Lansoprazole, Clarithromycin, and Amoxicillin
A combination pack of three medicines (lansoprazole, amoxicillin and clarithromycin) used together to clear H. pylori infection in people with a duodenal ulcer, which lowers the chance the ulcer comes back.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
This pack combines lansoprazole, which cuts stomach acid, with the antibiotics amoxicillin and clarithromycin, which kill the germ, to clear H. pylori (a stomach bacterium) in people with a duodenal ulcer and lower the chance the ulcer returns. It is a long-standing standard combination, on the U.S. market in this form since about 2016 and available as a generic. Most people get through the course without much trouble, though diarrhea, nausea and an odd, bitter taste are common. Get help quickly for a severe allergic reaction, a blistering rash, yellow skin or eyes, a racing or irregular heartbeat, or severe or bloody diarrhea.
Clinical pearls
- Finish the full 10 or 14 day course even once you feel better, since stopping early can leave the infection behind.
- Take the doses before meals, because lansoprazole works best that way, and the two antibiotics are fine with or without food.
- Clarithromycin clashes with many drugs, including simvastatin, lovastatin, colchicine and warfarin, so give your pharmacist your full medicine list.
- Mention any past penicillin, cephalosporin or macrolide allergy before starting, since amoxicillin and clarithromycin can trigger serious reactions.
Patient information guide A plain-language walkthrough of Lansoprazole, Clarithromycin, and Amoxicillin, written from its FDA label.
What Lansoprazole, Clarithromycin, and Amoxicillin is used for
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This combination treats one condition.
- H. pylori infection in people with duodenal ulcer disease (an active ulcer or one within the past year), to clear the infection.
- Clearing H. pylori lowers the risk of the duodenal ulcer coming back.
How Lansoprazole, Clarithromycin, and Amoxicillin works
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Lansoprazole is a proton pump inhibitor. It blocks the proton pump in the stomach’s acid-making cells, so the stomach makes less acid. Amoxicillin and clarithromycin are antibiotics used against the H. pylori bacteria. Together, they treat the infection from different angles.
To help prevent drug-resistant bacteria, these medicines should be used only for infections that are proven or strongly suspected to be caused by susceptible bacteria.
Lansoprazole, Clarithromycin, and Amoxicillin dosage
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The three medicines are taken by mouth together, twice a day (morning and evening), for 10 or 14 days in adults.
- Lansoprazole works best before meals. Taking it 30 minutes after food lowers how much your body absorbs.
- Amoxicillin and clarithromycin can be taken with or without food.
- Not recommended if creatinine clearance is under 30 mL/min.
Follow your prescriber’s directions and your label.
Dosing details from the FDA-approved label
From the Lansoprazole, Clarithromycin, and Amoxicillin prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence (adults)
- 30 mg lansoprazole delayed-release capsules, 1 g amoxicillin, and 500 mg clarithromycin administered together twice daily (morning and evening) for 10 or 14 days
- Not recommended in patients with creatinine clearance less than 30 mL/min
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence The recommended adult oral dose is 30 mg lansoprazole delayed-release capsules, 1 g amoxicillin, and 500 mg clarithromycin administered together twice daily (morning and evening) for 10 or 14 days (see INDICATIONS AND USAGE ). Lansoprazole delayed-release capsules, 30 mg, amoxicillin capsules, 500 mg, and clarithromycin tablets, 500 mg are not recommended in patients with creatinine clearance less than 30 mL/min.
Read the full Dosage and Administration section on DailyMed →
Lansoprazole, Clarithromycin, and Amoxicillin side effects
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Most side effects are mild and involve the digestive system or taste.
Common side effects
- Diarrhea
- Headache
- Altered or bad taste
- Nausea or vomiting
- Abdominal pain
- Dizziness
- Dark stools
- Vaginal yeast infection or thrush
- Dark stools or tongue discoloration
- Yeast infections such as thrush or vaginitis
When to get medical help
- Get emergency help for signs of a severe allergic reaction: swelling of the face or throat, trouble breathing, hives, or fainting.
- Stop the medicine and call your doctor right away for a severe skin reaction, such as blistering, peeling or a spreading rash with fever.
- Call your doctor for signs of liver trouble: yellow skin or eyes, dark urine, itching, loss of appetite or a tender belly.
- Call your doctor if you have severe, lasting or bloody diarrhea. It can happen during treatment or even weeks to two months after.
- Seek help for a fast, pounding or irregular heartbeat, or fainting. Clarithromycin can affect heart rhythm (QT prolongation).
- In children, repeated vomiting 1 to 4 hours after a dose, with paleness or sleepiness, can be a reaction to amoxicillin (DIES).
- Tell your doctor if you develop a new rash, especially on sun-exposed skin, or joint pain. Acid-reducing medicines like lansoprazole have been linked to lupus.
- Tell your doctor if symptoms return soon after treatment ends.
Lansoprazole, Clarithromycin, and Amoxicillin warnings and precautions
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- Serious allergic reactions can occur with amoxicillin, especially if you have had penicillin allergy. Stop the medicine and get urgent help.
- Severe skin reactions (such as SJS, TEN, DRESS, AGEP) have been reported. Stop at the first signs.
- Liver problems from clarithromycin can occasionally be severe. Stop it if hepatitis symptoms appear.
- QT prolongation and abnormal heart rhythms have been linked to clarithromycin, and some cases were fatal.
- C. difficile diarrhea can occur with antibiotics, even weeks later.
- Kidney inflammation and lupus have been reported with lansoprazole.
- Stomach cancer: symptom relief does not rule it out.
Lansoprazole, Clarithromycin, and Amoxicillin interactions
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Clarithromycin has the most serious interactions, and lansoprazole and amoxicillin have some too.
- Cisapride, pimozide, astemizole, terfenadine, ergotamine, dihydroergotamine and lurasidone: contraindicated, risk of dangerous heart rhythms or toxicity.
- Lovastatin and simvastatin: contraindicated, risk of muscle breakdown.
- Colchicine: toxicity risk. Contraindicated with kidney or liver impairment.
- Warfarin: bleeding risk, needs INR monitoring.
- Diabetes medicines and insulin: low blood sugar risk.
- Rilpivirine: contraindicated with lansoprazole. Other HIV drugs may be affected.
- Digoxin, methotrexate, tacrolimus and theophylline: levels may change.
- St John’s Wort and rifampin: reduce lansoprazole.
- Sucralfate: take lansoprazole at least 30 minutes before it.
- Probenecid: raises amoxicillin levels.
- Combined birth control pills: amoxicillin may reduce effectiveness.
Interactions listed in the FDA-approved label
From the Lansoprazole, Clarithromycin, and Amoxicillin prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Antiretrovirals (rilpivirine, atazanavir, nelfinavir, saquinavir): Effect of PPIs on antiretrovirals is variable; lansoprazole may decrease exposure of rilpivirine, atazanavir and nelfinavir (reducing antiviral effect and promoting resistance) and increase exposure of saquinavir (may increase toxicity). Rilpivirine-containing products: contraindicated. Nelfinavir: avoid concomitant use. Atazanavir: see atazanavir prescribing information for dosing. Saquinavir: monitor for potential saquinavir toxicities. Other antiretrovirals: see prescribing information.
- Warfarin: Increased INR and prothrombin time in patients receiving PPIs and warfarin, which may lead to abnormal bleeding and even death. Monitor INR and prothrombin time; warfarin dose adjustment may be needed to maintain target INR range.
- Methotrexate: Concomitant PPIs with methotrexate (primarily at high dose) may elevate and prolong serum concentrations of methotrexate and/or hydroxymethotrexate, possibly leading to methotrexate toxicities. A temporary withdrawal of lansoprazole may be considered in some patients receiving high-dose methotrexate.
- Digoxin: Potential for increased exposure of digoxin; clarithromycin inhibits Pgp and may also increase digoxin exposure, with reports of digoxin toxicity including potentially fatal arrhythmias. Monitor digoxin concentrations; dose adjustment of digoxin may be needed. Clarithromycin: use with caution.
- Theophylline: Increased clearance of theophylline. Individual patients may require additional titration of theophylline dosage when lansoprazole is started or stopped.
- Drugs dependent on gastric pH for absorption (iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole): Lansoprazole can reduce the absorption of other drugs by reducing intragastric acidity; MMF exposure to mycophenolic acid may be reduced. Use with caution in transplant patients receiving MMF; see prescribing information for other pH-dependent drugs.
- Tacrolimus: Potentially increased exposure of tacrolimus, especially in transplant patients who are intermediate or poor CYP2C19 metabolizers. Monitor tacrolimus whole blood trough concentrations; dose adjustment may be needed.
- St John's Wort, rifampin (CYP2C19 or CYP3A4 inducers): Decreased exposure of lansoprazole with strong inducers. Avoid concomitant use with lansoprazole.
- Sucralfate: Decreased and delayed absorption of lansoprazole. Take lansoprazole delayed-release capsules at least 30 minutes prior to sucralfate.
- Probenecid (amoxicillin): Probenecid decreases renal tubular secretion of amoxicillin, which may result in increased and prolonged blood levels of amoxicillin.
Read the label’s full interactions text
Drug Interactions No drug interaction studies have been conducted specifically with lansoprazole delayed-release capsules, amoxicillin capsules, and clarithromycin tablets. The following drug interactions are for the individual drug components: lansoprazole, amoxicillin, and clarithromycin. Therefore, the decision to adjust dosage should depend on the clinician’s assessment of among other things, the cumulative or net effect of the drug components of lansoprazole delayed-release capsules, amoxicillin capsules, and clarithromycin tablets. Lansoprazole Delayed-Release Capsules Tables 5 and 6 include drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with lansoprazole delayed-release capsules and instructions for preventing or managing them. Consult the labeling of concomitantly used drugs to obtain further information about interactions with PPIs. Table 5. Clinically Relevant Interactions Affecting Drugs Coadministered with Lansoprazole Delayed-release Capsules and Interactions with Diagnostics Antiretrovirals Clinical Impact: The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with lansoprazole may reduce antiviral effect and promote the development of drug resistance. Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with lansoprazole may increase toxicity of the antiretroviral drugs. There are other antiretroviral drugs which do not result in clinically relevant interactions with lansoprazole. Intervention: Rilpivirine-containing products: Concomitant use with lansoprazole is contraindicated (see CONTRAINDICATIONS ). See prescribing information. Atazanavir : See prescribing information for atazanavir for dosing information.
Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Lansoprazole, Clarithromycin, and Amoxicillin
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- Known severe allergy to lansoprazole components, amoxicillin or other penicillins and cephalosporins, or clarithromycin, erythromycin or other macrolides.
- Past liver problems linked to clarithromycin.
- History of QT prolongation or serious abnormal heart rhythms.
- Low potassium or magnesium, or a very slow heartbeat.
- Pregnancy: clarithromycin should not be used unless no alternative is suitable.
- Severely reduced kidney function.
- Older adults may be more sensitive to heart rhythm effects, and older adults on certain calcium channel blockers had more kidney injury.
Lansoprazole, Clarithromycin, and Amoxicillin overdose
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Contact a doctor, poison control (1-800-222-1222) or an emergency room if you take too much. Overdose of clarithromycin can cause abdominal pain, vomiting, nausea and diarrhea. Amoxicillin overdose has been linked to kidney problems, so staying well hydrated matters. Treatment is symptom-based and supportive.
What Lansoprazole, Clarithromycin, and Amoxicillin does in the body
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Lansoprazole’s acid-lowering effect lasts more than 24 hours, even though the drug leaves the bloodstream in under two hours. This acid reduction can raise chromogranin A levels, which may affect certain tumor tests.
How your body processes Lansoprazole, Clarithromycin, and Amoxicillin
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Lansoprazole is enteric-coated and absorbed after leaving the stomach, with peak levels around 1.7 hours. It is broken down by the liver and cleared mainly through feces. Amoxicillin is absorbed rapidly, has a half-life of about an hour and is mostly cleared unchanged by the kidneys. Clarithromycin is absorbed well from the gut, and food only slightly delays absorption. These details come from each medicine studied alone, not all three together.
How to store Lansoprazole, Clarithromycin, and Amoxicillin
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Store between 20ºC to 25ºC (68ºF to 77ºF) . Protect from light and moisture.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Lansoprazole, Clarithromycin, and Amoxicillin: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Lansoprazole, Clarithromycin, and Amoxicillin — the kind of thing our pharmacy team would talk through with you at the counter.
What is this combination for?
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How do I take it?
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What side effects should I expect?
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When should I call my doctor?
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Can I take my other medicines with this?
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Is it safe in pregnancy?
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Is Lansoprazole, Clarithromycin, and Amoxicillin available over the counter?
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When was Lansoprazole, Clarithromycin, and Amoxicillin first available?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Lansoprazole, Clarithromycin, and Amoxicillin on HelloPharmacist
Lansoprazole, Clarithromycin, and Amoxicillin on the U.S. market: products, makers and brands
How Lansoprazole, Clarithromycin, and Amoxicillin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
1 company lists 1 Lansoprazole, Clarithromycin, and Amoxicillin product record with the FDA; the earliest marketing or approval year on record is 2016. Brand names on the directory include Prevpac, Biaxin, Prevacid and 1 more; the rest are generics.
Also listed with the FDA, not a patient dose form: Kit (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
How widely Lansoprazole, Clarithromycin, and Amoxicillin is used (Medicaid data)
A general measure of how commonly Lansoprazole, Clarithromycin, and Amoxicillin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Lansoprazole, Clarithromycin, and Amoxicillin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Lansoprazole, Clarithromycin, and Amoxicillin prescribed? Of the 1,601 medications we measure, Lansoprazole, Clarithromycin, and Amoxicillin ranks #1,519 by Medicaid prescriptions — more than 5% of them.
Utilization by Lansoprazole, Clarithromycin, and Amoxicillin product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
Other Lansoprazole, Clarithromycin, and Amoxicillin products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)
Summed across the 1 of 1 listed NDC products with Medicaid activity.
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Lansoprazole, Clarithromycin, and Amoxicillin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 1 of 1 listed Lansoprazole, Clarithromycin, and Amoxicillin NDCs with Medicaid activity.
Compare Lansoprazole, Clarithromycin, and Amoxicillin products
A representative set of FDA-listed product records for Lansoprazole, Clarithromycin, and Amoxicillin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|
| 💊Kits | ||
| Rising Pharma Holdings, Inc. | ANDA | View NDC → |
Showing 1 of 1 products — FDA National Drug Code Directory. See every product, package size and price: browse all 1 Lansoprazole, Clarithromycin, and Amoxicillin NDCs →
Lansoprazole, Clarithromycin, and Amoxicillin side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Lansoprazole, Clarithromycin, and Amoxicillin — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Lansoprazole, Clarithromycin, and Amoxicillin in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Lansoprazole, Clarithromycin, and Amoxicillin FDA approval history
How Lansoprazole, Clarithromycin, and Amoxicillin went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Lansoprazole, Clarithromycin, and Amoxicillin recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Lansoprazole, Clarithromycin, and Amoxicillin recalls since July 2021.
✅No Lansoprazole, Clarithromycin, and Amoxicillin recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
Lansoprazole, Clarithromycin, and Amoxicillin supply and shortage status
Whether Lansoprazole, Clarithromycin, and Amoxicillin is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
Lansoprazole, Clarithromycin, and Amoxicillin brand names
Lansoprazole, Clarithromycin, and Amoxicillin is sold under 4 brand names in the FDA directory — Prevpac, Biaxin, Prevacid, Trimox. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Lansoprazole, Clarithromycin, and Amoxicillin: manufacturers and labelers
One company lists Lansoprazole, Clarithromycin, and Amoxicillin products with the FDA. By number of product records, the largest are Rising Pharma Holdings, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Lansoprazole, Clarithromycin, and Amoxicillin drug class (RxNorm)
Lansoprazole, Clarithromycin, and Amoxicillin belongs to the Proton Pump Inhibitor class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Lansoprazole, Clarithromycin, and Amoxicillin page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Rising Health, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →