Panobinostat

Generic name: Pronounced as (pan'' oh bin' oh stat)
Brand names
  • Farydak®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2017

Panobinostat may cause severe diarrhea and other serious gastrointestinal (GI; affecting the stomach or intestines) side effects. If you experience any of the following symptoms, call your doctor immediately: stomach cramps; loose stools; diarrhea; vomiting; or dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration. Talk to your doctor about what you should do if you develop diarrhea during your treatment with panobinostat. Also talk to your doctor before taking any laxatives or stool softeners while you are taking this medication.

Panobinostat may cause serious or life-threatening heart problems during your treatment. Tell your doctor if you have recently had a heart attack or if you have long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death), angina (chest pain), or other heart problems. Your doctor will order tests such as an electrocardiogram (ECG; test that records the electrical activity of the heart) before and during your treatment to see if it is safe for you to take panobinostat. If you experience any of the following symptoms, call your doctor immediately: chest pain, rapid, pounding, or irregular heart beat, lightheadedness, feeling faint, dizziness, blue-colored lips, shortness of breath, or swelling of the hands, arms, feet, ankles, or lower legs.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to panobinostat.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with panobinostat and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of taking panobinostat.

Panobinostat is used in combination with bortezomib (Velcade) and dexamethasone to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated two other medications, including bortezomib (Velcade). Panobinostat is in a class of medications called histone deacetylase (HDAC) inhibitors. It works by killing cancer cells.

Panobinostat comes as a capsule to take by mouth. It is usually taken with or without food once daily on certain days of a 21-day cycle. The cycle may be repeated for up to 16 cycles. Take panobinostat at around the same time on each scheduled day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take panobinostat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with a glass of water; do not crush, chew, or open them. Handle the capsules as little as possible. If you touch a broken panobinostat capsule or the medicine in the capsule, wash that area of your body with soap and water. If the medicine in the capsule gets into your mouth, nose, or eyes, wash it away with plenty of water.

If you vomit after taking panobinostat, do not take another dose. Continue your regular dosing schedule.

Be sure to tell your doctor how you are feeling during your treatment. Your doctor may decrease your dose of panobinostat or stop your treatment for a while or permanently, if you experience side effects of the medication.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking panobinostat,

  • tell your doctor and pharmacist if you are allergic to panobinostat, any other medications, or any of the ingredients in panobinostat capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); antifungals such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); atomoxetine (Strattera); bepridil (Vascor; no longer available in the U.S.); boceprevir (Victrelis); carbamazepine (Carbatrol, Tegretol, Teril, others); chloroquine (Aralen); clarithromycin (Biaxin, in PrevPac); conivaptan (Vaprisol); desipramine (Norpramin); dextromethorphan; disopyramide (Norpace); dolasetron (Anzemet); certain medications for HIV such as indinavir (Crixivan), lopinavir/ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), saquinavir (Invirase); methadone (Dolophine, Methadose); metoprolol (Lopressor, Toprol-XL); moxifloxacin (Avelox); nebivolol (Bystolic); nefazodone; ondansetron (Zofran, Zuplenz); perphenazine; pimozide (Orap); phenobarbital; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sotalol (Betapace, Sorine, Sotylize); telaprevir (Incivek; no longer available in U.S.); telithromycin (Ketek); thioridazine; tolterodine (Detrol); and venlafaxine (Effexor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St John's wort.

  • tell your doctor if you have an infection or have or have ever had bleeding problems or liver disease.

  • tell your doctor if you are pregnant or plan to become pregnant. Panobinostat may harm the fetus. Use birth control to prevent pregnancy during your treatment with panobinostat and for at least 1 month after the last dose. If you are a man and your partner can become pregnant, you should use a condom while taking this medication and for 90 days after your treatment is completed. Ask your doctor if you have questions about types of birth control that will work for you. If you become pregnant while taking panobinostat, call your doctor immediately.

  • tell your doctor if you are breastfeeding. You should not breastfeed while taking panobinostat.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking panobinostat.

Do not eat pomegranate, grapefruit or star fruit or drink grapefruit or pomegranate juice while taking this medication.

If it has been 12 hours or less since you were scheduled to take the dose, take the missed dose as soon as you remember it. If it has been more than 12 hours since your scheduled dose, skip the dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed.

  • Panobinostat may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • weight loss

    • headache

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

    • black, tarry, or bloody stools

    • bloody vomit or vomited material that looks like coffee grounds

    • unusual bruising or bleeding

    • pink or brown urine

    • blood in phlegm

    • confusion

    • changes in your speech

    • fever, cough, chills, sweating or other signs of infection

    • pale skin

    • nausea, vomiting, loss of appetite, dark urine, stomach pain, extreme tiredness, lack of energy, or yellowing of skin or white of eyes

  • Panobinostat may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • diarrhea

  • nausea

  • vomiting

  • decreased appetite

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Panobinostat.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Panobinostat is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Panobinostat can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Panobinostat can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The metabolism of Panobinostat can be decreased when combined with Dolasetron.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Anagrelide.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Panobinostat.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Panobinostat can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Panobinostat can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Panobinostat can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Panobinostat.
Paregoric Paregoric The serum concentration of Panobinostat can be increased when it is combined with Morphine.
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Panobinostat.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Panobinostat.
Reserpine Reserpine The serum concentration of Panobinostat can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Panobinostat.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Panobinostat.
Triamcinolone Triamcinolone The metabolism of Panobinostat can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Panobinostat can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Panobinostat.
Fluconazole Injection Fluconazole Injection The metabolism of Panobinostat can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Panobinostat.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Panobinostat.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Panobinostat.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Panobinostat.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Panobinostat.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Panobinostat can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The metabolism of Panobinostat can be decreased when combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Panobinostat can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Panobinostat can be increased when it is combined with Morphine.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Panobinostat.
Altretamine Altretamine The metabolism of Amphetamine can be decreased when combined with Panobinostat.
Cyclosporine Cyclosporine Panobinostat may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Panobinostat can be decreased when combined with Ondansetron.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Panobinostat.
Olanzapine Olanzapine The metabolism of Olanzapine can be decreased when combined with Panobinostat.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Dofetilide.
Hydroxychloroquine Hydroxychloroquine The metabolism of Panobinostat can be decreased when combined with Hydroxychloroquine.
Orlistat Orlistat The metabolism of Panobinostat can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Panobinostat can be increased when combined with Oxcarbazepine.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Panobinostat.
Anakinra Anakinra The metabolism of Panobinostat can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Panobinostat.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Panobinostat.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Panobinostat.
Etanercept Injection Etanercept Injection The metabolism of Panobinostat can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Panobinostat can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Panobinostat.
Sirolimus Sirolimus The risk or severity of adverse effects can be increased when Panobinostat is combined with Sirolimus.
Epinephrine Injection Epinephrine Injection The metabolism of Panobinostat can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Panobinostat.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Panobinostat.
Zonisamide Zonisamide The serum concentration of Panobinostat can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Panobinostat can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Panobinostat.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Panobinostat.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Panobinostat.
Atazanavir Atazanavir The metabolism of Panobinostat can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Panobinostat.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Panobinostat.
Mefloquine Mefloquine The metabolism of Panobinostat can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Panobinostat can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Panobinostat.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Panobinostat.
Aprepitant Aprepitant The metabolism of Panobinostat can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Panobinostat.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Panobinostat.
Progesterone Progesterone The metabolism of Panobinostat can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Panobinostat.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Panobinostat.
Infliximab Injection Infliximab Injection The metabolism of Panobinostat can be increased when combined with Infliximab.
Protriptyline Protriptyline The metabolism of Protriptyline can be decreased when combined with Panobinostat.
Rifaximin Rifaximin The metabolism of Panobinostat can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Panobinostat can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Panobinostat can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Panobinostat can be increased when combined with Bosentan.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Natalizumab.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Panobinostat.
Solifenacin Solifenacin The metabolism of Panobinostat can be decreased when combined with Solifenacin.
Voriconazole Voriconazole The metabolism of Panobinostat can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The metabolism of Amphetamine can be decreased when combined with Panobinostat.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Panobinostat.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Panobinostat.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Panobinostat.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Panobinostat.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Panobinostat.
Deferasirox Deferasirox The metabolism of Panobinostat can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Panobinostat.
Felbamate Felbamate The metabolism of Panobinostat can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Panobinostat can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Panobinostat can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Panobinostat can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Panobinostat can be increased when it is combined with Sitagliptin.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Panobinostat.
Gefitinib Gefitinib The metabolism of Panobinostat can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Panobinostat.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Panobinostat.
Bortezomib Bortezomib The metabolism of Panobinostat can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Panobinostat.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Panobinostat.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Panobinostat.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Panobinostat.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Panobinostat.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Panobinostat.
Posaconazole Posaconazole The metabolism of Panobinostat can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Panobinostat can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Panobinostat.
Darunavir Darunavir The serum concentration of Darunavir can be increased when it is combined with Panobinostat.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Panobinostat.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Panobinostat.
Lisdexamfetamine Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Panobinostat.
Vorinostat Vorinostat The risk or severity of gastrointestinal bleeding and thrombocytopenia can be increased when Panobinostat is combined with Vorinostat.
Sorafenib Sorafenib The metabolism of Panobinostat can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Panobinostat can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Panobinostat can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Panobinostat.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Panobinostat.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Panobinostat.
Armodafinil Armodafinil The metabolism of Panobinostat can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Panobinostat.
Ivermectin Ivermectin The metabolism of Panobinostat can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Panobinostat.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Panobinostat.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Panobinostat.
Nilotinib Nilotinib The metabolism of Panobinostat can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Toremifene can be increased when it is combined with Panobinostat.
Bexarotene Bexarotene The metabolism of Panobinostat can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Panobinostat can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Panobinostat can be decreased when combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Panobinostat.
Etravirine Etravirine The metabolism of Panobinostat can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Panobinostat.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Panobinostat can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Panobinostat can be decreased when combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Panobinostat.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Panobinostat.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Panobinostat.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Bendamustine.
Pilocarpine Pilocarpine The metabolism of Panobinostat can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Panobinostat.
Certolizumab Injection Certolizumab Injection The metabolism of Certolizumab pegol can be increased when combined with Panobinostat.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Ixabepilone is combined with Panobinostat.
Irinotecan Injection Irinotecan Injection The risk or severity of adverse effects can be increased when Irinotecan is combined with Panobinostat.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Panobinostat.
Mitotane Mitotane The metabolism of Panobinostat can be increased when combined with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Panobinostat.
Rufinamide Rufinamide The metabolism of Panobinostat can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Panobinostat can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Panobinostat can be decreased when combined with Midazolam.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Panobinostat.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Panobinostat.
Milnacipran Milnacipran The metabolism of Panobinostat can be decreased when combined with Milnacipran.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Panobinostat.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Panobinostat.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Panobinostat.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Panobinostat.
Lacosamide Lacosamide The metabolism of Panobinostat can be decreased when combined with Lacosamide.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Panobinostat is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Panobinostat.
Dronedarone Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Panobinostat.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Pralatrexate.
Palonosetron Injection Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Panobinostat.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Telavancin is combined with Panobinostat.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Romidepsin.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Panobinostat.
Topotecan Topotecan The metabolism of Panobinostat can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Golimumab can be increased when combined with Panobinostat.
Pazopanib Pazopanib The metabolism of Panobinostat can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Asenapine.
Albendazole Albendazole The metabolism of Panobinostat can be decreased when combined with Albendazole.
Oxymorphone Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Panobinostat.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Panobinostat.
Tocilizumab Injection Tocilizumab Injection The metabolism of Panobinostat can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Panobinostat may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Cabazitaxel.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Panobinostat.
Acetaminophen Injection Acetaminophen Injection The metabolism of Panobinostat can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Panobinostat.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Panobinostat can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Panobinostat.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Panobinostat.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Belimumab.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Busulfan is combined with Panobinostat.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Panobinostat.
Linagliptin Linagliptin The metabolism of Panobinostat can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Panobinostat can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Panobinostat can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Panobinostat can be increased when combined with Cyclophosphamide.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Panobinostat.
Rivaroxaban Rivaroxaban The serum concentration of Panobinostat can be increased when it is combined with Rivaroxaban.
Ticagrelor Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Panobinostat.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Panobinostat.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Panobinostat is combined with Ruxolitinib.
Vandetanib Vandetanib The serum concentration of Vandetanib can be increased when it is combined with Panobinostat.
Clobazam Clobazam The metabolism of Panobinostat can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Panobinostat can be increased when it is combined with Vemurafenib.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Belatacept.
Ivacaftor Ivacaftor The metabolism of Panobinostat can be decreased when combined with Ivacaftor.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Panobinostat.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Panobinostat.
Crizotinib Crizotinib The metabolism of Panobinostat can be decreased when combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Panobinostat.
Cabergoline Cabergoline The metabolism of Panobinostat can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Panobinostat can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Panobinostat can be increased when it is combined with Ambrisentan.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Panobinostat.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Panobinostat.
Enzalutamide Enzalutamide The metabolism of Panobinostat can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Panobinostat.
Regorafenib Regorafenib The metabolism of Panobinostat can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Panobinostat.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Panobinostat can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Panobinostat is combined with Teriflunomide.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Bedaquiline.
Tofacitinib Tofacitinib Panobinostat may increase the immunosuppressive activities of Tofacitinib.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Panobinostat.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Panobinostat is combined with Dimethyl fumarate.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Panobinostat.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Panobinostat is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Panobinostat can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Panobinostat.
Canagliflozin Canagliflozin The serum concentration of Panobinostat can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Panobinostat.
Trametinib Trametinib The metabolism of Panobinostat can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Panobinostat.
Afatinib Afatinib The serum concentration of Panobinostat can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Panobinostat.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Panobinostat.
Perampanel Perampanel The metabolism of Panobinostat can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Panobinostat.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Panobinostat.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Obinutuzumab.
Simeprevir Simeprevir The metabolism of Panobinostat can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Panobinostat.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Panobinostat.
Apremilast Apremilast The metabolism of Panobinostat can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Panobinostat.
Siltuximab Injection Siltuximab Injection The metabolism of Siltuximab can be increased when combined with Panobinostat.
Eslicarbazepine Eslicarbazepine The metabolism of Panobinostat can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Panobinostat.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Idelalisib is combined with Panobinostat.
Testosterone Injection Testosterone Injection The metabolism of Panobinostat can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Panobinostat can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Panobinostat can be increased when it is combined with Vorapaxar.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Panobinostat.
Suvorexant Suvorexant The serum concentration of Panobinostat can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Panobinostat.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Panobinostat.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Blinatumomab.
Methamphetamine Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Panobinostat.
Tasimelteon Tasimelteon The metabolism of Panobinostat can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Panobinostat can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Panobinostat.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Panobinostat.
Secukinumab Injection Secukinumab Injection The metabolism of Secukinumab can be increased when combined with Panobinostat.
Risperidone Injection Risperidone Injection The metabolism of Panobinostat can be decreased when combined with Risperidone.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Panobinostat.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Haloperidol is combined with Panobinostat.
Ivabradine Ivabradine Ivabradine may increase the QTc-prolonging activities of Panobinostat.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Panobinostat can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Panobinostat can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Panobinostat can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Panobinostat can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Panobinostat can be increased when it is combined with Daclatasvir.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Panobinostat.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Panobinostat.
Cobimetinib Cobimetinib The metabolism of Panobinostat can be decreased when combined with Cobimetinib.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Mepolizumab.
Trabectedin Injection Trabectedin Injection The metabolism of Panobinostat can be decreased when combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Panobinostat.
Rifapentine Rifapentine The metabolism of Panobinostat can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Panobinostat can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Panobinostat can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Panobinostat can be increased when combined with Dexamethasone.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Ixekizumab.
Venetoclax Venetoclax The metabolism of Panobinostat can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Panobinostat can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Panobinostat.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Panobinostat.
Rucaparib Rucaparib The metabolism of Panobinostat can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Panobinostat can be decreased when combined with Ribociclib.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Brodalumab.
Brigatinib Brigatinib The metabolism of Panobinostat can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Panobinostat.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Panobinostat.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Panobinostat.
Deflazacort Deflazacort The metabolism of Deflazacort can be increased when combined with Panobinostat.
Ocrelizumab Injection Ocrelizumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Ocrelizumab.
Sarilumab Injection Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Panobinostat.
Midostaurin Midostaurin The metabolism of Panobinostat can be decreased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Panobinostat can be increased when it is combined with Neratinib.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Guselkumab.
Enasidenib Enasidenib The metabolism of Panobinostat can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Panobinostat can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Panobinostat can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Panobinostat.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Panobinostat.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Panobinostat.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Panobinostat.
Acalabrutinib Acalabrutinib The metabolism of Panobinostat can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Panobinostat.
Letermovir Letermovir The metabolism of Panobinostat can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Panobinostat.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Panobinostat.
Buprenorphine Injection Buprenorphine Injection The metabolism of Panobinostat can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Panobinostat can be decreased when it is combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Panobinostat.
Fostamatinib Fostamatinib The metabolism of Panobinostat can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Panobinostat.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Panobinostat is combined with Baricitinib.
Lofexidine Lofexidine The metabolism of Lofexidine can be decreased when combined with Panobinostat.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Panobinostat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Panobinostat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Panobinostat.
Ivosidenib Ivosidenib The metabolism of Panobinostat can be increased when combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Panobinostat.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Panobinostat.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Panobinostat.
Dacomitinib Dacomitinib The metabolism of Panobinostat can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Panobinostat.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Panobinostat.
Sarecycline Sarecycline The serum concentration of Panobinostat can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Panobinostat can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Panobinostat.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Panobinostat.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Panobinostat.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Panobinostat.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Panobinostat.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Panobinostat.
Rifamycin Rifamycin The metabolism of Panobinostat can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Panobinostat can be decreased when combined with Prucalopride.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Emapalumab can be increased when combined with Panobinostat.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Panobinostat is combined with Siponimod.
Erdafitinib Erdafitinib The serum concentration of Panobinostat can be increased when it is combined with Erdafitinib.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Panobinostat is combined with Risankizumab.
Alpelisib Alpelisib The metabolism of Panobinostat can be increased when combined with Alpelisib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Panobinostat.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Panobinostat.
Triclabendazole Triclabendazole The metabolism of Panobinostat can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Panobinostat.
Pitolisant Pitolisant The serum concentration of Panobinostat can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Panobinostat can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin Lefamulin may increase the QTc-prolonging activities of Panobinostat.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Panobinostat.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Panobinostat can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Panobinostat.
Voxelotor Voxelotor The serum concentration of Panobinostat can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Panobinostat can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Panobinostat.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Panobinostat.
Cenobamate Cenobamate The serum concentration of Panobinostat can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Panobinostat is combined with Ozanimod.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Panobinostat.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Panobinostat.
Tucatinib Tucatinib Panobinostat may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Panobinostat.
Ripretinib Ripretinib The serum concentration of Panobinostat can be increased when it is combined with Ripretinib.
Capmatinib Capmatinib The serum concentration of Panobinostat can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Panobinostat.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Panobinostat.
Octreotide Octreotide The serum concentration of Panobinostat can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Panobinostat can be increased when it is combined with Belantamab mafodotin.
Pralsetinib Pralsetinib The metabolism of Panobinostat can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Panobinostat can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Relugolix is combined with Panobinostat.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Panobinostat can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Panobinostat can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Panobinostat.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Panobinostat.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Panobinostat.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Panobinostat.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Panobinostat.
Phenobarbital Phenobarbital The metabolism of Panobinostat can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Panobinostat.
Primidone Primidone The metabolism of Panobinostat can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Panobinostat.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Panobinostat.
Diazepam Diazepam The metabolism of Panobinostat can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Panobinostat can be decreased when combined with Lorazepam.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Panobinostat.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Panobinostat.
Codeine Codeine The metabolism of Codeine can be decreased when combined with Panobinostat.
Bromocriptine Bromocriptine The metabolism of Panobinostat can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Panobinostat can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Panobinostat can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Panobinostat.
Tetracycline Tetracycline The metabolism of Panobinostat can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Panobinostat.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Panobinostat.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Panobinostat.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Panobinostat.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Panobinostat.
Methadone Methadone The metabolism of Panobinostat can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Panobinostat can be decreased when combined with Oxybutynin.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Panobinostat.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Panobinostat.
Orphenadrine Orphenadrine The metabolism of Panobinostat can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Panobinostat.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Panobinostat.
Phentermine Phentermine The metabolism of Panobinostat can be decreased when combined with Phentermine.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Panobinostat.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Panobinostat.
Hydrocortisone Hydrocortisone The metabolism of Panobinostat can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Panobinostat.
Doxorubicin Doxorubicin The metabolism of Panobinostat can be decreased when combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Panobinostat.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Panobinostat.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Panobinostat.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Panobinostat.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Panobinostat.
Hydralazine Hydralazine The metabolism of Panobinostat can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Panobinostat can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Panobinostat can be increased when combined with Warfarin.
Loperamide Loperamide The metabolism of Panobinostat can be decreased when combined with Loperamide.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Panobinostat.
Daunorubicin Daunorubicin The metabolism of Panobinostat can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Panobinostat can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Panobinostat.
Loxapine Loxapine The serum concentration of Panobinostat can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Panobinostat.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Panobinostat.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Panobinostat.
Calcitriol Calcitriol The metabolism of Panobinostat can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Panobinostat can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Panobinostat can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Panobinostat.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Panobinostat.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Panobinostat.
Probenecid Probenecid The metabolism of Panobinostat can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Panobinostat can be increased when it is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Panobinostat.
Isoniazid Isoniazid The metabolism of Panobinostat can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Panobinostat can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Disopyramide.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Panobinostat.
Tamoxifen Tamoxifen The metabolism of Panobinostat can be decreased when combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Panobinostat.
Levothyroxine Levothyroxine The serum concentration of Panobinostat can be decreased when it is combined with Levothyroxine.
Methimazole Methimazole The metabolism of Panobinostat can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Panobinostat.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Panobinostat.
Niacin Niacin The metabolism of Panobinostat can be decreased when combined with Niacin.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Panobinostat.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Panobinostat.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Panobinostat.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Panobinostat.
Meclizine Meclizine The metabolism of Meclizine can be decreased when combined with Panobinostat.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Panobinostat.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Panobinostat.
Danazol Danazol The metabolism of Panobinostat can be decreased when combined with Danazol.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Panobinostat.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Panobinostat.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Panobinostat.
Amphotericin B Injection Amphotericin B Injection The metabolism of Panobinostat can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Panobinostat.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Panobinostat.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Panobinostat.
Clomiphene Clomiphene The serum concentration of Panobinostat can be increased when it is combined with Clomifene.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Panobinostat.
Fluorouracil Injection Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Panobinostat.
Colchicine Colchicine The metabolism of Panobinostat can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Panobinostat can be decreased when combined with Cephalexin.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Panobinostat.
Acetazolamide Acetazolamide The metabolism of Panobinostat can be decreased when combined with Acetazolamide.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Panobinostat.
Ketoconazole Ketoconazole The metabolism of Panobinostat can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Thiotepa is combined with Panobinostat.
Vincristine Injection Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Panobinostat.
Vinblastine Vinblastine The metabolism of Panobinostat can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Panobinostat.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Panobinostat.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Panobinostat.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Panobinostat.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Panobinostat.
Diltiazem Diltiazem The metabolism of Panobinostat can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Panobinostat can be decreased when combined with Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Panobinostat.
Verapamil Verapamil The metabolism of Panobinostat can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Panobinostat.
Pindolol Pindolol The metabolism of Pindolol can be decreased when combined with Panobinostat.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Panobinostat.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Panobinostat.
Etoposide Etoposide The metabolism of Panobinostat can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Panobinostat can be decreased when combined with Glyburide.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Panobinostat.
Dicloxacillin Dicloxacillin The metabolism of Panobinostat can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Panobinostat can be increased when combined with Nafcillin.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Panobinostat.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Panobinostat.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Panobinostat.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Panobinostat.
Amiodarone Amiodarone The serum concentration of Panobinostat can be increased when it is combined with Amiodarone.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Panobinostat.
Lovastatin Lovastatin The metabolism of Panobinostat can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Panobinostat can be decreased when combined with Ciprofloxacin.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Panobinostat.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Panobinostat.
Clozapine Clozapine The metabolism of Panobinostat can be decreased when combined with Clozapine.
Idarubicin Idarubicin The metabolism of Panobinostat can be decreased when combined with Idarubicin.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Panobinostat.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Panobinostat.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Panobinostat.
Clarithromycin Clarithromycin The metabolism of Panobinostat can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Panobinostat can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Panobinostat can be increased when it is combined with Pravastatin.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Panobinostat.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Panobinostat.
Teniposide Injection Teniposide Injection The metabolism of Panobinostat can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Panobinostat can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Panobinostat can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Panobinostat.
Bisoprolol Bisoprolol The serum concentration of Panobinostat can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Panobinostat.
Doxazosin Doxazosin The metabolism of Panobinostat can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Panobinostat can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Panobinostat can be increased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Panobinostat can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Panobinostat can be decreased when combined with Venlafaxine.
Famciclovir Famciclovir The metabolism of Panobinostat can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Panobinostat can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Panobinostat can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Panobinostat.
Losartan Losartan The metabolism of Panobinostat can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Panobinostat.
Vinorelbine Injection Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Panobinostat.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Panobinostat.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Panobinostat.
Lansoprazole Lansoprazole The metabolism of Panobinostat can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Panobinostat can be increased when combined with Ifosfamide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Panobinostat.
Nicardipine Nicardipine The metabolism of Panobinostat can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Panobinostat.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Panobinostat.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Panobinostat.
Ritonavir Ritonavir The metabolism of Panobinostat can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Panobinostat can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Panobinostat.
Zafirlukast Zafirlukast The metabolism of Panobinostat can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Panobinostat.
Topiramate Topiramate The metabolism of Panobinostat can be increased when combined with Topiramate.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Panobinostat.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Panobinostat.
Fexofenadine Fexofenadine The serum concentration of Panobinostat can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Panobinostat can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The metabolism of Panobinostat can be decreased when combined with Carvedilol.
Selegiline Selegiline The metabolism of Panobinostat can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Panobinostat can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Panobinostat can be decreased when combined with Sertraline.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Panobinostat.
Raloxifene Raloxifene The metabolism of Panobinostat can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Panobinostat can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Panobinostat.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Panobinostat.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Panobinostat.
Paroxetine Paroxetine The metabolism of Panobinostat can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Citalopram can be decreased when combined with Panobinostat.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Panobinostat.
Efavirenz Efavirenz The metabolism of Panobinostat can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Panobinostat.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Panobinostat.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Panobinostat.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Panobinostat.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Panobinostat.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Panobinostat.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Panobinostat.
Rabeprazole Rabeprazole The metabolism of Panobinostat can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Panobinostat can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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