Drug & supplement interaction

Cannabinol (cbn) + Quinupristin, Dalfopristin

Quinupristin, Dalfopristin brand name: Synercid.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Cannabinol (cbn) has a moderate interaction with Quinupristin, Dalfopristin. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cannabinol (cbn) and Quinupristin, Dalfopristin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) INHIBITORS

Why this applies to Quinupristin, Dalfopristin

Quinupristin, Dalfopristin falls under CYTOCHROME P450 3A4 (CYP3A4) INHIBITORS — the group Cannabinol (cbn) interacts with.

Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.
In vitro research shows that CYP3A4 enzymes are involved in the 8-hydroxylation of cannabinol. So far, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Synercid (quinupristin/dalfopristin) is an IV antibiotic that happens to slow down a liver enzyme called CYP3A4. As it turns out, that same enzyme helps break down CBN. So if you used CBN while getting this antibiotic, the CBN could clear out of your body more slowly and build up a bit. In plain terms, you might feel more of whatever CBN does to you, things like extra drowsiness or grogginess, especially since people often take it for sleep.

I want to be honest about how soft this evidence is. It comes only from lab (test tube) studies, and it has never actually been reported in people. So I wouldn't lose sleep over it, but since Synercid is given for a serious infection, please run any CBN use past your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80(15):1415-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cannabinol (cbn) Also Interacts With Other Medications

Cannabinol (cbn) has 389 moderate known drug interactions in our database — the Quinupristin, Dalfopristin one above is one of them. If you take anything else, check it against the full list below.

Moderate 389 No known interaction 2,441 (incl. Quinupristin, Dalfopristin)
Taking anything else?

Check Another of Your Medications Against Cannabinol (cbn)

Covers the 2,830 medications we’ve checked against Cannabinol (cbn). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Quinupristin, Dalfopristin

This page covers Cannabinol (cbn) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Quinupristin, Dalfopristin page lists 40 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Adrafinil (moderate), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate) and Bifidobacterium Bifidum (moderate).

By severity: 38 moderate · 2 minor.

From our pharmacist’s overview on the Quinupristin, Dalfopristin page

“Quinupristin and dalfopristin (Synercid) is an intravenous antibiotic reserved for serious, often resistant infections, so it is usually given under close medical supervision. Even so, 40 supplement and herbal ingredients are on file as interacting with it, and none rises above moderate (38 moderate, 2 minor).”

Reviewed by 2 · Jul 18, 2026

Open the Quinupristin, Dalfopristin interaction page

How much people look this up

Where Cannabinol (cbn) and Quinupristin, Dalfopristin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabinol (cbn)
Steady interest

#987 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Quinupristin, Dalfopristin
Top 5%

#94 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cannabinol (cbn)

What is Cannabinol (cbn)?

  • Sleep support
  • Relaxation
  • Pain or discomfort
  • Appetite-related concerns

Cannabinol (CBN) is a minor cannabinoid found in the cannabis plant, often marketed as a 'sleep' aid, but solid human research is very limited. Because it comes from cannabis and product quality varies widely, talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Read the full Cannabinol (cbn) monograph & all interactions
Medication

About Quinupristin and Dalfopristin Injection

What Is Quinupristin and Dalfopristin Injection Used For?

Brand name: Synercid

  • The combination of quinupristin and dalfopristin injection is used to prevent and treat certain serious skin infections. Quinupristin and dalfopristin are in a class of medications called streptogramin antibiotics. They work by killing bacteria that cause infections.

  • Antibiotics such as quinupristin and dalfopristin injection will not work for colds, flu, or other viral infections. Taking or using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

See full Quinupristin and Dalfopristin Injection drug information
Keep checking

Other Drugs & Cannabinol (cbn)

Browse every other medication we’ve checked against Cannabinol (cbn) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
389Moderate
0Minor
2,440No known interaction
389 Moderate 2,440 No interaction
Moderate

389 interactions

Showing 60 of 389 moderate interactions — see all 389 on the Cannabinol (cbn) page.

No interaction 2,440 drugs checked — show the list

We also checked Cannabinol (cbn) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,440 medications checked with no known interaction — see the full Cannabinol (cbn) list.

See the full Cannabinol (cbn) interactions page
See every supplement checked against Quinupristin, Dalfopristin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cannabinol (cbn) monograph › Uses, safety, and every drug interaction in one place Quinupristin, Dalfopristin supplement interactions › Every supplement checked against Quinupristin, Dalfopristin, ranked by severity Quinupristin and Dalfopristin Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cannabinol (cbn) and Quinupristin, Dalfopristin Together: Common Questions

Can you take Cannabinol (cbn) with Quinupristin, Dalfopristin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cannabinol (cbn) and Quinupristin, Dalfopristin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Quinupristin, Dalfopristin and Cannabinol (cbn)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.