Medication interaction hub

What Supplements Interact with Ibuprofen lysine?

Ibuprofen lysine brand name: NeoProfen. Every interaction below applies to the brands too.

268 Interactions 6 Major 235 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ibuprofen lysine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ibuprofen lysine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ibuprofen lysine (NeoProfen) is an injectable form of the NSAID ibuprofen, and this list warrants real attention, starting with its six major entries. The dominant pattern is bleeding: 202 of the 268 ingredients on file can thin the blood or slow clotting, which stacks on an NSAID's own tendency to irritate the stomach and blunt platelets. Beer and wine sit among those majors, since alcohol plus an NSAID raises the odds of stomach bleeding.

Kidneys need protecting too. NSAIDs can stress them, and six herbs here carry kidney toxicity of their own, with Siberian cocklebur the worst rated. Another 64 ingredients slow the enzyme that clears ibuprofen, so more of it lingers in the body, and 20 can make skin extra sensitive to sun. The 235 moderate and 27 minor entries mostly call for watching for easy bruising or black, tarry stools rather than avoiding a product outright.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 235 Minor 27 No known interaction 1,184

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ibuprofen lysine: Top Interactions at a Glance

The Ibuprofen lysine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 268 interacting ingredients — plus 1,184 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ibuprofen lysine Combinations Today

The Ibuprofen lysine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Dimethylsulfoxide (dmso) + Ibuprofen lysinei

Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Possible Turkey Tail Mushroom + Ibuprofen lysinei

Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.

Read the full interaction Moderate Likelihood Possible Serrapeptase + Ibuprofen lysinei

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.

Read the full interaction Minor Likelihood Unlikely Tocotrienols + Ibuprofen lysinei

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Lycopene + Ibuprofen lysinei

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Jiaogulan + Ibuprofen lysinei

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Ibuprofen lysine

All 1,452 ingredients in our database, ranked by severity — 268 with a Ibuprofen lysine interaction on file and 1,184 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ibuprofen lysine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Dimethylsulfoxide (dmso) with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Dimethylsulfoxide (dmso) + Ibuprofen lysine answer

Can you take Turkey Tail Mushroom with Ibuprofen lysine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.

Full Turkey Tail Mushroom + Ibuprofen lysine answer

Can you take Serrapeptase with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleedi...

Full Serrapeptase + Ibuprofen lysine answer

Can you take Tocotrienols with Ibuprofen lysine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Tocotrienols + Ibuprofen lysine answer

Can you take Lycopene with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Lycopene + Ibuprofen lysine answer

Can you take Borage with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Borage + Ibuprofen lysine answer

Can you take Boswellia Serrata with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.

Full Boswellia Serrata + Ibuprofen lysine answer

Can you take Breadfruit with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Breadfruit + Ibuprofen lysine answer

Can you take Bromelain with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Ibuprofen lysine answer

Can you take Buchu with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu may have antiplatelet effects.

Full Buchu + Ibuprofen lysine answer

Can you take Bulbine Natalensis with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP2C9 substrates.

Full Bulbine Natalensis + Ibuprofen lysine answer

Can you take Bupleurum with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Bupleurum + Ibuprofen lysine answer

Can you take Burdock with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Burdock + Ibuprofen lysine answer

Can you take Caffeic Acid with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.

Full Caffeic Acid + Ibuprofen lysine answer

Can you take Caffeine with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Caffeine + Ibuprofen lysine answer

Can you take Canadian Fleabane with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Canadian fleabane might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.

Full Canadian Fleabane + Ibuprofen lysine answer

Can you take Cannabinol (cbn) with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabinol might increase the levels and clinical effects of CYP2C9 substrates.

Full Cannabinol (cbn) + Ibuprofen lysine answer

Can you take Cannabis with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might increase the levels and adverse effects of CYP2C9 substrates.

Full Cannabis + Ibuprofen lysine answer

Can you take Caprylic Acid with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.

Full Caprylic Acid + Ibuprofen lysine answer

Can you take Capsicum with Ibuprofen lysine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Capsicum + Ibuprofen lysine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ibuprofen lysine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ibuprofen lysine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ibuprofen lysine sits in 8 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

Ibuprofen (Advil, Others) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ibuprofen lysine through this category.

About Ibuprofen lysine

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches.

Generic name: Ibuprofen lysine  ·  Brand name: NeoProfen.

See the full Ibuprofen drug information

Related: does Ibuprofen lysine deplete any nutrients?

Ibuprofen lysine has 1 reported nutrient association in the research literature — see the Ibuprofen lysine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ibuprofen lysine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ibuprofen lysine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Ibuprofen lysine & Supplements: Common Questions

What supplements interact with Ibuprofen lysine?
More than you might expect — 268 in total, though they are far from equal: 6 are rated major, 235 moderate, and 27 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Beer, Danshen.
Which Ibuprofen lysine supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Beer, Danshen, Piracetam and Wine, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ibuprofen lysine?
Usually yes — most people on Ibuprofen lysine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like NeoProfen have the same supplement interactions as Ibuprofen lysine?
Yes — NeoProfen all contain Ibuprofen lysine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ibuprofen lysine deplete any vitamins or nutrients?
It might — Ibuprofen lysine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ibuprofen lysine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ibuprofen lysine and my other medications?
This page covers Ibuprofen lysine against supplements and herbal ingredients. Checking Ibuprofen lysine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ibuprofen drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.