Drug & supplement interaction

Higenamine + Acetaminophen

Acetaminophen brand names: Tylenol Ex Strength, Children's Tylenol, Tylenol, Children's Tylenol Meltaways.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Higenamine and Acetaminophen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Higenamine and Acetaminophen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Acetaminophen and Higenamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Higenamine safety at a glance

Higenamine overall Use caution It acts as a stimulant on the heart and is banned in competitive sports, so it should be used with caution if at all.
Pregnancy Avoid There is no safety data in pregnancy, so it should be avoided.
Breastfeeding Avoid There is no safety data during breastfeeding, so it should be avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Acetaminophen and Higenamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Acetaminophen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Acetaminophen is filed under 8 classifications — including cytochrome p450 2e1 (cyp2e1) substrates, glucuronidated drugs, cytochrome p450 1a2 (cyp1a2) substrates. Higenamine has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 2d6 (cyp2d6) substrates (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Acetaminophen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Higenamine Does Interact With Other Medications

Higenamine has 891 moderate known drug interactions in our database — Acetaminophen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 891 No known interaction 1,939 (incl. Acetaminophen)
Taking anything else?

Check Another of Your Medications Against Higenamine

Covers the 2,830 medications we’ve checked against Higenamine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Higenamine and Acetaminophen May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Higenamine

    “Orally and intravenously, higenamine may be unsafe. Research on the use of higenamine alone is limited; however, aconite, a plant that contains higenamine, can cause serious cardiovascular toxicity. It is unclear if higenamine alone might have similar effects.

    Most Common Adverse Effects:

    Orally: Headache.

    Intravenously: Dizziness and headache.

    Serious Adverse Effects (Rare):

    Orally: Rhabdomyolysis.

    Intravenously: Dy…”

    Higenamine · Natural Medicines adverse-effect record, reported in cluster headache.

    Acetaminophen

    Listed in the ADVERSE REACTIONS section of the FDA label for Acetaminophen. Read the label on DailyMed ›

  • Muscle pain Additional detail

    Higenamine

    “Orally, higenamine might cause rhabdomyolysis. In a case report, a 22-year-old active duty male experienced paraspinal rhabdomyolysis after consuming higenamine-containing supplement (JACK3D micro) at 150% the recommended dose and performing heavy exercise shortly after consumption. Renal function returned to normal after a couple of days; however, severe muscle pain improved only after 3 months.”

    Higenamine · Natural Medicines adverse-effect record, reported in muscle breakdown.

    1 source cited
    1. 95551. Jeter J, DeZee KJ, Kennedy L. A Case of Paraspinal Muscle Rhabdomyolysis in a 22-Year-Old Male After Ingesting a Supplement Containing Higenamine. Mil Med. 2015;180(7):e847-9. PubMed

    Acetaminophen

    Listed in the ADVERSE REACTIONS section of the FDA label for Acetaminophen. Read the label on DailyMed ›

  • Headache reported in 5.7% of FDA reports for Acetaminophen Additional detail

    Higenamine

    “Orally, higenamine may cause headache.

    Intravenously, higenamine may cause dizziness and headache.”

    Higenamine · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 107431. Rasic JS, Ivanovic ND, Andjelkovic MS, et al. Influence of higenamine on exercise performance of recreational female athletes: a randomized double-blinded placebo-controlled trial. Front Psychol 2021;12:633110. PubMed
    2. 97577. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin Toxicol (Phila). 2018:1-6. PubMed

    Acetaminophen

    Listed in the ADVERSE REACTIONS section of the FDA label for Acetaminophen, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Higenamine but not commonly for Acetaminophen: an irregular heartbeat, chest pain, severe muscle breakdown and a fast or pounding heartbeat.

Effects for Acetaminophen come from the ADVERSE REACTIONS section of its FDA label; effects for Higenamine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 679,604 voluntary FDA FAERS reports for Acetaminophen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Acetaminophen Is Prescribed For, and What Higenamine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Acetaminophen is a prescription medicine with approved uses on its FDA label. Higenamine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Acetaminophen is prescribed for: Acetaminophen temporarily relieves minor aches and pains caused by headaches, the common cold, backaches, muscle aches, toothaches, minor arthritis pain, and premenstrual or menstrual cramps. It also temporarily reduces fever. These uses apply across oral tablet, suspension, and oral liquid products. The intravenous (IV) injection form is used in clinical settings to treat acute pain and fever, including in pediatric patients 2 years and older.

Higenamine has been studied for:

  • Osteoarthritis studied, not established Higenamine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Higenamine for osteoarthritis

    Although there has been interest in using oral higenamine for osteoarthritis, there is insufficient reliable information about the clinical effects of higenamine for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Acetaminophen on your own; if you are taking Higenamine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Higenamine or Acetaminophen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Higenamine or Acetaminophen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Acetaminophen

This page covers Higenamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 114 moderate · 36 minor.

From our pharmacist’s overview on the Acetaminophen page

“Acetaminophen (Tylenol) feels harmless because it sits on every shelf, but this list deserves real attention, mostly because of your liver. Of the 155 supplements and herbs on file, five carry a major rating, and the largest serious group, 38 ingredients, adds liver strain on top of acetaminophen's own well-known potential to harm the…”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen interaction page

One more smart check

Taking Higenamine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 154 real supplement products containing Higenamine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Higenamine. Even though Higenamine itself has no known interaction with Acetaminophen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Higenamine and Acetaminophen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Higenamine
Top half

#415 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen
Top 1%

#25 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Higenamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Higenamine and Acetaminophen records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Higenamine

What is Higenamine?

  • Weight loss and fat burning
  • Pre-workout energy and performance
  • Appetite suppression
  • Athletic stimulant
  • Traditional medicine remedies

Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidence that it works and real concerns about heart and blood pressure effects. It is banned in sports by the World Anti-Doping Agency (WADA), and product labels often list inaccurate amounts, so most people should approach it with caution and talk to a pharmacist or doctor first.

Plant-derived alkaloid (found in plants such as Aconitum, Nelumbo/lotus, and Annona species) · Capsules, tablets, powders, pre-workout and fat-burner blends

An interaction check asks whether these two react with each other — it does not ask whether Higenamine is a good idea for someone in your situation. Here is what our Higenamine record says about it on its own.

Higenamine: dosing

There is no established or proven safe dose of higenamine. Supplement products vary widely, and testing has shown that the labeled amount is often unreliable, so it is hard to know how much you are actually taking.Because of this uncertainty and the potential heart effects, we do not recommend a specific dose.

From our Higenamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Higenamine monograph & all interactions
Medication

About Acetaminophen

What Is Acetaminophen Used For?

Brand names: Tylenol Ex Strength, Children's Tylenol, Tylenol, Children's Tylenol Meltaways

Acetaminophen temporarily relieves minor aches and pains caused by headaches, the common cold, backaches, muscle aches, toothaches, minor arthritis pain, and premenstrual or menstrual cramps. It also temporarily reduces fever.

These uses apply across oral tablet, suspension, and oral liquid products. The intravenous (IV) injection form is used in clinical settings to treat acute pain and fever, including in pediatric patients 2 years and older.

Most-Reported Side Effects for Acetaminophen

From FAERS, the FDA’s public side-effect reporting system (679,604 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 45,791 reports
Nausea 41,932 reports
Overdose 40,941 reports
Drug dependence 39,209 reports
Headache 38,738 reports
See full Acetaminophen drug information
Keep checking

Other Drugs & Higenamine

Browse every other medication we’ve checked against Higenamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
891Moderate
0Minor
1,938No known interaction
891 Moderate 1,938 No interaction
Moderate

891 interactions

Showing 60 of 891 moderate interactions — see all 891 on the Higenamine page.

No interaction 1,938 drugs checked — show the list

We also checked Higenamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,938 medications checked with no known interaction — see the full Higenamine list.

See the full Higenamine interactions page
See every supplement checked against Acetaminophen, ranked by severity
Evidence & sources

Higenamine References

The 14 references that drive our Higenamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tai YT, But PP, Young K, et al. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992;340:1254-6. PubMed
  2. But PP, Tai YT, Young K. Three fatal cases of herbal aconite poisoning. Vet Hum Toxicol 1994;36:212-5.
  3. Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9. PubMed
  4. Wagner H, Reiter M, Ferstl W. New drugs with cardiotonic activity. Part 1. Chemistry and pharmacology of the cardiotonic active principle of Annona squamosa L. Planta Med 1980;40:77-85.
  5. Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther 1984;267:279-88.
  6. Liu WH, Zhou YP, Zeng GY. Effects of dl-demethylcoclaurine on experimental heart failure. Acta Pharm Sinica 1988;23:81-5.
  7. Yun-Choi HS, Pyo MK, Park KM, et al. Anti-thrombotic effects of higenamine. Planta Med 2001;67:619-22. PubMed
  8. Zhang Z, Liu X, Tao Z, et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study. Zhonghua Yi Xue Za Zhi 2002;82:352-5.
  9. Kam SC, Do JM, Choi JH, et al. The relaxation effect and mechanism of action of higenamine in the rat corpus cavernosum. Int J Impot Res 2012;24:77-83. PubMed
  10. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
  11. Jeter J, DeZee KJ, Kennedy L. A Case of Paraspinal Muscle Rhabdomyolysis in a 22-Year-Old Male After Ingesting a Supplement Containing Higenamine. Mil Med. 2015;180(7):e847-9. PubMed
  12. Zhang N, Lian Z, Peng X, Li Z, Zhu H. Applications of Higenamine in pharmacology and medicine. J Ethnopharmacol. 2017;196:242-252. PubMed
  13. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin Toxicol (Phila). 2018:1-6. PubMed
  14. Rasic JS, Ivanovic ND, Andjelkovic MS, et al. Influence of higenamine on exercise performance of recreational female athletes: a randomized double-blinded placebo-controlled trial. Front Psychol 2021;12:633110. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Higenamine and Acetaminophen Together: Common Questions

Is it safe to take Higenamine with Acetaminophen?
We do not list a known interaction between Higenamine and Acetaminophen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Higenamine and Acetaminophen have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Higenamine and Acetaminophen used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Higenamine in each. That is a conversation for your prescriber, especially if Acetaminophen is being adjusted to a target.
How was the Higenamine and Acetaminophen combination checked?
Interactions in our licensed database are recorded against drug classes. Acetaminophen is filed under 8 classifications, and Higenamine has documented interactions with 5 drug classes — none of Acetaminophen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Higenamine interact with any other medications?
Yes. Higenamine has 891 documented drug interactions in our database — Acetaminophen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Acetaminophen interact with any supplements?
Yes. Acetaminophen has documented interactions with 155 supplements in our database — Higenamine is not one of them. The Acetaminophen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Higenamine monograph Uses, safety profile, and every drug interaction in one place Acetaminophen drug information The full plain-English guide to this medication Acetaminophen supplement interactions Every supplement checked against Acetaminophen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Acetaminophen and Higenamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.