Drug & supplement interaction

Jequirity + Sacubitril, Valsartan

Sacubitril, Valsartan brand name: Entresto.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Jequirity and Sacubitril, Valsartan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jequirity and Sacubitril, Valsartan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sacubitril, Valsartan and Jequirity in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jequirity safety at a glance

Jequirity overall Avoid The seeds contain abrin, a potentially deadly toxin, so jequirity is not safe to take.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sacubitril, Valsartan and Jequirity? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sacubitril, Valsartan

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sacubitril, Valsartan is filed under 6 classifications — including angiotensin receptor blockers (arbs), potassium-sparing diuretics, diuretic drugs. Jequirity has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (minor) — and none of Sacubitril, Valsartan’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jequirity Does Interact With Other Medications

Jequirity has 208 moderate, 603 minor known drug interactions in our database — Sacubitril, Valsartan isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 Minor 603 No known interaction 2,019 (incl. Sacubitril, Valsartan)
Taking anything else?

Check Another of Your Medications Against Jequirity

Covers the 2,830 medications we’ve checked against Jequirity. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jequirity and Sacubitril, Valsartan May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    Jequirity

    “Orally, jequirity is associated with serious adverse effects. Chewing jequirity seeds or consuming seeds with cracked shells can cause stomach cramping, nausea, vomiting, severe diarrhea (possibly bloody), cold sweats, fever, drowsiness, anxiety, weakness, hypertension, tachycardia, pulmonary edema, kidney failure, liver toxicity, coma, circulatory collapse, cerebral edema, and death.”

    Jequirity · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 3499. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
    2. 5608. Niyogi SK. Deadly crab's eye: Abrus precatorius poisoning. N Engl J Med 1969;281:51-2.
    3. 11473. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed
    4. 95220. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
    5. 95221. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed
    6. 100257. Huang J, Zhang W, Li X, et al. Acute abrin poisoning treated with continuous renal replacement therapy and hemoperfusion successfully: A case report. Medicine (Baltimore). 2017;96(27):e7423. PubMed

    “Orally, crushed or cracked jequirity beans have been reported to cause kidney failure. Death has occurred following kidney failure in a 2-year old child who ingested crushed jequirity beans.”

    Jequirity · Natural Medicines adverse-effect record, reported in kidney failure.

    2 sources cited
    1. 11473. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed
    2. 95221. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed

    Sacubitril, Valsartan

    Listed in the ADVERSE REACTIONS section of the FDA label for Sacubitril, Valsartan. Read the label on DailyMed ›

  • A skin rash Additional detail

    Jequirity

    “Topically, wearing jewelry made with jequirity beans can cause dermatitis (6).”

    Jequirity · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    Sacubitril, Valsartan

    Listed in the ADVERSE REACTIONS section of the FDA label for Sacubitril, Valsartan. Read the label on DailyMed ›

Reported for Jequirity but not commonly for Sacubitril, Valsartan: liver problems, raised blood pressure, a fast or pounding heartbeat and sweating.

Effects for Sacubitril, Valsartan come from the ADVERSE REACTIONS section of its FDA label; effects for Jequirity come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Jequirity in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Sacubitril, Valsartan

This page covers Jequirity only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sacubitril, Valsartan page lists 249 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 206 moderate · 36 minor.

From our pharmacist’s overview on the Sacubitril, Valsartan page

“Entresto (sacubitril and valsartan) is a heart failure medicine, and heart failure patients tend to be heavy supplement users, reaching for fish oil, potassium, and herbal blood-pressure remedies. That instinct carries real risk here.”

Reviewed by 2 · Jul 18, 2026

Open the Sacubitril, Valsartan interaction page

How much people look this up

Where Jequirity and Sacubitril, Valsartan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jequirity
Steady interest

#1,185 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sacubitril, Valsartan
Top 25%

#330 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jequirity reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Jequirity and Sacubitril, Valsartan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jequirity

What is Jequirity?

Jequirity
  • Asthma and cough
  • Fever
  • Sore throat and bronchitis
  • Liver complaints (hepatitis)
  • Constipation
  • Traditional infectious-disease remedies

Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins known. Despite a long history in traditional medicine, the seeds are dangerously poisonous and there is no reliable evidence that it is safe or effective. It should not be used as a supplement or medicine.

Abrus precatorius · Fabaceae · Seeds, roots, and leaves · Traditional preparations (rarely used today); seeds are sometimes used in jewelry and beadwork

An interaction check asks whether these two react with each other — it does not ask whether Jequirity is a good idea for someone in your situation. Here is what our Jequirity record says about it on its own.

Jequirity: dosing

There is no safe or established dose of jequirity for use as a supplement or medicine. Because the seeds contain a deadly toxin, no amount is considered safe to swallow.We do not recommend taking jequirity in any form.

From our Jequirity monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jequirity monograph & all interactions
Medication

About Valsartan and Sacubitril

What Is Valsartan and Sacubitril Used For?

Brand name: Entresto

Sacubitril and valsartan is used to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. The benefit is most clearly seen in patients whose heart pumps with a lower-than-normal ejection fraction (the percentage of blood the heart pushes out with each beat).

It is also approved to treat symptomatic heart failure with reduced left ventricular function in children aged 1 year and older. In pediatric patients, it lowers a blood marker of heart stress (NT-proBNP) and is expected to improve heart outcomes.

See full Valsartan and Sacubitril drug information
Keep checking

Other Drugs & Jequirity

Browse every other medication we’ve checked against Jequirity — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
603Minor
2,018No known interaction
208 Moderate 603 Minor 2,018 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Jequirity page.

Minor

603 interactions

Showing 60 of 603 minor interactions — see all 603 on the Jequirity page.

No interaction 2,018 drugs checked — show the list

We also checked Jequirity against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,018 medications checked with no known interaction — see the full Jequirity list.

See the full Jequirity interactions page
See every supplement checked against Sacubitril, Valsartan, ranked by severity
Evidence & sources

Jequirity References

The 17 references that drive our Jequirity monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
  3. Kuo SC, Chen SC, Chen LH, et al. Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius. Planta Med 1995;61:307-12.
  4. Niyogi SK. Deadly crab's eye: Abrus precatorius poisoning. N Engl J Med 1969;281:51-2.
  5. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed
  6. Agarwal SS, Ghatak N, Arora RB, Bhardwaj MM. Antifertility activity of the roots of Abrus precatorius, Linn. Pharma Res Comm 1970;2(2):159-163. DOI
  7. Jang DH, Hoffman RS, Nelson LS. Attempted suicide, by mail order: Abrus precatorius. J Med Toxicol 2010;6(4):427-430. PubMed
  8. Nwanjo HU. Hypoglycemic and hypolipidemic effects of aqueous extracts of Abrus precatorius Linn seeds in streptozotocin-induced diabetic Wistar rats. J Herbs Spice Med Plants 2008;14(1-2):68-76.
  9. Sahoo R, Hamide A, Amalnath SD, Narayana BS. Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy. Clin Toxicol (Phila) 2008;46(10):1071-1073.
  10. Sahni V, Agarwal SK, Singh NP, Sikdar S. Acute demyelinating encephalitis after jequirity pea ingestion (Abrus precatorius). Clin Toxicol (Phila) 2007;45(1):77-79.
  11. Subrahmanyan D, Mathew J, Raj M. An unusual manifestation of Abrus precatorius poisoning: a report of two cases. Clin Toxicol (Phila) 2008;46(2):173-175. PubMed
  12. Somerset EJ. SELF INFLICTED CONJUNCTIVITIS: An account of cases produced by the jequirity and castor oil seeds. Br J Ophthalmol 1945;29(4):196-204. PubMed
  13. Andrews JA. Jequirity Ophthalmia. Trans Am Ophthalmol Soc 1884;3:679-685.
  14. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
  15. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jequirity and Sacubitril, Valsartan Together: Common Questions

Is it safe to take Jequirity with Sacubitril, Valsartan?
We do not list a known interaction between Jequirity and Sacubitril, Valsartan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jequirity and Sacubitril, Valsartan have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Jequirity and Sacubitril, Valsartan combination checked?
Interactions in our licensed database are recorded against drug classes. Sacubitril, Valsartan is filed under 6 classifications, and Jequirity has documented interactions with 3 drug classes — none of Sacubitril, Valsartan's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jequirity interact with any other medications?
Yes. Jequirity has 811 documented drug interactions in our database — Sacubitril, Valsartan is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sacubitril, Valsartan interact with any supplements?
Yes. Sacubitril, Valsartan has documented interactions with 249 supplements in our database — Jequirity is not one of them. The Sacubitril, Valsartan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jequirity monograph Uses, safety profile, and every drug interaction in one place Valsartan and Sacubitril drug information The full plain-English guide to this medication Sacubitril, Valsartan supplement interactions Every supplement checked against Sacubitril, Valsartan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sacubitril, Valsartan and Jequirity?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.