Medication interaction hub

What Supplements Interact with Indomethacin?

Indomethacin brand names: Indocin, Indocin SR, Indo-Lemmon, Indomethagan, Tivorbex. Every interaction below applies to the brands too.

100 Interactions 5 Major 68 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Indomethacin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Indomethacin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

100 supplements and herbal ingredients have interactions with Indomethacin on file in the HelloPharmacist interaction database — 5 rated major, 68 moderate, and 27 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer, Wine and Asarabacca.

Our assessment: with 5 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Indomethacin.

Major 5 Moderate 68 Minor 27 No known interaction 1,352

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Indomethacin: Top Interactions at a Glance

The Indomethacin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 100 interacting ingredients — plus 1,352 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Indomethacin Combinations Today

The Indomethacin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Indomethacini

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Wine + Indomethacini

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Read the full interaction Moderate Likelihood Possible Feverfew + Indomethacini

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.

Read the full interaction Minor Likelihood Unlikely Soy + Indomethacini

Soy might modestly induce CYP2C9 enzymes.

Read the full interaction Moderate Likelihood Possible German Chamomile + Indomethacini

Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.

Read the full interaction Moderate Likelihood Possible Kava + Indomethacini

Theoretically, kava might increase levels of CYP2C9 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Indomethacin

All 1,452 ingredients in our database, ranked by severity — 100 with a Indomethacin interaction on file and 1,352 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Indomethacin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Activated Charcoal with Indomethacin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Indomethacin answer

Can you take Wine with Indomethacin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Wine + Indomethacin answer

Can you take Feverfew with Indomethacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.

Full Feverfew + Indomethacin answer

Can you take Soy with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Soy might modestly induce CYP2C9 enzymes.

Full Soy + Indomethacin answer

Can you take German Chamomile with Indomethacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Indomethacin answer

Can you take Tinospora Cordifolia with Indomethacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.

Full Tinospora Cordifolia + Indomethacin answer

Can you take Tragacanth with Indomethacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Indomethacin answer

Can you take Tree Turmeric with Indomethacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.

Full Tree Turmeric + Indomethacin answer

Can you take Vinpocetine with Indomethacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vinpocetine might increase levels of drugs metabolized by CYP2C9.

Full Vinpocetine + Indomethacin answer

Can you take Thyroid Extract with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Indomethacin answer

Can you take Agar with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Indomethacin answer

Can you take Algin with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Indomethacin answer

Can you take Alpinia with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, alpinia might reduce the levels and clinical effects of indomethacin.

Full Alpinia + Indomethacin answer

Can you take Black Psyllium with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Indomethacin answer

Can you take Blond Psyllium with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Indomethacin answer

Can you take Carob with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Indomethacin answer

Can you take Chromium with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. NSAIDs might increase chromium levels in the body.

Full Chromium + Indomethacin answer

Can you take Evening Primrose with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, evening primrose may increase the levels and clinical effects of CYP2C9 substrates.

Full Evening Primrose + Indomethacin answer

Can you take Fucus Vesiculosus with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2C9 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Indomethacin answer

Can you take Genistein Combined Polysaccharide with Indomethacin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some evidence suggests that genistein can alter the pharmacokinetics of CYP2C9 substrates and should be used cautiously with them.

Full Genistein Combined Polysaccharide + Indomethacin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Indomethacin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Indomethacin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Indomethacin sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Indomethacin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Indomethacin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Indomethacin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Indomethacin through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Indomethacin through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Indomethacin through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Indomethacin through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Indomethacin through this category.

Indomethacin (Tivorbex) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Indomethacin through this category.

About Indomethacin

Indomethacin is an NSAID used to relieve pain, swelling, and stiffness from arthritis and other inflammatory joint conditions.

Generic name: Indomethacin  ·  Brand names: Indocin, Indocin SR, Indo-Lemmon, Indomethagan, Tivorbex.

See the full Indomethacin drug information

Related: does Indomethacin deplete any nutrients?

Indomethacin has 5 reported nutrient associations in the research literature — see the Indomethacin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Indomethacin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Indomethacin.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Indomethacin-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Indomethacin.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur Super S.G. by Princess Lifestyle contains Asarabacca Wild Ginger by Hawaii Pharm contains Asarabacca
Pharmacist Counseling Corner

Indomethacin & Supplements: Common Questions

What supplements interact with Indomethacin?
In our interaction database, 100 supplement and herbal ingredients have an interaction with Indomethacin on file — 5 rated major, 68 moderate, and 27 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Indomethacin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer, Wine and Asarabacca. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Indomethacin?
That depends entirely on which supplement. The honest answer for Indomethacin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Indocin have the same supplement interactions as Indomethacin?
Yes — Indocin, Indocin SR, Indo-Lemmon, Indomethagan, Tivorbex all contain Indomethacin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Indomethacin deplete any vitamins or nutrients?
It might — Indomethacin has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Indomethacin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Indomethacin and my other medications?
This page covers Indomethacin against supplements and herbal ingredients. Checking Indomethacin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Indomethacin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.