Medication interaction hub

What Supplements Interact with Propafenone?

Propafenone brand names: Rythmol, Arythmol. Every interaction below applies to the brands too.

138 Interactions 1 Major 99 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Propafenone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Propafenone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Propafenone (Rythmol) steadies abnormal heart rhythms, and medicines with that job leave little room for error, so the 138 supplements and herbs on this list deserve genuine attention before any of them get added on top. The single major-rated entry is activated charcoal, which can soak up an oral dose in the gut and cut how much medication actually reaches your bloodstream. Most of the rest act through the liver enzymes, CYP1A2 and CYP2D6, that break propafenone down, nudging its blood level up or down when the point of treatment is keeping it steady.

Ninety-nine of the 138 rate moderate and 38 minor, so few are outright dangerous, but with a rhythm drug even a modest shift in level matters. Everyday products sit in that middle tier, cannabidiol and melatonin among them. A smaller cluster of charcoals and bulky fibers can blunt absorption of anything swallowed near them, so space those well apart from your dose. For a medicine whose job is a steady heartbeat, steadiness in what you take around it counts nearly as much.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 99 Minor 38 No known interaction 1,314

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Propafenone: Top Interactions at a Glance

The Propafenone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 138 interacting ingredients — plus 1,314 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Propafenone Combinations Today

The Propafenone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Turmeric + Propafenonei

Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Unlikely Kava + Propafenonei

It is unclear if kava inhibits CYP1A2; research is conflicting.

Read the full interaction Moderate Likelihood Possible Parsley + Propafenonei

Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Shiitake Mushroom + Propafenonei

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Fever Bark + Propafenonei

Theoretically, fever bark might increase the levels and clinical effects of CYP2D6 substrates.

Read the full interaction Minor Likelihood Possible Beet + Propafenonei

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Propafenone

All 1,452 ingredients in our database, ranked by severity — 138 with a Propafenone interaction on file and 1,314 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Propafenone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Turmeric with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, turmeric might increase levels of drugs metabolized by CYP1A2.

Full Turmeric + Propafenone answer

Can you take Kava with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Propafenone answer

Can you take Parsley with Propafenone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Full Parsley + Propafenone answer

Can you take Shiitake Mushroom with Propafenone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Full Shiitake Mushroom + Propafenone answer

Can you take Fever Bark with Propafenone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase the levels and clinical effects of CYP2D6 substrates.

Full Fever Bark + Propafenone answer

Can you take Atractylodes with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.

Full Atractylodes + Propafenone answer

Can you take Bael with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.

Full Bael + Propafenone answer

Can you take Beet with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Full Beet + Propafenone answer

Can you take Bitter Orange with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.

Full Bitter Orange + Propafenone answer

Can you take Black Psyllium with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Propafenone answer

Can you take Blond Psyllium with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Propafenone answer

Can you take Broccoli Sprout with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.

Full Broccoli Sprout + Propafenone answer

Can you take Carob with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Propafenone answer

Can you take Eurycoma Longifolia with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.

Full Eurycoma Longifolia + Propafenone answer

Can you take Fucus Vesiculosus with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.

Full Fucus Vesiculosus + Propafenone answer

Can you take Ginger with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP1A2 substrates.

Full Ginger + Propafenone answer

Can you take Hemp with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.

Full Hemp + Propafenone answer

Can you take Hibiscus Sabdariffa with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2D6 substrates.

Full Hibiscus Sabdariffa + Propafenone answer

Can you take Hordenine with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Hordenine weakly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full Hordenine + Propafenone answer

Can you take Karaya Gum with Propafenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Propafenone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Propafenone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Propafenone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Propafenone sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Propafenone through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Propafenone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Propafenone through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Propafenone through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Propafenone through this category.

About Propafenone

Propafenone is an antiarrhythmic medication used to treat irregular heartbeat and help maintain a normal heart rate.

Generic name: Propafenone  ·  Brand names: Rythmol, Arythmol.

See the full Propafenone drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Propafenone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Propafenone.

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Pharmacist Counseling Corner

Propafenone & Supplements: Common Questions

What supplements interact with Propafenone?
More than you might expect — 138 in total, though they are far from equal: 1 are rated major, 99 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Ayahuasca, Cannabidiol (cbd).
Which Propafenone supplement interactions are the most serious?
Focus on the major group: Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Propafenone?
Usually yes — most people on Propafenone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Rythmol have the same supplement interactions as Propafenone?
Yes — Rythmol, Arythmol all contain Propafenone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Propafenone and my other medications?
This page covers Propafenone against supplements and herbal ingredients. Checking Propafenone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Propafenone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.