Drug & supplement interaction

Agmatine + Cabotegravir

Cabotegravir brand name: Apretude.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Agmatine and Cabotegravir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Agmatine and Cabotegravir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cabotegravir and Agmatine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Agmatine safety at a glance

Agmatine overall Use caution Short-term use appears generally well tolerated, but long-term safety in humans is not well studied.
Pregnancy Avoid There is not enough safety data, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is not enough safety data, so it is best to avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cabotegravir and Agmatine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cabotegravir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cabotegravir is filed under a single classification — glucuronidated drugs. Agmatine has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of Cabotegravir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Agmatine Does Interact With Other Medications

Agmatine has 258 moderate known drug interactions in our database — Cabotegravir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. Cabotegravir)
Taking anything else?

Check Another of Your Medications Against Agmatine

Covers the 2,830 medications we’ve checked against Agmatine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Agmatine and Cabotegravir May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Nausea Additional detail

    Agmatine

    “Orally, agmatine has been reported to cause diarrhea, dyspepsia, and nausea in two small clinical studies. Mild-to-moderate diarrhea and nausea were reported in 3 out of 24 patients taking agmatine sulfate 3.56 grams daily. These adverse effects appeared within 2-3 days of therapy and resolved upon treatment discontinuation.”

    Agmatine · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 94736. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
    2. 94742. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

    Cabotegravir

    Listed in the ADVERSE REACTIONS section of the FDA label for Cabotegravir. Read the label on DailyMed ›

Reported for Agmatine but not commonly for Cabotegravir: stomach upset.

Effects for Cabotegravir come from the ADVERSE REACTIONS section of its FDA label; effects for Agmatine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 15,229 voluntary FDA FAERS reports for Cabotegravir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Cabotegravir

This page covers Agmatine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cabotegravir page lists 12 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Breadfruit (moderate), Brussels Sprout (moderate), Cabbage (moderate), Calcium D-glucarate (moderate) and Cannabidiol (cbd) (moderate).

By severity: 11 moderate · 1 minor.

From our pharmacist’s overview on the Cabotegravir page

“Cabotegravir (Apretude) prevents HIV only while its blood level stays steady, which is why this particular list, mild as it looks, deserves a real read. Every one of the interactions works through the same pathway, glucuronidation, the process the body uses to clear the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Cabotegravir interaction page

One more smart check

Taking Agmatine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,058 real supplement products containing Agmatine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Agmatine. Even though Agmatine itself has no known interaction with Cabotegravir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Agmatine and Cabotegravir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Agmatine
Top 25%

#175 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cabotegravir
Steady interest

#2,160 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Agmatine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Agmatine and Cabotegravir records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Agmatine

What is Agmatine?

Agmatine
  • Pre- and post-workout support
  • Muscle pumps and exercise performance
  • Cognitive support and mood
  • Nerve pain
  • General well-being

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and preliminary, so its true effects are uncertain. If you want to try it, talk with your pharmacist or doctor first, especially if you have health conditions or take other medicines.

Not a plant part; a compound made from the amino acid arginine · Capsules, tablets, bulk powder (usually as agmatine sulfate)

An interaction check asks whether these two react with each other — it does not ask whether Agmatine is a good idea for someone in your situation. Here is what our Agmatine record says about it on its own.

Agmatine: dosing

There is no officially established or standardized dose for agmatine. Doses used in supplements and small studies vary, and there is not enough evidence to recommend a single best amount.The safest approach is to follow the directions on the product label and start with the lowest suggested amount. Do not assume that taking more will work better or be safer.

From our Agmatine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Agmatine monograph & all interactions
Medication

About Cabotegravir

What Is Cabotegravir Used For?

Brand name: Apretude

Vocabria (cabotegravir) tablets are used in combination with rilpivirine (Edurant) to treat HIV-1 infection in adults and adolescents aged 12 and older who weigh at least 35 kg and whose HIV is already virologically suppressed (virus levels undetectable or very low on their current regimen). Vocabria tablets serve as a short-term oral lead-in — taken for roughly one month — before switching to long-acting injectable therapy.

Cabotegravir tablets are also used as an oral lead-in for HIV-1 pre-exposure prophylaxis (PrEP) — helping HIV-negative adults and adolescents (weighing at least 35 kg) confirm they tolerate the drug before starting injectable PrEP. Both uses require confirmed HIV-negative status before starting.

Most-Reported Side Effects for Cabotegravir

From FAERS, the FDA’s public side-effect reporting system (15,229 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injection site pain 1,618 reports
Viral load increased 962 reports
Virologic failure 684 reports
Product use in unapproved therapeutic environment 683 reports
Pathogen resistance 575 reports
See full Cabotegravir drug information
Keep checking

Other Drugs & Agmatine

Browse every other medication we’ve checked against Agmatine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
258Moderate
0Minor
2,571No known interaction
258 Moderate 2,571 No interaction
Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Agmatine page.

No interaction 2,571 drugs checked — show the list

We also checked Agmatine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Agmatine list.

See the full Agmatine interactions page
See every supplement checked against Cabotegravir, ranked by severity
Evidence & sources

Agmatine References

The 3 references that drive our Agmatine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Agmatine and Cabotegravir Together: Common Questions

Is it safe to take Agmatine with Cabotegravir?
We do not list a known interaction between Agmatine and Cabotegravir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Agmatine and Cabotegravir have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Agmatine and Cabotegravir combination checked?
Interactions in our licensed database are recorded against drug classes. Cabotegravir is filed under 1 classification, and Agmatine has documented interactions with 2 drug classes — none of Cabotegravir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Agmatine interact with any other medications?
Yes. Agmatine has 258 documented drug interactions in our database — Cabotegravir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cabotegravir interact with any supplements?
Yes. Cabotegravir has documented interactions with 12 supplements in our database — Agmatine is not one of them. The Cabotegravir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Agmatine monograph Uses, safety profile, and every drug interaction in one place Cabotegravir drug information The full plain-English guide to this medication Cabotegravir supplement interactions Every supplement checked against Cabotegravir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cabotegravir and Agmatine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.