Taking Eliquis With Motherwort

In our latest question and answer, the pharmacist discusses the combined use of Eliquis and motherwort.


If Eliquis interacts with motherwort, is there a serious interaction?

Asked by Samuel On Apr 28, 2024

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published May 06, 2024
Last updated May 19, 2024


Hello, and thank you for reaching out to us!

It's certainly a good idea to investigate potential interactions between over-the-counter supplements and prescription drugs, especially when taking an anticoagulant medication like Eliquis, as many supplements have been shown to affect how blood can clot.

Motherwort, which you asked about in your question to us, is a versatile herb used for various purposes. Research suggests it possesses anti-inflammatory, antimicrobial, and antioxidant properties. Additionally, it has been traditionally used to address nervous system disorders, menstrual disorders and support cardiovascular health.

Regarding a possible interaction between Eliquis (apixaban) and motherwort, data is limited, making it challenging to draw definitive conclusions. Research indicates that taking motherwort orally does not seem to affect blood coagulation to a clinically significant extent or interact with Eliquis, as reported on our interaction page.

However, one study found that regular intravenous administration of a motherwort extract over 15 days reduced blood viscosity, lowered fibrinogen levels, and inhibited platelet aggregation. It is unclear whether consuming motherwort orally have these effects. I could not find reports of oral motherwort causing an increased bleeding risk (which would of course cause a problem in those already taking antiplatelet or anticoagulant drugs, like Eliquis).

Overall, there is no strong evidence of an interaction between Eliquis and motherwort when taken orally, but targeted studies are lacking.

Before starting motherwort, it is advisable to consult with your doctor so you can be appropriately monitored and for specific guidance about your medical situation. If you take both Eliquis and motherwort, monitor for signs of bleeding, such as easy bruising, gum bleeding, or darkened stools.

Final Words

I hope this information is helpful! Please feel free to reach out with any further questions.


  • Effect of motherwort on blood hyperviscosity, PubMed
  • Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology, PubMed

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