Drug & supplement interaction

Chrysin + Levothyroxine, Liothyronine

Levothyroxine, Liothyronine brand name: Armour Thyroid.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chrysin and Levothyroxine, Liothyronine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Chrysin and Levothyroxine, Liothyronine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levothyroxine, Liothyronine and Chrysin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chrysin safety at a glance

Chrysin overall Use caution Generally seems well tolerated in short-term use, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levothyroxine, Liothyronine and Chrysin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Levothyroxine, Liothyronine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Levothyroxine, Liothyronine is filed under 3 classifications — including thyroid hormone, oral drugs. Chrysin has documented interactions with 9 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), aromatase inhibitors (moderate) and contraceptive drugs (moderate) — and none of Levothyroxine, Liothyronine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chrysin Does Interact With Other Medications

Chrysin has 179 moderate, 179 minor known drug interactions in our database — Levothyroxine, Liothyronine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 179 Minor 179 No known interaction 2,472 (incl. Levothyroxine, Liothyronine)
Taking anything else?

Check Another of Your Medications Against Chrysin

Covers the 2,830 medications we’ve checked against Chrysin. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Levothyroxine, Liothyronine

This page covers Chrysin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levothyroxine, Liothyronine page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 39 moderate · 9 minor.

From our pharmacist’s overview on the Levothyroxine, Liothyronine page

“For anyone taking levothyroxine or liothyronine (Armour Thyroid), this list earns real caution, not just a passing glance. Most of these 50 ingredients pull in one of two directions.”

Reviewed by 2 · Jul 18, 2026

Open the Levothyroxine, Liothyronine interaction page

One more smart check

Taking Chrysin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Chrysin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysin. Even though Chrysin itself has no known interaction with Levothyroxine, Liothyronine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysin and Levothyroxine, Liothyronine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysin
Top 25%

#336 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levothyroxine, Liothyronine
Top 5%

#61 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chrysin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chrysin and Levothyroxine, Liothyronine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chrysin

What is Chrysin?

  • Bodybuilding and testosterone support
  • Anxiety and stress
  • Anti-inflammatory
  • Antioxidant support
  • Prostate health

Chrysin is a plant flavonoid sold mainly as a bodybuilding supplement claimed to raise testosterone or block estrogen, but human studies have not shown these benefits, largely because the body absorbs very little of it. Evidence for its other proposed uses is mostly limited to laboratory and animal research, so its real-world value is unclear. Talk with your pharmacist or doctor before using it.

Flavonoid extracted from plants such as passionflower and from honey and propolis · Capsules, tablets, powders, topical gels

An interaction check asks whether these two react with each other — it does not ask whether Chrysin is a good idea for someone in your situation. Here is what our Chrysin record says about it on its own.

Chrysin: dosing

There is no well-established or proven dose for chrysin. Amounts in commercial products vary widely, and because so little is absorbed by the body, the right dose for any benefit is unknown.If you choose to try it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist can help you review the product and decide whether it makes sense for you.

From our Chrysin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chrysin monograph & all interactions
Medication

About Levothyroxine, Liothyronine

Most-Reported Side Effects for Levothyroxine, Liothyronine

From FAERS, the FDA’s public side-effect reporting system (15 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 4 reports
Asthenia 3 reports
Dizziness 3 reports
Arthralgia 2 reports
Disorientation 2 reports
Keep checking

Other Drugs & Chrysin

Browse every other medication we’ve checked against Chrysin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
179Moderate
179Minor
2,471No known interaction
179 Moderate 179 Minor 2,471 No interaction
Moderate

179 interactions

Showing 60 of 179 moderate interactions — see all 179 on the Chrysin page.

Minor

179 interactions

Showing 60 of 179 minor interactions — see all 179 on the Chrysin page.

No interaction 2,471 drugs checked — show the list

We also checked Chrysin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,471 medications checked with no known interaction — see the full Chrysin list.

See the full Chrysin interactions page
See every supplement checked against Levothyroxine, Liothyronine, ranked by severity
Evidence & sources

Chrysin References

The 23 references that drive our Chrysin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica 1999;29:1241-56. PubMed
  2. Lee H, Yeom H, Kim YG, et al. Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem Pharmacol 1998;55:1369-75. PubMed
  3. Galijatovic A, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells. Pharm Res 2000;17:21-6.
  4. Walle UK, Galijatovic A, Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol 1999;58:431-8. PubMed
  5. Kao YC, Zhou C, Sherman M, et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect 1998;106:85-92. PubMed
  6. Jeong HJ, Shin YG, Kim IH, Pezzuto JM. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 1999;22:309-12. PubMed
  7. Walle T, Otake Y, Galijatovic A, et al. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000;28:1077-82. DOI
  8. Walle T, Otake Y, Brubaker JA, et al. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol 2001;51:143-6. DOI
  9. Galijatovic A, Otake Y, Walle UK, Walle T. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation. Pharm Res 2001;18:374-9. PubMed
  10. Lautraite S, Musonda AC, Doehmer J, et al. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis 2002;17:45-53. PubMed
  11. Han, D. H., Denison, M. S., Tachibana, H., and Yamada, K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem 2002;66(7):1479-1487. PubMed
  12. O'Leary, K. A., de Pascual-Tereasa, S., Needs, P. W., Bao, Y. P., O'Brien, N. M., and Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat.Res 7-13-2004;551(1-2):245-254. PubMed
  13. Woodman, O. L. and Chan, E. C. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786-790. PubMed
  14. Simons, A. L., Renouf, M., Hendrich, S., and Murphy, P. A. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric.Food Chem 5-18-2005;53(10):4258-4263. PubMed
  15. Kim, H. J., Lee, S. B., Park, S. K., Kim, H. M., Park, Y. I., and Dong, M. S. Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. Arch Pharm Res 2005;28(10):1114-1121 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chrysin and Levothyroxine, Liothyronine Together: Common Questions

Is it safe to take Chrysin with Levothyroxine, Liothyronine?
We do not list a known interaction between Chrysin and Levothyroxine, Liothyronine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Chrysin and Levothyroxine, Liothyronine combination checked?
Interactions in our licensed database are recorded against drug classes. Levothyroxine, Liothyronine is filed under 3 classifications, and Chrysin has documented interactions with 9 drug classes — none of Levothyroxine, Liothyronine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chrysin interact with any other medications?
Yes. Chrysin has 358 documented drug interactions in our database — Levothyroxine, Liothyronine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Levothyroxine, Liothyronine interact with any supplements?
Yes. Levothyroxine, Liothyronine has documented interactions with 50 supplements in our database — Chrysin is not one of them. The Levothyroxine, Liothyronine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chrysin monograph Uses, safety profile, and every drug interaction in one place Levothyroxine, Liothyronine supplement interactions Every supplement checked against Levothyroxine, Liothyronine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 23 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.