Drug & supplement interaction

Higenamine + Belinostat

Belinostat brand name: Beleodaq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Higenamine and Belinostat in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Higenamine and Belinostat

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Belinostat and Higenamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Higenamine safety at a glance

Higenamine overall Use caution It acts as a stimulant on the heart and is banned in competitive sports, so it should be used with caution if at all.
Pregnancy Avoid There is no safety data in pregnancy, so it should be avoided.
Breastfeeding Avoid There is no safety data during breastfeeding, so it should be avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Belinostat and Higenamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Belinostat

Interactions in our licensed database are recorded against drug classes, not just single drug names. Belinostat is filed under 4 classifications — including cytochrome p450 2c9 (cyp2c9) inhibitors, glucuronidated drugs, p-glycoprotein substrates. Higenamine has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 2d6 (cyp2d6) substrates (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Belinostat’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Higenamine Does Interact With Other Medications

Higenamine has 891 moderate known drug interactions in our database — Belinostat isn’t one of them. If you take anything else, check it against the full list below.

Moderate 891 No known interaction 1,939 (incl. Belinostat)
Taking anything else?

Check Another of Your Medications Against Higenamine

Covers the 2,830 medications we’ve checked against Higenamine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Higenamine and Belinostat May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on reported in 10.1% of FDA reports for Belinostat Additional detail

    Higenamine

    “Orally and intravenously, higenamine may be unsafe. Research on the use of higenamine alone is limited; however, aconite, a plant that contains higenamine, can cause serious cardiovascular toxicity. It is unclear if higenamine alone might have similar effects.

    Most Common Adverse Effects:

    Orally: Headache.

    Intravenously: Dizziness and headache.

    Serious Adverse Effects (Rare):

    Orally: Rhabdomyolysis.

    Intravenously: Dy…”

    Higenamine · Natural Medicines adverse-effect record, reported in cluster headache.

    Belinostat

    Listed in the ADVERSE REACTIONS section of the FDA label for Belinostat, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Dizziness / Headache Additional detail

    Higenamine

    “Orally, higenamine may cause headache.

    Intravenously, higenamine may cause dizziness and headache.”

    Higenamine · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 107431. Rasic JS, Ivanovic ND, Andjelkovic MS, et al. Influence of higenamine on exercise performance of recreational female athletes: a randomized double-blinded placebo-controlled trial. Front Psychol 2021;12:633110. PubMed
    2. 97577. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin Toxicol (Phila). 2018:1-6. PubMed

    Belinostat

    Listed in the ADVERSE REACTIONS section of the FDA label for Belinostat. Read the label on DailyMed ›

Reported for Higenamine but not commonly for Belinostat: an irregular heartbeat, chest pain, severe muscle breakdown and a fast or pounding heartbeat.

Effects for Belinostat come from the ADVERSE REACTIONS section of its FDA label; effects for Higenamine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 347 voluntary FDA FAERS reports for Belinostat that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Belinostat

This page covers Higenamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Belinostat page lists 83 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), St. John's Wort (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 73 moderate · 6 minor.

From our pharmacist’s overview on the Belinostat page

“Belinostat (Beleodaq) is chemotherapy for peripheral T-cell lymphoma, and the 83 supplement interactions on record for it deserve real scrutiny, not a skim. Four rate major, and they cluster around two dangers.”

Reviewed by 2 · Jul 18, 2026

Open the Belinostat interaction page

One more smart check

Taking Higenamine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 154 real supplement products containing Higenamine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Higenamine. Even though Higenamine itself has no known interaction with Belinostat, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Higenamine and Belinostat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Higenamine
Top 25%

#323 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Belinostat
Top 25%

#682 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Higenamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Higenamine and Belinostat records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Higenamine

What is Higenamine?

  • Weight loss and fat burning
  • Pre-workout energy and performance
  • Appetite suppression
  • Athletic stimulant
  • Traditional medicine remedies

Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidence that it works and real concerns about heart and blood pressure effects. It is banned in sports by the World Anti-Doping Agency (WADA), and product labels often list inaccurate amounts, so most people should approach it with caution and talk to a pharmacist or doctor first.

Plant-derived alkaloid (found in plants such as Aconitum, Nelumbo/lotus, and Annona species) · Capsules, tablets, powders, pre-workout and fat-burner blends

An interaction check asks whether these two react with each other — it does not ask whether Higenamine is a good idea for someone in your situation. Here is what our Higenamine record says about it on its own.

Higenamine: dosing

There is no established or proven safe dose of higenamine. Supplement products vary widely, and testing has shown that the labeled amount is often unreliable, so it is hard to know how much you are actually taking.Because of this uncertainty and the potential heart effects, we do not recommend a specific dose.

From our Higenamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Higenamine monograph & all interactions
Medication

About Belinostat Injection

What Is Belinostat Injection Used For?

Brand name: Beleodaq

Beleodaq (belinostat) injection is approved to treat adult patients with relapsed or refractory peripheral T-cell lymphoma (PTCL) — a fast-growing type of lymphoma (blood cancer) that either came back after treatment or never fully responded to it.

This approval is based on how well the cancer responded to the drug, including how long those responses lasted. Whether Beleodaq extends overall survival or improves disease-related symptoms has not yet been established. Continued approval may depend on results from a confirmatory trial.

Most-Reported Side Effects for Belinostat

From FAERS, the FDA’s public side-effect reporting system (347 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 73 reports
Nausea 58 reports
Anemia 46 reports
Vomiting 42 reports
Dyspnea 35 reports
See full Belinostat Injection drug information
Keep checking

Other Drugs & Higenamine

Browse every other medication we’ve checked against Higenamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
891Moderate
0Minor
1,938No known interaction
891 Moderate 1,938 No interaction
Moderate

891 interactions

Showing 60 of 891 moderate interactions — see all 891 on the Higenamine page.

No interaction 1,938 drugs checked — show the list

We also checked Higenamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,938 medications checked with no known interaction — see the full Higenamine list.

See the full Higenamine interactions page
See every supplement checked against Belinostat, ranked by severity
Evidence & sources

Higenamine References

The 14 references that drive our Higenamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tai YT, But PP, Young K, et al. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992;340:1254-6. PubMed
  2. But PP, Tai YT, Young K. Three fatal cases of herbal aconite poisoning. Vet Hum Toxicol 1994;36:212-5.
  3. Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9. PubMed
  4. Wagner H, Reiter M, Ferstl W. New drugs with cardiotonic activity. Part 1. Chemistry and pharmacology of the cardiotonic active principle of Annona squamosa L. Planta Med 1980;40:77-85.
  5. Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther 1984;267:279-88.
  6. Liu WH, Zhou YP, Zeng GY. Effects of dl-demethylcoclaurine on experimental heart failure. Acta Pharm Sinica 1988;23:81-5.
  7. Yun-Choi HS, Pyo MK, Park KM, et al. Anti-thrombotic effects of higenamine. Planta Med 2001;67:619-22. PubMed
  8. Zhang Z, Liu X, Tao Z, et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study. Zhonghua Yi Xue Za Zhi 2002;82:352-5.
  9. Kam SC, Do JM, Choi JH, et al. The relaxation effect and mechanism of action of higenamine in the rat corpus cavernosum. Int J Impot Res 2012;24:77-83. PubMed
  10. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
  11. Jeter J, DeZee KJ, Kennedy L. A Case of Paraspinal Muscle Rhabdomyolysis in a 22-Year-Old Male After Ingesting a Supplement Containing Higenamine. Mil Med. 2015;180(7):e847-9. PubMed
  12. Zhang N, Lian Z, Peng X, Li Z, Zhu H. Applications of Higenamine in pharmacology and medicine. J Ethnopharmacol. 2017;196:242-252. PubMed
  13. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin Toxicol (Phila). 2018:1-6. PubMed
  14. Rasic JS, Ivanovic ND, Andjelkovic MS, et al. Influence of higenamine on exercise performance of recreational female athletes: a randomized double-blinded placebo-controlled trial. Front Psychol 2021;12:633110. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Higenamine and Belinostat Together: Common Questions

Is it safe to take Higenamine with Belinostat?
We do not list a known interaction between Higenamine and Belinostat. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Higenamine and Belinostat have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Higenamine and Belinostat combination checked?
Interactions in our licensed database are recorded against drug classes. Belinostat is filed under 4 classifications, and Higenamine has documented interactions with 5 drug classes — none of Belinostat's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Higenamine interact with any other medications?
Yes. Higenamine has 891 documented drug interactions in our database — Belinostat is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Belinostat interact with any supplements?
Yes. Belinostat has documented interactions with 83 supplements in our database — Higenamine is not one of them. The Belinostat interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Higenamine monograph Uses, safety profile, and every drug interaction in one place Belinostat Injection drug information The full plain-English guide to this medication Belinostat supplement interactions Every supplement checked against Belinostat, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Belinostat and Higenamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.