Drug & supplement interaction

Smartweed + Ivacaftor, Lumacaftor

Ivacaftor, Lumacaftor brand name: Orkambi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Smartweed and Ivacaftor, Lumacaftor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Smartweed and Ivacaftor, Lumacaftor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ivacaftor, Lumacaftor and Smartweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Smartweed safety at a glance

Smartweed overall Use caution There is little modern safety data, so use cautiously and talk to a healthcare provider first.
Pregnancy Avoid Traditionally used to affect menstruation and the uterus, so avoid during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ivacaftor, Lumacaftor and Smartweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ivacaftor, Lumacaftor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ivacaftor, Lumacaftor is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inducers, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Smartweed has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Ivacaftor, Lumacaftor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Smartweed Does Interact With Other Medications

Smartweed has 2 moderate known drug interactions in our database — Ivacaftor, Lumacaftor isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Ivacaftor, Lumacaftor)
Taking anything else?

Check Another of Your Medications Against Smartweed

Covers the 2,830 medications we’ve checked against Smartweed. Pick one to open its full report.

What to actually watch for

What Ivacaftor, Lumacaftor’s Own FDA Label Lists

This is not an interaction — none of it involves Smartweed. These are the most notable effects listed in the ADVERSE REACTIONS section of Ivacaftor, Lumacaftor’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on
  • Severe muscle breakdown Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • A severe allergic reaction Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Bloating or gas

Showing the 10 most notable of 16 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ivacaftor, Lumacaftor. Read the label on DailyMed › Smartweed’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Smartweed side to compare — that is a limit of the record, not a statement that Smartweed has no side effects.

Everything else you take

See Every Supplement That Interacts With Ivacaftor, Lumacaftor

This page covers Smartweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ivacaftor, Lumacaftor page lists 153 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 110 moderate · 40 minor.

From our pharmacist’s overview on the Ivacaftor, Lumacaftor page

“Ivacaftor with lumacaftor (Orkambi) only works against cystic fibrosis if its blood level stays steady, and most of the supplements on this page can tug that level up or down through a shared liver pathway called CYP3A4. Grapefruit can push the level higher, St.”

Reviewed by 2 · Jul 18, 2026

Open the Ivacaftor, Lumacaftor interaction page

One more smart check

Taking Smartweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Smartweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Smartweed. Even though Smartweed itself has no known interaction with Ivacaftor, Lumacaftor, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Smartweed and Ivacaftor, Lumacaftor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Smartweed
Top half

#694 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ivacaftor, Lumacaftor
Top half

#1,080 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Smartweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Smartweed and Ivacaftor, Lumacaftor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Smartweed

What is Smartweed?

Smartweed
  • Digestive upset
  • Minor skin irritation
  • Heavy menstrual bleeding (traditional)
  • Wound and bleeding (traditional topical use)
  • Antioxidant and anti-inflammatory support

Smartweed (Persicaria hydropiper) is a peppery wetland plant with a long history in traditional medicine for digestive complaints, bleeding, and skin problems. Modern human studies are very limited, so its benefits are not well proven. Because safety data are thin, it's best to use cautiously and avoid it during pregnancy and breastfeeding.

Persicaria hydropiper · Polygonaceae · Aerial parts (leaves, stems, and flowering tops); sometimes the whole plant · Tea, tincture, liquid extract, dried herb, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Smartweed is a good idea for someone in your situation. Here is what our Smartweed record says about it on its own.

Smartweed: dosing

There is no well-established or standardized dose for smartweed. Because it has not been carefully studied in people, experts cannot recommend a safe and effective amount.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Smartweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Smartweed monograph & all interactions
Medication

About Lumacaftor and Ivacaftor

What Is Lumacaftor and Ivacaftor Used For?

Brand name: Orkambi

Orkambi is approved to treat cystic fibrosis (CF) in patients age 1 year and older who have two copies of the F508del mutation in the CFTR gene — one on each chromosome. This is called being homozygous for F508del. If a patient's genetic type is unknown, a lab test approved by the FDA should confirm the mutation before starting treatment.

Orkambi has not been proven safe or effective for people with CF who have a different mutation pattern. It is only for the F508del/F508del genotype.

See full Lumacaftor and Ivacaftor drug information
Keep checking

Other Drugs & Smartweed

Browse every other medication we’ve checked against Smartweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Smartweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Smartweed list.

See the full Smartweed interactions page
See every supplement checked against Ivacaftor, Lumacaftor, ranked by severity
Evidence & sources

Smartweed References

The 2 references that drive our Smartweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Smartweed and Ivacaftor, Lumacaftor Together: Common Questions

Is it safe to take Smartweed with Ivacaftor, Lumacaftor?
We do not list a known interaction between Smartweed and Ivacaftor, Lumacaftor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Smartweed and Ivacaftor, Lumacaftor combination checked?
Interactions in our licensed database are recorded against drug classes. Ivacaftor, Lumacaftor is filed under 3 classifications, and Smartweed has documented interactions with 1 drug class — none of Ivacaftor, Lumacaftor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Smartweed interact with any other medications?
Yes. Smartweed has 2 documented drug interactions in our database — Ivacaftor, Lumacaftor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ivacaftor, Lumacaftor interact with any supplements?
Yes. Ivacaftor, Lumacaftor has documented interactions with 153 supplements in our database — Smartweed is not one of them. The Ivacaftor, Lumacaftor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Smartweed monograph Uses, safety profile, and every drug interaction in one place Lumacaftor and Ivacaftor drug information The full plain-English guide to this medication Ivacaftor, Lumacaftor supplement interactions Every supplement checked against Ivacaftor, Lumacaftor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ivacaftor, Lumacaftor and Smartweed?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.