Drug & supplement interaction

Jequirity + Aspirin, Caffeine, Hydrocodone

Aspirin, Caffeine, Hydrocodone brand name: Damason-P.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Aspirin, Caffeine, Hydrocodone falls into 2 drug categories that Jequirity can interact with; the most serious is rated moderate. Evidence from in vitro research suggests that constituents of jequirity beans can inhibit platelet aggregation.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Jequirity and Aspirin, Caffeine, Hydrocodone

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Jequirity interacts with whole categories of medication. Aspirin, Caffeine, Hydrocodone falls into 2 of those categories, so it can interact with Jequirity in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 2

Why this applies to Aspirin, Caffeine, Hydrocodone

Aspirin, Caffeine, Hydrocodone falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Jequirity interacts with.

Evidence from in vitro research suggests that constituents of jequirity beans can inhibit platelet aggregation. Theoretically, jequirity might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

First, the big picture: jequirity seeds are genuinely poisonous (they contain abrin, a relative of ricin), so this isn't a supplement anyone should be taking in the first place. That said, here's the specific concern with your Damason-P combo. The aspirin part of this medicine already thins your blood by keeping platelets from clumping together. Lab studies hint that compounds in jequirity may do the same thing.

So in theory, pairing the two could stack one blood-thinning effect on another, raising the chance of easy bruising, nosebleeds, bleeding gums, or stomach bleeding. Keep in mind this is only a theoretical concern from test-tube research, not proven in people. The real takeaway is simpler: don't use jequirity at all, and check with your pharmacist or doctor about any supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kuo SC, Chen SC, Chen LH, et al. Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius. Planta Med 1995;61:307-12.
Minor

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

2 of 2

Aspirin, Caffeine, Hydrocodone also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

In vitro research shows that jequirity extract inhibits CYP3A4 enzymes. Theoretically, taking jequirity may inhibit the metabolism of CYP3A4 substrates.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

First things first: jequirity seeds are genuinely poisonous (they contain abrin, a toxin in the same family as ricin), so I'd never recommend taking them at all. Setting that aside, the interaction on file is theoretical and comes only from lab dish studies, not from people. In those studies, jequirity extract slowed down an enzyme called CYP3A4.

Why that matters here: the hydrocodone part of Damason-P leans on that enzyme. If it were truly blocked, hydrocodone could build up and push its effects harder (think extra drowsiness, dizziness, slowed breathing, constipation). The aspirin and caffeine aren't really affected this way. Honestly though, the real concern is the toxicity of jequirity itself, not this minor enzyme effect. Please don't use it, and check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ai C, Miao X, Wang L, He J. Discovery and Activity Evaluation of the Inhibitory Effect of Four Kinds Traditional Chinese Medicine Extracts on the CYP3A4 Enzyme. Comb Chem High Throughput Screen 2022.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jequirity Also Interacts With Other Medications

Jequirity has 207 moderate, 605 minor known drug interactions in our database — the Aspirin, Caffeine, Hydrocodone one above is among them. If you take anything else, check it against the full list below.

Moderate 207 Minor 605 No known interaction 2,018 (incl. Aspirin, Caffeine, Hydrocodone)
Taking anything else?

Check Another of Your Medications Against Jequirity

Covers the 2,830 medications we’ve checked against Jequirity. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Aspirin, Caffeine, Hydrocodone

This page covers Jequirity only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Hydrocodone page lists 398 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 17 major · 334 moderate · 47 minor.

From our pharmacist’s overview on the Aspirin, Caffeine, Hydrocodone page

“Damason-P packs three drugs into one tablet, the opioid hydrocodone, aspirin, and caffeine, so a supplement can collide with any one of them, and its list of 398 interacting ingredients earns real respect. More than 200 of those can add to aspirin's bleeding risk, while 78 can deepen the opioid's sedation.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Caffeine, Hydrocodone interaction page

How much people look this up

Where Jequirity and Aspirin, Caffeine, Hydrocodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jequirity
Top half

#527 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Caffeine, Hydrocodone
Top 25%

#402 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jequirity

What is Jequirity?

Jequirity
  • Asthma and cough
  • Fever
  • Sore throat and bronchitis
  • Liver complaints (hepatitis)
  • Constipation
  • Traditional infectious-disease remedies

Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins known. Despite a long history in traditional medicine, the seeds are dangerously poisonous and there is no reliable evidence that it is safe or effective. It should not be used as a supplement or medicine.

Read the full Jequirity monograph & all interactions
Keep checking

Other Drugs & Jequirity

Browse every other medication we’ve checked against Jequirity — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
605Minor
2,017No known interaction
207 Moderate 605 Minor 2,017 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Jequirity page.

Minor

605 interactions

Showing 60 of 605 minor interactions — see all 605 on the Jequirity page.

No interaction 2,017 drugs checked — show the list

We also checked Jequirity against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,017 medications checked with no known interaction — see the full Jequirity list.

See the full Jequirity interactions page
See every supplement checked against Aspirin, Caffeine, Hydrocodone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jequirity monograph › Uses, safety, and every drug interaction in one place Aspirin, Caffeine, Hydrocodone supplement interactions › Every supplement checked against Aspirin, Caffeine, Hydrocodone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jequirity and Aspirin, Caffeine, Hydrocodone Together: Common Questions

Can you take Jequirity with Aspirin, Caffeine, Hydrocodone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Jequirity and Aspirin, Caffeine, Hydrocodone?
Aspirin, Caffeine, Hydrocodone belongs to more than one drug category, and Jequirity interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Jequirity and Aspirin, Caffeine, Hydrocodone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.