Propafenone

Generic name: Pronounced as (proe pa feen' one)
Brand names
  • Rythmol®
  • Rythmol® SR
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2018

In clinical studies, people who had recently had a heart attack and took certain medications for irregular heartbeat that are similar to propafenone were more likely to die than people who did not take one of the medications. Propafenone may also cause life-threatening irregular heartbeat and increase the risk of death in certain patients. Tell your doctor if you have had a heart attack within the past two years or if you have heart disease.

Because of the risks of taking propafenone, it should be used only to treat life-threatening irregular heartbeat. Talk to your doctor about the risks of taking propafenone.

Your doctor may examine you and may order certain lab tests and electrocardiogram (EKG) tests to check your body's response to propafenone. Keep all appointments with your doctor and the laboratory.

Propafenone is used to treat arrhythmia (irregular heartbeat) and to maintain a normal heart rate. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.

Propafenone comes as a tablet and an extended-release (long-acting) capsule to take by mouth. The tablet is usually taken three times a day, once every 8 hours. The extended-release capsule is usually taken two times a day, once every 12 hours, with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take propafenone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not crush or open the capsules or divide the contents of a capsule into more than one dose.

You may begin taking propafenone in a hospital so that your doctor can monitor you carefully as your body gets used to the medication. Your doctor may start you on a low dose of propafenone and gradually increase your dose, not more often than once every 5 days.

Propafenone may control your irregular heartbeat, but will not cure it. Continue to take propafenone even if you feel well. Do not stop taking propafenone without talking to your doctor. Your heartbeat may become irregular if you suddenly stop taking propafenone.

This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking propafenone,

  • tell your doctor and pharmacist if you are allergic to propafenone, any other medications, or any of the ingredients in propafenone tablets or extended-release capsules. Ask your doctor or pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); certain antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin, in Prevpac), and erythromycin (E.E.S., others);antihistamines; beta-blockers such as atenolol (Tenormin), carteolol (Cartrol), labetalol (Normodyne, Trandate), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), and timolol (Blocadren); certain antidepressants such as desipramine (Norpramin) and imipramine (Tofranil);cimetidine (Tagamet); cisapride (Propulsid) (not available in the U.S.); digoxin (Lanoxin); haloperidol (Haldol); ketoconazole (Nizoral); lidocaine; medications for irregular heartbeat such as amiodarone (Cordarone, Pacerone), bepredil (not available in the U.S.), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide, and quinidine (Quinaglute, others). medications for mental illness and nausea; orlistat (Alli, Xenical); ritonavir (Norvir);rifampin (Rifadin, Rimactane); saquinavir (Invirase); selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem, in Symbyax), paroxetine (Paxil, Pexeva) and sertraline (Zoloft); and venlafaxine (Effexor).

  • tell your doctor if you have excessive diarrhea, sweating, vomiting, loss of appetite, or decreased thirst and if you have or have ever had a slow heartbeat; low blood pressure; low or high levels of sodium, potassium, chloride, or bicarbonate in your blood; heart failure; or asthma or any other condition that causes your airways to become narrow. Your doctor may tell you not to take propafenone.

  • in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had a pacemaker; myasthenia gravis (a disorder of the nervous system that causes muscle weakness),or liver or kidney disease,

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking propafenone, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking propafenone.

  • you should know that this medication may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how it affects you.

  • tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.

Talk to your doctor about eating foods and salt substitutes that contain potassium.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while you are taking this medication.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Propafenone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dizziness

    • dry mouth

    • headache

    • nausea

    • vomiting

    • diarrhea

    • constipation

    • loss of appetite

    • unusual taste in the mouth

    • gas

    • tiredness

    • anxiety

    • blurred vision

    • uncontrollable shaking of a part of the body

    • difficulty falling asleep or staying asleep

    • difficulty with coordination

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • difficulty breathing

    • wheezing

    • chest pain

    • new or worsening irregular heartbeat

    • slow, fast, or pounding heartbeat

    • swelling of the hands, feet, ankles, or lower legs

    • sudden, unexplained weight gain

    • fainting

    • skin rash

    • unexplained fever, chills, weakness, or sore throat

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • tiredness

  • slow or irregular heartbeat

  • seizures

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Propafenone can be decreased when combined with Moxifloxacin.
Repaglinide Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Propafenone.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Propafenone can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Propafenone can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Propafenone.
Dolasetron Dolasetron The metabolism of Dolasetron can be decreased when combined with Propafenone.
Aminophylline Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Propafenone.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Propafenone is combined with Anagrelide.
Calcium Carbonate Calcium Carbonate The therapeutic efficacy of Propafenone can be decreased when used in combination with Calcium carbonate.
Candesartan Candesartan The risk or severity of hyperkalemia can be increased when Propafenone is combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Propafenone.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Propafenone.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Erythromycin is combined with Propafenone.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Propafenone can be decreased when combined with Conjugated estrogens.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Propafenone.
Methylergonovine Methylergonovine Propafenone may increase the vasoconstricting activities of Methylergometrine.
Miglitol Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Propafenone.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Propafenone.
Olsalazine Olsalazine Olsalazine may decrease the antihypertensive activities of Propafenone.
Paregoric Paregoric The serum concentration of Propafenone can be increased when it is combined with Morphine.
Penbutolol Penbutolol The risk or severity of adverse effects can be increased when Propafenone is combined with Acebutolol.
Potassium Potassium Potassium may increase the hyperkalemic activities of Propafenone.
Ranitidine Ranitidine The metabolism of Ranitidine can be decreased when combined with Propafenone.
Reserpine Reserpine Reserpine may increase the hypotensive activities of Propafenone.
Rizatriptan Rizatriptan The risk or severity of hypertension can be increased when Rizatriptan is combined with Propafenone.
Sumatriptan Sumatriptan The risk or severity of hypertension can be increased when Sumatriptan is combined with Propafenone.
Tacrolimus Tacrolimus The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Propafenone.
Tizanidine Tizanidine The therapeutic efficacy of Tizanidine can be decreased when used in combination with Propafenone.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Propafenone.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Propafenone.
Fluconazole Injection Fluconazole Injection The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Propafenone.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Propafenone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Propafenone can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Propafenone can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Propafenone can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The metabolism of Propafenone can be decreased when combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The metabolism of Metoclopramide can be decreased when combined with Propafenone.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Propafenone.
Morphine Injection Morphine Injection The serum concentration of Propafenone can be increased when it is combined with Morphine.
Altretamine Altretamine The therapeutic efficacy of Propafenone can be decreased when used in combination with Amphetamine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Propafenone.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Propafenone.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Propafenone is combined with Enoxaparin.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Propafenone.
Torsemide Torsemide Propafenone may decrease the antihypertensive activities of Torasemide.
Olanzapine Olanzapine The metabolism of Olanzapine can be decreased when combined with Propafenone.
Alosetron Alosetron The metabolism of Propafenone can be decreased when combined with Alosetron.
Dofetilide Dofetilide Propafenone may increase the arrhythmogenic activities of Dofetilide.
Entacapone Entacapone The metabolism of Propafenone can be decreased when combined with Entacapone.
Eprosartan Eprosartan The risk or severity of hyperkalemia can be increased when Eprosartan is combined with Propafenone.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be decreased when Hydroxychloroquine is combined with Propafenone.
Meloxicam Meloxicam Meloxicam may decrease the antihypertensive activities of Propafenone.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Propafenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of hyperkalemia can be increased when Telmisartan is combined with Propafenone.
Anakinra Anakinra The metabolism of Propafenone can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Propafenone.
Linezolid Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Propafenone.
Rivastigmine Rivastigmine Propafenone may increase the bradycardic activities of Rivastigmine.
Trimipramine Trimipramine The serum concentration of Propafenone can be increased when it is combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Propafenone can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Propafenone can be increased when combined with Modafinil.
Perindopril Perindopril Propafenone may decrease the antihypertensive activities of Perindopril.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Propafenone.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the antihypertensive activities of Propafenone.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Propafenone.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Propafenone.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Epinephrine can be decreased when used in combination with Propafenone.
Eplerenone Eplerenone The risk or severity of hyperkalemia can be increased when Propafenone is combined with Eplerenone.
Escitalopram Escitalopram The serum concentration of Escitalopram can be increased when it is combined with Propafenone.
Olmesartan Olmesartan The risk or severity of hyperkalemia can be increased when Olmesartan is combined with Propafenone.
Zonisamide Zonisamide The risk or severity of bradycardia can be increased when Zonisamide is combined with Propafenone.
Adalimumab Injection Adalimumab Injection The metabolism of Propafenone can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Propafenone.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Propafenone.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Propafenone is combined with Dexmethylphenidate.
Atazanavir Atazanavir The risk or severity of QTc prolongation can be increased when Atazanavir is combined with Propafenone.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Propafenone.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Propafenone.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be decreased when Mefloquine is combined with Propafenone.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Propafenone.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Propafenone.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Propafenone can be decreased when combined with Interferon beta-1a.
Memantine Memantine Memantine may increase the bradycardic activities of Propafenone.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Propafenone.
Tadalafil Tadalafil Propafenone may decrease the antihypertensive activities of Tadalafil.
Fosamprenavir Fosamprenavir The serum concentration of Propafenone can be increased when it is combined with Fosamprenavir.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Propafenone.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Propafenone.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Propafenone.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Propafenone.
Infliximab Injection Infliximab Injection The metabolism of Propafenone can be increased when combined with Infliximab.
Protriptyline Protriptyline The metabolism of Propafenone can be decreased when combined with Protriptyline.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Propafenone.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Propafenone.
Trospium Trospium The metabolism of Propafenone can be decreased when combined with Trospium.
Bosentan Bosentan Propafenone may decrease the antihypertensive activities of Bosentan.
Cinacalcet Cinacalcet The metabolism of Propafenone can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Propafenone.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin aspart.
Solifenacin Solifenacin The metabolism of Solifenacin can be decreased when combined with Propafenone.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Propafenone.
Dextroamphetamine Dextroamphetamine The therapeutic efficacy of Propafenone can be decreased when used in combination with Amphetamine.
Entecavir Entecavir The metabolism of Entecavir can be decreased when combined with Propafenone.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Propafenone can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Propafenone can be increased when it is combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The therapeutic efficacy of Pramlintide can be increased when used in combination with Propafenone.
Exenatide Injection Exenatide Injection The therapeutic efficacy of Exenatide can be increased when used in combination with Propafenone.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Propafenone.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Propafenone is combined with Isocarboxazid.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Propafenone.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Propafenone.
Fentanyl Fentanyl Fentanyl may increase the bradycardic activities of Propafenone.
Pregabalin Pregabalin Pregabalin may increase the arrhythmogenic activities of Propafenone.
Deferasirox Deferasirox The serum concentration of Propafenone can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The therapeutic efficacy of Phenylephrine can be decreased when used in combination with Propafenone.
Tipranavir Tipranavir The serum concentration of Propafenone can be increased when it is combined with Tipranavir.
Felbamate Felbamate The risk or severity of QTc prolongation can be increased when Felbamate is combined with Propafenone.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin detemir.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Propafenone.
Abatacept Injection Abatacept Injection The metabolism of Propafenone can be increased when combined with Abatacept.
Rasagiline Rasagiline The metabolism of Rasagiline can be decreased when combined with Propafenone.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Propafenone.
Sitagliptin Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Propafenone.
Varenicline Varenicline The risk or severity of adverse effects can be increased when Propafenone is combined with Varenicline.
Gefitinib Gefitinib The metabolism of Gefitinib can be decreased when combined with Propafenone.
Albuterol Albuterol The therapeutic efficacy of Salbutamol can be decreased when used in combination with Propafenone.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Propafenone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Propafenone.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin glulisine.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Propafenone.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Propafenone.
Primaquine Primaquine The metabolism of Propafenone can be decreased when combined with Primaquine.
Aliskiren Aliskiren The risk or severity of hyperkalemia can be increased when Propafenone is combined with Aliskiren.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be decreased when combined with Propafenone.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Propafenone.
Lisdexamfetamine Lisdexamfetamine The therapeutic efficacy of Propafenone can be decreased when used in combination with Lisdexamfetamine.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Propafenone.
Sorafenib Sorafenib The metabolism of Sorafenib can be decreased when combined with Propafenone.
Sunitinib Sunitinib The therapeutic efficacy of Sunitinib can be increased when used in combination with Propafenone.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Lapatinib is combined with Propafenone.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Propafenone.
Dasatinib Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Propafenone.
Mexiletine Mexiletine Propafenone may increase the arrhythmogenic activities of Mexiletine.
Armodafinil Armodafinil The metabolism of Propafenone can be increased when combined with Armodafinil.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Propafenone.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Propafenone.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Propafenone is combined with Toremifene.
Desmopressin Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Propafenone.
Betaine Betaine Glycine betaine may increase the bradycardic activities of Propafenone.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Propafenone is combined with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The serum concentration of Propafenone can be increased when it is combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Propafenone.
Nebivolol Nebivolol The risk or severity of adverse effects can be increased when Propafenone is combined with Nebivolol.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Propafenone.
Pilocarpine Pilocarpine The risk or severity of adverse effects can be increased when Propafenone is combined with Pilocarpine.
Flecainide Flecainide Propafenone may increase the arrhythmogenic activities of Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Propafenone can be increased when combined with Certolizumab pegol.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Propafenone.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Propafenone.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Propafenone.
Milnacipran Milnacipran The serum concentration of Propafenone can be increased when it is combined with Milnacipran.
Sodium Phosphate Sodium Phosphate Sodium phosphate, monobasic may increase the hyperkalemic activities of Propafenone.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Propafenone.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Propafenone.
Betaxolol Betaxolol The risk or severity of adverse effects can be increased when Propafenone is combined with Betaxolol.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Propafenone.
Lacosamide Lacosamide Propafenone may increase the bradycardic activities of Lacosamide.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Propafenone.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Propafenone.
Dronedarone Dronedarone Propafenone may increase the arrhythmogenic activities of Dronedarone.
Palonosetron Injection Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Propafenone.
Saxagliptin Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Propafenone.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Propafenone is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Propafenone.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Propafenone.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Propafenone.
Golimumab Injection Golimumab Injection The metabolism of Propafenone can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Propafenone.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Propafenone is combined with Asenapine.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Propafenone.
Oxymorphone Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Propafenone.
Liraglutide Injection Liraglutide Injection The therapeutic efficacy of Liraglutide can be increased when used in combination with Propafenone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Propafenone can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Propafenone may increase the bradycardic activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Propafenone.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Propafenone.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Propafenone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Propafenone.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Propafenone.
Terbutaline Injection Terbutaline Injection The therapeutic efficacy of Terbutaline can be decreased when used in combination with Propafenone.
Azilsartan Azilsartan The risk or severity of hyperkalemia can be increased when Propafenone is combined with Azilsartan medoxomil.
Linagliptin Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Propafenone.
Rilpivirine Rilpivirine The metabolism of Propafenone can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Propafenone.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Propafenone.
Abiraterone Abiraterone The serum concentration of Propafenone can be increased when it is combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Propafenone.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Propafenone.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Propafenone.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Propafenone.
Ruxolitinib Ruxolitinib Ruxolitinib may increase the bradycardic activities of Propafenone.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Propafenone is combined with Vandetanib.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Propafenone.
Vemurafenib Vemurafenib The serum concentration of Propafenone can be increased when it is combined with Vemurafenib.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Propafenone.
Crizotinib Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Propafenone.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Propafenone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Propafenone.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Propafenone.
Mirabegron Mirabegron The metabolism of Propafenone can be decreased when combined with Mirabegron.
Regorafenib Regorafenib Regorafenib may increase the bradycardic activities of Propafenone.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Propafenone.
Teriflunomide Teriflunomide The serum concentration of Propafenone can be decreased when it is combined with Teriflunomide.
Lorcaserin Lorcaserin The therapeutic efficacy of Mecasermin can be increased when used in combination with Propafenone.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Propafenone is combined with Bedaquiline.
Tofacitinib Tofacitinib Propafenone may increase the bradycardic activities of Tofacitinib.
Alogliptin Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Propafenone.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Propafenone.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Propafenone.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Propafenone.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Propafenone.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Propafenone.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Propafenone.
Ospemifene Ospemifene The metabolism of Propafenone can be decreased when combined with Ospemifene.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Propafenone.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Propafenone.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Propafenone.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Propafenone.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Propafenone.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Propafenone.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the antihypertensive activities of Propafenone.
Simeprevir Simeprevir The metabolism of Propafenone can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Propafenone.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Propafenone.
Apremilast Apremilast The metabolism of Propafenone can be increased when combined with Apremilast.
Droxidopa Droxidopa The therapeutic efficacy of Droxidopa can be decreased when used in combination with Propafenone.
Ceritinib Ceritinib Propafenone may increase the bradycardic activities of Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Propafenone can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection The therapeutic efficacy of Albiglutide can be increased when used in combination with Propafenone.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Propafenone.
Idelalisib Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Propafenone.
Oritavancin Injection Oritavancin Injection The metabolism of Propafenone can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Propafenone.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Propafenone.
Dulaglutide Injection Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be increased when used in combination with Propafenone.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Propafenone.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Propafenone can be decreased when combined with Peginterferon beta-1a.
Methamphetamine Methamphetamine The therapeutic efficacy of Propafenone can be decreased when used in combination with Metamfetamine.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Propafenone.
Riociguat Riociguat Propafenone may decrease the antihypertensive activities of Riociguat.
Lanreotide Injection Lanreotide Injection Propafenone may increase the bradycardic activities of Lanreotide.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Propafenone.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Propafenone.
Secukinumab Injection Secukinumab Injection The metabolism of Propafenone can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Propafenone.
Insulin Human Inhalation Insulin Human Inhalation The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin human.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Propafenone.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Propafenone.
Panobinostat Panobinostat The metabolism of Propafenone can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Propafenone is combined with Haloperidol.
Ivabradine Ivabradine Propafenone may increase the bradycardic activities of Ivabradine.
Amiloride Amiloride The risk or severity of hyperkalemia can be increased when Amiloride is combined with Propafenone.
Macitentan Macitentan Propafenone may decrease the antihypertensive activities of Macitentan.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Propafenone is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Propafenone can be decreased when combined with Rolapitant.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Propafenone.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Propafenone is combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Propafenone.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin degludec.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Propafenone.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Propafenone.
Osimertinib Osimertinib The serum concentration of Propafenone can be decreased when it is combined with Osimertinib.
Rifapentine Rifapentine The metabolism of Propafenone can be increased when combined with Rifapentine.
Venetoclax Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Propafenone.
Cobicistat Cobicistat The metabolism of Propafenone can be decreased when combined with Cobicistat.
Midodrine Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Propafenone.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Propafenone.
Obeticholic Acid Obeticholic Acid The metabolism of Propafenone can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Propafenone.
Furosemide Injection Furosemide Injection Propafenone may decrease the antihypertensive activities of Furosemide.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Propafenone.
Lixisenatide Injection Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be increased when used in combination with Propafenone.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Propafenone is combined with Ribociclib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Propafenone.
Deutetrabenazine Deutetrabenazine The serum concentration of the active metabolites of Deutetrabenazine can be increased when Deutetrabenazine is used in combination with Propafenone.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Propafenone.
Safinamide Safinamide The metabolism of Propafenone can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Propafenone can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Propafenone.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Propafenone.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Propafenone.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Propafenone.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Propafenone.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Propafenone.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Propafenone.
Semaglutide Injection Semaglutide Injection The therapeutic efficacy of Semaglutide can be increased when used in combination with Propafenone.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Propafenone.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Propafenone.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Propafenone.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Propafenone.
Baricitinib Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Propafenone.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Propafenone.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Propafenone.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Propafenone.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Propafenone.
Ivosidenib Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Propafenone.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Propafenone.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Propafenone.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Propafenone.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Propafenone.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Propafenone.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Propafenone.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Propafenone.
Stiripentol Stiripentol The metabolism of Propafenone can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Propafenone.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Propafenone.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Propafenone is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Propafenone.
Rifamycin Rifamycin The metabolism of Propafenone can be increased when combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Propafenone.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Propafenone can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of hypertension can be increased when Propafenone is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be decreased when combined with Propafenone.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Propafenone.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Propafenone.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Propafenone.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Propafenone is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Propafenone.
Pitolisant Pitolisant The serum concentration of Pitolisant can be increased when it is combined with Propafenone.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Propafenone.
Lefamulin Lefamulin Propafenone may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Propafenone.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Propafenone can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Propafenone.
Lasmiditan Lasmiditan Lasmiditan may increase the bradycardic activities of Propafenone.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Propafenone.
Calcium Acetate Calcium Acetate The therapeutic efficacy of Propafenone can be decreased when used in combination with Calcium acetate.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Propafenone.
Cenobamate Cenobamate The serum concentration of Propafenone can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Propafenone.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Propafenone.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Propafenone.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Propafenone.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Propafenone.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Propafenone is combined with Selpercatinib.
Capmatinib Capmatinib The metabolism of Propafenone can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Propafenone.
Fenfluramine Fenfluramine The metabolism of Propafenone can be decreased when combined with Fenfluramine.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Propafenone.
Octreotide Octreotide The serum concentration of the active metabolites of Propafenone can be increased when Propafenone is used in combination with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Propafenone.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Propafenone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Propafenone can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Propafenone is combined with Naxitamab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Propafenone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Propafenone is combined with Drospirenone.
Viloxazine Viloxazine The metabolism of Propafenone can be decreased when combined with Viloxazine.
Theophylline Theophylline The serum concentration of Theophylline can be increased when it is combined with Propafenone.
Fenoprofen Fenoprofen Fenoprofen may decrease the antihypertensive activities of Propafenone.
Indomethacin Indomethacin Indomethacin may decrease the antihypertensive activities of Propafenone.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the antihypertensive activities of Propafenone.
Naproxen Naproxen Naproxen may decrease the antihypertensive activities of Propafenone.
Tolmetin Tolmetin Tolmetin may decrease the antihypertensive activities of Propafenone.
Sulindac Sulindac Sulindac may decrease the antihypertensive activities of Propafenone.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Propafenone.
Hydroxyurea Hydroxyurea The metabolism of Propafenone can be decreased when combined with Hydroxyurea.
Phenobarbital Phenobarbital The serum concentration of Propafenone can be decreased when it is combined with Phenobarbital.
Primidone Primidone The metabolism of Propafenone can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of bradycardia can be increased when Methsuximide is combined with Propafenone.
Diethylpropion Diethylpropion The therapeutic efficacy of Propafenone can be decreased when used in combination with Diethylpropion.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Propafenone.
Phenoxybenzamine Phenoxybenzamine Propafenone may increase the orthostatic hypotensive activities of Phenoxybenzamine.
Carmustine Carmustine The metabolism of Carmustine can be decreased when combined with Propafenone.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Propafenone.
Codeine Codeine The metabolism of Codeine can be decreased when combined with Propafenone.
Bromocriptine Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Propafenone.
Metaproterenol Metaproterenol The therapeutic efficacy of Orciprenaline can be decreased when used in combination with Propafenone.
Tranylcypromine Tranylcypromine The metabolism of Propafenone can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Propafenone can be decreased when combined with Phenelzine.
Ergoloid Mesylates Ergoloid Mesylates Propafenone may increase the vasoconstricting activities of Ergoloid mesylate.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Propafenone.
Thioridazine Thioridazine The metabolism of Propafenone can be decreased when combined with Thioridazine.
Trifluoperazine Trifluoperazine The serum concentration of Propafenone can be increased when it is combined with Trifluoperazine.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Propafenone.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Propafenone.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Propafenone.
Oxybutynin Oxybutynin The metabolism of Propafenone can be decreased when combined with Oxybutynin.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Propafenone.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Propafenone.
Ibuprofen Ibuprofen Ibuprofen may decrease the antihypertensive activities of Propafenone.
Orphenadrine Orphenadrine The metabolism of Propafenone can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Propafenone.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Propafenone.
Fluphenazine Fluphenazine The serum concentration of Propafenone can be increased when it is combined with Fluphenazine.
Phentermine Phentermine The therapeutic efficacy of Propafenone can be decreased when used in combination with Phentermine.
Methylphenidate Methylphenidate The risk or severity of hypertension can be increased when Methylphenidate is combined with Propafenone.
Amoxapine Amoxapine The metabolism of Propafenone can be decreased when combined with Amoxapine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the antihypertensive activities of Propafenone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Propafenone.
Mechlorethamine Mechlorethamine Mechlorethamine may increase the bradycardic activities of Propafenone.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Propafenone.
Pyridostigmine Pyridostigmine Pyridostigmine may increase the bradycardic activities of Propafenone.
Carbamazepine Carbamazepine The metabolism of Propafenone can be increased when combined with Carbamazepine.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Propafenone.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Propafenone.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Propafenone.
Hydralazine Hydralazine Propafenone may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine The serum concentration of Propafenone can be increased when it is combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Propafenone.
Loperamide Loperamide The risk or severity of bradycardia can be increased when Propafenone is combined with Loperamide.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Propafenone.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the antihypertensive activities of Propafenone.
Nitrofurantoin Nitrofurantoin The risk or severity of hyperkalemia can be increased when Nitrofurantoin is combined with Propafenone.
Griseofulvin Griseofulvin The metabolism of Propafenone can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Propafenone.
Chloroquine Chloroquine The metabolism of Propafenone can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Propafenone.
Ethosuximide Ethosuximide The risk or severity of bradycardia can be increased when Ethosuximide is combined with Propafenone.
Triamterene Triamterene The metabolism of Triamterene can be decreased when combined with Propafenone.
Chlorothiazide Chlorothiazide Propafenone may decrease the antihypertensive activities of Chlorothiazide.
Chlorthalidone Chlorthalidone Propafenone may decrease the antihypertensive activities of Chlorthalidone.
Metolazone Metolazone Propafenone may decrease the antihypertensive activities of Metolazone.
Secobarbital Secobarbital The serum concentration of Propafenone can be decreased when it is combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Propafenone.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Propafenone.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Propafenone.
Quinidine Quinidine Quinidine may decrease the QTc-prolonging activities of Propafenone.
Procainamide Procainamide Propafenone may increase the arrhythmogenic activities of Procainamide.
Isoniazid Isoniazid The metabolism of Propafenone can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Propafenone can be increased when combined with Rifampicin.
Disopyramide Disopyramide Propafenone may increase the arrhythmogenic activities of Disopyramide.
Valproic Acid Valproic Acid The risk or severity of QTc prolongation can be increased when Propafenone is combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Propafenone.
Butabarbital Butabarbital The serum concentration of Propafenone can be decreased when it is combined with Butabarbital.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Propafenone.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Propafenone.
Methimazole Methimazole The excretion of Propafenone can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Propafenone.
Glucagon Injection Glucagon Injection The therapeutic efficacy of Propafenone can be decreased when used in combination with Glucagon.
Tolbutamide Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Propafenone.
Tolazamide Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Propafenone.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Propafenone.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Propafenone.
Niacin Niacin The metabolism of Propafenone can be decreased when combined with Niacin.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Propafenone.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Propafenone.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Propafenone is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Propafenone.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Propafenone.
Meclizine Meclizine The metabolism of Meclizine can be decreased when combined with Propafenone.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Propafenone.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Propafenone is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Propafenone.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Propafenone.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propafenone can be increased when it is combined with Propranolol.
Minoxidil Minoxidil Propafenone may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Propafenone can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Propafenone.
Spironolactone Spironolactone The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Propafenone.
Mercaptopurine Mercaptopurine The serum concentration of Mercaptopurine can be increased when it is combined with Propafenone.
Nadolol Nadolol The risk or severity of adverse effects can be increased when Propafenone is combined with Nadolol.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Propafenone.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Propafenone.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Propafenone.
Fluorouracil Injection Fluorouracil Injection The metabolism of Propafenone can be decreased when combined with Fluorouracil.
Colchicine Colchicine The serum concentration of Colchicine can be increased when it is combined with Propafenone.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Propafenone.
Ketoconazole Ketoconazole The metabolism of Propafenone can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection Thiotepa may increase the bradycardic activities of Propafenone.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Propafenone.
Captopril Captopril The risk or severity of hyperkalemia can be increased when Propafenone is combined with Captopril.
Dipyridamole Dipyridamole Dipyridamole may increase the bradycardic activities of Propafenone.
Isoxsuprine Isoxsuprine The therapeutic efficacy of Isoxsuprine can be decreased when used in combination with Propafenone.
Vinblastine Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Propafenone.
Bethanechol Bethanechol The risk or severity of adverse effects can be increased when Propafenone is combined with Bethanechol.
Metoprolol Metoprolol The risk or severity of adverse effects can be increased when Propafenone is combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Propafenone.
Thiothixene Thiothixene The metabolism of Thiothixene can be decreased when combined with Propafenone.
Aspirin Aspirin Acetylsalicylic acid may decrease the antihypertensive activities of Propafenone.
Salsalate Salsalate Salsalate may decrease the antihypertensive activities of Propafenone.
Hyoscyamine Hyoscyamine Hyoscyamine may increase the arrhythmogenic activities of Propafenone.
Trimethoprim Trimethoprim The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Propafenone.
Diltiazem Diltiazem The risk or severity of bradycardia can be increased when Propafenone is combined with Diltiazem.
Nifedipine Nifedipine The risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Propafenone.
Timolol Timolol The risk or severity of adverse effects can be increased when Timolol is combined with Propafenone.
Verapamil Verapamil The risk or severity of adverse effects can be increased when Propafenone is combined with Verapamil.
Atenolol Atenolol The risk or severity of adverse effects can be increased when Propafenone is combined with Atenolol.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Propafenone is combined with Pindolol.
Cisplatin Injection Cisplatin Injection Cisplatin may increase the bradycardic activities of Propafenone.
Diflunisal Diflunisal Diflunisal may decrease the antihypertensive activities of Propafenone.
Piroxicam Piroxicam Piroxicam may decrease the antihypertensive activities of Propafenone.
Streptozocin Streptozocin The metabolism of Propafenone can be increased when combined with Streptozocin.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Propafenone.
Glyburide Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Propafenone.
Glipizide Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Propafenone.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Propafenone.
Nafcillin Injection Nafcillin Injection The metabolism of Propafenone can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline The serum concentration of Pentoxifylline can be increased when it is combined with Propafenone.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Pentamidine can be increased when used in combination with Propafenone.
Labetalol Labetalol The risk or severity of adverse effects can be increased when Propafenone is combined with Labetalol.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Propafenone.
Gemfibrozil Gemfibrozil The metabolism of Propafenone can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Propafenone.
Ketoprofen Ketoprofen Ketoprofen may decrease the antihypertensive activities of Propafenone.
Pimozide Pimozide The metabolism of Propafenone can be decreased when combined with Pimozide.
Enalapril Enalapril The risk or severity of hyperkalemia can be increased when Enalapril is combined with Propafenone.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the antihypertensive activities of Propafenone.
Amiodarone Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Propafenone.
Buspirone Buspirone The metabolism of Propafenone can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Propafenone can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Propafenone can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the antihypertensive activities of Propafenone.
Diclofenac Diclofenac Diclofenac may decrease the antihypertensive activities of Propafenone.
Fluoxetine Fluoxetine The serum concentration of Fluoxetine can be increased when it is combined with Propafenone.
Nimodipine Nimodipine The risk or severity of bradycardia can be increased when Nimodipine is combined with Propafenone.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Propafenone can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Propafenone.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Propafenone.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Propafenone.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Propafenone is combined with Clarithromycin.
Benazepril Benazepril The risk or severity of hyperkalemia can be increased when Benazepril is combined with Propafenone.
Etodolac Etodolac Etodolac may decrease the antihypertensive activities of Propafenone.
Felodipine Felodipine The risk or severity of bradycardia can be increased when Felodipine is combined with Propafenone.
Fosinopril Fosinopril The risk or severity of hyperkalemia can be increased when Fosinopril is combined with Propafenone.
Nabumetone Nabumetone Nabumetone may decrease the antihypertensive activities of Propafenone.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Propafenone.
Quinapril Quinapril The risk or severity of hyperkalemia can be increased when Quinapril is combined with Propafenone.
Ramipril Ramipril Propafenone may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Propafenone.
Amlodipine Amlodipine The risk or severity of bradycardia can be increased when Amlodipine is combined with Propafenone.
Itraconazole Itraconazole The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Propafenone.
Lisinopril Lisinopril The risk or severity of hyperkalemia can be increased when Lisinopril is combined with Propafenone.
Oxaprozin Oxaprozin Oxaprozin may decrease the antihypertensive activities of Propafenone.
Sotalol Sotalol The risk or severity of adverse effects can be increased when Propafenone is combined with Sotalol.
Bisoprolol Bisoprolol The risk or severity of adverse effects can be increased when Bisoprolol is combined with Propafenone.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Propafenone.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Propafenone.
Terazosin Terazosin Propafenone may increase the orthostatic hypotensive activities of Terazosin.
Isradipine Isradipine The risk or severity of bradycardia can be increased when Isradipine is combined with Propafenone.
Omeprazole Omeprazole The metabolism of Propafenone can be increased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Propafenone is combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Propafenone.
Venlafaxine Venlafaxine The serum concentration of Venlafaxine can be increased when it is combined with Propafenone.
Nizatidine Nizatidine Nizatidine may increase the bradycardic activities of Propafenone.
Fluvoxamine Fluvoxamine The metabolism of Propafenone can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Propafenone can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of bradycardia can be increased when Lamotrigine is combined with Propafenone.
Losartan Losartan Propafenone may increase the arrhythmogenic activities of Losartan.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Propafenone.
Vinorelbine Injection Vinorelbine Injection The metabolism of Propafenone can be decreased when combined with Vinorelbine.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Propafenone.
Lansoprazole Lansoprazole The metabolism of Propafenone can be decreased when combined with Lansoprazole.
Nicardipine Nicardipine The metabolism of Nicardipine can be decreased when combined with Propafenone.
Bupropion Bupropion The metabolism of Propafenone can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Propafenone.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Propafenone.
Metformin Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Propafenone.
Dalteparin Injection Dalteparin Injection The risk or severity of hyperkalemia can be increased when Propafenone is combined with Dalteparin.
Nisoldipine Nisoldipine The risk or severity of bradycardia can be increased when Propafenone is combined with Nisoldipine.
Riluzole Riluzole The metabolism of Riluzole can be decreased when combined with Propafenone.
Acarbose Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Propafenone.
Glimepiride Glimepiride Propafenone may increase the arrhythmogenic activities of Glimepiride.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Propafenone.
Ritonavir Ritonavir The serum concentration of Propafenone can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Propafenone.
Zafirlukast Zafirlukast The metabolism of Propafenone can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Propafenone.
Trandolapril Trandolapril The risk or severity of hyperkalemia can be increased when Trandolapril is combined with Propafenone.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Propafenone.
Valsartan Valsartan The risk or severity of hyperkalemia can be increased when Valsartan is combined with Propafenone.
Insulin Lispro Injection Insulin Lispro Injection The therapeutic efficacy of Propafenone can be increased when used in combination with Insulin lispro.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Propafenone.
Nelfinavir Nelfinavir The metabolism of Propafenone can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Propafenone.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Propafenone.
Carvedilol Carvedilol The risk or severity of adverse effects can be increased when Propafenone is combined with Carvedilol.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Propafenone.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Propafenone.
Bicalutamide Bicalutamide The metabolism of Propafenone can be decreased when combined with Bicalutamide.
Sertraline Sertraline Sertraline may increase the QTc-prolonging activities of Propafenone.
Irbesartan Irbesartan The risk or severity of hyperkalemia can be increased when Propafenone is combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Propafenone.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Propafenone is combined with Ropinirole.
Finasteride Finasteride The risk or severity of hypertension can be increased when Propafenone is combined with Finasteride.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Propafenone.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Propafenone.
Paroxetine Paroxetine The metabolism of Propafenone can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Citalopram can be decreased when combined with Propafenone.
Efavirenz Efavirenz The metabolism of Propafenone can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Propafenone.
Pioglitazone Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Propafenone.
Celecoxib Celecoxib Celecoxib may decrease the antihypertensive activities of Propafenone.
Rosiglitazone Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Propafenone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Propafenone.
Balsalazide Balsalazide Balsalazide may decrease the antihypertensive activities of Propafenone.
Nateglinide Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Propafenone.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Propafenone.
Rabeprazole Rabeprazole The metabolism of Propafenone can be increased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Propafenone can be decreased when combined with Terbinafine.

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