Indomethacin

Name: Indomethacin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

95 interactions 5 explained in plain English

Also sold as: Indocin Indocin® Tivorbex Tivorbex®

About Indomethacin

Indomethacin is an NSAID used to relieve pain, swelling, and stiffness from arthritis and other inflammatory joint conditions. Read the full Indomethacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Injection Ketorolac Nasal Spray Ketorolac Epoprostenol Pemetrexed Injection

4 Contraindicated 55 Major 34 Moderate 2 Minor

All (95) Contraindicated (4) Major (55) Moderate (34) Minor (2)

Minor

Indomethacin Cyclophosphamide Cytoxan® Fluid retention Details Indomethacin Cyclophosphamide Injection Cytoxan® Injection Fluid retention Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.