Indomethacin

95 interactions 5 explained in plain English
Also sold as: Indocin Indocin® Tivorbex Tivorbex®
About Indomethacin

Indomethacin is an NSAID used to relieve pain, swelling, and stiffness from arthritis and other inflammatory joint conditions. Read the full Indomethacin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Injection Ketorolac Nasal Spray Ketorolac Epoprostenol Pemetrexed Injection
4 Contraindicated 55 Major 34 Moderate 2 Minor
All (95) Contraindicated (4) Major (55) Moderate (34) Minor (2)

Contraindicated

Indomethacin Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Indomethacin Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Indomethacin Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Indomethacin Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Indomethacin Amitriptyline Elavil Explained An increased risk of bleeding Details Indomethacin Sertraline Explained An increased risk of bleeding Details Indomethacin Apixaban Eliquis Explained An increased risk of bleeding Details Indomethacin Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Indomethacin Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Indomethacin Azathioprine Azasan An increased risk of hepatotoxicity Details Indomethacin Betrixaban Bevyxxa® An increased risk of bleeding Details Indomethacin Anagrelide Agrylin An increased risk of bleeding Details Indomethacin Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Indomethacin Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Indomethacin Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Indomethacin Clopidogrel Plavix An increased risk of bleeding Details Indomethacin Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Indomethacin Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Indomethacin Dabigatran Pradaxa® An increased risk of bleeding Details Indomethacin Dabigatran Etexilate An increased risk of bleeding Details Indomethacin Dalteparin Injection Fragmin An increased risk of bleeding Details Indomethacin Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Indomethacin Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Indomethacin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Indomethacin Digoxin Cardoxin® Increased digoxin exposure Details Indomethacin Dipyridamole Permole® An increased risk of bleeding Details Indomethacin Edoxaban Savaysa An increased risk of bleeding Details Indomethacin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Indomethacin Enoxaparin Lovenox An increased risk of bleeding Details Indomethacin Enoxaparin Injection Lovenox An increased risk of bleeding Details Indomethacin Epoprostenol Flolan An increased risk of bleeding Details Indomethacin Fondaparinux Arixtra An increased risk of bleeding Details Indomethacin Fondaparinux Injection Arixtra An increased risk of bleeding Details Indomethacin Furosemide Injection Disal Increased risk of acute renal failure and decreased antihypertensive and diuretic efficacy Details Indomethacin Glucagon Injection Baqsimi Decreased glucagon efficacy and increased risk of hypoglycemia Details Indomethacin Glucagon Injection / Solution Baqsimi Decreased glucagon efficacy and increased risk of hypoglycemia Details Indomethacin Glucagon Nasal Powder Baqsimi Decreased glucagon efficacy and increased risk of hypoglycemia Details Indomethacin Heparin An increased risk of bleeding Details Indomethacin Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Indomethacin Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.