Indomethacin

Name: Indomethacin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

95 interactions 5 explained in plain English

Also sold as: Indocin Indocin® Tivorbex Tivorbex®

About Indomethacin

Indomethacin is an NSAID used to relieve pain, swelling, and stiffness from arthritis and other inflammatory joint conditions. Read the full Indomethacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Injection Ketorolac Nasal Spray Ketorolac Epoprostenol Pemetrexed Injection

4 Contraindicated 55 Major 34 Moderate 2 Minor

All (95) Contraindicated (4) Major (55) Moderate (34) Minor (2)

Moderate

Indomethacin Labetalol Normodyne® Reduced antihypertensive effect Details Indomethacin Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Indomethacin Levofloxacin Levaquin An increased risk of seizures Details Indomethacin Levofloxacin Injection Levaquin An increased risk of seizures Details Indomethacin Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Indomethacin Nadolol Corgard Reduced antihypertensive effect Details Indomethacin Nebivolol Bystolic Reduced antihypertensive effect Details Indomethacin Ofloxacin Floxin® An increased risk of seizures Details Indomethacin Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Indomethacin Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Indomethacin Penbutolol Levatol® Reduced antihypertensive effect Details Indomethacin Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

Minor

Indomethacin Cyclophosphamide Cytoxan® Fluid retention Details Indomethacin Cyclophosphamide Injection Cytoxan® Injection Fluid retention Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.