Temsirolimus

Temsirolimus is used to treat advanced renal cell carcinoma (RCC, a type of cancer that begins in the kidney). Temsirolimus is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that tells the cancer cells to multiply. This may help slow the growth of tumors.

Temsirolimus comes as a solution (liquid) to be given by infusion (slow injection into a vein) over 30 to 60 minutes. It is usually given by a doctor or nurse in a doctor's office or infusion center. Temsirolimus is usually given once every week.

You may experience symptoms such as hives, rash, itching, difficulty breathing or swallowing, swelling of the face, flushing, or chest pain. Tell your doctor or other healthcare provider if you experience these symptoms while you are receiving temsirolimus. Your doctor may prescribe other medications to help prevent or relieve these symptoms. Your doctor will probably give you these medications before you receive each dose of temsirolimus.

Before taking temsirolimus,

• tell your doctor if you are allergic to temsirolimus, sirolimus, antihistamines, any other medications, polysorbate 80, or any of the ingredients in the temsirolimus solution. Ask your doctor for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); certain antifungal medications such as itraconazole (Sporanox); ketoconazole (Nizoral); and voriconazole (Vfen); clarithromycin (Biaxin); dexamethasone (Decadron); certain medications used to treat HIV/AIDS such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Equetro, Tegretol), phenobarbital (Luminal),and phenytoin (Dilantin, Phenytek); medications to lower cholesterol and lipids; nefazodone; rifabutin (Mycobutin); rifampin (Rifadin, Rifamate, Rifiter); selective serotonin re-uptake inhibitors such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sirolimus (Rapamune, Rapamycin); sunitinib (Sutent); and telithromycin (Ketek). Many other medications may also interact with temsirolimus, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Also be sure to tell your doctor and pharmacist if you stop taking one of the medications listed above while you are receiving treatment with temsirolimus.

• tell your doctor what herbal products you are taking, especially St. John's Wort.

• tell your doctor if you have or have ever had diabetes, high cholesterol or triglycerides, a tumor in the central nervous system (brain or spinal cord), cancer, or kidney, liver, or lung disease.

• tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are receiving temsirolimus and for 3 months after treatment with temsirolimus has ended. Talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant while taking temsirolimus, call your doctor immediately. Temsirolimus may harm the fetus.

• tell your doctor if you are breast-feeding. You should not breastfeed while receiving temsirolimus.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving temsirolimus.

• you should know that you may be more at risk of getting an infection while you are receiving temsirolimus. Be sure to wash your hands frequently and avoid contact with people who are sick.

• do not have any vaccinations (e.g., measles, chicken pox, or flu shots) without talking to your doctor.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

If you miss an appointment to receive a dose of temsirolimus, call your doctor right away.

• Temsirolimus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • weakness

  • swelling of the eyes, hands, feet, ankles, or lower legs

  • headache

  • itchy, watery, or red eye(s)

  • change in the way things taste

  • swelling, redness, pain, or sores inside the mouth or throat

  • loss of appetite

  • weight loss

  • nausea

  • vomiting

  • constipation

  • frequent need to urinate

  • pain or burning during urination

  • blood in the urine

  • back pain

  • muscle or joint pain

  • bloody nose

  • changes in fingernails or toenails

  • dry skin

  • pale skin

  • excessive tiredness

  • fast heart beat

  • acne

  • difficulty falling asleep or staying asleep

  • depression

• Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • hives

  • rash

  • itching

  • difficulty breathing or swallowing

  • flushing

  • chest pain

  • shortness of breath

  • fast breathing or panting

  • leg pain, swelling, tenderness, redness, or warmth

  • extreme thirst

  • extreme hunger

  • fever, sore throat, chills, cough, and other signs of infection

  • fainting

  • new or worsening abdominal pain

  • diarrhea

  • red blood in stools

  • decrease in amount of urine

  • blurred vision

  • slow or difficult speech

  • confusion

  • dizziness or faintness

  • weakness or numbness of an arm or leg

• Temsirolimus may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

This medication will be stored at your doctor's office or clinic.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• seizure

• hallucinating (seeing things or hearing voices that do not exist)

• difficulty thinking clearly, understanding reality, or using good judgment

• cough

• shortness of breath

• fever

• new or worsening abdominal pain

• panting or fast breathing

• red blood in stools

• diarrhea

• leg pain, swelling, tenderness, redness, or warmth

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to temsirolimus.

Ask your doctor if you have any questions about your treatment with temsirolimus.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Temsirolimus.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Insulin glargine can be decreased when used in combination with Temsirolimus.
Leflunomide	Leflunomide The risk or severity of adverse effects can be increased when Temsirolimus is combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Temsirolimus can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Temsirolimus.
Atorvastatin	Atorvastatin The risk or severity of adverse effects can be increased when Temsirolimus is combined with Atorvastatin.
Dolasetron	Dolasetron The metabolism of Dolasetron can be decreased when combined with Temsirolimus.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Temsirolimus.
Anagrelide	Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Temsirolimus.
Cilostazol	Cilostazol The metabolism of Temsirolimus can be decreased when combined with Cilostazol.
Clopidogrel	Clopidogrel The metabolism of Temsirolimus can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Temsirolimus can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The risk or severity of angioedema can be increased when Conjugated estrogens is combined with Temsirolimus.
Fenofibrate	Fenofibrate The metabolism of Temsirolimus can be decreased when combined with Fenofibrate.
Methylergonovine	Methylergonovine The metabolism of Temsirolimus can be decreased when combined with Methylergometrine.
Miglitol	Miglitol The therapeutic efficacy of Miglitol can be decreased when used in combination with Temsirolimus.
Mycophenolate	Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Temsirolimus.
Paregoric	Paregoric The serum concentration of Temsirolimus can be increased when it is combined with Morphine.
Penbutolol	Penbutolol The metabolism of Acebutolol can be decreased when combined with Temsirolimus.
Prednisone	Prednisone The serum concentration of Temsirolimus can be increased when it is combined with Prednisone.
Reserpine	Reserpine The serum concentration of Temsirolimus can be increased when it is combined with Reserpine.
Tacrolimus	Tacrolimus The risk or severity of adverse effects can be increased when Tacrolimus is combined with Temsirolimus.
Triamcinolone	Triamcinolone Triamcinolone may decrease the excretion rate of Temsirolimus which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection The metabolism of Temsirolimus can be decreased when combined with Doxycycline.
Fluconazole Injection	Fluconazole Injection The serum concentration of Temsirolimus can be increased when it is combined with Fluconazole.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Temsirolimus.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Temsirolimus.
Meperidine Injection	Meperidine Injection The metabolism of Temsirolimus can be increased when combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The serum concentration of Temsirolimus can be increased when it is combined with Methylprednisolone.
Metoclopramide Injection	Metoclopramide Injection The metabolism of Metoclopramide can be decreased when combined with Temsirolimus.
Metronidazole Injection	Metronidazole Injection The metabolism of Temsirolimus can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The serum concentration of Temsirolimus can be increased when it is combined with Morphine.
Zidovudine Injection	Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Temsirolimus.
Altretamine	Altretamine The metabolism of Amphetamine can be decreased when combined with Temsirolimus.
Cyclosporine	Cyclosporine Temsirolimus may increase the immunosuppressive activities of Cyclosporine.
Ondansetron	Ondansetron The metabolism of Temsirolimus can be decreased when combined with Ondansetron.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Temsirolimus.
Olanzapine	Olanzapine The metabolism of Olanzapine can be decreased when combined with Temsirolimus.
Eprosartan	Eprosartan The risk or severity of angioedema can be increased when Eprosartan is combined with Temsirolimus.
Hydroxychloroquine	Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Temsirolimus.
Orlistat	Orlistat The metabolism of Temsirolimus can be increased when combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The metabolism of Temsirolimus can be increased when combined with Oxcarbazepine.
Telmisartan	Telmisartan The risk or severity of angioedema can be increased when Telmisartan is combined with Temsirolimus.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Temsirolimus.
Zaleplon	Zaleplon The metabolism of Temsirolimus can be decreased when combined with Zaleplon.
Anakinra	Anakinra The metabolism of Temsirolimus can be increased when combined with Anakinra.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Temsirolimus.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Temsirolimus.
Trimipramine	Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Temsirolimus.
Etanercept Injection	Etanercept Injection The metabolism of Temsirolimus can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Temsirolimus can be increased when combined with Modafinil.
Perindopril	Perindopril The risk or severity of angioedema can be increased when Perindopril is combined with Temsirolimus.
Tenofovir	Tenofovir The metabolism of Temsirolimus can be decreased when combined with Tenofovir.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Temsirolimus.
Dutasteride	Dutasteride The metabolism of Temsirolimus can be decreased when combined with Dutasteride.
Epinephrine Injection	Epinephrine Injection The metabolism of Temsirolimus can be decreased when combined with Epinephrine.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Temsirolimus.
Eplerenone	Eplerenone The metabolism of Temsirolimus can be decreased when combined with Eplerenone.
Escitalopram	Escitalopram The metabolism of Escitalopram can be decreased when combined with Temsirolimus.
Zonisamide	Zonisamide The serum concentration of Temsirolimus can be increased when it is combined with Zonisamide.
Adalimumab Injection	Adalimumab Injection The metabolism of Temsirolimus can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Temsirolimus can be decreased when combined with Aripiprazole.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Temsirolimus.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Temsirolimus.
Atazanavir	Atazanavir The metabolism of Temsirolimus can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The metabolism of Almotriptan can be decreased when combined with Temsirolimus.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Temsirolimus.
Mefloquine	Mefloquine The metabolism of Temsirolimus can be decreased when combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Temsirolimus can be decreased when combined with Rosuvastatin.
Vardenafil	Vardenafil The serum concentration of Temsirolimus can be increased when it is combined with Vardenafil.
Aprepitant	Aprepitant The metabolism of Temsirolimus can be decreased when combined with Aprepitant.
Tegaserod	Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Temsirolimus.
Tadalafil	Tadalafil The metabolism of Temsirolimus can be decreased when combined with Tadalafil.
Progesterone	Progesterone The metabolism of Temsirolimus can be increased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Temsirolimus.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Temsirolimus.
Infliximab Injection	Infliximab Injection The metabolism of Temsirolimus can be increased when combined with Infliximab.
Protriptyline	Protriptyline The metabolism of Protriptyline can be decreased when combined with Temsirolimus.
Rifaximin	Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Temsirolimus.
Duloxetine	Duloxetine The metabolism of Temsirolimus can be decreased when combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Temsirolimus can be decreased when combined with Norethisterone.
Bosentan	Bosentan The metabolism of Temsirolimus can be increased when combined with Bosentan.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Natalizumab.
Erlotinib	Erlotinib The metabolism of Temsirolimus can be decreased when combined with Erlotinib.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Insulin aspart can be decreased when used in combination with Temsirolimus.
Palifermin	Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Temsirolimus.
Solifenacin	Solifenacin The metabolism of Solifenacin can be decreased when combined with Temsirolimus.
Voriconazole	Voriconazole The serum concentration of Temsirolimus can be increased when it is combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine The metabolism of Amphetamine can be decreased when combined with Temsirolimus.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Temsirolimus.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Temsirolimus.
Pramlintide Injection	Pramlintide Injection The therapeutic efficacy of Pramlintide can be decreased when used in combination with Temsirolimus.
Exenatide Injection	Exenatide Injection The therapeutic efficacy of Exenatide can be decreased when used in combination with Temsirolimus.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Temsirolimus.
Fentanyl	Fentanyl The metabolism of Temsirolimus can be decreased when combined with Fentanyl.
Pregabalin	Pregabalin The risk or severity of angioedema can be increased when Pregabalin is combined with Temsirolimus.
Deferasirox	Deferasirox The metabolism of Temsirolimus can be increased when combined with Deferasirox.
Tipranavir	Tipranavir The serum concentration of Temsirolimus can be increased when it is combined with Tipranavir.
Felbamate	Felbamate The metabolism of Temsirolimus can be increased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Temsirolimus.
Ranolazine	Ranolazine The serum concentration of Temsirolimus can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Temsirolimus can be increased when combined with Abatacept.
Imatinib	Imatinib The metabolism of Temsirolimus can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin The serum concentration of Temsirolimus can be increased when it is combined with Sitagliptin.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Temsirolimus.
Gefitinib	Gefitinib The metabolism of Temsirolimus can be decreased when combined with Gefitinib.
Paliperidone	Paliperidone The serum concentration of Temsirolimus can be increased when it is combined with Paliperidone.
Bortezomib	Bortezomib The serum concentration of Temsirolimus can be increased when it is combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Temsirolimus.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Temsirolimus.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Temsirolimus.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Temsirolimus.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Temsirolimus.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Temsirolimus.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Temsirolimus.
Posaconazole	Posaconazole The metabolism of Posaconazole can be decreased when combined with Temsirolimus.
Primaquine	Primaquine The metabolism of Temsirolimus can be decreased when combined with Primaquine.
Rituximab Injection	Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Temsirolimus.
Darunavir	Darunavir The serum concentration of Temsirolimus can be increased when it is combined with Darunavir.
Pemetrexed Injection	Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Temsirolimus.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Temsirolimus.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Temsirolimus.
Sorafenib	Sorafenib The serum concentration of Temsirolimus can be increased when it is combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Temsirolimus can be decreased when combined with Sunitinib.
Lapatinib	Lapatinib The serum concentration of Temsirolimus can be increased when it is combined with Lapatinib.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Temsirolimus.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Temsirolimus.
Armodafinil	Armodafinil The metabolism of Temsirolimus can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Temsirolimus.
Ivermectin	Ivermectin The metabolism of Temsirolimus can be increased when combined with Ivermectin.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Temsirolimus.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Temsirolimus.
Nilotinib	Nilotinib The serum concentration of Temsirolimus can be increased when it is combined with Nilotinib.
Toremifene	Toremifene The serum concentration of Temsirolimus can be increased when it is combined with Toremifene.
Bexarotene	Bexarotene The metabolism of Temsirolimus can be increased when combined with Bexarotene.
Budesonide	Budesonide The serum concentration of Temsirolimus can be increased when it is combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Temsirolimus can be decreased when combined with Chloramphenicol.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Temsirolimus.
Etravirine	Etravirine The metabolism of Temsirolimus can be increased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Arsenic trioxide.
Mitoxantrone Injection	Mitoxantrone Injection The metabolism of Temsirolimus can be decreased when combined with Mitoxantrone.
Desvenlafaxine	Desvenlafaxine The metabolism of Temsirolimus can be decreased when combined with Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Temsirolimus.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Temsirolimus.
Tretinoin	Tretinoin The metabolism of Temsirolimus can be decreased when combined with Tretinoin.
Bendamustine Injection	Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Temsirolimus.
Pilocarpine	Pilocarpine The metabolism of Temsirolimus can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Temsirolimus.
Certolizumab Injection	Certolizumab Injection The metabolism of Temsirolimus can be increased when combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Temsirolimus can be decreased when combined with Ixabepilone.
Irinotecan Injection	Irinotecan Injection The metabolism of Temsirolimus can be decreased when combined with Irinotecan.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Temsirolimus.
Praziquantel	Praziquantel The metabolism of Temsirolimus can be decreased when combined with Praziquantel.
Mitotane	Mitotane The metabolism of Temsirolimus can be increased when combined with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Temsirolimus.
Rufinamide	Rufinamide The metabolism of Temsirolimus can be increased when combined with Rufinamide.
Silodosin	Silodosin The serum concentration of Silodosin can be increased when it is combined with Temsirolimus.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Temsirolimus.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Temsirolimus.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Temsirolimus.
Milnacipran	Milnacipran The metabolism of Temsirolimus can be decreased when combined with Milnacipran.
Fesoterodine	Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Temsirolimus.
Betaxolol	Betaxolol The metabolism of Betaxolol can be decreased when combined with Temsirolimus.
Iloperidone	Iloperidone The metabolism of Temsirolimus can be decreased when combined with Iloperidone.
Prasugrel	Prasugrel The risk or severity of bleeding can be increased when Prasugrel is combined with Temsirolimus.
Lacosamide	Lacosamide The metabolism of Temsirolimus can be decreased when combined with Lacosamide.
Everolimus	Everolimus The serum concentration of Temsirolimus can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Temsirolimus.
Dronedarone	Dronedarone The serum concentration of Temsirolimus can be increased when it is combined with Dronedarone.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Pralatrexate.
Palonosetron Injection	Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Temsirolimus.
Saxagliptin	Saxagliptin The metabolism of Temsirolimus can be decreased when combined with Saxagliptin.
Romidepsin Injection	Romidepsin Injection The metabolism of Temsirolimus can be decreased when combined with Romidepsin.
Tapentadol	Tapentadol The metabolism of Tapentadol can be decreased when combined with Temsirolimus.
Topotecan	Topotecan The serum concentration of Topotecan can be increased when it is combined with Temsirolimus.
Golimumab Injection	Golimumab Injection The metabolism of Temsirolimus can be increased when combined with Golimumab.
Pazopanib	Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Temsirolimus.
Albendazole	Albendazole The metabolism of Temsirolimus can be decreased when combined with Albendazole.
Levonorgestrel	Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Temsirolimus.
Oxymorphone	Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Temsirolimus.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Temsirolimus.
Dabigatran	Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Temsirolimus.
Liraglutide Injection	Liraglutide Injection The therapeutic efficacy of Liraglutide can be decreased when used in combination with Temsirolimus.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Temsirolimus can be increased when combined with Tocilizumab.
Fingolimod	Fingolimod Temsirolimus may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Eribulin.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Temsirolimus.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Temsirolimus can be increased when combined with Acetaminophen.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Temsirolimus.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The metabolism of Temsirolimus can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Temsirolimus.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Belimumab.
Azilsartan	Azilsartan The risk or severity of angioedema can be increased when Temsirolimus is combined with Azilsartan medoxomil.
Busulfan Injection	Busulfan Injection The risk or severity of adverse effects can be increased when Busulfan is combined with Temsirolimus.
Roflumilast	Roflumilast Roflumilast may increase the immunosuppressive activities of Temsirolimus.
Linagliptin	Linagliptin The serum concentration of Temsirolimus can be increased when it is combined with Linagliptin.
Rilpivirine	Rilpivirine The metabolism of Temsirolimus can be decreased when combined with Rilpivirine.
Telaprevir	Telaprevir The serum concentration of Temsirolimus can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Temsirolimus can be increased when combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban The metabolism of Temsirolimus can be decreased when combined with Rivaroxaban.
Ticagrelor	Ticagrelor The serum concentration of Temsirolimus can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Temsirolimus.
Ruxolitinib	Ruxolitinib The risk or severity of adverse effects can be increased when Temsirolimus is combined with Ruxolitinib.
Vandetanib	Vandetanib The serum concentration of Temsirolimus can be increased when it is combined with Vandetanib.
Clobazam	Clobazam The metabolism of Temsirolimus can be increased when combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Temsirolimus can be increased when it is combined with Vemurafenib.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Belatacept.
Ivacaftor	Ivacaftor The serum concentration of Temsirolimus can be increased when it is combined with Ivacaftor.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Temsirolimus.
Axitinib	Axitinib The metabolism of Temsirolimus can be decreased when combined with Axitinib.
Crizotinib	Crizotinib The metabolism of Temsirolimus can be decreased when combined with Crizotinib.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Temsirolimus.
Cabergoline	Cabergoline The metabolism of Temsirolimus can be decreased when combined with Cabergoline.
Naloxone Injection	Naloxone Injection The metabolism of Temsirolimus can be decreased when combined with Naloxone.
Ambrisentan	Ambrisentan The metabolism of Temsirolimus can be decreased when combined with Ambrisentan.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Temsirolimus.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Temsirolimus.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Temsirolimus.
Iloprost	Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Temsirolimus.
Enzalutamide	Enzalutamide The serum concentration of Temsirolimus can be increased when it is combined with Enzalutamide.
Mirabegron	Mirabegron The serum concentration of Temsirolimus can be increased when it is combined with Mirabegron.
Regorafenib	Regorafenib The serum concentration of Temsirolimus can be increased when it is combined with Regorafenib.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Temsirolimus.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The serum concentration of Temsirolimus can be increased when it is combined with Corticotropin.
Teriflunomide	Teriflunomide The risk or severity of adverse effects can be increased when Temsirolimus is combined with Teriflunomide.
Lorcaserin	Lorcaserin The therapeutic efficacy of Mecasermin can be decreased when used in combination with Temsirolimus.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Temsirolimus.
Tofacitinib	Tofacitinib Temsirolimus may increase the immunosuppressive activities of Tofacitinib.
Alogliptin	Alogliptin The therapeutic efficacy of Alogliptin can be decreased when used in combination with Temsirolimus.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Temsirolimus is combined with Dimethyl fumarate.
Ponatinib	Ponatinib The serum concentration of Temsirolimus can be increased when it is combined with Ponatinib.
Pomalidomide	Pomalidomide The serum concentration of Temsirolimus can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Temsirolimus can be decreased when combined with Trastuzumab emtansine.
Apixaban	Apixaban The metabolism of Temsirolimus can be decreased when combined with Apixaban.
Canagliflozin	Canagliflozin The serum concentration of Temsirolimus can be increased when it is combined with Canagliflozin.
Dabrafenib	Dabrafenib The metabolism of Temsirolimus can be increased when combined with Dabrafenib.
Trametinib	Trametinib The metabolism of Temsirolimus can be increased when combined with Trametinib.
Dolutegravir	Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Temsirolimus.
Afatinib	Afatinib The serum concentration of Afatinib can be increased when it is combined with Temsirolimus.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Temsirolimus.
Vortioxetine	Vortioxetine The metabolism of Temsirolimus can be decreased when combined with Vortioxetine.
Perampanel	Perampanel The metabolism of Temsirolimus can be increased when combined with Perampanel.
Ibrutinib	Ibrutinib The metabolism of Temsirolimus can be decreased when combined with Ibrutinib.
Lomitapide	Lomitapide The serum concentration of Temsirolimus can be increased when it is combined with Lomitapide.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Obinutuzumab.
Simeprevir	Simeprevir The serum concentration of Temsirolimus can be increased when it is combined with Simeprevir.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Temsirolimus.
Dapagliflozin	Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Temsirolimus.
Apremilast	Apremilast The metabolism of Temsirolimus can be increased when combined with Apremilast.
Ceritinib	Ceritinib The metabolism of Temsirolimus can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Temsirolimus can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection The therapeutic efficacy of Albiglutide can be decreased when used in combination with Temsirolimus.
Eslicarbazepine	Eslicarbazepine The metabolism of Temsirolimus can be increased when combined with Eslicarbazepine.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Vedolizumab.
Belinostat Injection	Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Temsirolimus.
Idelalisib	Idelalisib The risk or severity of adverse effects can be increased when Temsirolimus is combined with Idelalisib.
Testosterone Injection	Testosterone Injection The metabolism of Temsirolimus can be increased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Temsirolimus can be increased when combined with Oritavancin.
Empagliflozin	Empagliflozin The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Temsirolimus.
Vorapaxar	Vorapaxar The serum concentration of Temsirolimus can be increased when it is combined with Vorapaxar.
Hydrocodone	Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Temsirolimus.
Suvorexant	Suvorexant The serum concentration of Temsirolimus can be increased when it is combined with Suvorexant.
Dulaglutide Injection	Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Temsirolimus.
Edoxaban	Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Temsirolimus.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Temsirolimus can be decreased when combined with Olaparib.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Blinatumomab.
Methamphetamine	Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Temsirolimus.
Tasimelteon	Tasimelteon The metabolism of Temsirolimus can be decreased when combined with Tasimelteon.
Lanreotide Injection	Lanreotide Injection The metabolism of Temsirolimus can be decreased when combined with Lanreotide.
Pirfenidone	Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Temsirolimus.
Nintedanib	Nintedanib The metabolism of Temsirolimus can be decreased when combined with Nintedanib.
Secukinumab Injection	Secukinumab Injection The metabolism of Temsirolimus can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The metabolism of Temsirolimus can be decreased when combined with Risperidone.
Palbociclib	Palbociclib The serum concentration of Temsirolimus can be increased when it is combined with Palbociclib.
Insulin Human Inhalation	Insulin Human Inhalation The therapeutic efficacy of Insulin human can be decreased when used in combination with Temsirolimus.
Lenvatinib	Lenvatinib The metabolism of Temsirolimus can be increased when combined with Lenvatinib.
Naloxegol	Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Temsirolimus.
Panobinostat	Panobinostat The serum concentration of Temsirolimus can be increased when it is combined with Panobinostat.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The serum concentration of Temsirolimus can be increased when it is combined with Haloperidol.
Isavuconazonium Injection	Isavuconazonium Injection The serum concentration of Temsirolimus can be increased when it is combined with Isavuconazonium.
Flibanserin	Flibanserin The serum concentration of Temsirolimus can be increased when it is combined with Flibanserin.
Rolapitant	Rolapitant The serum concentration of Temsirolimus can be increased when it is combined with Rolapitant.
Prednisolone	Prednisolone The serum concentration of Temsirolimus can be increased when it is combined with Prednisolone.
Daclatasvir	Daclatasvir The serum concentration of Temsirolimus can be increased when it is combined with Daclatasvir.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Temsirolimus.
Ziprasidone Injection	Ziprasidone Injection The metabolism of Temsirolimus can be decreased when combined with Ziprasidone.
Cariprazine	Cariprazine The metabolism of Cariprazine can be decreased when combined with Temsirolimus.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be decreased when used in combination with Temsirolimus.
Cobimetinib	Cobimetinib The serum concentration of Temsirolimus can be increased when it is combined with Cobimetinib.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Mepolizumab.
Trabectedin Injection	Trabectedin Injection The metabolism of Temsirolimus can be decreased when combined with Trabectedin.
Osimertinib	Osimertinib The metabolism of Temsirolimus can be increased when combined with Osimertinib.
Rifapentine	Rifapentine The metabolism of Temsirolimus can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Temsirolimus can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The metabolism of Temsirolimus can be decreased when combined with Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The serum concentration of Temsirolimus can be increased when it is combined with Dexamethasone.
Defibrotide Injection	Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Temsirolimus.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Ixekizumab.
Venetoclax	Venetoclax The serum concentration of Temsirolimus can be increased when it is combined with Venetoclax.
Cobicistat	Cobicistat The serum concentration of Temsirolimus can be increased when it is combined with Cobicistat.
Selexipag	Selexipag The serum concentration of Temsirolimus can be increased when it is combined with Selexipag.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Temsirolimus.
Rucaparib	Rucaparib The serum concentration of Temsirolimus can be increased when it is combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Temsirolimus.
Ribociclib	Ribociclib The metabolism of Temsirolimus can be decreased when combined with Ribociclib.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Brodalumab.
Brigatinib	Brigatinib The metabolism of Temsirolimus can be increased when combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Temsirolimus.
Deutetrabenazine	Deutetrabenazine The metabolism of Temsirolimus can be decreased when combined with Deutetrabenazine.
Valbenazine	Valbenazine The metabolism of Temsirolimus can be decreased when combined with Valbenazine.
Deflazacort	Deflazacort The serum concentration of Temsirolimus can be increased when it is combined with Deflazacort.
Safinamide	Safinamide The metabolism of Temsirolimus can be decreased when combined with Safinamide.
Ocrelizumab Injection	Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Temsirolimus.
Sarilumab Injection	Sarilumab Injection The metabolism of Temsirolimus can be increased when combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Temsirolimus can be increased when combined with Midostaurin.
Neratinib	Neratinib The serum concentration of Temsirolimus can be increased when it is combined with Neratinib.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Guselkumab.
Enasidenib	Enasidenib The serum concentration of Temsirolimus can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Temsirolimus.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Temsirolimus can be increased when combined with Fosaprepitant.
Copanlisib Injection	Copanlisib Injection The metabolism of Temsirolimus can be decreased when combined with Copanlisib.
Abemaciclib	Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Temsirolimus.
Betrixaban	Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Temsirolimus.
Acalabrutinib	Acalabrutinib The metabolism of Temsirolimus can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Temsirolimus.
Letermovir	Letermovir The metabolism of Temsirolimus can be decreased when combined with Letermovir.
Semaglutide Injection	Semaglutide Injection The therapeutic efficacy of Semaglutide can be decreased when used in combination with Temsirolimus.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Temsirolimus.
Ertugliflozin	Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Temsirolimus.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Temsirolimus can be decreased when combined with Buprenorphine.
Apalutamide	Apalutamide The serum concentration of Temsirolimus can be decreased when it is combined with Apalutamide.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Temsirolimus.
Fostamatinib	Fostamatinib The metabolism of Temsirolimus can be decreased when combined with Fostamatinib.
Avatrombopag	Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Temsirolimus.
Baricitinib	Baricitinib The risk or severity of adverse effects can be increased when Baricitinib is combined with Temsirolimus.
Lofexidine	Lofexidine The metabolism of Lofexidine can be decreased when combined with Temsirolimus.
Eliglustat	Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Temsirolimus.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Temsirolimus.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Temsirolimus.
Ivosidenib	Ivosidenib The serum concentration of Temsirolimus can be increased when it is combined with Ivosidenib.
Lusutrombopag	Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Temsirolimus.
Elagolix	Elagolix The serum concentration of Elagolix can be increased when it is combined with Temsirolimus.
Doravirine	Doravirine The metabolism of Temsirolimus can be decreased when combined with Doravirine.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Temsirolimus.
Cannabidiol	Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Temsirolimus.
Dacomitinib	Dacomitinib The serum concentration of Temsirolimus can be increased when it is combined with Dacomitinib.
Duvelisib	Duvelisib The metabolism of Temsirolimus can be decreased when combined with Duvelisib.
Omadacycline	Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Temsirolimus.
Sarecycline	Sarecycline The serum concentration of Temsirolimus can be increased when it is combined with Sarecycline.
Stiripentol	Stiripentol The metabolism of Temsirolimus can be decreased when combined with Stiripentol.
Talazoparib	Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Temsirolimus.
Gilteritinib	Gilteritinib The metabolism of Temsirolimus can be decreased when combined with Gilteritinib.
Glasdegib	Glasdegib The serum concentration of Temsirolimus can be increased when it is combined with Glasdegib.
Lorlatinib	Lorlatinib The metabolism of Temsirolimus can be decreased when combined with Lorlatinib.
Larotrectinib	Larotrectinib The serum concentration of Temsirolimus can be increased when it is combined with Larotrectinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Temsirolimus.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Temsirolimus can be increased when combined with Paclitaxel.
Rifamycin	Rifamycin The metabolism of Temsirolimus can be increased when combined with Rifamycin.
Prucalopride	Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Temsirolimus.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Temsirolimus can be increased when combined with Emapalumab.
Siponimod	Siponimod The risk or severity of adverse effects can be increased when Temsirolimus is combined with Siponimod.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Temsirolimus.
Erdafitinib	Erdafitinib The serum concentration of Temsirolimus can be increased when it is combined with Erdafitinib.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Temsirolimus is combined with Risankizumab.
Alpelisib	Alpelisib The metabolism of Temsirolimus can be increased when combined with Alpelisib.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Temsirolimus.
Darolutamide	Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Temsirolimus.
Triclabendazole	Triclabendazole The metabolism of Temsirolimus can be decreased when combined with Triclabendazole.
Entrectinib	Entrectinib The serum concentration of Entrectinib can be increased when it is combined with Temsirolimus.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Temsirolimus.
Pitolisant	Pitolisant The serum concentration of Temsirolimus can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Temsirolimus.
Lefamulin	Lefamulin Temsirolimus may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection	Phenytoin Injection The metabolism of Temsirolimus can be increased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Temsirolimus can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Temsirolimus.
Voxelotor	Voxelotor The serum concentration of Temsirolimus can be increased when it is combined with Voxelotor.
Lasmiditan	Lasmiditan The serum concentration of Temsirolimus can be increased when it is combined with Lasmiditan.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Temsirolimus.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Temsirolimus.
Cenobamate	Cenobamate The serum concentration of Temsirolimus can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod The risk or severity of adverse effects can be increased when Temsirolimus is combined with Ozanimod.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Temsirolimus.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Temsirolimus.
Tucatinib	Tucatinib Temsirolimus may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection	Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Temsirolimus.
Ripretinib	Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Temsirolimus.
Capmatinib	Capmatinib The serum concentration of Temsirolimus can be increased when it is combined with Capmatinib.
Lemborexant	Lemborexant The metabolism of Lemborexant can be decreased when combined with Temsirolimus.
Fostemsavir	Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Temsirolimus.
Octreotide	Octreotide The serum concentration of Temsirolimus can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Temsirolimus.
Pralsetinib	Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Temsirolimus.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Temsirolimus can be decreased when it is combined with Satralizumab.
Relugolix	Relugolix The serum concentration of Relugolix can be increased when it is combined with Temsirolimus.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Temsirolimus can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol)	Vitamin E (Alpha-Tocopherol) The metabolism of Temsirolimus can be increased when combined with Vitamin E.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Temsirolimus.
Indomethacin	Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Temsirolimus.
Trazodone	Trazodone The metabolism of Temsirolimus can be decreased when combined with Trazodone.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Temsirolimus.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Temsirolimus.
Phenobarbital	Phenobarbital The metabolism of Temsirolimus can be increased when combined with Phenobarbital.
Methotrexate Injection	Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Temsirolimus.
Primidone	Primidone The metabolism of Temsirolimus can be increased when combined with Primidone.
Chlorpromazine	Chlorpromazine The metabolism of Temsirolimus can be increased when combined with Chlorpromazine.
Diazepam	Diazepam The metabolism of Temsirolimus can be decreased when combined with Diazepam.
Lorazepam	Lorazepam The metabolism of Temsirolimus can be decreased when combined with Lorazepam.
Carmustine	Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Temsirolimus.
Codeine	Codeine The metabolism of Codeine can be decreased when combined with Temsirolimus.
Bromocriptine	Bromocriptine The metabolism of Temsirolimus can be decreased when combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The metabolism of Temsirolimus can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Temsirolimus can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Temsirolimus.
Ergoloid Mesylates	Ergoloid Mesylates The serum concentration of Ergoloid mesylate can be increased when it is combined with Temsirolimus.
Tetracycline	Tetracycline The metabolism of Temsirolimus can be decreased when combined with Tetracycline.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Temsirolimus.
Prochlorperazine	Prochlorperazine The metabolism of Temsirolimus can be decreased when combined with Prochlorperazine.
Thioridazine	Thioridazine The metabolism of Thioridazine can be decreased when combined with Temsirolimus.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Temsirolimus.
Dapsone	Dapsone The metabolism of Temsirolimus can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Temsirolimus.
Oxycodone	Oxycodone The metabolism of Temsirolimus can be decreased when combined with Oxycodone.
Methadone	Methadone The metabolism of Temsirolimus can be increased when combined with Methadone.
Oxybutynin	Oxybutynin The metabolism of Temsirolimus can be decreased when combined with Oxybutynin.
Benztropine	Benztropine The metabolism of Benzatropine can be decreased when combined with Temsirolimus.
Maprotiline	Maprotiline The metabolism of Maprotiline can be decreased when combined with Temsirolimus.
Ibuprofen	Ibuprofen The risk or severity of angioedema can be increased when Ibuprofen is combined with Temsirolimus.
Orphenadrine	Orphenadrine The metabolism of Temsirolimus can be decreased when combined with Orphenadrine.
Perphenazine	Perphenazine The metabolism of Perphenazine can be decreased when combined with Temsirolimus.
Azathioprine	Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Temsirolimus.
Phentermine	Phentermine The metabolism of Temsirolimus can be decreased when combined with Phentermine.
Amoxapine	Amoxapine The metabolism of Amoxapine can be decreased when combined with Temsirolimus.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Temsirolimus.
Hydrocortisone	Hydrocortisone The serum concentration of Temsirolimus can be increased when it is combined with Hydrocortisone.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Temsirolimus.
Doxorubicin	Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Temsirolimus.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Temsirolimus.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Temsirolimus.
Dactinomycin	Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Temsirolimus.
Carbamazepine	Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Temsirolimus.
Clonidine	Clonidine The metabolism of Temsirolimus can be decreased when combined with Clonidine.
Hydralazine	Hydralazine The metabolism of Temsirolimus can be decreased when combined with Hydralazine.
Cimetidine	Cimetidine The metabolism of Temsirolimus can be decreased when combined with Cimetidine.
Warfarin	Warfarin The metabolism of Temsirolimus can be increased when combined with Warfarin.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Temsirolimus.
Promethazine	Promethazine The metabolism of Promethazine can be decreased when combined with Temsirolimus.
Daunorubicin	Daunorubicin The metabolism of Temsirolimus can be decreased when combined with Daunorubicin.
Griseofulvin	Griseofulvin The metabolism of Temsirolimus can be increased when combined with Griseofulvin.
Digoxin	Digoxin The serum concentration of Digoxin can be increased when it is combined with Temsirolimus.
Loxapine	Loxapine The serum concentration of Temsirolimus can be increased when it is combined with Loxapine.
Chloroquine	Chloroquine The metabolism of Temsirolimus can be decreased when combined with Chloroquine.
Quinine	Quinine The serum concentration of Quinine can be increased when it is combined with Temsirolimus.
Calcitriol	Calcitriol The metabolism of Temsirolimus can be increased when combined with Calcitriol.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Temsirolimus can be increased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Chlorothiazide is combined with Temsirolimus.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Temsirolimus.
Secobarbital	Secobarbital The metabolism of Temsirolimus can be increased when combined with Secobarbital.
Desipramine	Desipramine The metabolism of Temsirolimus can be decreased when combined with Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Temsirolimus.
Imipramine	Imipramine The metabolism of Temsirolimus can be decreased when combined with Imipramine.
Probenecid	Probenecid The metabolism of Temsirolimus can be increased when combined with Probenecid.
Quinidine	Quinidine The serum concentration of Quinidine can be increased when it is combined with Temsirolimus.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Temsirolimus.
Isoniazid	Isoniazid The metabolism of Temsirolimus can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Temsirolimus can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Temsirolimus may increase the QTc-prolonging activities of Disopyramide.
Valproic Acid	Valproic Acid The metabolism of Temsirolimus can be decreased when combined with Valproic acid.
Tamoxifen	Tamoxifen The metabolism of Temsirolimus can be increased when combined with Tamoxifen.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Temsirolimus.
Levothyroxine	Levothyroxine The serum concentration of Levothyroxine can be decreased when it is combined with Temsirolimus.
Methimazole	Methimazole The metabolism of Temsirolimus can be decreased when combined with Methimazole.
Propylthiouracil	Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Temsirolimus.
Chlorpropamide	Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Temsirolimus.
Tolbutamide	Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Temsirolimus.
Tolazamide	Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Temsirolimus.
Dextromethorphan	Dextromethorphan The metabolism of Temsirolimus can be decreased when combined with Dextromethorphan.
Niacin	Niacin The metabolism of Temsirolimus can be decreased when combined with Niacin.
Chlorpheniramine	Chlorpheniramine The metabolism of Temsirolimus can be decreased when combined with Chlorpheniramine.
Meclizine	Meclizine The metabolism of Meclizine can be decreased when combined with Temsirolimus.
Methyclothiazide	Methyclothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Methyclothiazide is combined with Temsirolimus.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Temsirolimus.
Chlorzoxazone	Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Temsirolimus.
Danazol	Danazol The metabolism of Temsirolimus can be decreased when combined with Danazol.
Disulfiram	Disulfiram The metabolism of Temsirolimus can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Temsirolimus.
Nortriptyline	Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Temsirolimus.
Amphotericin B Injection	Amphotericin B Injection The metabolism of Temsirolimus can be decreased when combined with Amphotericin B.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Temsirolimus.
Nadolol	Nadolol The metabolism of Nadolol can be decreased when combined with Temsirolimus.
Allopurinol	Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Temsirolimus.
Clomiphene	Clomiphene The serum concentration of Clomifene can be increased when it is combined with Temsirolimus.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Temsirolimus.
Colchicine	Colchicine The serum concentration of Colchicine can be increased when it is combined with Temsirolimus.
Cephalexin	Cephalexin The metabolism of Temsirolimus can be decreased when combined with Cephalexin.
Dacarbazine	Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Temsirolimus.
Acetazolamide	Acetazolamide The metabolism of Temsirolimus can be decreased when combined with Acetazolamide.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Temsirolimus.
Ketoconazole	Ketoconazole The serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with Ketoconazole.
Thiotepa Injection	Thiotepa Injection The risk or severity of adverse effects can be increased when Thiotepa is combined with Temsirolimus.
Vincristine Injection	Vincristine Injection The excretion of Vincristine can be decreased when combined with Temsirolimus.
Captopril	Captopril The risk or severity of angioedema can be increased when Temsirolimus is combined with Captopril.
Dipyridamole	Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Temsirolimus.
Vinblastine	Vinblastine The metabolism of Temsirolimus can be increased when combined with Vinblastine.
Metoprolol	Metoprolol The metabolism of Temsirolimus can be decreased when combined with Metoprolol.
Hydroxyzine	Hydroxyzine The metabolism of Hydroxyzine can be decreased when combined with Temsirolimus.
Aspirin	Aspirin The risk or severity of angioedema can be increased when Acetylsalicylic acid is combined with Temsirolimus.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Temsirolimus.
Alprazolam	Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Temsirolimus.
Triazolam	Triazolam The serum concentration of Triazolam can be increased when it is combined with Temsirolimus.
Diltiazem	Diltiazem The metabolism of Temsirolimus can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Temsirolimus can be increased when combined with Nifedipine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Temsirolimus.
Verapamil	Verapamil The serum concentration of Temsirolimus can be increased when it is combined with Verapamil.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Temsirolimus.
Pindolol	Pindolol The metabolism of Pindolol can be decreased when combined with Temsirolimus.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Temsirolimus.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Temsirolimus.
Etoposide	Etoposide The metabolism of Etoposide can be decreased when combined with Temsirolimus.
Glyburide	Glyburide The metabolism of Temsirolimus can be decreased when combined with Glyburide.
Glipizide	Glipizide The therapeutic efficacy of Glipizide can be decreased when used in combination with Temsirolimus.
Dicloxacillin	Dicloxacillin The metabolism of Temsirolimus can be increased when combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The metabolism of Temsirolimus can be increased when combined with Nafcillin.
Pentoxifylline	Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Temsirolimus.
Pentamidine Injection	Pentamidine Injection The metabolism of Temsirolimus can be decreased when combined with Pentamidine.
Labetalol	Labetalol The metabolism of Labetalol can be decreased when combined with Temsirolimus.
Pimozide	Pimozide The metabolism of Temsirolimus can be decreased when combined with Pimozide.
Enalapril	Enalapril The risk or severity of angioedema can be increased when Temsirolimus is combined with Enalapril.
Amiodarone	Amiodarone The metabolism of Temsirolimus can be decreased when combined with Amiodarone.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Temsirolimus.
Lovastatin	Lovastatin The metabolism of Temsirolimus can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Temsirolimus can be decreased when combined with Ciprofloxacin.
Diclofenac	Diclofenac The risk or severity of angioedema can be increased when Diclofenac is combined with Temsirolimus.
Fluoxetine	Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Temsirolimus.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Temsirolimus.
Clozapine	Clozapine The risk or severity of neutropenia can be increased when Temsirolimus is combined with Clozapine.
Estazolam	Estazolam The serum concentration of Estazolam can be increased when it is combined with Temsirolimus.
Idarubicin	Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Temsirolimus.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Temsirolimus.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Temsirolimus.
Clarithromycin	Clarithromycin The metabolism of Temsirolimus can be decreased when combined with Clarithromycin.
Benazepril	Benazepril The risk or severity of angioedema can be increased when Benazepril is combined with Temsirolimus.
Felodipine	Felodipine The metabolism of Temsirolimus can be decreased when combined with Felodipine.
Fosinopril	Fosinopril The risk or severity of angioedema can be increased when Fosinopril is combined with Temsirolimus.
Pravastatin	Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Temsirolimus.
Quinapril	Quinapril The risk or severity of angioedema can be increased when Quinapril is combined with Temsirolimus.
Ramipril	Ramipril The risk or severity of angioedema can be increased when Ramipril is combined with Temsirolimus.
Simvastatin	Simvastatin The metabolism of Temsirolimus can be decreased when combined with Simvastatin.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Temsirolimus.
Teniposide Injection	Teniposide Injection The metabolism of Temsirolimus can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with Itraconazole.
Lisinopril	Lisinopril The risk or severity of angioedema can be increased when Lisinopril is combined with Temsirolimus.
Rifabutin	Rifabutin The metabolism of Temsirolimus can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Temsirolimus.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Temsirolimus.
Zolpidem	Zolpidem The metabolism of Zolpidem can be decreased when combined with Temsirolimus.
Doxazosin	Doxazosin The metabolism of Temsirolimus can be decreased when combined with Doxazosin.
Isradipine	Isradipine The metabolism of Temsirolimus can be decreased when combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Temsirolimus can be increased when combined with Omeprazole.
Cisapride	Cisapride The serum concentration of Cisapride can be increased when it is combined with Temsirolimus.
Fluvastatin	Fluvastatin The metabolism of Temsirolimus can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Temsirolimus.
Famciclovir	Famciclovir The metabolism of Temsirolimus can be decreased when combined with Famciclovir.
Fluvoxamine	Fluvoxamine The metabolism of Temsirolimus can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Temsirolimus can be decreased when combined with Nefazodone.
Losartan	Losartan The metabolism of Temsirolimus can be decreased when combined with Losartan.
Tramadol	Tramadol The metabolism of Temsirolimus can be decreased when combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Temsirolimus.
Carboplatin Injection	Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Temsirolimus.
Moexipril	Moexipril The risk or severity of angioedema can be increased when Moexipril is combined with Temsirolimus.
Lansoprazole	Lansoprazole The metabolism of Temsirolimus can be increased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Temsirolimus can be increased when combined with Ifosfamide.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Temsirolimus.
Nicardipine	Nicardipine The metabolism of Temsirolimus can be decreased when combined with Nicardipine.
Ticlopidine	Ticlopidine The metabolism of Temsirolimus can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Temsirolimus can be decreased when combined with Saquinavir.
Metformin	Metformin The therapeutic efficacy of Metformin can be decreased when used in combination with Temsirolimus.
Dalteparin Injection	Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Temsirolimus.
Nisoldipine	Nisoldipine The metabolism of Temsirolimus can be decreased when combined with Nisoldipine.
Acarbose	Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Temsirolimus.
Glimepiride	Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Temsirolimus.
Gemcitabine Injection	Gemcitabine Injection The serum concentration of Temsirolimus can be increased when it is combined with Gemcitabine.
Indinavir	Indinavir The metabolism of Temsirolimus can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Temsirolimus can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Temsirolimus can be decreased when combined with Docetaxel.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Temsirolimus.
Zafirlukast	Zafirlukast The metabolism of Temsirolimus can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine The metabolism of Temsirolimus can be decreased when combined with Mirtazapine.
Trandolapril	Trandolapril The risk or severity of angioedema can be increased when Trandolapril is combined with Temsirolimus.
Topiramate	Topiramate The metabolism of Temsirolimus can be increased when combined with Topiramate.
Valsartan	Valsartan The risk or severity of angioedema can be increased when Valsartan is combined with Temsirolimus.
Insulin Lispro Injection	Insulin Lispro Injection The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Temsirolimus.
Donepezil	Donepezil The metabolism of Donepezil can be decreased when combined with Temsirolimus.
Nelfinavir	Nelfinavir The metabolism of Temsirolimus can be decreased when combined with Nelfinavir.
Fexofenadine	Fexofenadine The serum concentration of Temsirolimus can be increased when it is combined with Fexofenadine.
Azithromycin	Azithromycin The metabolism of Temsirolimus can be decreased when combined with Azithromycin.
Carvedilol	Carvedilol The serum concentration of Temsirolimus can be increased when it is combined with Carvedilol.
Flutamide	Flutamide The metabolism of Temsirolimus can be decreased when combined with Flutamide.
Selegiline	Selegiline The metabolism of Selegiline can be decreased when combined with Temsirolimus.
Bicalutamide	Bicalutamide The metabolism of Temsirolimus can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Sertraline can be decreased when combined with Temsirolimus.
Propafenone	Propafenone The serum concentration of Temsirolimus can be increased when it is combined with Propafenone.
Raloxifene	Raloxifene The metabolism of Raloxifene can be decreased when combined with Temsirolimus.
Irbesartan	Irbesartan The metabolism of Temsirolimus can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Temsirolimus.
Finasteride	Finasteride The metabolism of Temsirolimus can be decreased when combined with Finasteride.
Quetiapine	Quetiapine The metabolism of Temsirolimus can be decreased when combined with Quetiapine.
Paroxetine	Paroxetine The metabolism of Temsirolimus can be decreased when combined with Paroxetine.
Citalopram	Citalopram The metabolism of Temsirolimus can be decreased when combined with Citalopram.
Capecitabine	Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Temsirolimus.
Efavirenz	Efavirenz The metabolism of Temsirolimus can be increased when combined with Efavirenz.
Sildenafil	Sildenafil The serum concentration of Temsirolimus can be increased when it is combined with Sildenafil.
Pioglitazone	Pioglitazone The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Temsirolimus.
Trastuzumab Injection	Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Temsirolimus.
Celecoxib	Celecoxib The metabolism of Celecoxib can be decreased when combined with Temsirolimus.
Rosiglitazone	Rosiglitazone The therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Temsirolimus.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Temsirolimus.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Temsirolimus.
Nateglinide	Nateglinide The metabolism of Temsirolimus can be decreased when combined with Nateglinide.
Galantamine	Galantamine The metabolism of Galantamine can be decreased when combined with Temsirolimus.
Rabeprazole	Rabeprazole The metabolism of Temsirolimus can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Temsirolimus can be increased when combined with Terbinafine.