Drug & supplement interaction

Cannabinol (cbn) + Allopurinol

Allopurinol brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cannabinol (cbn) and Allopurinol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cannabinol (cbn) and Allopurinol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Allopurinol and Cannabinol (cbn) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cannabinol (cbn) safety at a glance

Cannabinol (cbn) overall Use caution CBN is generally considered mild, but human safety data are limited and product quality varies.
Pregnancy Avoid Cannabis-derived compounds are not considered safe in pregnancy, so avoid CBN.
Breastfeeding Avoid Cannabinoids can pass into breast milk, so avoid CBN while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Allopurinol and Cannabinol (cbn)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Allopurinol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Allopurinol is filed under 5 classifications — including antigout drugs, nephrotoxic drugs, hepatotoxic drugs. Cannabinol (cbn) has documented interactions with 5 drug classes — the most serious being cytochrome p450 2b6 (cyp2b6) substrates (moderate), cytochrome p450 2c9 (cyp2c9) inhibitors (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (moderate) — and none of Allopurinol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cannabinol (cbn) Does Interact With Other Medications

Cannabinol (cbn) has 389 moderate known drug interactions in our database — Allopurinol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 389 No known interaction 2,441 (incl. Allopurinol)
Taking anything else?

Check Another of Your Medications Against Cannabinol (cbn)

Covers the 2,830 medications we’ve checked against Cannabinol (cbn). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cannabinol (cbn) and Allopurinol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Drowsiness / Headache Additional detail

    Cannabinol (cbn)

    “Orally, cannabinol may cause headache and somnolence.”

    Cannabinol (cbn) · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 113055. Bonn-Miller MO, Feldner MT, Bynion TM, Eglit GML, Brunstetter M, Kalaba M, Zvorsky I, Peters EN, Hennesy M. A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality. Exp Clin Psychopharmac PubMed

    Allopurinol

    Listed in the ADVERSE REACTIONS section of the FDA label for Allopurinol. Read the label on DailyMed ›

Effects for Allopurinol come from the ADVERSE REACTIONS section of its FDA label; effects for Cannabinol (cbn) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Allopurinol

This page covers Cannabinol (cbn) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Allopurinol page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 45 moderate · 10 minor.

From our pharmacist’s overview on the Allopurinol page

“Allopurinol (Zyloprim) prevents gout attacks by lowering uric acid, and I would give this list real weight, because 5 of the 60 supplements and herbs on file carry a major rating. The largest cluster, 38 ingredients, is products that can stress the liver on their own, and regular beer or wine sits in that major group, since alcohol on…”

Reviewed by 2 · Jul 18, 2026

Open the Allopurinol interaction page

How much people look this up

Where Cannabinol (cbn) and Allopurinol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cannabinol (cbn)
Top half

#535 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Allopurinol
Top half

#839 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cannabinol (cbn) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cannabinol (cbn) and Allopurinol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cannabinol (cbn)

What is Cannabinol (cbn)?

  • Sleep support
  • Relaxation
  • Pain or discomfort
  • Appetite-related concerns

Cannabinol (CBN) is a minor cannabinoid found in the cannabis plant, often marketed as a 'sleep' aid, but solid human research is very limited. Because it comes from cannabis and product quality varies widely, talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.

Cannabaceae · Aged cannabis flower and resin (where THC degrades into CBN) · Oils and tinctures, gummies, capsules, vape products, topicals

An interaction check asks whether these two react with each other — it does not ask whether Cannabinol (cbn) is a good idea for someone in your situation. Here is what our Cannabinol (cbn) record says about it on its own.

Cannabinol (cbn): dosing

There is no established, standardized dose for CBN. Research is too limited to recommend a specific milligram amount, and products vary widely in strength and quality.If you choose to try a CBN product, follow the directions on the label and start with the lowest amount.

From our Cannabinol (cbn) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cannabinol (cbn) monograph & all interactions
Medication

About Allopurinol

What Is Allopurinol Used For?

Brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric

Allopurinol tablets (including Zyloprim) are used in adults to treat the signs and symptoms of gout — including gout attacks, tophi (uric acid deposits), joint damage, and kidney problems caused by uric acid. Allopurinol tablets are also used in adults to reduce recurrent calcium oxalate kidney stones when uric acid in the urine is too high, even after lifestyle changes.

For adults and children with leukemia, lymphoma, or solid tumor cancers, allopurinol is used to control uric acid levels that rise during cancer treatment. The injectable forms — Allopurinol sodium for injection and Aloprim — are specifically for patients who cannot take medicine by mouth and are given intravenously (through a vein) in a hospital or clinical setting. Note: allopurinol tablets are not recommended for people who have high uric acid levels but no symptoms.

Most-Reported Side Effects for Allopurinol

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 8,726 reports
Fatigue 8,284 reports
Dyspnea 7,956 reports
Nausea 7,333 reports
Acute kidney injury 6,761 reports
See full Allopurinol drug information
Keep checking

Other Drugs & Cannabinol (cbn)

Browse every other medication we’ve checked against Cannabinol (cbn) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
389Moderate
0Minor
2,440No known interaction
389 Moderate 2,440 No interaction
Moderate

389 interactions

Showing 60 of 389 moderate interactions — see all 389 on the Cannabinol (cbn) page.

No interaction 2,440 drugs checked — show the list

We also checked Cannabinol (cbn) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,440 medications checked with no known interaction — see the full Cannabinol (cbn) list.

See the full Cannabinol (cbn) interactions page
See every supplement checked against Allopurinol, ranked by severity
Evidence & sources

Cannabinol (cbn) References

The 3 references that drive our Cannabinol (cbn) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80(15):1415-9. PubMed
  2. Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P. Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos 2021;49(12):1070-1080. PubMed
  3. Bonn-Miller MO, Feldner MT, Bynion TM, Eglit GML, Brunstetter M, Kalaba M, Zvorsky I, Peters EN, Hennesy M. A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality. Exp Clin Psychopharmac PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cannabinol (cbn) and Allopurinol Together: Common Questions

Is it safe to take Cannabinol (cbn) with Allopurinol?
We do not list a known interaction between Cannabinol (cbn) and Allopurinol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cannabinol (cbn) and Allopurinol have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Cannabinol (cbn) and Allopurinol combination checked?
Interactions in our licensed database are recorded against drug classes. Allopurinol is filed under 5 classifications, and Cannabinol (cbn) has documented interactions with 5 drug classes — none of Allopurinol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cannabinol (cbn) interact with any other medications?
Yes. Cannabinol (cbn) has 389 documented drug interactions in our database — Allopurinol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Allopurinol interact with any supplements?
Yes. Allopurinol has documented interactions with 60 supplements in our database — Cannabinol (cbn) is not one of them. The Allopurinol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cannabinol (cbn) monograph Uses, safety profile, and every drug interaction in one place Allopurinol drug information The full plain-English guide to this medication Allopurinol supplement interactions Every supplement checked against Allopurinol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Allopurinol and Cannabinol (cbn)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.