Drug & supplement interaction

Fulvic Acid + Pazopanib

Pazopanib brand name: Votrient.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Pazopanib falls into 2 drug categories that Fulvic Acid can interact with; the most serious is rated moderate. Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Fulvic Acid and Pazopanib

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Fulvic Acid interacts with whole categories of medication. Pazopanib falls into 2 of those categories, so it can interact with Fulvic Acid in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 2

Why this applies to Pazopanib

Pazopanib falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Fulvic Acid interacts with.

Theoretically, taking fulvic acid may decrease the effectiveness of anticoagulant and antiplatelet drugs.
In vitro evidence shows that fulvic acid, formed from the oxidation and polymerization of protocatechuic acid, can shorten prothrombin time in human plasma, increasing the risk of clot formation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture with this pairing. The interaction we have on file is about fulvic acid possibly making blood-thinning and anti-clotting medicines work a little less well, based on lab studies where it shortened clotting time. That's a clot-promoting tendency, not a bleeding one.

Now, Pazopanib (Votrient) isn't a classic blood thinner, but it does carry its own clotting-related risks. People on it can develop blood clots (like in the legs or lungs) as well as bleeding problems. In theory, fulvic acid's tendency to nudge blood toward clotting could add to that clot risk. This is only test-tube evidence, so I wouldn't panic, but I also wouldn't add fulvic acid on your own. Please run it by your oncologist or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lu, FJ. Arsenic as a promoter in the effect of humic substances on plasma prothrombin time in vitro. Thromb Res 6-15-1990;58(6):537-541. PubMed
Moderate

IMMUNOSUPPRESSANTS

2 of 2

Pazopanib also falls under IMMUNOSUPPRESSANTS.

Theoretically, taking fulvic acid might decrease the effects of immunosuppressive therapy.
Animal research shows that fulvic acid stimulates immune function.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing fulvic acid with pazopanib (Votrient). This isn't about your liver breaking the drug down faster or slower. The concern is the immune system itself. In animal studies, fulvic acid seemed to rev up immune activity. Pazopanib is a cancer drug that works by blocking the signals tumors use to grow and feed their blood supply, and it's often grouped with medicines that quiet the immune system.

The worry, in theory, is that a supplement nudging the immune system the other way could work against what your treatment is trying to do. I'll be honest: this is based on lab and animal research, not real human studies, so it's more of a caution than a proven problem. Since pazopanib is serious cancer therapy, please don't add fulvic acid without first running it by your oncology team or pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Fulvic Acid Also Interacts With Other Medications

Fulvic Acid has 256 moderate known drug interactions in our database — the Pazopanib one above is among them. If you take anything else, check it against the full list below.

Moderate 256 No known interaction 2,574 (incl. Pazopanib)
Taking anything else?

Check Another of Your Medications Against Fulvic Acid

Covers the 2,830 medications we’ve checked against Fulvic Acid. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Pazopanib

This page covers Fulvic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pazopanib page lists 349 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Asarabacca (major) and Beer (major).

By severity: 14 major · 297 moderate · 38 minor.

From our pharmacist’s overview on the Pazopanib page

“Take a careful look before mixing supplements with pazopanib (Votrient), an oral pill for advanced kidney cancer and certain sarcomas. Fourteen of the 349 ingredients on file are rated major, grapefruit among them, since it can raise pazopanib levels enough to intensify side effects.”

Reviewed by 2 · Jul 18, 2026

Open the Pazopanib interaction page

One more smart check

Taking Fulvic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 294 real supplement products containing Fulvic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fulvic Acid. Your product may carry other ingredients that interact with Pazopanib too, on top of Fulvic Acid — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fulvic Acid and Pazopanib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fulvic Acid
Top half

#569 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pazopanib
Steady interest

#2,259 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Fulvic Acid

What is Fulvic Acid?

  • General wellness and energy
  • Gut health
  • Antioxidant support
  • Mineral and nutrient supplementation
  • Immune support

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall wellness. Human research is very limited, so most claims are unproven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding due to a lack of safety data.

Read the full Fulvic Acid monograph & all interactions
Medication

About Pazopanib

What Is Pazopanib Used For?

Brand name: Votrient

Pazopanib tablets — sold as the brand Votrient and as generic pazopanib — are used to treat two types of advanced cancer in adults: advanced renal cell carcinoma (RCC), the most common form of kidney cancer, and advanced soft tissue sarcoma (STS) in patients who have already received prior chemotherapy.

Important limitation: Pazopanib has not been shown to work in adipocytic soft tissue sarcoma (a subtype involving fat cells) or in gastrointestinal stromal tumors (GISTs), so it is not used for those cancers.

See full Pazopanib drug information
Keep checking

Other Drugs & Fulvic Acid

Browse every other medication we’ve checked against Fulvic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
256Moderate
0Minor
2,573No known interaction
256 Moderate 2,573 No interaction
Moderate

256 interactions

Showing 60 of 256 moderate interactions — see all 256 on the Fulvic Acid page.

No interaction 2,573 drugs checked — show the list

We also checked Fulvic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,573 medications checked with no known interaction — see the full Fulvic Acid list.

See the full Fulvic Acid interactions page
See every supplement checked against Pazopanib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Fulvic Acid monograph › Uses, safety, and every drug interaction in one place Pazopanib supplement interactions › Every supplement checked against Pazopanib, ranked by severity Pazopanib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Fulvic Acid and Pazopanib Together: Common Questions

Can you take Fulvic Acid with Pazopanib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Fulvic Acid and Pazopanib?
Pazopanib belongs to more than one drug category, and Fulvic Acid interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Fulvic Acid and Pazopanib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pazopanib and Fulvic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.