Drug & supplement interaction

Alpha-lipoic Acid + Ibuprofen

Ibuprofen brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Alpha-lipoic Acid has a moderate interaction with Ibuprofen. Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Alpha-lipoic Acid and Ibuprofen

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Ibuprofen

Ibuprofen falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Alpha-lipoic Acid interacts with.

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: ibuprofen already nudges your blood toward bleeding more easily because it dampens platelets, the tiny cells that help you clot. Alpha-lipoic acid may do a little of the same thing. So stacking the two could, in theory, add up to a slightly higher chance of things like bruising, nosebleeds, or stomach irritation and bleeding (something ibuprofen can cause on its own).

I want to be honest about the evidence, though. This concern comes only from lab (test tube) studies, not from real people taking them together. For most folks using occasional ibuprofen, it's likely a minor issue. Still, if you take ibuprofen often, are on a blood thinner, or notice unusual bruising or bleeding, check in with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Alpha-lipoic Acid Also Interacts With Other Medications

Alpha-lipoic Acid has 176 moderate, 86 minor known drug interactions in our database — the Ibuprofen one above is one of them. If you take anything else, check it against the full list below.

Moderate 176 Minor 86 No known interaction 2,568 (incl. Ibuprofen)
Taking anything else?

Check Another of Your Medications Against Alpha-lipoic Acid

Covers the 2,830 medications we’ve checked against Alpha-lipoic Acid. Pick one to open its full report.

From our Q&A

Questions About Alpha-lipoic Acid or Ibuprofen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Alpha-lipoic Acid or Ibuprofen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ibuprofen

This page covers Alpha-lipoic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen page lists 286 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 243 moderate · 36 minor.

From our pharmacist’s overview on the Ibuprofen page

“Most people treat ibuprofen (Advil, Motrin) as an everyday pain reliever, which is exactly why this list of 286 interacting supplements deserves real attention rather than a shrug. The dominant pattern by far is bleeding: 202 of these ingredients can add to the bleeding and stomach irritation ibuprofen already causes, and the seven maj…”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen interaction page

One more smart check

Taking Alpha-lipoic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,223 real supplement products containing Alpha-lipoic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Alpha-lipoic Acid. Your product may carry other ingredients that interact with Ibuprofen too, on top of Alpha-lipoic Acid — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Alpha-lipoic Acid and Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-lipoic Acid
Top 5%

#34 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen
Top 1%

#19 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Alpha-lipoic Acid

What is Alpha-lipoic Acid?

Alpha-lipoic Acid
  • Diabetic nerve pain (neuropathy)
  • Blood sugar support in diabetes
  • Antioxidant support
  • Liver health
  • Skin aging (topical and oral)

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help, but evidence for most other uses is limited. It is generally well tolerated, but talk to your pharmacist or doctor before using it, especially if you have diabetes or thyroid problems.

Read the full Alpha-lipoic Acid monograph & all interactions
Medication

About Ibuprofen

What Is Ibuprofen Used For?

Brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, Ibugel Forte, Arthrofen, Ebufac, Rimafen, Calprofen, Fenpaed, Galprofen, Nurofen for Children, Orbifen for Children, Brufen, Brufen Retard, Fenbid, Tab-Profen, Ibuprofen, Calodor

Oral ibuprofen products (tablets, coated tablets, and liquid-filled capsules) are used to temporarily relieve minor aches and pains from headache, backache, toothache, muscular aches, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever. The oral prescription tablet (Ibu) is also indicated for the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea (painful periods).

Caldolor, an intravenous (IV) form, is approved for adults and children 3 months and older to manage mild to moderate pain, to manage moderate to severe pain alongside opioid pain medicines, and to reduce fever. A separate intravenous solution, Ibuprofen Lysine, is used specifically in premature infants to close a patent ductus arteriosus (PDA) — an abnormal blood vessel connection near the heart — when standard medical management has not worked.

See full Ibuprofen drug information
Keep checking

Other Drugs & Alpha-lipoic Acid

Browse every other medication we’ve checked against Alpha-lipoic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
176Moderate
86Minor
2,567No known interaction
176 Moderate 86 Minor 2,567 No interaction
Moderate

176 interactions

Showing 60 of 176 moderate interactions — see all 176 on the Alpha-lipoic Acid page.

Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Alpha-lipoic Acid page.

No interaction 2,567 drugs checked — show the list

We also checked Alpha-lipoic Acid against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,567 medications checked with no known interaction — see the full Alpha-lipoic Acid list.

See the full Alpha-lipoic Acid interactions page
See every supplement checked against Ibuprofen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Alpha-lipoic Acid monograph › Uses, safety, and every drug interaction in one place Ibuprofen supplement interactions › Every supplement checked against Ibuprofen, ranked by severity Ibuprofen drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Alpha-lipoic Acid and Ibuprofen Together: Common Questions

Can you take Alpha-lipoic Acid with Ibuprofen?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Alpha-lipoic Acid and Ibuprofen interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ibuprofen and Alpha-lipoic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.