Ibuprofen

302 interactions 942 cited references
Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen
About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal
4 Contraindicated 235 Major 63 Moderate
All (302) Contraindicated (4) Major (235) Moderate (63)

Contraindicated

Ibuprofen Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ibuprofen Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ibuprofen Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Ibuprofen Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Ibuprofen Amitriptyline Elavil An increased risk of bleeding Details Ibuprofen Sertraline An increased risk of bleeding Details Ibuprofen Apixaban Eliquis An increased risk of bleeding Details Ibuprofen Aspirin Acuprin® Decreased antiplatelet effect of aspirin, additive risk of bleeding, decreased renal function, and an increased risk of cardiovasc... Details Ibuprofen Aspirin Rectal Aspirin Decreased antiplatelet effect of aspirin, additive risk of bleeding, decreased renal function, and an increased risk of cardiovasc... Details Ibuprofen Betrixaban Bevyxxa® An increased risk of bleeding Details Ibuprofen Anagrelide Agrylin An increased risk of bleeding Details Ibuprofen Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Ibuprofen Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Ibuprofen Clopidogrel Plavix An increased risk of bleeding Details Ibuprofen Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Ibuprofen Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Ibuprofen Dabigatran Pradaxa® An increased risk of bleeding Details Ibuprofen Dabigatran Etexilate An increased risk of bleeding Details Ibuprofen Dalteparin Injection Fragmin An increased risk of bleeding Details Ibuprofen Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Ibuprofen Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Ibuprofen Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Ibuprofen Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Ibuprofen Dipyridamole Permole® An increased risk of bleeding Details Ibuprofen Edoxaban Savaysa An increased risk of bleeding Details Ibuprofen Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ibuprofen Enoxaparin Lovenox An increased risk of bleeding Details Ibuprofen Enoxaparin Injection Lovenox An increased risk of bleeding Details Ibuprofen Epoprostenol Flolan An increased risk of bleeding Details Ibuprofen Etodolac Lodine Increased risk of bleeding Details Ibuprofen Fenoprofen Fenopron Increased risk of bleeding Details Ibuprofen Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Ibuprofen Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Ibuprofen Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.