatinib. |
Pomalidomide | Pomalidomide The metabolism of Duvelisib can be decreased when combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Duvelisib can be decreased when combined with Trastuzumab emtansine. |
Apixaban | Apixaban The serum concentration of Duvelisib can be increased when it is combined with Apixaban. |
Canagliflozin | Canagliflozin The serum concentration of Duvelisib can be increased when it is combined with Canagliflozin. |
Dabrafenib | Dabrafenib The metabolism of Duvelisib can be decreased when combined with Dabrafenib. |
Trametinib | Trametinib The metabolism of Duvelisib can be increased when combined with Trametinib. |
Dolutegravir | Dolutegravir The serum concentration of Duvelisib can be increased when it is combined with Dolutegravir. |
Afatinib | Afatinib The serum concentration of Duvelisib can be increased when it is combined with Afatinib. |
Perampanel | Perampanel The metabolism of Duvelisib can be increased when combined with Perampanel. |
Lomitapide | Lomitapide The metabolism of Duvelisib can be decreased when combined with Lomitapide. |
Simeprevir | Simeprevir Simeprevir may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Sofosbuvir | Sofosbuvir The serum concentration of Duvelisib can be increased when it is combined with Sofosbuvir. |
Apremilast | Apremilast The metabolism of Duvelisib can be increased when combined with Apremilast. |
Ceritinib | Ceritinib The metabolism of Duvelisib can be decreased when combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Duvelisib can be increased when combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The metabolism of Duvelisib can be increased when combined with Eslicarbazepine. |
Belinostat Injection | Belinostat Injection The serum concentration of Duvelisib can be increased when it is combined with Belinostat. |
Idelalisib | Idelalisib The metabolism of Idelalisib can be decreased when combined with Duvelisib. |
Testosterone Injection | Testosterone Injection The metabolism of Duvelisib can be increased when combined with Testosterone. |
Oritavancin Injection | Oritavancin Injection The metabolism of Duvelisib can be increased when combined with Oritavancin. |
Vorapaxar | Vorapaxar The serum concentration of Duvelisib can be increased when it is combined with Vorapaxar. |
Suvorexant | Suvorexant The serum concentration of Duvelisib can be increased when it is combined with Suvorexant. |
Edoxaban | Edoxaban The serum concentration of Duvelisib can be increased when it is combined with Edoxaban. |
Olaparib | Olaparib The metabolism of Duvelisib can be decreased when combined with Olaparib. |
Tasimelteon | Tasimelteon The metabolism of Duvelisib can be decreased when combined with Tasimelteon. |
Lanreotide Injection | Lanreotide Injection The metabolism of Duvelisib can be decreased when combined with Lanreotide. |
Nintedanib | Nintedanib The serum concentration of Duvelisib can be increased when it is combined with Nintedanib. |
Secukinumab Injection | Secukinumab Injection The metabolism of Duvelisib can be increased when combined with Secukinumab. |
Palbociclib | Palbociclib The metabolism of Duvelisib can be decreased when combined with Palbociclib. |
Lenvatinib | Lenvatinib The serum concentration of Duvelisib can be increased when it is combined with Lenvatinib. |
Panobinostat | Panobinostat The metabolism of Duvelisib can be decreased when combined with Panobinostat. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Duvelisib. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Duvelisib can be increased when it is combined with Isavuconazonium. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be decreased when combined with Duvelisib. |
Flibanserin | Flibanserin The serum concentration of Duvelisib can be increased when it is combined with Flibanserin. |
Rolapitant | Rolapitant The serum concentration of Duvelisib can be increased when it is combined with Rolapitant. |
Prednisolone | Prednisolone The metabolism of Duvelisib can be increased when combined with Prednisolone. |
Daclatasvir | Daclatasvir The serum concentration of Duvelisib can be increased when it is combined with Daclatasvir. |
Ziprasidone Injection | Ziprasidone Injection The metabolism of Duvelisib can be decreased when combined with Ziprasidone. |
Cobimetinib | Cobimetinib The metabolism of Duvelisib can be decreased when combined with Cobimetinib. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Duvelisib. |
Osimertinib | Osimertinib The metabolism of Duvelisib can be decreased when combined with Osimertinib. |
Alectinib | Alectinib The metabolism of Duvelisib can be decreased when combined with Alectinib. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be decreased when combined with Duvelisib. |
Rifapentine | Rifapentine The metabolism of Duvelisib can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad The metabolism of Duvelisib can be increased when combined with Lesinurad. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection The metabolism of Duvelisib can be decreased when combined with Amphotericin B. |
Dexamethasone Injection | Dexamethasone Injection The metabolism of Duvelisib can be increased when combined with Dexamethasone. |
Venetoclax | Venetoclax The metabolism of Duvelisib can be decreased when combined with Venetoclax. |
Cobicistat | Cobicistat The metabolism of Duvelisib can be decreased when combined with Cobicistat. |
Selexipag | Selexipag The serum concentration of Duvelisib can be increased when it is combined with Selexipag. |
Rucaparib | Rucaparib The serum concentration of Duvelisib can be increased when it is combined with Rucaparib. |
Ribociclib | Ribociclib The metabolism of Duvelisib can be decreased when combined with Ribociclib. |
Brigatinib | Brigatinib The metabolism of Duvelisib can be decreased when combined with Brigatinib. |
Deflazacort | Deflazacort The metabolism of Duvelisib can be increased when combined with Deflazacort. |
Safinamide | Safinamide Safinamide may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Sarilumab Injection | Sarilumab Injection The metabolism of Duvelisib can be increased when combined with Sarilumab. |
Midostaurin | Midostaurin The metabolism of Duvelisib can be decreased when combined with Midostaurin. |
Neratinib | Neratinib The metabolism of Duvelisib can be decreased when combined with Neratinib. |
Enasidenib | Enasidenib The metabolism of Duvelisib can be decreased when combined with Enasidenib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Duvelisib can be increased when it is combined with Inotuzumab ozogamicin. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Duvelisib can be increased when combined with Fosaprepitant. |
Copanlisib Injection | Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Duvelisib. |
Abemaciclib | Abemaciclib The metabolism of Duvelisib can be decreased when combined with Abemaciclib. |
Betrixaban | Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Duvelisib. |
Acalabrutinib | Acalabrutinib The metabolism of Duvelisib can be decreased when combined with Acalabrutinib. |
Letermovir | Letermovir Letermovir may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Ertugliflozin | Ertugliflozin The serum concentration of Duvelisib can be increased when it is combined with Ertugliflozin. |
Buprenorphine Injection | Buprenorphine Injection Buprenorphine may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Apalutamide | Apalutamide The serum concentration of Duvelisib can be decreased when it is combined with Apalutamide. |
Fostamatinib | Fostamatinib Fostamatinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Avatrombopag | Avatrombopag Avatrombopag may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Baricitinib | Baricitinib The metabolism of Duvelisib can be decreased when combined with Baricitinib. |
Eliglustat | Eliglustat The serum concentration of Duvelisib can be increased when it is combined with Eliglustat. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Duvelisib. |
Ivosidenib | Ivosidenib The metabolism of Duvelisib can be decreased when combined with Ivosidenib. |
Lusutrombopag | Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Duvelisib. |
Elagolix | Elagolix The serum concentration of Elagolix can be increased when it is combined with Duvelisib. |
Cannabidiol | Cannabidiol Cannabidiol may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Dacomitinib | Dacomitinib The metabolism of Duvelisib can be decreased when combined with Dacomitinib. |
Omadacycline | Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Duvelisib. |
Sarecycline | Sarecycline The serum concentration of Duvelisib can be increased when it is combined with Sarecycline. |
Stiripentol | Stiripentol The metabolism of Duvelisib can be decreased when combined with Stiripentol. |
Talazoparib | Talazoparib The serum concentration of Duvelisib can be increased when it is combined with Talazoparib. |
Gilteritinib | Gilteritinib Gilteritinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Glasdegib | Glasdegib Glasdegib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Larotrectinib | Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Duvelisib. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Duvelisib. |
Rifamycin | Rifamycin The metabolism of Duvelisib can be increased when combined with Rifamycin. |
Prucalopride | Prucalopride The metabolism of Duvelisib can be decreased when combined with Prucalopride. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Duvelisib can be increased when combined with Emapalumab. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Duvelisib. |
Erdafitinib | Erdafitinib The serum concentration of Duvelisib can be increased when it is combined with Erdafitinib. |
Alpelisib | Alpelisib The metabolism of Duvelisib can be decreased when combined with Alpelisib. |
Darolutamide | Darolutamide The serum concentration of Duvelisib can be increased when it is combined with Darolutamide. |
Triclabendazole | Triclabendazole The metabolism of Duvelisib can be decreased when combined with Triclabendazole. |
Entrectinib | Entrectinib The metabolism of Duvelisib can be decreased when combined with Entrectinib. |
Pexidartinib | Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Duvelisib. |
Istradefylline | Istradefylline Istradefylline may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Pitolisant | Pitolisant The serum concentration of Duvelisib can be decreased when it is combined with Pitolisant. |
Fedratinib | Fedratinib Fedratinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Lefamulin | Lefamulin The metabolism of Lefamulin can be decreased when combined with Duvelisib. |
Phenytoin Injection | Phenytoin Injection The metabolism of Duvelisib can be increased when combined with Phenytoin. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Duvelisib can be increased when combined with Fosphenytoin. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Duvelisib. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Duvelisib. |
Lasmiditan | Lasmiditan The serum concentration of Duvelisib can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Duvelisib. |
Tazemetostat | Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Duvelisib. |
Cenobamate | Cenobamate The serum concentration of Duvelisib can be decreased when it is combined with Cenobamate. |
Selumetinib | Selumetinib The serum concentration of Duvelisib can be increased when it is combined with Selumetinib. |
Rimegepant | Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Duvelisib. |
Tucatinib | Tucatinib Tucatinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Remdesivir Injection | Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Duvelisib. |
Ripretinib | Ripretinib Ripretinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Capmatinib | Capmatinib The serum concentration of Duvelisib can be increased when it is combined with Capmatinib. |
Lemborexant | Lemborexant The serum concentration of Duvelisib can be increased when it is combined with Lemborexant. |
Fostemsavir | Fostemsavir Fostemsavir may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Octreotide | Octreotide The metabolism of Duvelisib can be decreased when combined with Octreotide. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Duvelisib. |
Pralsetinib | Pralsetinib Pralsetinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Duvelisib can be decreased when it is combined with Satralizumab. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Duvelisib can be decreased when combined with Drospirenone. |
Vitamin E (Alpha-Tocopherol) | Vitamin E (Alpha-Tocopherol) The metabolism of Duvelisib can be increased when combined with Vitamin E. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Duvelisib. |
Phenobarbital | Phenobarbital The metabolism of Duvelisib can be increased when combined with Phenobarbital. |
Methotrexate Injection | Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Duvelisib. |
Primidone | Primidone The metabolism of Duvelisib can be increased when combined with Primidone. |
Chlorpromazine | Chlorpromazine The metabolism of Duvelisib can be increased when combined with Chlorpromazine. |
Diazepam | Diazepam The metabolism of Duvelisib can be decreased when combined with Diazepam. |
Lorazepam | Lorazepam The metabolism of Duvelisib can be decreased when combined with Lorazepam. |
Bromocriptine | Bromocriptine The metabolism of Duvelisib can be decreased when combined with Bromocriptine. |
Tranylcypromine | Tranylcypromine The metabolism of Duvelisib can be decreased when combined with Tranylcypromine. |
Phenelzine | Phenelzine The metabolism of Duvelisib can be decreased when combined with Phenelzine. |
Tetracycline | Tetracycline The metabolism of Duvelisib can be decreased when combined with Tetracycline. |
Prochlorperazine | Prochlorperazine The metabolism of Duvelisib can be decreased when combined with Prochlorperazine. |
Methadone | Methadone The metabolism of Duvelisib can be increased when combined with Methadone. |
Oxybutynin | Oxybutynin The metabolism of Duvelisib can be decreased when combined with Oxybutynin. |
Orphenadrine | Orphenadrine The metabolism of Duvelisib can be decreased when combined with Orphenadrine. |
Phentermine | Phentermine The metabolism of Duvelisib can be decreased when combined with Phentermine. |
Sulfasalazine | Sulfasalazine Sulfasalazine may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Hydrocortisone | Hydrocortisone The metabolism of Duvelisib can be increased when combined with Hydrocortisone. |
Doxorubicin | Doxorubicin The metabolism of Duvelisib can be decreased when combined with Doxorubicin. |
Dactinomycin | Dactinomycin The serum concentration of Duvelisib can be increased when it is combined with Dactinomycin. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be increased when combined with Duvelisib. |
Clonidine | Clonidine The metabolism of Clonidine can be decreased when combined with Duvelisib. |
Hydralazine | Hydralazine The metabolism of Duvelisib can be decreased when combined with Hydralazine. |
Cimetidine | Cimetidine The metabolism of Duvelisib can be decreased when combined with Cimetidine. |
Warfarin | Warfarin The metabolism of Warfarin can be decreased when combined with Duvelisib. |
Loperamide | Loperamide The metabolism of Duvelisib can be decreased when combined with Loperamide. |
Daunorubicin | Daunorubicin The metabolism of Duvelisib can be decreased when combined with Daunorubicin. |
Griseofulvin | Griseofulvin The metabolism of Duvelisib can be increased when combined with Griseofulvin. |
Digoxin | Digoxin The serum concentration of Digoxin can be increased when it is combined with Duvelisib. |
Loxapine | Loxapine The serum concentration of Duvelisib can be increased when it is combined with Loxapine. |
Quinine | Quinine The serum concentration of Duvelisib can be increased when it is combined with Quinine. |
Calcitriol | Calcitriol The metabolism of Duvelisib can be increased when combined with Calcitriol. |
Sulfinpyrazone | Sulfinpyrazone The metabolism of Duvelisib can be increased when combined with Sulfinpyrazone. |
Secobarbital | Secobarbital The metabolism of Duvelisib can be increased when combined with Secobarbital. |
Desipramine | Desipramine The metabolism of Duvelisib can be decreased when combined with Desipramine. |
Imipramine | Imipramine The serum concentration of Imipramine can be increased when it is combined with Duvelisib. |
Probenecid | Probenecid The metabolism of Duvelisib can be increased when combined with Probenecid. |
Quinidine | Quinidine The metabolism of Quinidine can be decreased when combined with Duvelisib. |
Isoniazid | Isoniazid The metabolism of Duvelisib can be decreased when combined with Isoniazid. |
Rifampin | Rifampin The metabolism of Rifampicin can be increased when combined with Duvelisib. |
Valproic Acid | Valproic Acid The metabolism of Duvelisib can be decreased when combined with Valproic acid. |
Tamoxifen | Tamoxifen The metabolism of Duvelisib can be decreased when combined with Tamoxifen. |
Methimazole | Methimazole The metabolism of Duvelisib can be decreased when combined with Methimazole. |
Niacin | Niacin The metabolism of Duvelisib can be decreased when combined with Niacin. |
Danazol | Danazol The metabolism of Duvelisib can be decreased when combined with Danazol. |
Nortriptyline | Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Duvelisib. |
Amphotericin B Injection | Amphotericin B Injection The metabolism of Duvelisib can be decreased when combined with Amphotericin B. |
Clomiphene | Clomiphene The serum concentration of Duvelisib can be increased when it is combined with Clomifene. |
Colchicine | Colchicine The metabolism of Duvelisib can be increased when combined with Colchicine. |
Cephalexin | Cephalexin The metabolism of Duvelisib can be decreased when combined with Cephalexin. |
Acetazolamide | Acetazolamide The metabolism of Duvelisib can be decreased when combined with Acetazolamide. |
Ketoconazole | Ketoconazole The metabolism of Duvelisib can be decreased when combined with Ketoconazole. |
Thiotepa Injection | Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Duvelisib. |
Vincristine Injection | Vincristine Injection The metabolism of Vincristine can be decreased when combined with Duvelisib. |
Vinblastine | Vinblastine The metabolism of Duvelisib can be decreased when combined with Vinblastine. |
Metoprolol | Metoprolol The metabolism of Duvelisib can be decreased when combined with Metoprolol. |
Diltiazem | Diltiazem The metabolism of Duvelisib can be decreased when combined with Diltiazem. |
Nifedipine | Nifedipine The metabolism of Duvelisib can be increased when combined with Nifedipine. |
Verapamil | Verapamil The metabolism of Duvelisib can be decreased when combined with Verapamil. |
Etoposide | Etoposide The metabolism of Duvelisib can be decreased when combined with Etoposide. |
Glyburide | Glyburide The metabolism of Duvelisib can be decreased when combined with Glyburide. |
Dicloxacillin | Dicloxacillin The metabolism of Duvelisib can be increased when combined with Dicloxacillin. |
Nafcillin Injection | Nafcillin Injection The metabolism of Duvelisib can be increased when combined with Nafcillin. |
Pimozide | Pimozide The metabolism of Pimozide can be decreased when combined with Duvelisib. |
Amiodarone | Amiodarone The metabolism of Amiodarone can be decreased when combined with Duvelisib. |
Lovastatin | Lovastatin The metabolism of Duvelisib can be decreased when combined with Lovastatin. |
Ciprofloxacin | Ciprofloxacin The metabolism of Duvelisib can be decreased when combined with Ciprofloxacin. |
Clozapine | Clozapine The metabolism of Duvelisib can be decreased when combined with Clozapine. |
Clarithromycin | Clarithromycin The metabolism of Duvelisib can be decreased when combined with Clarithromycin. |
Felodipine | Felodipine The metabolism of Duvelisib can be decreased when combined with Felodipine. |
Pravastatin | Pravastatin Pravastatin may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Simvastatin | Simvastatin The serum concentration of Duvelisib can be increased when it is combined with Simvastatin. |
Teniposide Injection | Teniposide Injection The metabolism of Duvelisib can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The metabolism of Duvelisib can be decreased when combined with Itraconazole. |
Rifabutin | Rifabutin The metabolism of Duvelisib can be increased when combined with Rifabutin. |
Bisoprolol | Bisoprolol The serum concentration of Duvelisib can be increased when it is combined with Bisoprolol. |
Doxazosin | Doxazosin The metabolism of Duvelisib can be decreased when combined with Doxazosin. |
Isradipine | Isradipine The metabolism of Duvelisib can be decreased when combined with Isradipine. |
Omeprazole | Omeprazole Omeprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Cisapride | Cisapride The metabolism of Duvelisib can be decreased when combined with Cisapride. |
Fluvastatin | Fluvastatin The metabolism of Duvelisib can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine Venlafaxine may increase the excretion rate of Duvelisib which could result in a lower serum level and potentially a reduction in efficacy. |
Famciclovir | Famciclovir The metabolism of Duvelisib can be decreased when combined with Famciclovir. |
Fluvoxamine | Fluvoxamine The metabolism of Duvelisib can be decreased when combined with Fluvoxamine. |
Nefazodone | Nefazodone The metabolism of Duvelisib can be decreased when combined with Nefazodone. |
Losartan | Losartan The metabolism of Duvelisib can be decreased when combined with Losartan. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Duvelisib. |
Lansoprazole | Lansoprazole Lansoprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Ifosfamide Injection | Ifosfamide Injection The metabolism of Duvelisib can be decreased when combined with Ifosfamide. |
Nicardipine | Nicardipine The metabolism of Duvelisib can be decreased when combined with Nicardipine. |
Ticlopidine | Ticlopidine The metabolism of Duvelisib can be decreased when combined with Ticlopidine. |
Saquinavir | Saquinavir The metabolism of Saquinavir can be decreased when combined with Duvelisib. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Duvelisib. |
Ritonavir | Ritonavir The metabolism of Duvelisib can be decreased when combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Duvelisib can be decreased when combined with Docetaxel. |
Clomipramine | Clomipramine The metabolism of Clomipramine can be decreased when combined with Duvelisib. |
Zafirlukast | Zafirlukast The metabolism of Duvelisib can be decreased when combined with Zafirlukast. |
Mirtazapine | Mirtazapine The metabolism of Duvelisib can be decreased when combined with Mirtazapine. |
Topiramate | Topiramate The metabolism of Duvelisib can be increased when combined with Topiramate. |
Nelfinavir | Nelfinavir Nelfinavir may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Fexofenadine | Fexofenadine The serum concentration of Duvelisib can be increased when it is combined with Fexofenadine. |
Azithromycin | Azithromycin The metabolism of Duvelisib can be decreased when combined with Azithromycin. |
Carvedilol | Carvedilol The serum concentration of Duvelisib can be increased when it is combined with Carvedilol. |
Bicalutamide | Bicalutamide The metabolism of Duvelisib can be decreased when combined with Bicalutamide. |
Propafenone | Propafenone The serum concentration of Duvelisib can be increased when it is combined with Propafenone. |
Raloxifene | Raloxifene The metabolism of Duvelisib can be decreased when combined with Raloxifene. |
Irbesartan | Irbesartan The metabolism of Duvelisib can be decreased when combined with Irbesartan. |
Paroxetine | Paroxetine The metabolism of Duvelisib can be decreased when combined with Paroxetine. |
Citalopram | Citalopram The metabolism of Duvelisib can be decreased when combined with Citalopram. |
Efavirenz | Efavirenz The metabolism of Duvelisib can be decreased when combined with Efavirenz. |
Sildenafil | Sildenafil The serum concentration of Duvelisib can be increased when it is combined with Sildenafil. |
Rabeprazole | Rabeprazole Rabeprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
Terbinafine | Terbinafine The metabolism of Duvelisib can be increased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists