Diflorasone Topical
Diflorasone topical is a high-potency corticosteroid (steroid) cream, ointment, or gel applied to the skin to relieve inflammation and itching caused by corticosteroid-responsive skin conditions.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 4 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
📖 Diflorasone Topical: Patient Information Guide
A plain-language walkthrough of Diflorasone Topical — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
Diflorasone topical is a high-potency corticosteroid used to treat inflammatory and itchy skin conditions that respond to steroid treatment.
- Psorcon (diflorasone diacetate cream, 0.05%) is indicated for the relief of inflammation and itching from corticosteroid-responsive dermatoses (skin conditions that improve with steroid treatment)
- Diflorasone diacetate ointment is used for similar inflammatory skin conditions, including resistant cases such as psoriasis
⚙️How it works▾
Diflorasone is a topical corticosteroid that works on the skin to reduce inflammation, relieve itching, and narrow small blood vessels (a property called vasoconstriction). The precise cellular mechanism behind its anti-inflammatory effect isn't fully known, but laboratory testing suggests that its ability to constrict blood vessels in the skin is closely tied to how effective it is clinically.
💊How it's taken▾
Diflorasone diacetate ointment is applied as a thin film directly to the affected skin, typically one to three times daily — the exact frequency depends on how severe or treatment-resistant the condition is. Your prescriber may recommend using an occlusive dressing (an airtight wrap placed over the treated area) to boost absorption for stubborn conditions like psoriasis.
- Always follow the specific directions on your prescription label
- Do not use occlusive dressings without your doctor's instruction
- If a skin infection develops, stop any occlusive dressing and contact your doctor right away
🤒Side effects — in detail▾
Most side effects from diflorasone are local — meaning they happen at the site where you apply it. They tend to be more common when occlusive dressings are used.
- Burning, stinging, or irritation
- Itching
- Skin dryness
- Folliculitis (inflamed hair follicles)
- Acne-like breakouts
- Hypopigmentation (lightening or loss of skin color)
- Perioral dermatitis (rash around the mouth)
- Allergic contact dermatitis (allergic skin reaction)
- Secondary skin infections
- Skin atrophy (thinning of the skin) or striae (stretch marks)
- Miliaria (heat rash)
Contact your doctor if you notice signs of a skin infection, significant skin thinning, stretch marks, or an allergic reaction — these need prompt attention.
⚠️Warnings & precautions▾
- Systemic absorption: Diflorasone can be absorbed through the skin in amounts large enough to cause body-wide steroid effects, especially when applied to large areas, used under occlusive dressings, or when skin is broken or inflamed. Use only as directed to minimize this risk.
- Occlusive dressings and infection: If a skin infection develops while using an occlusive dressing, stop the dressing immediately and seek appropriate treatment. Do not use occlusive dressings unless your doctor recommends them.
- Hypersensitivity: Do not use Psorcon or any diflorasone product if you have a known allergy to any of its ingredients.
🔀What it interacts with▾
The FDA label for diflorasone topical does not describe specific drug, food, or supplement interactions.
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Tell your doctor if you have ever had an allergic reaction to any corticosteroid or any ingredient in diflorasone products
- Let your prescriber know if you develop a skin infection while on treatment — occlusive dressings must be stopped if this happens
- Discuss use during pregnancy or breastfeeding with your doctor before starting
- Children may absorb more of this medication through their skin; talk to your doctor about appropriate use in pediatric patients
🚑If you take too much▾
Applying too much diflorasone topical, or using it over a large skin area or under occlusive dressings for extended periods, can allow enough medication to be absorbed to cause systemic (body-wide) corticosteroid effects. If you're concerned about overuse or notice unexpected symptoms, contact your doctor or seek medical guidance promptly.
📡Pharmacodynamics — effects in the body▾
Diflorasone topical acts on the skin to produce three main effects: it reduces inflammation, relieves itching (antipruritic), and constricts small blood vessels (vasoconstriction). These effects work together to calm irritated, inflamed skin. Laboratory studies measuring its vasoconstricting ability are used to gauge how potent it is — and potency is closely linked to how well it works clinically.
🔬Pharmacokinetics — how your body processes it▾
How much diflorasone gets absorbed through the skin depends on several factors: the formulation used, the condition of the skin barrier, and whether an occlusive dressing is in place. Inflamed or broken skin absorbs more of the medication, and occlusive dressings can substantially increase absorption. Once it enters the bloodstream, diflorasone is processed similarly to other corticosteroids — it binds to proteins in the blood, is broken down (metabolized) mainly in the liver, and is cleared from the body through the kidneys, with some eliminated through bile.
📦How to store it▾
Store at 20 ° to 25 ° C (68 ° to 77 ° F) .
📄 Written from Diflorasone Topical’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
Supplements & herbs that interact with Diflorasone Topical
3 supplements and herbal products have documented interactions with Diflorasone Topical in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Moderate · 2
- Minor · 1
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Diflorasone Topical — the kind of thing our pharmacy team would talk through with you at the counter.
What skin conditions does diflorasone treat? ▾
How do I apply it correctly? ▾
My doctor mentioned an occlusive dressing — what does that mean, and is it safe? ▾
What side effects should I watch for? ▾
Is it safe to use over a large area of skin or for a long time? ▾
Can I use this if I'm pregnant or breastfeeding? ▾
Is Diflorasone Topical available over the counter? ▾
When was Diflorasone Topical first available? ▾
Who makes Diflorasone Topical? ▾
💬 Answers drafted from Diflorasone Topical’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Diflorasone Topical comes
Diflorasone Topical is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Topical cream, ointment or gel
How this form is used
- Psorcon (diflorasone diacetate cream) is indicated for the relief of inflammatory and itchy skin conditions that respond to corticosteroid treatment
- Diflorasone diacetate ointment is used for inflammatory and itchy skin conditions, including resistant cases such as psoriasis
- Diflorasone diacetate ointment should be applied as a thin film to the affected area one to three times daily, depending on the severity of the condition
- Your doctor may recommend using an occlusive dressing (an airtight wrap or bandage) over diflorasone diacetate ointment to help manage psoriasis or stubborn skin conditions
- If a skin infection develops while using an occlusive dressing with diflorasone diacetate ointment, stop the dressing immediately and contact your doctor
- Follow your prescriber's specific directions for whichever brand or formulation you have been prescribed
📊 Diflorasone Topical across the U.S. market
How Diflorasone Topical appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
📈 How widely Diflorasone Topical is used
A general measure of how commonly Diflorasone Topical is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Diflorasone Topical is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Diflorasone Topical prescribed? Of the 1,596 medications we measure, Diflorasone Topical ranks #956 by Medicaid prescriptions — more than 40% of them.
Utilization by Diflorasone Topical product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
diflorasone diacetate 0.5 MG/ML Topical Cream Most dispensed
Summed across the 2 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 966577
diflorasone diacetate 0.0005 MG/MG Topical Ointment
Summed across the 3 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 966607
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Diflorasone Topical, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 5 of 16 listed Diflorasone Topical NDCs with Medicaid activity.
🔍 Compare Diflorasone Topical products
A representative set of FDA-listed product records for Diflorasone Topical — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Topical cream, ointment or gel | ||||
| 0.5 mg/g | Topical | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 0.5 mg/g | Topical | E. Fougera & Co. a division of Fougera Pharmaceuticals Inc. | ANDA | View NDC → |
| 0.5 mg/g | Topical | Emerald Therapeutics, LLC | ANDA | View NDC → |
| 0.5 mg/g | Topical | Innovida Pharmaceutique Corporation | ANDA | View NDC → |
| 0.5 mg/g | Topical | PharmaDerm a division of Fougera Pharmaceuticals Inc. | ANDA | View NDC → |
| 0.5 mg/g | Topical | Rising Pharmaceuticals, Inc. | ANDA | View NDC → |
| 0.5 mg/g | Topical | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
| 0.5 mg/g | Topical | Sola Pharmaceuticals | ANDA | Find on DailyMed ↗ |
| 0.5 mg/g | Topical | Sun Pharmaceutical Industries, Inc. × 2 listings | ANDA | View NDC → |
| 5 mg/g | Topical | Sun Pharmaceutical Industries, Inc. | ANDA | View NDC → |
| 0.5 mg/g | Topical | Taro Pharmaceuticals U.S.A., Inc. × 2 listings | ANDA | View NDC → |
| 5 mg/g | Topical | Taro Pharmaceuticals U.S.A., Inc. | ANDA | View NDC → |
| 0.5 mg/g | Topical | Teligent Pharma, Inc. | ANDA | Find on DailyMed ↗ |
Showing 15 of 15 products — FDA National Drug Code Directory. See every product, package size and price: browse all 15 Diflorasone Topical NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Diflorasone Topical — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Diflorasone Topical in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Diflorasone Topical went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 91311 2 dose forms · 2 strengths
-
Dose form (SCDF) Topical Cream RxCUI 378610In current FDA listingsClinical drug / strength (SCD) diacetate 0.5 MG/MLRxCUI 966577 -
Dose form (SCDF) Topical Ointment RxCUI 376493In current FDA listingsClinical drug / strength (SCD) diacetate 0.0005 MG/MGRxCUI 966607
Look up RxCUI 91311 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Diflorasone Topical is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
RxNorm drug class
Diflorasone Topical belongs to the Corticosteroid class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 4 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Taro Pharmaceuticals U.S.A., Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.