Medication interaction hub

What Supplements Interact with Ulipristal Acetate?

Ulipristal Acetate brand name: Ella. Every interaction below applies to the brands too.

158 Interactions 3 Major 107 Moderate 48 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ulipristal Acetate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ulipristal Acetate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

St. John's wort worries me most with ulipristal acetate (Ella), the emergency contraceptive that gets exactly one chance to work. By revving up the liver enzyme (CYP3A4) that clears the drug, it can leave too little in your system to prevent pregnancy. Activated charcoal can soak up the pill in the gut before it absorbs, while grapefruit pushes levels upward and raises the odds of side effects. Those are the three major-rated interactions, and each deserves genuine respect given what is at stake.

Most of the other 155 entries follow the same enzyme story, herbs and extracts that nudge drug levels up or down through CYP3A4, plus a cluster overlapping with contraceptives in gentler ways, like caffeine lingering longer in the body; 107 rate moderate and 48 minor. Since a single dose leaves no chance to adjust later, tell your pharmacist what you have taken recently before using Ella.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 107 Minor 48 No known interaction 1,294

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ulipristal Acetate: Top Interactions at a Glance

The Ulipristal Acetate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 158 interacting ingredients — plus 1,294 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ulipristal Acetate Combinations Today

The Ulipristal Acetate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Green Tea + Ulipristal Acetatei

Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in green tea.

Read the full interaction Minor Likelihood Possible Agar + Ulipristal Acetatei

Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Read the full interaction Moderate Likelihood Possible European Barberry + Ulipristal Acetatei

Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Fennel + Ulipristal Acetatei

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Aegeline + Ulipristal Acetatei

Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Read the full interaction Major Likelihood Likely Grapefruit + Ulipristal Acetatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Ulipristal Acetate

All 1,452 ingredients in our database, ranked by severity — 158 with a Ulipristal Acetate interaction on file and 1,294 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ulipristal Acetate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Green Tea with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in green tea.

Full Green Tea + Ulipristal Acetate answer

Can you take Agar with Ulipristal Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Ulipristal Acetate answer

Can you take European Barberry with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Ulipristal Acetate answer

Can you take Fennel with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Ulipristal Acetate answer

Can you take Aegeline with Ulipristal Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Ulipristal Acetate answer

Can you take Bitter Orange with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Ulipristal Acetate answer

Can you take Black Pepper with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Ulipristal Acetate answer

Can you take Bog Labrador Tea with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Ulipristal Acetate answer

Can you take Boswellia Serrata with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Ulipristal Acetate answer

Can you take Bulbine Natalensis with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Ulipristal Acetate answer

Can you take Calamus with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Ulipristal Acetate answer

Can you take Cannabis with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Ulipristal Acetate answer

Can you take Cat's Claw with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Ulipristal Acetate answer

Can you take Ceylon Leadwort with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Ulipristal Acetate answer

Can you take Chanca Piedra with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Ulipristal Acetate answer

Can you take Chokeberry with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Ulipristal Acetate answer

Can you take Chrysin with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chrysin might reduce the efficacy of estrogen-containing contraceptive drugs.

Full Chrysin + Ulipristal Acetate answer

Can you take Clove with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Ulipristal Acetate answer

Can you take Coleus with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Ulipristal Acetate answer

Can you take Corydalis Yanhusuo with Ulipristal Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Ulipristal Acetate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ulipristal Acetate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ulipristal Acetate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ulipristal Acetate sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ulipristal Acetate through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ulipristal Acetate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ulipristal Acetate through this category.

About Ulipristal Acetate

Ulipristal (ella) is an emergency contraceptive taken orally to help prevent pregnancy after unprotected intercourse or contraceptive failure.

Generic name: Ulipristal Acetate  ·  Brand name: Ella.

See the full Ulipristal drug information

Related: does Ulipristal Acetate deplete any nutrients?

Ulipristal Acetate has 2 reported nutrient associations in the research literature — see the Ulipristal Acetate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ulipristal Acetate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ulipristal Acetate.

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Pharmacist Counseling Corner

Ulipristal Acetate & Supplements: Common Questions

What supplements interact with Ulipristal Acetate?
More than you might expect — 158 in total, though they are far from equal: 3 are rated major, 107 moderate, and 48 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Ulipristal Acetate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ulipristal Acetate?
Usually yes — most people on Ulipristal Acetate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Ella have the same supplement interactions as Ulipristal Acetate?
Yes — Ella all contain Ulipristal Acetate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ulipristal Acetate deplete any vitamins or nutrients?
It might — Ulipristal Acetate has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ulipristal Acetate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ulipristal Acetate and my other medications?
This page covers Ulipristal Acetate against supplements and herbal ingredients. Checking Ulipristal Acetate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ulipristal drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.