Duvelisib

Generic name: Pronounced as (doo" ve lis' ib)
Brand names
  • Copiktra®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2018

Duvelisib may cause serious or life-threatening infections. Tell your doctor if you have an infection, or if you have or have ever had cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems). If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, shortness of breath, or other signs of infection.

Duvelisib may cause diarrhea or colitis (swelling of the large intestine). Tell your doctor if you have diarrhea or if you have ever had colitis or other conditions that affect your stomach or intestine. If you experience any of the following symptoms, call your doctor immediately: an increase in the number of bowel movements in a day, blood in your stool, or any stomach cramps or pain.

Duvelisib may cause serious or life-threatening skin reactions. If you experience any of the following symptoms, call your doctor immediately: new or worsening rash, rash with a fever, rash with itching, blisters or peeling skin, or painful sores or ulcers on your skin, lips, or in your mouth.

Duvelisib may cause serious or life-threatening pneumonitis (swelling of the lungs). Tell your doctor if you have lung disease or breathing problems. If you experience any of the following symptoms, call your doctor immediately: new or worsening cough, difficulty breathing, wheezing, or shortness of breath.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to duvelisib.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with duvelisib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Duvelisib is used to treat chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) or small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes) that has returned or is unresponsive to at least two other treatments. It is also used to treat certain types of follicular lymphoma (FL; a type of cancer that begins in the white blood cells) in adults whose cancer that has returned or is unresponsive to at least two other treatments. Duvelisib is in a class of medications called kinase inhibitors. It works by blocking the signals that cause cancer cells to multiply. This helps to stop the spread of cancer cells.

Duvelisib comes as a capsule to take by mouth. It is usually taken twice daily with or without food. Take duvelisib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take duvelisib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsule whole; do not open, chew, or break them.

Your doctor may decrease your dose of duvelisib or tell you to stop taking the medication for a time or permanently if you experience serious side effects during your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take duvelisib even if you feel well. Do not stop taking duvelisib without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking duvelisib,

  • tell your doctor and pharmacist if you are allergic to duvelisib, any other medications, or any of the ingredients in duvelisib capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Epitol, Tegretol, Teril, others); clarithromycin (Biaxin); medications used to treat human immunodeficiency virus (HIV) such as efavirenz (Sustiva, in Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), and ritonavir (Norvir, in others); itraconazole (Onmel, Sporanox); ketoconazole, midazolam; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate). Many other medications may also interact with duvelisib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had liver disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You must have a pregnancy test before you start taking duvelisib. You should not become pregnant during your treatment with duvelisib. If you are female, you should use birth control to prevent pregnancy during your treatment with duvelisib and at least 1 month after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control during your treatment and for 1 month after your final dose. If you or your partner become pregnant while taking duvelisib, call your doctor immediately. Duvelisib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking duvelisib and for at least 1 month after your final dose.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss a dose of duvelisib by less than 6 hours, take the missed dose as soon as you remember it and then take the next dose at the scheduled time. However, if you miss a dose by more than 6 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Duvelisib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • constipation

    • tiredness

    • headache

    • muscle or join pain

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

    • yellow eyes or skin; abdominal pain; unexplained bruising or bleeding; loss of appetite; yellow or brown-colored urine; pale stools; or pain in the upper right part of the stomach

  • Duvelisib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Duvelisib can be decreased when combined with Delavirdine.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Duvelisib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Duvelisib can be increased when it is combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Duvelisib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Duvelisib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Duvelisib can be increased when it is combined with Morphine.
Reserpine Reserpine The serum concentration of Duvelisib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Duvelisib.
Triamcinolone Triamcinolone The metabolism of Duvelisib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Duvelisib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The serum concentration of Duvelisib can be increased when it is combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Duvelisib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Duvelisib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Duvelisib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Duvelisib can be increased when it is combined with Morphine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Duvelisib.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Duvelisib.
Orlistat Orlistat The metabolism of Duvelisib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Duvelisib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Anakinra Anakinra The metabolism of Duvelisib can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Duvelisib.
Etanercept Injection Etanercept Injection The metabolism of Duvelisib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Duvelisib can be increased when combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Duvelisib.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Duvelisib.
Epinephrine Injection Epinephrine Injection The metabolism of Duvelisib can be decreased when combined with Epinephrine.
Zonisamide Zonisamide The serum concentration of Duvelisib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Duvelisib can be increased when combined with Adalimumab.
Atazanavir Atazanavir The metabolism of Duvelisib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Duvelisib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Duvelisib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Duvelisib can be increased when it is combined with Vardenafil.
Aprepitant Aprepitant The metabolism of Duvelisib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Duvelisib can be increased when it is combined with Tegaserod.
Progesterone Progesterone Progesterone may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Infliximab Injection Infliximab Injection The metabolism of Duvelisib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Duvelisib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Duvelisib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Duvelisib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Duvelisib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Duvelisib can be decreased when combined with Erlotinib.
Voriconazole Voriconazole The metabolism of Duvelisib can be decreased when combined with Voriconazole.
Deferasirox Deferasirox The metabolism of Duvelisib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Duvelisib.
Felbamate Felbamate The metabolism of Duvelisib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Duvelisib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Duvelisib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Duvelisib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Duvelisib can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Duvelisib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Duvelisib.
Posaconazole Posaconazole The metabolism of Duvelisib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Duvelisib can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Duvelisib.
Sorafenib Sorafenib The metabolism of Duvelisib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Duvelisib can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Duvelisib can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Duvelisib.
Armodafinil Armodafinil The metabolism of Duvelisib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Duvelisib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Duvelisib.
Nilotinib Nilotinib The metabolism of Duvelisib can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Duvelisib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Duvelisib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Duvelisib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Duvelisib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Duvelisib can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Duvelisib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Duvelisib can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Duvelisib.
Pilocarpine Pilocarpine The metabolism of Duvelisib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Duvelisib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Duvelisib.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Duvelisib.
Mitotane Mitotane The metabolism of Duvelisib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Duvelisib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Duvelisib can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Duvelisib can be decreased when combined with Midazolam.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Milnacipran Milnacipran The metabolism of Duvelisib can be decreased when combined with Milnacipran.
Lacosamide Lacosamide The metabolism of Duvelisib can be decreased when combined with Lacosamide.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Duvelisib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Duvelisib can be decreased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Duvelisib.
Romidepsin Injection Romidepsin Injection The metabolism of Duvelisib can be decreased when combined with Romidepsin.
Topotecan Topotecan The metabolism of Duvelisib can be decreased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Duvelisib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Duvelisib can be decreased when combined with Pazopanib.
Albendazole Albendazole The metabolism of Duvelisib can be decreased when combined with Albendazole.
Tocilizumab Injection Tocilizumab Injection The metabolism of Duvelisib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Duvelisib can be decreased when combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Duvelisib can be increased when combined with Acetaminophen.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Duvelisib can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Duvelisib.
Roflumilast Roflumilast The metabolism of Duvelisib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The serum concentration of Duvelisib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Telaprevir Telaprevir The serum concentration of Duvelisib can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Duvelisib can be decreased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Duvelisib can be increased when it is combined with Rivaroxaban.
Ticagrelor Ticagrelor The serum concentration of Duvelisib can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Duvelisib can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Duvelisib.
Vandetanib Vandetanib The metabolism of Duvelisib can be decreased when combined with Vandetanib.
Clobazam Clobazam The serum concentration of Duvelisib can be increased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Duvelisib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Duvelisib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Duvelisib.
Crizotinib Crizotinib The metabolism of Duvelisib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Duvelisib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Duvelisib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Duvelisib can be increased when it is combined with Ambrisentan.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Duvelisib can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The metabolism of Duvelisib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Duvelisib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Duvelisib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Duvelisib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Duvelisib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Duvelisib can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Duvelisib can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Duvelisib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The serum concentration of Duvelisib can be increased when it is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Duvelisib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Duvelisib can be decreased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Duvelisib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Duvelisib can be increased when it is combined with Dolutegravir.
Afatinib Afatinib The serum concentration of Duvelisib can be increased when it is combined with Afatinib.
Perampanel Perampanel The metabolism of Duvelisib can be increased when combined with Perampanel.
Lomitapide Lomitapide The metabolism of Duvelisib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Sofosbuvir Sofosbuvir The serum concentration of Duvelisib can be increased when it is combined with Sofosbuvir.
Apremilast Apremilast The metabolism of Duvelisib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Duvelisib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Duvelisib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Duvelisib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Duvelisib can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Duvelisib.
Testosterone Injection Testosterone Injection The metabolism of Duvelisib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Duvelisib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Duvelisib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Duvelisib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Duvelisib can be increased when it is combined with Edoxaban.
Olaparib Olaparib The metabolism of Duvelisib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Duvelisib can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Duvelisib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The serum concentration of Duvelisib can be increased when it is combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Duvelisib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Duvelisib can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The serum concentration of Duvelisib can be increased when it is combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Duvelisib can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Duvelisib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Duvelisib can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Duvelisib.
Flibanserin Flibanserin The serum concentration of Duvelisib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Duvelisib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Duvelisib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Duvelisib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Duvelisib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The metabolism of Duvelisib can be decreased when combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Duvelisib.
Osimertinib Osimertinib The metabolism of Duvelisib can be decreased when combined with Osimertinib.
Alectinib Alectinib The metabolism of Duvelisib can be decreased when combined with Alectinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Duvelisib.
Rifapentine Rifapentine The metabolism of Duvelisib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Duvelisib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Duvelisib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Duvelisib can be increased when combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Duvelisib can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Duvelisib can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Duvelisib can be increased when it is combined with Selexipag.
Rucaparib Rucaparib The serum concentration of Duvelisib can be increased when it is combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Duvelisib can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Duvelisib can be decreased when combined with Brigatinib.
Deflazacort Deflazacort The metabolism of Duvelisib can be increased when combined with Deflazacort.
Safinamide Safinamide Safinamide may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The metabolism of Duvelisib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Duvelisib can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Duvelisib can be decreased when combined with Neratinib.
Enasidenib Enasidenib The metabolism of Duvelisib can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Duvelisib can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Duvelisib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Duvelisib.
Abemaciclib Abemaciclib The metabolism of Duvelisib can be decreased when combined with Abemaciclib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Duvelisib.
Acalabrutinib Acalabrutinib The metabolism of Duvelisib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir Letermovir may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Ertugliflozin Ertugliflozin The serum concentration of Duvelisib can be increased when it is combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Duvelisib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Baricitinib Baricitinib The metabolism of Duvelisib can be decreased when combined with Baricitinib.
Eliglustat Eliglustat The serum concentration of Duvelisib can be increased when it is combined with Eliglustat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Duvelisib.
Ivosidenib Ivosidenib The metabolism of Duvelisib can be decreased when combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Duvelisib.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Duvelisib.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Dacomitinib Dacomitinib The metabolism of Duvelisib can be decreased when combined with Dacomitinib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Duvelisib.
Sarecycline Sarecycline The serum concentration of Duvelisib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Duvelisib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Duvelisib can be increased when it is combined with Talazoparib.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Duvelisib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Duvelisib.
Rifamycin Rifamycin The metabolism of Duvelisib can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Duvelisib can be decreased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Duvelisib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Duvelisib.
Erdafitinib Erdafitinib The serum concentration of Duvelisib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Duvelisib can be decreased when combined with Alpelisib.
Darolutamide Darolutamide The serum concentration of Duvelisib can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Duvelisib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Duvelisib can be decreased when combined with Entrectinib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Duvelisib.
Istradefylline Istradefylline Istradefylline may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Pitolisant Pitolisant The serum concentration of Duvelisib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Duvelisib.
Phenytoin Injection Phenytoin Injection The metabolism of Duvelisib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Duvelisib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Duvelisib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Duvelisib.
Lasmiditan Lasmiditan The serum concentration of Duvelisib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Duvelisib.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Duvelisib.
Cenobamate Cenobamate The serum concentration of Duvelisib can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Duvelisib can be increased when it is combined with Selumetinib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Duvelisib.
Tucatinib Tucatinib Tucatinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Duvelisib.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Duvelisib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Duvelisib can be increased when it is combined with Lemborexant.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Octreotide Octreotide The metabolism of Duvelisib can be decreased when combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Duvelisib.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Duvelisib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Duvelisib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Duvelisib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Duvelisib.
Phenobarbital Phenobarbital The metabolism of Duvelisib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Duvelisib.
Primidone Primidone The metabolism of Duvelisib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Duvelisib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Duvelisib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Duvelisib can be decreased when combined with Lorazepam.
Bromocriptine Bromocriptine The metabolism of Duvelisib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Duvelisib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Duvelisib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Duvelisib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Duvelisib can be decreased when combined with Prochlorperazine.
Methadone Methadone The metabolism of Duvelisib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Duvelisib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Duvelisib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Duvelisib can be decreased when combined with Phentermine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Duvelisib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Duvelisib can be decreased when combined with Doxorubicin.
Dactinomycin Dactinomycin The serum concentration of Duvelisib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Duvelisib.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Duvelisib.
Hydralazine Hydralazine The metabolism of Duvelisib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Duvelisib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Duvelisib.
Loperamide Loperamide The metabolism of Duvelisib can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin The metabolism of Duvelisib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Duvelisib can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Duvelisib.
Loxapine Loxapine The serum concentration of Duvelisib can be increased when it is combined with Loxapine.
Quinine Quinine The serum concentration of Duvelisib can be increased when it is combined with Quinine.
Calcitriol Calcitriol The metabolism of Duvelisib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Duvelisib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Duvelisib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Duvelisib can be decreased when combined with Desipramine.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Duvelisib.
Probenecid Probenecid The metabolism of Duvelisib can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Duvelisib.
Isoniazid Isoniazid The metabolism of Duvelisib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Rifampicin can be increased when combined with Duvelisib.
Valproic Acid Valproic Acid The metabolism of Duvelisib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Duvelisib can be decreased when combined with Tamoxifen.
Methimazole Methimazole The metabolism of Duvelisib can be decreased when combined with Methimazole.
Niacin Niacin The metabolism of Duvelisib can be decreased when combined with Niacin.
Danazol Danazol The metabolism of Duvelisib can be decreased when combined with Danazol.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Duvelisib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Duvelisib can be decreased when combined with Amphotericin B.
Clomiphene Clomiphene The serum concentration of Duvelisib can be increased when it is combined with Clomifene.
Colchicine Colchicine The metabolism of Duvelisib can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Duvelisib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Duvelisib can be decreased when combined with Acetazolamide.
Ketoconazole Ketoconazole The metabolism of Duvelisib can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Duvelisib.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Duvelisib.
Vinblastine Vinblastine The metabolism of Duvelisib can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Duvelisib can be decreased when combined with Metoprolol.
Diltiazem Diltiazem The metabolism of Duvelisib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Duvelisib can be increased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Duvelisib can be decreased when combined with Verapamil.
Etoposide Etoposide The metabolism of Duvelisib can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Duvelisib can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Duvelisib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Duvelisib can be increased when combined with Nafcillin.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Duvelisib.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Duvelisib.
Lovastatin Lovastatin The metabolism of Duvelisib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Duvelisib can be decreased when combined with Ciprofloxacin.
Clozapine Clozapine The metabolism of Duvelisib can be decreased when combined with Clozapine.
Clarithromycin Clarithromycin The metabolism of Duvelisib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Duvelisib can be decreased when combined with Felodipine.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Duvelisib can be increased when it is combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Duvelisib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Duvelisib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Duvelisib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Duvelisib can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Duvelisib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Duvelisib can be decreased when combined with Isradipine.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Cisapride Cisapride The metabolism of Duvelisib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Duvelisib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Duvelisib which could result in a lower serum level and potentially a reduction in efficacy.
Famciclovir Famciclovir The metabolism of Duvelisib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Duvelisib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Duvelisib can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Duvelisib can be decreased when combined with Losartan.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Duvelisib.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection The metabolism of Duvelisib can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Duvelisib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Duvelisib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Duvelisib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Duvelisib.
Ritonavir Ritonavir The metabolism of Duvelisib can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Duvelisib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Duvelisib.
Zafirlukast Zafirlukast The metabolism of Duvelisib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Duvelisib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Duvelisib can be increased when combined with Topiramate.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Duvelisib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Duvelisib can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The serum concentration of Duvelisib can be increased when it is combined with Carvedilol.
Bicalutamide Bicalutamide The metabolism of Duvelisib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Duvelisib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Duvelisib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Duvelisib can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Duvelisib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Duvelisib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Duvelisib can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Duvelisib can be increased when it is combined with Sildenafil.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Duvelisib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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