Medication interaction hub

What Supplements Interact with Cabotegravir?

Cabotegravir brand name: Apretude. Every interaction below applies to the brands too.

12 Interactions 11 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 29, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cabotegravir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cabotegravir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Cabotegravir (Apretude) prevents HIV only while its blood level stays steady, which is why this particular list, mild as it looks, deserves a real read. Every one of the interactions works through the same pathway, glucuronidation, the process the body uses to clear the drug. Some ingredients may speed that clearance and quietly thin out protection (a diet heavy in cabbage and Brussels sprouts is the best studied example), while others, including CBD and milk thistle, may slow it and push levels up. Workable for most people, but these are the combinations to actually keep an eye on.

Much of the evidence is theoretical or from lab research, so the useful move is checking whether anything you take regularly appears below and raising it with your pharmacist if so. None of the 12 entries rates major, incidentally; eleven are moderate and one minor.

— , Clinical Pharmacist · July 18, 2026

Moderate 11 Minor 1 No known interaction 1,440

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Cabotegravir: Top Interactions at a Glance

The most significant Cabotegravir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 12 interacting ingredients — plus 1,440 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Cabotegravir + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Brussels Sprout + Cabotegraviri

A cabbage and Brussels sprout-containing diet seems to boost elimination through glucuronide conjugation.

Read the full interaction Moderate Likelihood Probable Cabbage + Cabotegraviri

Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.

Read the full interaction Moderate Likelihood Possible Breadfruit + Cabotegraviri

Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).

Read the full interaction Moderate Likelihood Possible Calcium D-glucarate + Cabotegraviri

Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.

Read the full interaction Moderate Likelihood Possible Cannabidiol (cbd) + Cabotegraviri

Cannabidiol might increase levels of certain glucuronidated drugs.

Read the full interaction Moderate Likelihood Possible Dandelion + Cabotegraviri

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Cabotegravir

All 1,452 ingredients in our database, ranked by severity — 12 with a Cabotegravir interaction on file and 1,440 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cabotegravir?

One-line answers, one card per combination — scroll through today’s 16 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Milk Thistle with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Cabotegravir answer

Can you take Uva Ursi with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.

Full Uva Ursi + Cabotegravir answer

Can you take Valerian with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Cabotegravir answer

Can you take Chrysin with Cabotegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.

Full Chrysin + Cabotegravir answer

Can you take Brussels Sprout with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. A cabbage and Brussels sprout-containing diet seems to boost elimination through glucuronide conjugation.

Full Brussels Sprout + Cabotegravir answer

Can you take Cabbage with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cabbage might increase clearance and decrease the effects of drugs metabolized through glucuronide conjugation.

Full Cabbage + Cabotegravir answer

Can you take Breadfruit with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Breadfruit might increase the levels of drugs metabolized by uridine diphosphoglucuronosyl transferase (UGT).

Full Breadfruit + Cabotegravir answer

Can you take Calcium D-glucarate with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, calcium D-glucarate might increase the clearance of drugs that undergo glucuronidation.

Full Calcium D-glucarate + Cabotegravir answer

Can you take Cannabidiol (cbd) with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol might increase levels of certain glucuronidated drugs.

Full Cannabidiol (cbd) + Cabotegravir answer

Can you take Dandelion with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.

Full Dandelion + Cabotegravir answer

Can you take Danshen with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, danshen might affect the levels and clinical effects of drugs requiring glucuronidation.

Full Danshen + Cabotegravir answer

Can you take Lemongrass with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.

Full Lemongrass + Cabotegravir answer

Can you take Milk Thistle with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Cabotegravir answer

Can you take Uva Ursi with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.

Full Uva Ursi + Cabotegravir answer

Can you take Valerian with Cabotegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Cabotegravir answer

Can you take Chrysin with Cabotegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.

Full Chrysin + Cabotegravir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cabotegravir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cabotegravir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cabotegravir sits in 1 interaction category. Open any one to see what the group means:

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Cabotegravir through this category.

About Cabotegravir

Cabotegravir is an HIV-1 antiretroviral medication used to treat HIV-1 infection (as Vocabria tablets) and to prevent HIV-1 infection as pre-exposure prophylaxis (PrEP).

Generic name: Cabotegravir  ·  Brand name: Apretude.

See the full Cabotegravir drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cabotegravir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cabotegravir.

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Pharmacist Counseling Corner

Cabotegravir & Supplements: Common Questions

What supplements interact with Cabotegravir?
More than you might expect — 12 in total, though they are far from equal: 0 are rated major, 11 moderate, and 1 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Brussels Sprout, Cabbage, Breadfruit.
Which Cabotegravir supplement interactions are the most serious?
None of the Cabotegravir supplement interactions on file are currently rated major. The most significant are the 11 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Cabotegravir?
Usually yes — most people on Cabotegravir can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Apretude have the same supplement interactions as Cabotegravir?
Yes — Apretude all contain Cabotegravir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Cabotegravir and my other medications?
This page covers Cabotegravir against supplements and herbal ingredients. Checking Cabotegravir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Cabotegravir drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 29, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.