Concerns With Taking Both Metoprolol and Propafenone

In our latest question and answer, the pharmacist discusses a reader's concerns regarding taking two seemingly similar drugs, metoprolol and propafenone.

3 min read Updated Jun 2026 Read by 2,211 people
Concerns With Taking Both Metoprolol and Propafenone
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Cham asked

I’ve been experiencing a racing heart and was prescribed metoprolol 50 mg once daily by one doctor, and propafenone 425 mg every 12 hours by another. I’ve noticed dizziness, which seems to be a side effect of the propafenone. Based on what I’ve read online, the two medications appear to do similar things—do I really need to be taking both?

May 10, 2025
The quick answer
  • Both metoprolol and propafenone can be prescribed together for certain heart rhythm problems, though they work in different ways.
  • Dizziness is a known side effect of both medications, and taking them together can increase this risk, so it's important to tell your doctor if you're experiencing it.
  • Do not stop taking either medication on your own, but discuss your symptoms with your cardiologist so they can monitor you and make sure this combination is right for your specific condition.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
Medications in this answer — tap to explore

Answer

Thanks so much for reaching out!

I want to start off by stating that it’s not totally clear what your exact diagnosis is. A “racing heart” can point to several things, such as: atrial fibrillation, SVT (supraventricular tachycardia), inappropriate sinus tachycardia, or even something like anxiety.

Each of those has different treatment goals, so knowing the root cause really matters when you’re trying to figure out if both meds are necessary. Regardless, your question is more medication-focused, so let's dive into those.

Differences Between Metoprolol and Propafenone

Metoprolol is a cardioselective beta blocker (beta-1 blocker specifically). You'd likely hear it just referred to as a 'beta-blocker'. It slows the heart rate, reduces how hard the heart pumps, and lowers blood pressure. It’s commonly used to control rate in arrhythmias like AFib or for general heart protection in people with high blood pressure or a history of heart issues.

Propafenone is a Class IC antiarrhythmic. It works by slowing electrical signals in the heart, helping to prevent irregular rhythms from forming or recurring, especially atrial fibrillation. It also has some mild beta-blocking properties, which adds to the confusion here, but its primary role is to maintain sinus rhythm, not just slow the heart.

So yes, both drugs affect heart rhythm and rate, but they do it in different ways and are often prescribed together, especially for the treatment of certain diagnoses.

You're certainly correct to be concerned with the side effect of dizziness with propafenone and metoprolol. Both can cause that, and as you mentioned, you're experiencing it. Taking both drugs increases the risk of it happening.

Dizziness could be related to how your body’s responding to the drugs in a general sense, or it could be because the drugs are dropping your heart rate or blood pressure too low.

Either way, it’s worth talking to your cardiologist to make sure this combo is right for you. It's important that you don't stop either medication on your own — this applies regardless of who prescribed them. Stopping an antiarrhythmic like propafenone abruptly can be dangerous, so please reach out to both of your prescribers before making any changes., but be sure to discuss what is occurring so you can be appropriately monitored and treated.

Final Words

Overall, it's not unusual that metoprolol and propafenone would be prescribed together. They can have additive side effects, so it's important to understand what you are being treated for, and why you are taking those particular drugs. I recommend speaking to your doctor about it as they know your exact treatment details.

If you have any other drug related questions though, we're here for you!

References & sources
  1. Clinical experience with propafenone for cardiac arrhythmias in the young — PubMed
  2. Toprol XL Prescribing Information — PubMed
  3. RYTHMOL Prescribing Information — PubMed
Glossary — Terms in This Answer
Atrial fibrillation
A heart condition where the upper chambers of the heart beat irregularly and too quickly instead of in a normal rhythm.
SVT (supraventricular tachycardia)
A condition where the heart suddenly beats very fast due to electrical problems in the upper chambers of the heart.
Beta blocker
A medication that slows the heart rate and reduces the force of heart contractions to lower blood pressure and protect the heart.
Arrhythmias
Irregular heartbeats where the heart rhythm is abnormal or faster or slower than normal.
Antiarrhythmic
A medication that works to correct or prevent irregular heartbeats by controlling electrical signals in the heart.
Sinus rhythm
The normal, regular pattern of heartbeats controlled by the heart's natural pacemaker.
Additive side effects
When two medications cause similar side effects that combine together, making the side effect stronger or more noticeable.
Cardioselective
A property of a medication that primarily targets the heart rather than affecting other parts of the body equally.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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