Indomethacin

95 interactions 5 explained in plain English

Also sold as: Indocin Indocin® Tivorbex Tivorbex®

About Indomethacin

Indomethacin is an NSAID used to relieve pain, swelling, and stiffness from arthritis and other inflammatory joint conditions. Read the full Indomethacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Injection Ketorolac Nasal Spray Ketorolac Epoprostenol Pemetrexed Injection

4 Contraindicated 55 Major 34 Moderate 2 Minor

All (95) Contraindicated (4) Major (55) Moderate (34) Minor (2)

Moderate

Indomethacin Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Amikacin Injection Amikin® Amikacin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Amikacin Oral Inhalation Arikayce Amikacin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Atenolol Tenormin Explained Reduced antihypertensive effect Details Indomethacin Acebutolol Sectral® Reduced antihypertensive effect Details Indomethacin Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Betaxolol Betoptic S Reduced antihypertensive effect Details Indomethacin Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Indomethacin Bisoprolol Zebeta® Reduced antihypertensive effect Details Indomethacin Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Indomethacin Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Esmolol Brevibloc Reduced antihypertensive effect Details Indomethacin Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Gentamicin Injection Garamycin® I.V. Gentamicin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Gentamicin Ophthalmic Garamycin® Ophthalmic Gentamicin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Gentamicin Topical Garamycin® Gentamicin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Hydralazine Apresoline® Decreased hydrALAZINE effectiveness Details Indomethacin Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Labetalol Normodyne® Reduced antihypertensive effect Details Indomethacin Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Indomethacin Levofloxacin Levaquin An increased risk of seizures Details Indomethacin Levofloxacin Injection Levaquin An increased risk of seizures Details Indomethacin Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Nadolol Corgard Reduced antihypertensive effect Details Indomethacin Nebivolol Bystolic Reduced antihypertensive effect Details Indomethacin Ofloxacin Floxin® An increased risk of seizures Details Indomethacin Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Indomethacin Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Indomethacin Penbutolol Levatol® Reduced antihypertensive effect Details Indomethacin Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.