Drug & supplement interaction

Cannabinol (cbn) + Asciminib

Asciminib brand name: Scemblix.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Asciminib falls into 2 drug categories that Cannabinol (cbn) can interact with; the most serious is rated moderate. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Cannabinol (cbn) and Asciminib

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Cannabinol (cbn) interacts with whole categories of medication. Asciminib falls into 2 of those categories, so it can interact with Cannabinol (cbn) in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 3A4 (CYP3A4) INHIBITORS

1 of 2

Why this applies to Asciminib

Asciminib falls under CYTOCHROME P450 3A4 (CYP3A4) INHIBITORS — the group Cannabinol (cbn) interacts with.

Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.
In vitro research shows that CYP3A4 enzymes are involved in the 8-hydroxylation of cannabinol. So far, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the key thing to understand about this pairing: the concern runs from your leukemia medicine toward the supplement, not the other way around. Asciminib (Scemblix) can mildly block an enzyme called CYP3A4, and lab studies suggest that same enzyme helps your body break down CBN. So in theory, taking them together could let CBN build up a bit, making its effects (like extra drowsiness or grogginess) stronger than expected.

I want to be honest about the evidence here: this is based only on test-tube research and has never actually been reported in real people, so it's more of a theoretical heads-up than a proven problem. Still, because CBN comes from cannabis and product quality varies a lot, please check with your oncologist or pharmacist before adding it while you're on Asciminib.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80(15):1415-9. PubMed
Moderate

CYTOCHROME P450 2C9 (CYP2C9) INHIBITORS

2 of 2

Asciminib also falls under CYTOCHROME P450 2C9 (CYP2C9) INHIBITORS.

Theoretically, CYP2C9 inhibitors might increase the levels and clinical effects of cannabinol.
In vitro research shows that CYP2C9 enzymes are involved in the 11-hydroxylation of cannabinol. So far, this interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep straight: in this pairing, it's your asciminib (Scemblix) that could affect the CBN, not the other way around. Lab studies suggest the CYP2C9 enzyme helps break down CBN, and asciminib can mildly block that enzyme. So in theory, asciminib might slow CBN's breakdown a little, letting it build up and feel stronger. That could mean more drowsiness, grogginess, or dizziness from the CBN.

I want to be honest about how soft this evidence is. It comes only from test-tube research and has never been reported in real people, so it's mostly theoretical. Still, since CBN products vary so much and you're on a serious leukemia therapy, please run it by your oncologist or pharmacist before adding CBN.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80(15):1415-9. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cannabinol (cbn) Also Interacts With Other Medications

Cannabinol (cbn) has 388 moderate known drug interactions in our database — the Asciminib one above is among them. If you take anything else, check it against the full list below.

Moderate 388 No known interaction 2,442 (incl. Asciminib)
Taking anything else?

Check Another of Your Medications Against Cannabinol (cbn)

Covers the 2,830 medications we’ve checked against Cannabinol (cbn). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Asciminib

This page covers Cannabinol (cbn) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Asciminib page lists 31 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Cannabidiol (cbd) (moderate), Cannabis (moderate) and Coffee Charcoal (moderate).

By severity: 1 major · 20 moderate · 10 minor.

From our pharmacist’s overview on the Asciminib page

“Asciminib (Scemblix) treats chronic myeloid leukemia, and a steady blood level is what keeps the cancer suppressed, so this list deserves real care rather than a quick skim. Seventeen of the 31 supplements on file are fibers, gums, and charcoals that can block or slow how much of each pill your gut actually absorbs.”

Reviewed by 2 · Jul 18, 2026

Open the Asciminib interaction page

How much people look this up

Where Cannabinol (cbn) and Asciminib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabinol (cbn)
Top half

#606 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Asciminib
Top half

#981 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cannabinol (cbn)

What is Cannabinol (cbn)?

  • Sleep support
  • Relaxation
  • Pain or discomfort
  • Appetite-related concerns

Cannabinol (CBN) is a minor cannabinoid found in the cannabis plant, often marketed as a 'sleep' aid, but solid human research is very limited. Because it comes from cannabis and product quality varies widely, talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Read the full Cannabinol (cbn) monograph & all interactions
Medication

About Asciminib

What Is Asciminib Used For?

Brand name: Scemblix

Scemblix (asciminib) is used to treat adult patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP) — a type of blood cancer driven by an abnormal protein called BCR-ABL1. It covers three groups: people newly diagnosed with Ph+ CML-CP, people who have already been treated for Ph+ CML-CP, and people whose cancer carries a specific mutation called T315I that makes it harder to treat.

The use in newly diagnosed Ph+ CML-CP was approved under accelerated approval based on early response data. Continued approval for that specific use may depend on results from confirmatory trials confirming long-term clinical benefit.

See full Asciminib drug information
Keep checking

Other Drugs & Cannabinol (cbn)

Browse every other medication we’ve checked against Cannabinol (cbn) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
388Moderate
0Minor
2,441No known interaction
388 Moderate 2,441 No interaction
Moderate

388 interactions

Showing 60 of 388 moderate interactions — see all 388 on the Cannabinol (cbn) page.

No interaction 2,441 drugs checked — show the list

We also checked Cannabinol (cbn) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,441 medications checked with no known interaction — see the full Cannabinol (cbn) list.

See the full Cannabinol (cbn) interactions page
See every supplement checked against Asciminib, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cannabinol (cbn) monograph › Uses, safety, and every drug interaction in one place Asciminib supplement interactions › Every supplement checked against Asciminib, ranked by severity Asciminib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cannabinol (cbn) and Asciminib Together: Common Questions

Can you take Cannabinol (cbn) with Asciminib?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Cannabinol (cbn) and Asciminib?
Asciminib belongs to more than one drug category, and Cannabinol (cbn) interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Cannabinol (cbn) and Asciminib interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Asciminib and Cannabinol (cbn)?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.