Can You Take Benadryl And Propranolol Together?

Answer

It is safe to take Benadry/Nytol (diphenhydramine) with propranolol as there is no interaction between the two medications.

They do, however, share some similar side effects that are important to be aware of.

Interaction Detail

Both Nytol and Benadryl are brand names for diphenhydramine, a sedating first-generation antihistamine that is often used for allergies and insomnia.

Propranolol, brand name Inderal, is a beta blocker that is indicated for a variety of conditions including angina, high blood pressure, and migraine prophylaxis.

While both Benadryl and propranolol can be used together, caution is advised in regard to the potential for additive adverse reactions such as sedation and dizziness.

Propranolol is known to cause sedation and orthostatic hypotension (a drop in blood pressure while standing), which can cause dizziness. Benadryl causes drowsiness as well.

Final Words

As stated, there is no drug-drug interaction between Benadryl and propranolol. Just be aware of the potential sedation they can both cause.