Eastern Red Cedar - Hexobarbitone Interaction
Herbal: Eastern Red Cedar
Drug: Hexobarbitone
Brand names:
Cyclonal, Evipan

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Hexobarbitone is classified as belonging to the following category: Barbiturates
In mice and rats given hexobarbital or pentobarbital, sleep time is reduced and metabolism of the drug is increased when they inhale essential oil vapor from Eastern red cedar wood chips in their bedding. Cedrol and cedrene in the essential oil are reported to induce liver microsomal enzymes. Theoretically, inhaling Eastern red cedar wood fragrance might reduce the efficacy of hexobarbital or pentobarbital in humans.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
References
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Johnson W. Final report on the safety assessment of Juniperus communis Extract, Juniperus oxycedrus Extract, Juniperus oxycedrus Tar, Juniperus phoenicea extract, and Juniperus virginiana Extract. Int J Toxicol 2001;20 Suppl 2:41-56.
Eastern Red Cedar - More Interactions
Eastern Red Cedar interacts with 49 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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