Motherwort + Pazopanib
Pazopanib brand name: Votrient.
We found no known interaction between Motherwort and Pazopanib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pazopanib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Motherwort and Pazopanib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pazopanib and Motherwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Motherwort safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Pazopanib
Interactions in our licensed database are recorded against drug classes, not just single drug names. Pazopanib is filed under 11 classifications — including immunosuppressants, anticoagulant/antiplatelet drugs, cytochrome p450 2d6 (cyp2d6) inhibitors. Motherwort has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Pazopanib’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Motherwort Does Interact With Other Medications
Motherwort has 248 moderate known drug interactions in our database — Pazopanib isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Motherwort
We haven’t checked that one against Motherwort yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Motherwort. Pick one to open its full report.
Motherwort in Pregnancy & Breastfeeding
When used orally or by injection. Alkaloids present in motherwort have uterine stimulant effects.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Pazopanib Products Have a Food Rule — Motherwort Should Not Break It
At least one FDA label for a product containing Pazopanib says to take it on an empty stomach. Most supplements — Motherwort included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Pazopanib on its own and move Motherwort to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pazopanib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended Dosage : 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal).
From the Dosage and Administration section of the FDA label we read for Pazopanib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Pazopanib Is Prescribed For, and What Motherwort Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Pazopanib is a prescription medicine with approved uses on its FDA label. Motherwort is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Pazopanib is prescribed for: Pazopanib tablets — sold as the brand Votrient and as generic pazopanib — are used to treat two types of advanced cancer in adults: advanced renal cell carcinoma (RCC), the most common form of kidney cancer, and advanced soft tissue sarcoma (STS) in patients who have already received prior chemotherapy. Important limitation: Pazopanib has not been shown to work in adipocytic soft tissue sarcoma (a subtype involving fat cells) or in gastrointestinal stromal tumors (GISTs), so it is not used for those cancers.
Motherwort has been studied for:
-
Cancer studied, not established Motherwort has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Motherwort for cancer
Although there has been interest in using oral motherwort for cancer, there is insufficient reliable information about the clinical effects of motherwort for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pazopanib on your own; if you are taking Motherwort for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Motherwort or Pazopanib
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Motherwort or Pazopanib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Pazopanib
This page covers Motherwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pazopanib page lists 349 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Asarabacca (major) and Beer (major).
By severity: 14 major · 297 moderate · 38 minor.
From our pharmacist’s overview on the Pazopanib page
“Take a careful look before mixing supplements with pazopanib (Votrient), an oral pill for advanced kidney cancer and certain sarcomas. Fourteen of the 349 ingredients on file are rated major, grapefruit among them, since it can raise pazopanib levels enough to intensify side effects.”
Reviewed by 2 · Jul 18, 2026
Taking Motherwort as Part of a Dietary Supplement Product? Check It for Interactions
We hold 400 real supplement products containing Motherwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Motherwort. Even though Motherwort itself has no known interaction with Pazopanib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Motherwort and Pazopanib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#329 of 1,452 supplements looked up here in the last 7 days
#2,192 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Motherwort reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Motherwort and Pazopanib records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Motherwort
What is Motherwort?
- Anxiety and stress
- Heart palpitations
- Menstrual discomfort
- Menopausal symptoms
- Insomnia
Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avoided during pregnancy and breastfeeding, and anyone with a heart condition or taking heart or blood-thinning medicines should talk to a doctor or pharmacist before using it.
Leonurus cardiaca · Lamiaceae · Aerial parts (leaves, stems, and flowering tops) · Tea, tincture, liquid extract, capsules, dried herb
An interaction check asks whether these two react with each other — it does not ask whether Motherwort is a good idea for someone in your situation. Here is what our Motherwort record says about it on its own.
Motherwort: dosing
There is no well-established standard dose for motherwort. Traditional preparations include teas made from the dried herb and liquid tinctures or extracts, and products vary widely in strength.Because doses are not standardized and product quality differs, the safest approach is to follow the directions on the specific product label and not exceed the suggested amount.
From our Motherwort monograph — the full record covers uses, side effects and every documented interaction.
About Pazopanib
What Is Pazopanib Used For?
Brand name: Votrient
Pazopanib tablets — sold as the brand Votrient and as generic pazopanib — are used to treat two types of advanced cancer in adults: advanced renal cell carcinoma (RCC), the most common form of kidney cancer, and advanced soft tissue sarcoma (STS) in patients who have already received prior chemotherapy.
Important limitation: Pazopanib has not been shown to work in adipocytic soft tissue sarcoma (a subtype involving fat cells) or in gastrointestinal stromal tumors (GISTs), so it is not used for those cancers.
Most-Reported Side Effects for Pazopanib
From FAERS, the FDA’s public side-effect reporting system (26,904 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Motherwort
Browse every other medication we’ve checked against Motherwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
248 interactions
- Diphenhydramine ›
- Flurazepam ›
- Triazolam ›
- Zopiclone ›
- Fentanyl ›
- Oxycodone ›
- Phenytoin ›
- Temazepam ›
- Carbamazepine ›
- Morphine Sulfate ›
- Nitrazepam ›
- Buprenorphine ›
- Diazepam ›
- Lofepramine ›
- Meprobamate ›
- Oxymorphone ›
- Propoxyphene ›
- Topiramate ›
- Aripiprazole ›
- Cetirizine ›
- Clobazam ›
- Clonazepam ›
- Clorazepate ›
- Desipramine ›
- Doxepin ›
- Hydromorphone ›
- Levetiracetam ›
- Metoclopramide ›
- Midazolam ›
- Phenobarbital ›
- Tramadol ›
- Valproic Acid ›
- Zolpidem ›
- Acetazolamide ›
- Alprazolam ›
- Aripiprazole Lauroxil ›
- Buprenorphine Hydrochloride ›
- Butabarbital Sodium ›
- Chlorpromazine ›
- Dexmedetomidine ›
- Gabapentin ›
- Hexobarbital ›
- Hydrocodone ›
- Hydrocodone Bitartrate ›
- Lithium Carbonate (prescription Drug) ›
- Loxapine ›
- Magnesium Sulfate (prescription Drug) ›
- Meperidine ›
- Oxcarbazepine ›
- Oxycodone Hydrochloride ›
- Pregabalin ›
- Tasimelteon ›
- Zaleplon ›
- Zonisamide ›
- Acepromazine ›
- Alfentanil ›
- Aminoglutethimide ›
- Amitriptyline ›
- Amobarbital ›
- Brexanolone ›
Showing 60 of 248 moderate interactions — see all 248 on the Motherwort page.
No interaction 2,581 drugs checked — show the list
We also checked Motherwort against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Hydroxyurea ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Dapsone ›
- Cephalexin ›
- Cyclopentolate ›
Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Motherwort list.
Motherwort References
The 6 references that drive our Motherwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
- Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
- Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Motherwort and Pazopanib Together: Common Questions
Is it safe to take Motherwort with Pazopanib?
Do Motherwort and Pazopanib have any of the same side effects?
Should I take Motherwort and Pazopanib at the same time of day?
Are Motherwort and Pazopanib used for the same thing?
How was the Motherwort and Pazopanib combination checked?
Does Motherwort interact with any other medications?
Does Pazopanib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.