Ibuprofen

302 interactions 942 cited references
Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen
About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal
4 Contraindicated 235 Major 63 Moderate
All (302) Contraindicated (4) Major (235) Moderate (63)

Moderate

Ibuprofen Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Amikacin Injection Amikin® Increase amikacin exposure Details Ibuprofen Amikacin Oral Inhalation Arikayce Increase amikacin exposure Details Ibuprofen Atenolol Tenormin Reduced antihypertensive effect Details Ibuprofen Acebutolol Sectral® Reduced antihypertensive effect Details Ibuprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Ibuprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Ibuprofen Bisoprolol Zebeta® Reduced antihypertensive effect Details Ibuprofen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Ibuprofen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Esmolol Brevibloc Reduced antihypertensive effect Details Ibuprofen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Amikacin Increase amikacin exposure Details Ibuprofen Anisindione An increased risk of bleeding Details Ibuprofen Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Carteolol Reduced antihypertensive effect Details Ibuprofen Carvedilol Coreg Reduced antihypertensive effect Details Ibuprofen Celiprolol Reduced antihypertensive effect Details Ibuprofen Ciprofloxacin An increased risk of convulsions Details Ibuprofen Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Ibuprofen Dicumarol An increased risk of bleeding Details Ibuprofen Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Ginkgo An increased risk of bleeding Details Ibuprofen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Labetalol Normodyne® Reduced antihypertensive effect Details Ibuprofen Levobunolol Betagan Reduced antihypertensive effect Details Ibuprofen Levofloxacin Levaquin An increased risk of seizures Details Ibuprofen L-Methylfolate Decreased l-methylfolate efficacy Details Ibuprofen Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Ma Huang Increased risk of developing gastric mucosal lesions Details Ibuprofen Mavacamten Camzyos Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Ibuprofen Metipranolol Reduced antihypertensive effect Details Ibuprofen Metoprolol Kapspargo Reduced antihypertensive effect Details Ibuprofen Mifepristone Korlym Increased NSAID exposure Details Ibuprofen Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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