Medication interaction hub

What Supplements Interact with Belinostat?

Belinostat brand name: Beleodaq. Every interaction below applies to the brands too.

83 Interactions 4 Major 73 Moderate 6 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Belinostat? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Belinostat against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Belinostat (Beleodaq) is chemotherapy for peripheral T-cell lymphoma, and the 83 supplement interactions on record for it deserve real scrutiny, not a skim. Four rate major, and they cluster around two dangers. Thirty-eight ingredients can strain the liver on their own, a bad pairing with a drug the liver already has to process; Siberian cocklebur and alcohol top that group. Another 37 involve P-glycoprotein, a pump that moves drugs across cell walls, and St. John's wort can drive drug levels down through it.

Belinostat also leaves the body largely through glucuronidation, so a dozen entries that speed or slow that pathway can nudge its levels either way. Run any supplement, even one that seems harmless, past the oncology pharmacist on your care team. The other 73 rate moderate and six minor, less urgent than the majors, but during active lymphoma treatment even modest shifts in drug exposure carry weight.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 73 Minor 6 No known interaction 1,369

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Belinostat: Top Interactions at a Glance

The Belinostat supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 83 interacting ingredients — plus 1,369 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Belinostat Combinations Today

The Belinostat + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Devil's Claw + Belinostati

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Read the full interaction Minor Likelihood Possible Grapefruit + Belinostati

Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Read the full interaction Moderate Likelihood Possible Sweet Orange + Belinostati

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Read the full interaction Moderate Likelihood Possible Valerian + Belinostati

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Belinostati

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Beer + Belinostati

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Belinostat

All 1,452 ingredients in our database, ranked by severity — 83 with a Belinostat interaction on file and 1,369 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Belinostat?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Devil's Claw with Belinostat?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Full Devil's Claw + Belinostat answer

Can you take Grapefruit with Belinostat?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Full Grapefruit + Belinostat answer

Can you take Sweet Orange with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Belinostat answer

Can you take Valerian with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Belinostat answer

Can you take Noni with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Belinostat answer

Can you take Oregon Grape with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.

Full Oregon Grape + Belinostat answer

Can you take Ostarine with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Belinostat answer

Can you take Padang Cassia with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Belinostat answer

Can you take Quercetin with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of P-glycoprotein substrates.

Full Quercetin + Belinostat answer

Can you take Rabdosia Rubescens with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Rabdosia rubescens might increase levels of p-glycoprotein substrates.

Full Rabdosia Rubescens + Belinostat answer

Can you take Red Yeast Rice with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Belinostat answer

Can you take Rhodiola with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Belinostat answer

Can you take Rhubarb with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Rhubarb + Belinostat answer

Can you take Sage with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase levels of drugs transported by P-glycoprotein.

Full Sage + Belinostat answer

Can you take Saigon Cinnamon with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Belinostat answer

Can you take Schisandra with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Belinostat answer

Can you take Spearmint with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Belinostat answer

Can you take Strawberry with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Belinostat answer

Can you take Sweet Annie with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Belinostat answer

Can you take Sweet Clover with Belinostat?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Belinostat answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Belinostat is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Belinostat, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Belinostat sits in 4 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Belinostat through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Belinostat through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Belinostat through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Belinostat through this category.

About Belinostat

Belinostat (Beleodaq) is a cancer medicine given by intravenous infusion to treat adults with relapsed or refractory peripheral T-cell lymphoma (PTCL) — a type of blood cancer that has come back or stopped responding to prior treatment.

Generic name: Belinostat  ·  Brand name: Beleodaq.

See the full Belinostat Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Belinostat

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Belinostat.

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Pharmacist Counseling Corner

Belinostat & Supplements: Common Questions

What supplements interact with Belinostat?
In our interaction database, 83 supplement and herbal ingredients have an interaction with Belinostat on file — 4 rated major, 73 moderate, and 6 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Beer, St. John's Wort.
Which Belinostat supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Beer, St. John's Wort and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Belinostat?
That depends entirely on which supplement. The honest answer for Belinostat is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Beleodaq have the same supplement interactions as Belinostat?
Yes — Beleodaq all contain Belinostat, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Belinostat and my other medications?
This page covers Belinostat against supplements and herbal ingredients. Checking Belinostat against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Belinostat Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.