Drug & supplement interaction

Chrysin + Belinostat

Belinostat brand name: Beleodaq.

Minor Interaction
Medically reviewed by · Updated October 2026
The bottom line Minor

Chrysin has a minor interaction with Belinostat. Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chrysin and Belinostat

Here is the interaction we found between these two, with the evidence behind it.

Minor

GLUCURONIDATED DRUGS

Why this applies to Belinostat

Belinostat falls under GLUCURONIDATED DRUGS — the group Chrysin interacts with.

Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.
In vitro research suggests that chrysin might induce UDP-glucuronosyltransferase 1A1 (UGT1A1).
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for your situation. Belinostat (Beleodaq) is cleared from the body largely by an enzyme called UGT1A1, which tacks on a sugar molecule so the drug can be removed. In test-tube research, chrysin appears to speed up that same enzyme. In theory, that could clear belinostat out faster and make this chemotherapy a little less effective at fighting your lymphoma.

Now, the honest part: this is a theoretical, lab-only concern rated minor and unlikely, and chrysin is poorly absorbed in people, so the real-world impact may be small. Still, belinostat is serious cancer treatment, so don't add chrysin without checking first. Please loop in your oncology team or pharmacist before using any supplement during treatment.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  2. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  3. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chrysin Also Interacts With Other Medications

Chrysin has 179 moderate, 178 minor known drug interactions in our database — the Belinostat one above is one of them. If you take anything else, check it against the full list below.

Moderate 179 Minor 178 No known interaction 2,473 (incl. Belinostat)
Taking anything else?

Check Another of Your Medications Against Chrysin

Covers the 2,830 medications we’ve checked against Chrysin. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Belinostat

This page covers Chrysin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Belinostat page lists 83 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), St. John's Wort (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 73 moderate · 6 minor.

From our pharmacist’s overview on the Belinostat page

“Belinostat (Beleodaq) is chemotherapy for peripheral T-cell lymphoma, and the 83 supplement interactions on record for it deserve real scrutiny, not a skim. Four rate major, and they cluster around two dangers.”

Reviewed by 2 · Jul 18, 2026

Open the Belinostat interaction page

One more smart check

Taking Chrysin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Chrysin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysin. Your product may carry other ingredients that interact with Belinostat too, on top of Chrysin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysin and Belinostat Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysin
Top half

#382 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Belinostat
Top half

#743 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chrysin

What is Chrysin?

  • Bodybuilding and testosterone support
  • Anxiety and stress
  • Anti-inflammatory
  • Antioxidant support
  • Prostate health

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the body absorbs very little of it. Evidence for its other proposed uses is mostly limited to laboratory and animal research, so its real-world value is unclear. Talk with your pharmacist or doctor before using it.

Read the full Chrysin monograph & all interactions
Medication

About Belinostat Injection

What Is Belinostat Injection Used For?

Brand name: Beleodaq

Beleodaq is used to treat adults with peripheral T-cell lymphoma (PTCL) that has come back (relapsed) or has not responded to earlier treatment (refractory).

It was approved under accelerated approval, based on how many tumors shrank and for how long. It has not been shown to improve survival or disease-related symptoms. Continued approval may depend on results from a confirmatory trial.

See full Belinostat Injection drug information
Keep checking

Other Drugs & Chrysin

Browse every other medication we’ve checked against Chrysin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
179Moderate
178Minor
2,472No known interaction
179 Moderate 178 Minor 2,472 No interaction
Moderate

179 interactions

Showing 60 of 179 moderate interactions — see all 179 on the Chrysin page.

Minor

178 interactions

Showing 60 of 178 minor interactions — see all 178 on the Chrysin page.

No interaction 2,472 drugs checked — show the list

We also checked Chrysin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,472 medications checked with no known interaction — see the full Chrysin list.

See the full Chrysin interactions page
See every supplement checked against Belinostat, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chrysin monograph › Uses, safety, and every drug interaction in one place Belinostat supplement interactions › Every supplement checked against Belinostat, ranked by severity Belinostat Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chrysin and Belinostat Together: Common Questions

Can you take Chrysin with Belinostat?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Chrysin and Belinostat interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Belinostat and Chrysin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.