Drug & supplement interaction

Clove + Propafenone

Propafenone brand names: Rythmol, Arythmol.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Propafenone falls into 2 drug categories that Clove can interact with; the most serious is rated moderate. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Clove and Propafenone

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Clove interacts with whole categories of medication. Propafenone falls into 2 of those categories, so it can interact with Clove in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES

1 of 2

Why this applies to Propafenone

Propafenone falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Clove interacts with.

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the basic idea with clove and your propafenone (Rythmol). Propafenone is cleared from your body mainly by a liver enzyme called CYP2D6. In lab studies, eugenol (the main compound in clove) can slow that enzyme down. If it did the same thing in people, your body would break propafenone down more slowly, so the level could creep up.

Because propafenone affects your heart rhythm, higher levels could mean more side effects like dizziness, a slow or irregular heartbeat, blurred vision, or a metallic taste. That said, this is only seen in a test tube, not in real patients, and ordinary cooking amounts of clove are very unlikely to matter. Concentrated clove oil or supplements are the bigger question mark. Please check with your pharmacist or doctor before using them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Alharbi NFM, Ahad A, Bin Jardan YA, Al-Jenoobi FI. Effect of eugenol on cytochrome P450 1A2, 2C9, 2D6, and 3A4 activity in human liver microsomes. Saudi Pharm J 2024;32(7):102118. PubMed
Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

2 of 2

Propafenone also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the idea with clove and propafenone. Your body uses a liver enzyme called CYP1A2 to help break down propafenone. Clove's main compound, eugenol, has been shown in lab dishes to slow that enzyme down. If that happened in real life, propafenone could clear more slowly and build up in your blood.

Since propafenone is an active heart rhythm drug (not a prodrug), more of it means stronger effects and possibly more side effects, things like dizziness, a slow or pounding heartbeat, blurred vision, or even worsening rhythm problems. Propafenone has a narrow safety window, so small changes matter. That said, this is only theoretical from lab work, not seen in people, and a sprinkle of clove in cooking is very unlikely to be an issue. Concentrated clove oil or supplements are the bigger question. Please check with your pharmacist or doctor before using clove medicinally.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Alharbi NFM, Ahad A, Bin Jardan YA, Al-Jenoobi FI. Effect of eugenol on cytochrome P450 1A2, 2C9, 2D6, and 3A4 activity in human liver microsomes. Saudi Pharm J 2024;32(7):102118. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Clove Also Interacts With Other Medications

Clove has 918 moderate, 60 minor known drug interactions in our database — the Propafenone one above is among them. If you take anything else, check it against the full list below.

Moderate 918 Minor 60 No known interaction 1,852 (incl. Propafenone)
Taking anything else?

Check Another of Your Medications Against Clove

Covers the 2,830 medications we’ve checked against Clove. Pick one to open its full report.

From our Q&A

Questions About Clove or Propafenone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Clove or Propafenone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Propafenone

This page covers Clove only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propafenone page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), 1,3-dmaa (moderate), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).

By severity: 1 major · 99 moderate · 38 minor.

From our pharmacist’s overview on the Propafenone page

“Propafenone (Rythmol) steadies abnormal heart rhythms, and medicines with that job leave little room for error, so the 138 supplements and herbs on this list deserve genuine attention before any of them get added on top. The single major-rated entry is activated charcoal, which can soak up an oral dose in the gut and cut how much medic…”

Reviewed by 2 · Jul 18, 2026

Open the Propafenone interaction page

One more smart check

Taking Clove as Part of a Dietary Supplement Product? Check It for Interactions

We hold 59 real supplement products containing Clove, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Clove. Your product may carry other ingredients that interact with Propafenone too, on top of Clove — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Clove and Propafenone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Clove
Top 25%

#160 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Propafenone
Steady interest

#1,893 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Clove

What is Clove?

Clove
  • Toothache and oral pain
  • Digestive upset
  • Antimicrobial and antifungal
  • Cough and respiratory complaints
  • Flavoring in food and drinks

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are generally safe, but concentrated clove oil and supplements can be irritating or toxic if overused, and human evidence for most health claims is limited. Talk to your pharmacist or doctor before using clove medicinally, especially in children or during pregnancy.

Read the full Clove monograph & all interactions
Medication

About Propafenone

What Is Propafenone Used For?

Brand names: Rythmol, Arythmol

Propafenone helps keep the heart in a steady rhythm. It is used in people without structural heart disease to lengthen the time before atrial fibrillation (AF) returns.

Propafenone hydrochloride tablets are also used for paroxysmal supraventricular tachycardia (PSVT) with disabling symptoms. They are also used for documented life-threatening ventricular arrhythmias, such as sustained ventricular tachycardia. Propafenone hydrochloride extended-release capsules are labeled only for symptomatic atrial fibrillation.

See full Propafenone drug information Propafenone NDC codes and packages
Keep checking

Other Drugs & Clove

Browse every other medication we’ve checked against Clove — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
918Moderate
60Minor
1,851No known interaction
918 Moderate 60 Minor 1,851 No interaction
Moderate

918 interactions

Showing 60 of 918 moderate interactions — see all 918 on the Clove page.

Minor

60 interactions

No interaction 1,851 drugs checked — show the list

We also checked Clove against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,851 medications checked with no known interaction — see the full Clove list.

See the full Clove interactions page
See every supplement checked against Propafenone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Clove monograph › Uses, safety, and every drug interaction in one place Propafenone supplement interactions › Every supplement checked against Propafenone, ranked by severity Propafenone drug information › The full plain-English guide to this medication Propafenone NDC codes and packages › Every package, labeler and price in the FDA directory Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Clove and Propafenone Together: Common Questions

Can you take Clove with Propafenone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Clove and Propafenone?
Propafenone belongs to more than one drug category, and Clove interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Clove and Propafenone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Propafenone and Clove?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.