Drug & supplement interaction

Ceylon Leadwort + Cabotegravir

Cabotegravir brand name: Apretude.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Ceylon Leadwort and Cabotegravir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ceylon Leadwort and Cabotegravir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cabotegravir and Ceylon Leadwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ceylon Leadwort safety at a glance

Ceylon Leadwort overall Use caution It contains plumbagin, which can irritate skin and the gut and may be toxic in higher doses.
Pregnancy Likely Unsafe When used orally or topically. Ceylon leadwort is traditionally used orally and intravaginally as an abortifacient or for permanent sterilization; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically. Ceylon leadwort is traditionally used orally and intravaginally as an abortifacient or for permanent sterilization; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cabotegravir and Ceylon Leadwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cabotegravir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cabotegravir is filed under a single classification — glucuronidated drugs. Ceylon Leadwort has documented interactions with 10 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Cabotegravir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ceylon Leadwort Does Interact With Other Medications

Ceylon Leadwort has 1,097 moderate known drug interactions in our database — Cabotegravir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1,097 No known interaction 1,733 (incl. Cabotegravir)
Taking anything else?

Check Another of Your Medications Against Ceylon Leadwort

Covers the 2,830 medications we’ve checked against Ceylon Leadwort. Pick one to open its full report.

What to actually watch for

What Cabotegravir’s Own FDA Label Lists

This is not an interaction — none of it involves Ceylon Leadwort. These are the most notable effects listed in the ADVERSE REACTIONS section of Cabotegravir’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Bloating or gas
  • Back pain
  • Drowsiness
  • Reduced appetite
  • Muscle pain
  • Fever
  • Stomach pain

Showing the 10 most notable of 17 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Cabotegravir. Read the label on DailyMed › Where a percentage is shown, it is the share of 15,229 voluntary FDA FAERS reports for Cabotegravir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Ceylon Leadwort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ceylon Leadwort side to compare — that is a limit of the record, not a statement that Ceylon Leadwort has no side effects.

Special populations

Ceylon Leadwort in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally or topically. Ceylon leadwort is traditionally used orally and intravaginally as an abortifacient or for permanent sterilization; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Cabotegravir

This page covers Ceylon Leadwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cabotegravir page lists 12 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Breadfruit (moderate), Brussels Sprout (moderate), Cabbage (moderate), Calcium D-glucarate (moderate) and Cannabidiol (cbd) (moderate).

By severity: 11 moderate · 1 minor.

From our pharmacist’s overview on the Cabotegravir page

“Cabotegravir (Apretude) prevents HIV only while its blood level stays steady, which is why this particular list, mild as it looks, deserves a real read. Every one of the interactions works through the same pathway, glucuronidation, the process the body uses to clear the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Cabotegravir interaction page

One more smart check

Taking Ceylon Leadwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 96 real supplement products containing Ceylon Leadwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ceylon Leadwort. Even though Ceylon Leadwort itself has no known interaction with Cabotegravir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ceylon Leadwort and Cabotegravir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ceylon Leadwort
Top half

#465 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cabotegravir
Top half

#1,241 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ceylon Leadwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Ceylon Leadwort and Cabotegravir records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ceylon Leadwort

What is Ceylon Leadwort?

  • Digestive complaints and poor appetite
  • Skin conditions and wounds (applied to the skin)
  • Joint pain and swelling
  • Traditional 'metabolism-boosting' tonics
  • Antimicrobial folk remedy

Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin problems, and pain. Solid human studies are lacking, and the plant contains plumbagin, a compound that can irritate skin and tissues and may be unsafe in larger amounts. Talk to a pharmacist or doctor before using it, and avoid it in pregnancy.

Plumbago zeylanica · Plumbaginaceae · Mainly the root and root bark; sometimes leaves · Dried root powder, decoctions, traditional pastes and oils, and capsules

An interaction check asks whether these two react with each other — it does not ask whether Ceylon Leadwort is a good idea for someone in your situation. Here is what our Ceylon Leadwort record says about it on its own.

Ceylon Leadwort: dosing

There is no well-established or standardized dose for Ceylon Leadwort. Traditional preparations vary widely, and the amount of plumbagin in a product can be hard to know.If you choose to use a commercial product, follow the directions on the label and do not exceed them. Because of safety concerns, it is best to start only after talking with a pharmacist or doctor. Do not use the raw plant on your skin or take homemade preparations without guidance.

From our Ceylon Leadwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ceylon Leadwort monograph & all interactions
Medication

About Cabotegravir

What Is Cabotegravir Used For?

Brand name: Apretude

Vocabria (cabotegravir) tablets are used in combination with rilpivirine (Edurant) to treat HIV-1 infection in adults and adolescents aged 12 and older who weigh at least 35 kg and whose HIV is already virologically suppressed (virus levels undetectable or very low on their current regimen). Vocabria tablets serve as a short-term oral lead-in — taken for roughly one month — before switching to long-acting injectable therapy.

Cabotegravir tablets are also used as an oral lead-in for HIV-1 pre-exposure prophylaxis (PrEP) — helping HIV-negative adults and adolescents (weighing at least 35 kg) confirm they tolerate the drug before starting injectable PrEP. Both uses require confirmed HIV-negative status before starting.

Most-Reported Side Effects for Cabotegravir

From FAERS, the FDA’s public side-effect reporting system (15,229 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injection site pain 1,618 reports
Viral load increased 962 reports
Virologic failure 684 reports
Product use in unapproved therapeutic environment 683 reports
Pathogen resistance 575 reports
See full Cabotegravir drug information
Keep checking

Other Drugs & Ceylon Leadwort

Browse every other medication we’ve checked against Ceylon Leadwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1,097Moderate
0Minor
1,732No known interaction
1,097 Moderate 1,732 No interaction
Moderate

1,097 interactions

Showing 60 of 1,097 moderate interactions — see all 1,097 on the Ceylon Leadwort page.

No interaction 1,732 drugs checked — show the list

We also checked Ceylon Leadwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,732 medications checked with no known interaction — see the full Ceylon Leadwort list.

See the full Ceylon Leadwort interactions page
See every supplement checked against Cabotegravir, ranked by severity
Evidence & sources

Ceylon Leadwort References

The 10 references that drive our Ceylon Leadwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mandavkar, YD, Jalalpure, SS. A comprehensive review on Plumbago zeylanica Linn. African J. Pharmacy and Pharmacology. 2011;5(25):2738-2747. DOI
  2. Kumar SS, Shanmugasundaram KR. Amrita Bindu-an antioxidant inducer therapy in asthma children. J. Ethnopharmacol. 2004;90:105-114. PubMed
  3. Sandeep G, Dheeraj A, Sharma NK, Jhade D, Bharti A. Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats. Asian Pac J Trop Med. 2011 Dec;4(12):978-84. PubMed
  4. Vijayakumar R, Senthilvelan M, Ravindran R, Devi RS. Plumbago zeylanica action on blood coagulation profile with and without blood volume reduction. Vascul Pharmacol. 2006 Aug;45(2):86-90. PubMed
  5. Olagunju JA, Jobi AA, Oyedapo OO. An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract of plumbago zeylanica. Phytother Res. 1999 Jun;13(4):346-8.
  6. Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
  7. Sunil C, Duraipandiyan V, Agastian P, Ignacimuthu S. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2012 Dec;50(12):4356-63. PubMed
  8. Checker R, Sharma D, Sandur SK, Khanam S, Poduval TB. Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes. Int Immunopharmacol. 2009 Jul;9(7-8):949-58. PubMed
  9. Jia Y, Jing J, Bai Y, Li Z, Liu L, Luo J, Liu M, Chen H. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-?B signaling pathways. PLoS One. 2011;6(10):e27006. PubMed
  10. Poosarla A, D N R, Athota RR, Sunkara VG. Modulation of T cell proliferation and cytokine response by Plumbagin, extracted from Plumbago zeylanica in collagen induced arthritis. BMC Complement Altern Med. 2011 Nov 16;11:114. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ceylon Leadwort and Cabotegravir Together: Common Questions

Is it safe to take Ceylon Leadwort with Cabotegravir?
We do not list a known interaction between Ceylon Leadwort and Cabotegravir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Ceylon Leadwort and Cabotegravir combination checked?
Interactions in our licensed database are recorded against drug classes. Cabotegravir is filed under 1 classification, and Ceylon Leadwort has documented interactions with 10 drug classes — none of Cabotegravir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ceylon Leadwort interact with any other medications?
Yes. Ceylon Leadwort has 1,097 documented drug interactions in our database — Cabotegravir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cabotegravir interact with any supplements?
Yes. Cabotegravir has documented interactions with 12 supplements in our database — Ceylon Leadwort is not one of them. The Cabotegravir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ceylon Leadwort monograph Uses, safety profile, and every drug interaction in one place Cabotegravir drug information The full plain-English guide to this medication Cabotegravir supplement interactions Every supplement checked against Cabotegravir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cabotegravir and Ceylon Leadwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.