Indomethacin
95 interactions 5 explained in plain EnglishIndomethacin is an NSAID used to relieve pain, swelling, and stiffness from arthritis and other inflammatory joint conditions. Read the full Indomethacin drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Indomethacin Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Indomethacin Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Indomethacin Iloprost Aurlumyn An increased risk of bleeding Details Indomethacin Ketoprofen Actron® Increased risk of bleeding Details Indomethacin Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Indomethacin Meclofenamate Meclodium® Increased risk of bleeding Details Indomethacin Mefenamic Acid Ponstel® Increased risk of bleeding Details Indomethacin Meloxicam Alloxate Increased risk of bleeding Details Indomethacin Meloxicam Injection Alloxate Increased risk of bleeding Details Indomethacin Melphalan Alkeran An increased risk of bleeding Details Indomethacin Melphalan Injection Alkeran An increased risk of bleeding Details Indomethacin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Indomethacin Mesalamine Apriso Increased risk of bleeding Details Indomethacin Mesalamine Rectal Canasa Increased risk of bleeding Details Indomethacin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Indomethacin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Indomethacin Nabumetone Relafen Increased risk of bleeding Details Indomethacin Naproxen Aleve Increased risk of bleeding Details Indomethacin Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... DetailsModerate
Indomethacin Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Amikacin Injection Amikin® Amikacin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Amikacin Oral Inhalation Arikayce Amikacin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Atenolol Tenormin Explained Reduced antihypertensive effect Details Indomethacin Acebutolol Sectral® Reduced antihypertensive effect Details Indomethacin Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Betaxolol Betoptic S Reduced antihypertensive effect Details Indomethacin Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Indomethacin Bisoprolol Zebeta® Reduced antihypertensive effect Details Indomethacin Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Indomethacin Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Esmolol Brevibloc Reduced antihypertensive effect Details Indomethacin Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Gentamicin Injection Garamycin® I.V. Gentamicin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Gentamicin Ophthalmic Garamycin® Ophthalmic Gentamicin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Gentamicin Topical Garamycin® Gentamicin toxicity (renal dysfunction, ototoxicity) Details Indomethacin Hydralazine Apresoline® Decreased hydrALAZINE effectiveness Details Indomethacin Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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