Rice Bran Arabinoxylan Compound - Caplyta (Lumateperone) Interaction

Interaction Details

Lumateperone is classified as belonging to the following category: Immunosuppressants

Theoretically, rice bran arabinoxylan compound might interfere with immunosuppressants by stimulating the immune system. In laboratory and human research, rice bran arabinoxylan compound has been shown to stimulate the activity of immune cells.
Some immunosuppressants include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Ghoneum M, Namatalia G, Kim C. Effect of MGN-3 on human natural killer cell activity and interferon-y synthesis in vitro. FASEB 1996;10:26-32.
• Ghoneum M, Jewett A. Synergistic effect of modified arabinoxylane (MGN-3) and low dose of recombinant IL-2 on human NK cell activity and TNF-a production. American Academy of Anti-Aging Medicine, Education Conference 1998.
• Salama H, Medhat E, Shaheen M, Zekri AN, Darwish T, Ghoneum M. Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial. Int J Immunopathol Pharmacol. 2016;29(4):647-653.
• Ghoneum M, Agrawal S. Mgn-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells. Int J Immunopathol Pharmacol. 2014;27(4):523-30.
• Cholujova D, Jakubikova J, Czako B, et al. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother. 2013;62(3):437-45.
• Ghoneum M, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran). Int J Immunopathol Pharmacol. 2011;24(4):941-8.
• Ghoneum M, Matsuura M. Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran). Int J Immunopathol Pharmacol. 2004;17(3):283-92.
• Ghoneum M, Jewett A. Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro. Cancer Detect Prev. 2000;24(4):314-2

Lumateperone Overview

• Lumateperone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Lumateperone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.

Rice Bran Arabinoxylan Compound - More Interactions

Rice Bran Arabinoxylan Compound interacts with 112 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.