Drug & supplement interaction

Chaga + Pazopanib

Pazopanib brand name: Votrient.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Pazopanib falls into 2 drug categories that Chaga can interact with; the most serious is rated moderate. Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chaga and Pazopanib

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Chaga interacts with whole categories of medication. Pazopanib falls into 2 of those categories, so it can interact with Chaga in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

1 of 2

Why this applies to Pazopanib

Pazopanib falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Chaga interacts with.

Theoretically, chaga may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that chaga extract can inhibit platelet aggregation. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the connection to keep in mind with Votrient (pazopanib). Pazopanib itself can raise your bleeding risk, and it's also linked to high blood pressure and clotting concerns, so anything that nudges bleeding in either direction matters here. Chaga is the wrinkle: in lab and animal studies, chaga extract slowed platelets from clumping together, which could theoretically add to a bleeding tendency.

I want to be honest about the strength of this, though. This effect has not been seen in actual people, so it's a theoretical caution, not a proven problem. Still, since you're on a cancer therapy that already touches bleeding and blood pressure, I'd loop in your oncology team or pharmacist before adding chaga rather than starting it on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hyun KW, Jeong SC, Lee DH, et al. Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 2006;27(6):1173-8. PubMed
Moderate

IMMUNOSUPPRESSANTS

2 of 2

Pazopanib also falls under IMMUNOSUPPRESSANTS.

Theoretically, chaga might interfere with immunosuppressive therapy.
In vitro research suggests that certain constituents of chaga stimulate immune function. This has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing about Chaga and your Votrient. Pazopanib isn't a classic immunosuppressant, it's a targeted kinase inhibitor that helps slow kidney cancer growth. The concern on file comes from lab (test tube) studies suggesting Chaga might rev up the immune system. In theory, anything that stirs up immune activity could work against treatments meant to calm or control your body's response, but this has never actually been shown to happen in people taking pazopanib.

So I'd file this under theoretical and low-priority rather than something proven. Still, with a serious cancer medication like this, I wouldn't add any new supplement on my own. Please run Chaga past your oncologist or pharmacist first so they can weigh in on your specific situation.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kim YO, Han SB, Lee HW, et al. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 2005;77(19):2438-56. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chaga Also Interacts With Other Medications

Chaga has 326 moderate known drug interactions in our database — the Pazopanib one above is among them. If you take anything else, check it against the full list below.

Moderate 326 No known interaction 2,504 (incl. Pazopanib)
Taking anything else?

Check Another of Your Medications Against Chaga

Covers the 2,830 medications we’ve checked against Chaga. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Pazopanib

This page covers Chaga only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pazopanib page lists 349 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Asarabacca (major) and Beer (major).

By severity: 14 major · 297 moderate · 38 minor.

From our pharmacist’s overview on the Pazopanib page

“Take a careful look before mixing supplements with pazopanib (Votrient), an oral pill for advanced kidney cancer and certain sarcomas. Fourteen of the 349 ingredients on file are rated major, grapefruit among them, since it can raise pazopanib levels enough to intensify side effects.”

Reviewed by 2 · Jul 18, 2026

Open the Pazopanib interaction page

One more smart check

Taking Chaga as Part of a Dietary Supplement Product? Check It for Interactions

We hold 889 real supplement products containing Chaga, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chaga. Your product may carry other ingredients that interact with Pazopanib too, on top of Chaga — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chaga and Pazopanib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chaga
Top 25%

#297 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pazopanib
Steady interest

#2,357 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chaga

What is Chaga?

  • Immune support
  • Antioxidant support
  • General wellness/tonic
  • Blood sugar support
  • Inflammation

Chaga is a fungus that grows mostly on birch trees and is used as a tea or supplement, mainly for immune and antioxidant support. Human evidence for its benefits is very limited, and it may raise some safety concerns such as effects on blood sugar, bleeding, and kidney stones. Talk with your pharmacist or doctor before using it, especially if you have a health condition or take other medicines.

Read the full Chaga monograph & all interactions
Medication

About Pazopanib

What Is Pazopanib Used For?

Brand name: Votrient

Pazopanib tablets — sold as the brand Votrient and as generic pazopanib — are used to treat two types of advanced cancer in adults: advanced renal cell carcinoma (RCC), the most common form of kidney cancer, and advanced soft tissue sarcoma (STS) in patients who have already received prior chemotherapy.

Important limitation: Pazopanib has not been shown to work in adipocytic soft tissue sarcoma (a subtype involving fat cells) or in gastrointestinal stromal tumors (GISTs), so it is not used for those cancers.

See full Pazopanib drug information
Keep checking

Other Drugs & Chaga

Browse every other medication we’ve checked against Chaga — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
326Moderate
0Minor
2,503No known interaction
326 Moderate 2,503 No interaction
Moderate

326 interactions

Showing 60 of 326 moderate interactions — see all 326 on the Chaga page.

No interaction 2,503 drugs checked — show the list

We also checked Chaga against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,503 medications checked with no known interaction — see the full Chaga list.

See the full Chaga interactions page
See every supplement checked against Pazopanib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chaga monograph › Uses, safety, and every drug interaction in one place Pazopanib supplement interactions › Every supplement checked against Pazopanib, ranked by severity Pazopanib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chaga and Pazopanib Together: Common Questions

Can you take Chaga with Pazopanib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Chaga and Pazopanib?
Pazopanib belongs to more than one drug category, and Chaga interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Chaga and Pazopanib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Pazopanib and Chaga?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.