Drug & supplement interaction

Jequirity + Insulin (Human)

Insulin (Human) brand names: Novolin N, Novolin 70/30, Novolin R, Novolin L, Afrezza.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Jequirity has a moderate interaction with Insulin (Human). Evidence from animal research suggests that an extract of jequirity can reduce blood glucose levels.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Jequirity and Insulin (Human)

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin (Human)

Insulin (Human) falls under ANTIDIABETES DRUGS — the group Jequirity interacts with.

Evidence from animal research suggests that an extract of jequirity can reduce blood glucose levels. Theoretically, jequirity might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: in animal studies, an extract of jequirity seemed to lower blood sugar on its own. Insulin already pushes your sugar down, so stacking the two could, in theory, push it down too far. That's hypoglycemia, and with insulin it can show up as shakiness, sweating, a fast heartbeat, confusion, or in serious cases passing out.

I want to be honest about the evidence here: this is theoretical, based on lab and animal data, not on real people taking both. But honestly, my bigger worry is the plant itself. Jequirity seeds contain abrin, a potent toxin similar to ricin, and I would not recommend using it at all. Please talk with your pharmacist or doctor before adding any supplement to your insulin routine.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Nwanjo HU. Hypoglycemic and hypolipidemic effects of aqueous extracts of Abrus precatorius Linn seeds in streptozotocin-induced diabetic Wistar rats. J Herbs Spice Med Plants 2008;14(1-2):68-76.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jequirity Also Interacts With Other Medications

Jequirity has 207 moderate, 603 minor known drug interactions in our database — the Insulin (Human) one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 Minor 603 No known interaction 2,020 (incl. Insulin (Human))
Taking anything else?

Check Another of Your Medications Against Jequirity

Covers the 2,830 medications we’ve checked against Jequirity. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin (Human)

This page covers Jequirity only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin (Human) page lists 259 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate) and African Wild Potato (moderate).

By severity: 3 major · 218 moderate · 38 minor.

From our pharmacist’s overview on the Insulin (Human) page

“With human insulin (Novolin, Afrezza), extra glucose lowering is not a nuisance, it is the hazard itself, and this is one of the lists I treat as genuinely serious. Nearly every ingredient here either drops blood sugar on its own or adds to insulin's effect, and the combination can push a normal dose into hypoglycemia, a dangerous low.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin (Human) interaction page

How much people look this up

Where Jequirity and Insulin (Human) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jequirity
Steady interest

#1,149 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin (Human)
Top 10%

#169 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jequirity

What is Jequirity?

Jequirity
  • Asthma and cough
  • Fever
  • Sore throat and bronchitis
  • Liver complaints (hepatitis)
  • Constipation
  • Traditional infectious-disease remedies

Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins known. Despite a long history in traditional medicine, the seeds are dangerously poisonous and there is no reliable evidence that it is safe or effective. It should not be used as a supplement or medicine.

Read the full Jequirity monograph & all interactions
Medication

About Human Insulin Injection

What Is Human Insulin Injection Used For?

Brand names: Novolin N, Novolin 70/30, Novolin R, Novolin L, Afrezza

Novolin (human insulin injection) is used to improve glycemic control — meaning blood sugar management — in adults and children with diabetes mellitus.

Novolin 70/30 is a fixed-ratio mixture of intermediate-acting and short-acting human insulin. Because the ratio is fixed, it cannot be adjusted separately for background (basal) or mealtime (prandial) needs.

See full Human Insulin Injection drug information
Keep checking

Other Drugs & Jequirity

Browse every other medication we’ve checked against Jequirity — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
603Minor
2,019No known interaction
207 Moderate 603 Minor 2,019 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Jequirity page.

Minor

603 interactions

Showing 60 of 603 minor interactions — see all 603 on the Jequirity page.

No interaction 2,019 drugs checked — show the list

We also checked Jequirity against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,019 medications checked with no known interaction — see the full Jequirity list.

See the full Jequirity interactions page
See every supplement checked against Insulin (Human), ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jequirity monograph › Uses, safety, and every drug interaction in one place Insulin (Human) supplement interactions › Every supplement checked against Insulin (Human), ranked by severity Human Insulin Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jequirity and Insulin (Human) Together: Common Questions

Can you take Jequirity with Insulin (Human)?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Jequirity and Insulin (Human) interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin (Human) and Jequirity?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.