Humann Superbeets Heart Chews - Progesterone Interaction

Interaction Details

Progesterone is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates

Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews). Laboratory studies suggest that grape seed extract might have inhibitory effects on the CYP3A4 metabolizing enzyme. If this enzyme is inhibited, drugs metabolized by it may undergo slower metabolism, potentially leading to (in many cases) higher-than-normal drug levels. Elevated drug levels can increase the risk of experiencing side effects. However, it's important to point out that there is no documented or reported instance of this specific interaction occurring in human studies.

Interaction Rating

Likelihood of Occurrence

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Pharmacist Analysis

It is unlikely that grape seed extracts have a clinically significant interaction with drugs that are metabolized by CYP3A4. This effect has only been seen in lab studies and has not been seen in human ones.

Nevertheless, it may be worthwhile to know if the drug you are taking (such as the one in this interaction detail page) is metabolized by CYP3A4 and monitor yourself accordingly.

References

• An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. PubMed
• Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. PubMed
  

Progesterone Overview

• Progesterone is used as a part of hormone replacement therapy in women who have passed menopause (the change of life) and have not had a hysterectomy (surgery to remove the uterus). Hormone replacement therapy usually includes estrogen, which is used to treat symptoms of menopause and reduce the risk of developing certain diseases. However, estrogen can also cause abnormal thickening of the lining of the uterus and increase the risk of developing uterine cancer. Progesterone helps to prevent this thickening and decreases the risk of developing uterine cancer. Progesterone is also used to bring on menstruation (period) in women of childbearing age who have had normal periods and then stopped menstruating. Progesterone is in a class of medications called progestins (female hormones). It works as part of hormone replacement therapy by decreasing the amount of estrogen in the uterus. It works to bring on menstruation by replacing the natural progesterone that some women are missing.

Humann Superbeets Heart Chews - More Interactions

Humann Superbeets Heart Chews interacts with 870 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.