Cannabichromene (cbc) - Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride Interaction
Herbal: Cannabichromene (cbc)
Also Known As: Cannabichrome, Pentylcannabichromene, Cannabinochromene
Drug: Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride
Brand names:
Hycofenix

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride is classified as belonging to the following category: Cns Depressants
Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.
Animal research shows that cannabichromene, given as a single dose intraperitoneally, increases the sedative response to the drugs hexobarbital, barbital, and zoxazolamine. However, this effect was not maintained when cannabichromene was given continuously. After receiving cannabichromene daily for 7 days, the sedative effect of these drugs was reduced when compared with a control group or a single dose of cannabichromene.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Hatoum NS, Davis WM, Waters IW, Elsohly MA, Turner CE. Synergism of cannabichromene and CNS depressants in mice. Gen Pharmacol. 1981;12(5):351-6.
Cannabichromene (cbc) Overview

Cannabichromene (cbc) - More Interactions
Cannabichromene (cbc) interacts with 247 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.