Saxagliptin

Generic name: Pronounced as (sax' a glip tin)
Brand names
  • Onglyza®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 07/15/2019

Saxagliptin is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Saxagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amount of insulin produced by the body after meals when blood sugar is high. Saxagliptin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Saxagliptin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take saxagliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take saxagliptin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Saxagliptin controls type 2 diabetes but does not cure it. Continue to take saxagliptin even if you feel well. Do not stop taking saxagliptin without talking to your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with saxagliptin and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking saxagliptin,

  • tell your doctor and pharmacist if you are allergic to saxagliptin, any other medications, or any of the ingredients in saxagliptin tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungal medications such as itraconazole (Onmel, Sporanox) and ketoconazole (Nizoral); clarithromycin (Biaxin); certain medications for HIV (human immunodeficiency virus) or AIDS (acquired immunodeficiency syndrome) such as atazanavir (Reyataz, in Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); insulin or oral medications for diabetes such as chlorpropamide (Diabinese), glimepiride (Amaryl, in Duetact), glipizide (Glucotrol), glyburide (Diabeta, Glynase, in Glucovance), nateglinide (Starlix), pioglitazone (Actos, in Actoplus Met, in Duetact), repaglinide (Prandin, in Prandimet), rosiglitazone (Avandia), tolazamide, and tolbutamide; nefazodone; and telithromycin (no longer available in the U.S.; Ketek). You doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol, if you have or have ever had pancreatitis (swelling of the pancreas), gallstones, high levels of triglycerides (fatty substances) in your blood, heart failure, diabetic ketoacidosis, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking saxagliptin, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking saxagliptin.

  • talk to your doctor about what you should do if you get hurt or if you develop a fever or infection. These conditions may affect your blood sugar and the amount of saxagliptin you may need.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet, exercise regularly, and lose weight if necessary. This will help to control your diabetes and help saxagliptin work more effectively.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one unless your doctor tells you that you should.

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

  • Saxagliptin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • sore throat

    • headache

    • joint pain

  • Some side effects can be serious. If you experience any of these symptoms, stop taking saxagliptin and call your doctor immediately:

    • rash

    • hives

    • skin peeling

    • itching

    • swelling of the face, lips, tongue or throat

    • difficulty breathing or swallowing

    • hoarseness

    • ongoing pain, that begins in the upper left or middle of the stomach but may spread to the back

    • vomiting

    • loss of appetite

    • excessive tiredness

    • shortness of breath, especially when lying down

    • swelling of the feet, ankles, or legs

    • sudden weight gain

  • Saxagliptin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will probably order certain laboratory tests before and during your treatment with saxagliptin to check your body's response to it. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to saxagliptin. Your doctor may also tell you how to check your response to saxagliptin by measuring your blood or urine sugar levels at home. Follow these directions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Kombiglyze® XR (containing Metformin, Saxagliptin)
  • Qtern® (containing Dapagliflozin, Saxagliptin)
  • Qternmet® XR (containing Dapagliflozin, Metformin, Saxagliptin)

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Moxifloxacin.
Penbutolol Penbutolol The therapeutic efficacy of Saxagliptin can be increased when used in combination with Acebutolol.
Triamcinolone Triamcinolone The risk or severity of hyperglycemia can be increased when Triamcinolone is combined with Saxagliptin.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Saxagliptin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The excretion of Saxagliptin can be decreased when combined with Zidovudine.
Trimipramine Trimipramine Trimipramine may decrease the hypoglycemic activities of Saxagliptin.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Gemifloxacin.
Apomorphine Injection Apomorphine Injection The metabolism of Saxagliptin can be decreased when combined with Apomorphine.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Saxagliptin can be decreased when combined with Voriconazole.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Pramlintide is combined with Saxagliptin.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Saxagliptin may increase the hypoglycemic activities of Insulin detemir.
Rasagiline Rasagiline Rasagiline may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Saxagliptin can be decreased when combined with Tretinoin.
Betaxolol Betaxolol The therapeutic efficacy of Saxagliptin can be increased when used in combination with Betaxolol.
Everolimus Everolimus The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Everolimus.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Lurasidone Lurasidone The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Lurasidone.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of angioedema can be increased when Saxagliptin is combined with Azilsartan medoxomil.
Roflumilast Roflumilast Roflumilast may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Linagliptin Linagliptin The risk or severity of angioedema can be increased when Saxagliptin is combined with Linagliptin.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Ruxolitinib Ruxolitinib Saxagliptin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vemurafenib Vemurafenib The therapeutic efficacy of Saxagliptin can be increased when used in combination with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Saxagliptin.
Deferiprone Deferiprone Saxagliptin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Saxagliptin.
Crizotinib Crizotinib The metabolism of Saxagliptin can be decreased when combined with Crizotinib.
Enzalutamide Enzalutamide Saxagliptin may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Saxagliptin may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teriflunomide Teriflunomide The excretion of Saxagliptin can be decreased when combined with Teriflunomide.
Teduglutide Injection Teduglutide Injection Saxagliptin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin The risk or severity of angioedema can be increased when Alogliptin is combined with Saxagliptin.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Saxagliptin.
Pomalidomide Pomalidomide Saxagliptin may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Saxagliptin can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Saxagliptin.
Canagliflozin Canagliflozin Canagliflozin may increase the hypoglycemic activities of Saxagliptin.
Dabrafenib Dabrafenib The excretion of Saxagliptin can be decreased when combined with Dabrafenib.
Trametinib Trametinib Saxagliptin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The excretion of Saxagliptin can be decreased when combined with Dolutegravir.
Levomilnacipran Levomilnacipran The risk or severity of hypoglycemia can be increased when Saxagliptin is combined with Levomilnacipran.
Vortioxetine Vortioxetine Saxagliptin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Saxagliptin.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Saxagliptin.
Simeprevir Simeprevir The therapeutic efficacy of Saxagliptin can be increased when used in combination with Simeprevir.
Sofosbuvir Sofosbuvir Saxagliptin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast The metabolism of Saxagliptin can be increased when combined with Apremilast.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Ceritinib Ceritinib The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Saxagliptin can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection The risk or severity of hypoglycemia can be increased when Saxagliptin is combined with Albiglutide.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Saxagliptin is combined with Empagliflozin.
Tasimelteon Tasimelteon Saxagliptin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Macitentan Macitentan Saxagliptin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Ziprasidone.
Cobicistat Cobicistat The metabolism of Saxagliptin can be decreased when combined with Cobicistat.
Lixisenatide Injection Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Saxagliptin is combined with Lixisenatide.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Drospirenone.
Viloxazine Viloxazine Saxagliptin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Trazodone Trazodone The metabolism of Saxagliptin can be decreased when combined with Trazodone.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypoglycemic activities of Saxagliptin.
Tetracycline Tetracycline The excretion of Saxagliptin can be decreased when combined with Tetracycline.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Saxagliptin can be increased when used in combination with Sulfadiazine.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Warfarin Warfarin Warfarin may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Triamterene Triamterene Triamterene may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Valproic Acid Valproic Acid The excretion of Saxagliptin can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Saxagliptin can be decreased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Liothyronine.
Tolbutamide Tolbutamide Saxagliptin may increase the hypoglycemic activities of Tolbutamide.
Tolazamide Tolazamide Saxagliptin may increase the hypoglycemic activities of Tolazamide.
Baclofen Baclofen The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Baclofen.
Mercaptopurine Mercaptopurine The excretion of Saxagliptin can be decreased when combined with Mercaptopurine.
Vincristine Injection Vincristine Injection The metabolism of Saxagliptin can be decreased when combined with Vincristine.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Saxagliptin.
Temazepam Temazepam Temazepam may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Timolol Timolol The therapeutic efficacy of Saxagliptin can be increased when used in combination with Timolol.
Verapamil Verapamil The metabolism of Saxagliptin can be decreased when combined with Verapamil.
Atenolol Atenolol The therapeutic efficacy of Saxagliptin can be increased when used in combination with Atenolol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Teniposide Injection Teniposide Injection The metabolism of Saxagliptin can be decreased when combined with Teniposide.
Tramadol Tramadol Tramadol may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Indinavir Indinavir The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Indinavir.
Nelfinavir Nelfinavir The metabolism of Saxagliptin can be decreased when combined with Nelfinavir.
Sildenafil Sildenafil The metabolism of Saxagliptin can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The therapeutic efficacy of Saxagliptin can be increased when used in combination with Celecoxib.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Thalidomide Thalidomide The metabolism of Saxagliptin can be increased when combined with Thalidomide.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Saxagliptin which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists