Ulipristal

Generic name: Pronounced as (ue' li pris tal)
Brand names
  • Ella®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 08/15/2021

Ulipristal is used to prevent pregnancy after unprotected sexual intercourse (sex without any method of birth control or with a birth control method that failed or was not used properly [e.g., a condom that slipped or broke or birth control pills that were not taken as scheduled]). Ulipristal should not be used to prevent pregnancy on a regular basis. This medication is to be used as an emergency contraceptive or backup in case regular birth control fails or is used incorrectly. Ulipristal is in a class of medications called progestins. It works by preventing or delaying the release of an egg from the ovary. It also may work by changing the lining of the uterus (womb) to prevent development of a pregnancy. Ulipristal may prevent pregnancy, but it will not prevent the spread of human immunodeficiency virus (HIV, the virus that causes acquired immunodeficiency syndrome [AIDS]) and other sexually transmitted diseases.

Ulipristal comes as a tablet to take by mouth. It is usually taken with or without food as soon as possible after unprotected sexual intercourse or suspected failure of a hormonal contraceptive (such as birth control pills, rings or patches). Ulipristal may be taken up to 120 hours (5 days) after unprotected sexual intercourse, but the sooner it is taken, the more likely that it will prevent pregnancy. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ulipristal exactly as directed.

Ulipristal may be used at any time during the menstrual cycle. However, it should not be used more than once during the same menstrual cycle.

If you vomit less than 3 hours after you take ulipristal, call your doctor. You may need to take another dose of this medication.

Because you can become pregnant right after treatment with ulipristal, you should use a barrier method (condom or diaphragm with spermicide) every time you have sex until your next menstrual period. Using hormonal contraceptives within 5 days of taking ulipristal may make both medications less effective. You may begin or resume using hormonal contraceptives at least 5 days after taking ulipristal, but you must continue to also use a barrier method to prevent pregnancy until after you have your next period. If you took ulipristal because of a problem with your hormonal contraceptive, contact your doctor or follow the instructions provided for that specific birth control product.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ulipristal,

  • tell your doctor and pharmacist if you are allergic to ulipristal, any other medications, or any of the ingredients in ulipristal tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: certain antifungal medications such as griseofulvin (Gris-PEG), itraconazole (Onmel, Sporanox), or ketoconazole; barbiturates such as phenobarbital or secobarbital (Seconal); bosentan (Tracleer); certain medications for seizures such as carbamazepine (Equetro, Tegretol, Teril, others), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin, Phenytek), and topiramate (Topamax, in Qsymia); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Many other medications may also interact with ulipristal, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Ulipristal may not work as well or may be more likely to cause side effects if it is taken with these medications.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you are pregnant or think you may be pregnant. Your doctor will probably tell you not to take ulipristal. Do not take ulipristal taken to end an existing pregnancy.

  • tell your doctor if you have or have ever had any medical conditions or an ectopic pregnancy (pregnancy outside of the uterus).

  • tell your doctor if you are breastfeeding.

  • you should know that after you take ulipristal, it is normal for your next menstrual period to begin up to one week earlier or later than expected. If your next menstrual period is delayed for longer than one week after the expected date, call your doctor. You may be pregnant and your doctor will probably tell you to have a pregnancy test.

Unless your doctor tells you otherwise, continue your normal diet.

  • Ulipristal may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • painful menstrual periods

    • spotting or bleeding between menstrual periods

    • nausea

    • tiredness

    • headache

    • dizziness

  • Some side effects can be serious. If you experience the following symptom, call your doctor immediately:

    • severe lower abdominal pain (3 to 5 weeks after taking ulipristal)

    • rash, itching, hives, or swelling of the eyes, face, tongue, throat

  • Ulipristal may cause other side effects. Call your doctor if you have any unusual problems after you take this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Your prescription is probably not refillable. Ask your pharmacist any questions you have about ulipristal.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Mycophenolate Mycophenolate The serum concentration of Ulipristal can be decreased when it is combined with Mycophenolic acid.
Prednisone Prednisone The serum concentration of Prednisone can be increased when it is combined with Ulipristal.
Tizanidine Tizanidine The metabolism of Ulipristal can be increased when combined with Tizanidine.
Triamcinolone Triamcinolone The serum concentration of Triamcinolone can be increased when it is combined with Ulipristal.
Ampicillin Injection Ampicillin Injection The therapeutic efficacy of Ulipristal can be decreased when used in combination with Ampicillin.
Doxycycline Injection Doxycycline Injection The serum concentration of Ulipristal can be decreased when it is combined with Doxycycline.
Meperidine Injection Meperidine Injection The metabolism of Ulipristal can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Methylprednisolone can be increased when it is combined with Ulipristal.
Enoxaparin Injection Enoxaparin Injection The therapeutic efficacy of Enoxaparin can be decreased when used in combination with Ulipristal.
Orlistat Orlistat The metabolism of Ulipristal can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Ulipristal can be increased when combined with Oxcarbazepine.
Zaleplon Zaleplon The metabolism of Ulipristal can be increased when combined with Zaleplon.
Pentosan Polysulfate Pentosan Polysulfate The therapeutic efficacy of Pentosan polysulfate can be decreased when used in combination with Ulipristal.
Modafinil Modafinil The metabolism of Ulipristal can be increased when combined with Modafinil.
Zonisamide Zonisamide The metabolism of Ulipristal can be increased when combined with Zonisamide.
Aprepitant Aprepitant The serum concentration of Ulipristal can be decreased when it is combined with Aprepitant.
Progesterone Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Ulipristal.
Rifaximin Rifaximin The metabolism of Ulipristal can be increased when combined with Rifaximin.
Norethindrone Norethindrone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Ulipristal.
Bosentan Bosentan The serum concentration of Ulipristal can be decreased when it is combined with Bosentan.
Exenatide Injection Exenatide Injection Exenatide can cause a decrease in the absorption of Ulipristal resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pregabalin Pregabalin The metabolism of Ulipristal can be increased when combined with Pregabalin.
Deferasirox Deferasirox The metabolism of Ulipristal can be increased when combined with Deferasirox.
Felbamate Felbamate The metabolism of Ulipristal can be increased when combined with Felbamate.
Armodafinil Armodafinil The metabolism of Ulipristal can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Ulipristal can be increased when combined with Ivermectin.
Bexarotene Bexarotene The metabolism of Ulipristal can be increased when combined with Bexarotene.
Budesonide Budesonide The serum concentration of Budesonide can be increased when it is combined with Ulipristal.
Etravirine Etravirine The metabolism of Ulipristal can be increased when combined with Etravirine.
Mitotane Mitotane The metabolism of Ulipristal can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Ulipristal can be increased when combined with Rufinamide.
Prasugrel Prasugrel The therapeutic efficacy of Prasugrel can be decreased when used in combination with Ulipristal.
Lacosamide Lacosamide The metabolism of Ulipristal can be increased when combined with Lacosamide.
Topotecan Topotecan The metabolism of Ulipristal can be increased when combined with Topotecan.
Vigabatrin Vigabatrin The metabolism of Ulipristal can be increased when combined with Vigabatrin.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Ulipristal.
Dabigatran Dabigatran The therapeutic efficacy of Dabigatran can be decreased when used in combination with Ulipristal.
Tocilizumab Injection Tocilizumab Injection The metabolism of Ulipristal can be increased when combined with Tocilizumab.
Acetaminophen Injection Acetaminophen Injection The metabolism of Ulipristal can be increased when combined with Acetaminophen.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Ulipristal can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Ulipristal.
Ticagrelor Ticagrelor The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ulipristal.
Clobazam Clobazam The serum concentration of Ulipristal can be decreased when it is combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Ulipristal can be increased when combined with Vemurafenib.
Tranexamic Acid Tranexamic Acid Ulipristal may increase the thrombogenic activities of Tranexamic acid.
Fondaparinux Injection Fondaparinux Injection The therapeutic efficacy of Fondaparinux can be decreased when used in combination with Ulipristal.
Ezogabine Ezogabine The metabolism of Ulipristal can be increased when combined with Tiagabine.
Iloprost Iloprost The therapeutic efficacy of Iloprost can be decreased when used in combination with Ulipristal.
Enzalutamide Enzalutamide The metabolism of Ulipristal can be increased when combined with Enzalutamide.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Corticotropin can be increased when it is combined with Ulipristal.
Apixaban Apixaban The therapeutic efficacy of Apixaban can be decreased when used in combination with Ulipristal.
Dabrafenib Dabrafenib The metabolism of Ulipristal can be increased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Ulipristal can be increased when combined with Trametinib.
Tigecycline Injection Tigecycline Injection The serum concentration of Ulipristal can be decreased when it is combined with Tigecycline.
Perampanel Perampanel The metabolism of Ulipristal can be increased when combined with Perampanel.
Siltuximab Injection Siltuximab Injection The metabolism of Ulipristal can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Ulipristal can be increased when combined with Eslicarbazepine.
Testosterone Injection Testosterone Injection The metabolism of Ulipristal can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Ulipristal can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The therapeutic efficacy of Vorapaxar can be decreased when used in combination with Ulipristal.
Edoxaban Edoxaban The therapeutic efficacy of Edoxaban can be decreased when used in combination with Ulipristal.
Lenvatinib Lenvatinib The metabolism of Ulipristal can be increased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Ulipristal.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Ulipristal can be increased when combined with Isavuconazonium.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Ulipristal is combined with Flibanserin.
Prednisolone Prednisolone The serum concentration of Prednisolone can be increased when it is combined with Ulipristal.
Penicillin G Procaine Injection Penicillin G Procaine Injection The therapeutic efficacy of Ulipristal can be decreased when used in combination with Procaine benzylpenicillin.
Osimertinib Osimertinib The metabolism of Ulipristal can be increased when combined with Osimertinib.
Rifapentine Rifapentine The metabolism of Ulipristal can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Ulipristal can be increased when combined with Lesinurad.
Dexamethasone Injection Dexamethasone Injection The metabolism of Ulipristal can be increased when combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The therapeutic efficacy of Defibrotide can be decreased when used in combination with Ulipristal.
Brivaracetam Injection Brivaracetam Injection The metabolism of Ulipristal can be increased when combined with Brivaracetam.
Cobicistat Cobicistat The serum concentration of Ulipristal can be decreased when it is combined with Cobicistat.
Brigatinib Brigatinib The metabolism of Ulipristal can be increased when combined with Brigatinib.
Deflazacort Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Ulipristal.
Sarilumab Injection Sarilumab Injection The metabolism of Ulipristal can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Ulipristal can be increased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Ulipristal can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Ulipristal can be increased when combined with Fosaprepitant.
Betrixaban Betrixaban The therapeutic efficacy of Betrixaban can be decreased when used in combination with Ulipristal.
Apalutamide Apalutamide The metabolism of Ulipristal can be increased when combined with Apalutamide.
Ivosidenib Ivosidenib The metabolism of Ulipristal can be increased when combined with Ivosidenib.
Eravacycline Injection Eravacycline Injection The serum concentration of Ulipristal can be decreased when it is combined with Eravacycline.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be increased when combined with Ulipristal.
Omadacycline Omadacycline The serum concentration of Ulipristal can be decreased when it is combined with Omadacycline.
Sarecycline Sarecycline The serum concentration of Ulipristal can be decreased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Ulipristal can be increased when combined with Stiripentol.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Ulipristal can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Ulipristal can be increased when combined with Rifamycin.
Alpelisib Alpelisib The metabolism of Ulipristal can be increased when combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The metabolism of Ulipristal can be increased when combined with Brexanolone.
Pitolisant Pitolisant The serum concentration of Ulipristal can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The metabolism of Ulipristal can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Ulipristal can be increased when combined with Fosphenytoin.
Cenobamate Cenobamate The serum concentration of Ulipristal can be decreased when it is combined with Cenobamate.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Ulipristal.
Pralsetinib Pralsetinib The metabolism of Ulipristal can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Ulipristal can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Ulipristal.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Ulipristal can be increased when combined with Vitamin E.
Phenobarbital Phenobarbital The metabolism of Ulipristal can be increased when combined with Phenobarbital.
Primidone Primidone The metabolism of Ulipristal can be increased when combined with Primidone.
Methsuximide Methsuximide The metabolism of Ulipristal can be increased when combined with Methsuximide.
Chlorpromazine Chlorpromazine The metabolism of Ulipristal can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Ulipristal can be increased when combined with Diazepam.
Clorazepate Clorazepate The metabolism of Ulipristal can be increased when combined with Clorazepic acid.
Lorazepam Lorazepam The metabolism of Ulipristal can be increased when combined with Lorazepam.
Tetracycline Tetracycline The serum concentration of Ulipristal can be decreased when it is combined with Tetracycline.
Minocycline Minocycline The serum concentration of Ulipristal can be decreased when it is combined with Minocycline.
Demeclocycline Demeclocycline The serum concentration of Ulipristal can be decreased when it is combined with Demeclocycline.
Methadone Methadone The metabolism of Ulipristal can be increased when combined with Methadone.
Hydrocortisone Hydrocortisone The serum concentration of Hydrocortisone can be increased when it is combined with Ulipristal.
Carbamazepine Carbamazepine The metabolism of Ulipristal can be increased when combined with Carbamazepine.
Warfarin Warfarin The metabolism of Ulipristal can be increased when combined with Warfarin.
Clonazepam Clonazepam The metabolism of Ulipristal can be increased when combined with Clonazepam.
Griseofulvin Griseofulvin The metabolism of Ulipristal can be increased when combined with Griseofulvin.
Quinine Quinine The metabolism of Ulipristal can be increased when combined with Quinine.
Ethosuximide Ethosuximide The metabolism of Ethosuximide can be increased when combined with Ulipristal.
Calcitriol Calcitriol The metabolism of Ulipristal can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Ulipristal can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The serum concentration of Ulipristal can be decreased when it is combined with Secobarbital.
Probenecid Probenecid The metabolism of Ulipristal can be increased when combined with Probenecid.
Rifampin Rifampin The metabolism of Ulipristal can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Ulipristal can be increased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Ulipristal can be increased when combined with Tamoxifen.
Butabarbital Butabarbital The serum concentration of Ulipristal can be decreased when it is combined with Butabarbital.
Chlorpropamide Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Ulipristal.
Tolbutamide Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Ulipristal.
Tolazamide Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Ulipristal.
Colchicine Colchicine The metabolism of Ulipristal can be increased when combined with Colchicine.
Acetazolamide Acetazolamide The metabolism of Ulipristal can be increased when combined with Acetazolamide.
Dipyridamole Dipyridamole The therapeutic efficacy of Dipyridamole can be decreased when used in combination with Ulipristal.
Vinblastine Vinblastine The metabolism of Ulipristal can be increased when combined with Vinblastine.
Aspirin Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Ulipristal.
Nifedipine Nifedipine The metabolism of Ulipristal can be increased when combined with Nifedipine.
Etoposide Etoposide The metabolism of Ulipristal can be increased when combined with Etoposide.
Glyburide Glyburide The therapeutic efficacy of Ulipristal can be decreased when used in combination with Glyburide.
Glipizide Glipizide The therapeutic efficacy of Glipizide can be decreased when used in combination with Ulipristal.
Amoxicillin Amoxicillin The therapeutic efficacy of Ulipristal can be decreased when used in combination with Amoxicillin.
Dicloxacillin Dicloxacillin The metabolism of Ulipristal can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Ulipristal can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection The therapeutic efficacy of Ulipristal can be decreased when used in combination with Oxacillin.
Clozapine Clozapine The metabolism of Ulipristal can be increased when combined with Clozapine.
Estazolam Estazolam The metabolism of Ulipristal can be increased when combined with Estazolam.
Rifabutin Rifabutin The metabolism of Ulipristal can be increased when combined with Rifabutin.
Omeprazole Omeprazole The metabolism of Ulipristal can be increased when combined with Omeprazole.
Gabapentin Gabapentin The metabolism of Ulipristal can be increased when combined with Gabapentin.
Lamotrigine Lamotrigine The metabolism of Ulipristal can be increased when combined with Lamotrigine.
Lansoprazole Lansoprazole The metabolism of Ulipristal can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ulipristal can be increased when combined with Ifosfamide.
Dalteparin Injection Dalteparin Injection The therapeutic efficacy of Dalteparin can be decreased when used in combination with Ulipristal.
Riluzole Riluzole The metabolism of Ulipristal can be increased when combined with Riluzole.
Glimepiride Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Ulipristal.
Ritonavir Ritonavir The serum concentration of Ulipristal can be decreased when it is combined with Ritonavir.
Topiramate Topiramate The metabolism of Ulipristal can be increased when combined with Topiramate.
Efavirenz Efavirenz The metabolism of Ulipristal can be increased when combined with Efavirenz.
Thalidomide Thalidomide Ulipristal may increase the thrombogenic activities of Thalidomide.
Levetiracetam Levetiracetam The metabolism of Ulipristal can be increased when combined with Levetiracetam.
Terbinafine Terbinafine The metabolism of Ulipristal can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists