Medication interaction hub

What Supplements Interact with Allopurinol?

Allopurinol brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric. Every interaction below applies to the brands too.

60 Interactions 5 Major 45 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Allopurinol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Allopurinol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Allopurinol (Zyloprim) prevents gout attacks by lowering uric acid, and I would give this list real weight, because 5 of the 60 supplements and herbs on file carry a major rating. The largest cluster, 38 ingredients, is products that can stress the liver on their own, and regular beer or wine sits in that major group, since alcohol on top of a liver-taxing drug raises the odds of damage. Six more can strain the kidneys, the same organs that clear allopurinol from your body.

Another 17 entries, with activated charcoal the standout, can soak up or slow pills taken by mouth, so less of your dose reaches your blood. Keep those well separated from your tablet. High-dose niacin can also work against the uric-acid lowering, letting gout creep back. The rest of the list runs 45 moderate and 10 minor, but the five major entries deserve your attention first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 45 Minor 10 No known interaction 1,392

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Allopurinol: Top Interactions at a Glance

The Allopurinol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 60 interacting ingredients — plus 1,392 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Allopurinol Combinations Today

The Allopurinol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Rhubarb + Allopurinoli

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Read the full interaction Major Likelihood Probable Wine + Allopurinoli

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Allopurinoli

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Read the full interaction Moderate Likelihood Possible Kava + Allopurinoli

Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Read the full interaction Moderate Likelihood Possible Spearmint + Allopurinoli

Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Read the full interaction Moderate Likelihood Possible Noni + Allopurinoli

Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Read the full interaction
The complete list

Every Supplement Checked Against Allopurinol

All 1,452 ingredients in our database, ranked by severity — 60 with a Allopurinol interaction on file and 1,392 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Allopurinol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Rhubarb with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Allopurinol answer

Can you take Wine with Allopurinol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Allopurinol answer

Can you take Ashwagandha with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Allopurinol answer

Can you take Kava with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + Allopurinol answer

Can you take Spearmint with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Allopurinol answer

Can you take Siberian Cocklebur with Allopurinol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the kidney.

Full Siberian Cocklebur + Allopurinol answer

Can you take Activated Charcoal with Allopurinol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Allopurinol answer

Can you take Beer with Allopurinol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Allopurinol answer

Can you take Asarabacca with Allopurinol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Full Asarabacca + Allopurinol answer

Can you take Coffee Charcoal with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Allopurinol answer

Can you take European Mandrake with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Allopurinol answer

Can you take Glucomannan with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Allopurinol answer

Can you take Niacin with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.

Full Niacin + Allopurinol answer

Can you take Aristolochia with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aristolochia is nephrotoxic.

Full Aristolochia + Allopurinol answer

Can you take Black Cohosh with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Allopurinol answer

Can you take Boldo with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Allopurinol answer

Can you take Buchu with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Allopurinol answer

Can you take Camphor with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Allopurinol answer

Can you take Cassia Cinnamon with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Allopurinol answer

Can you take Chaparral with Allopurinol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Allopurinol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Allopurinol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Allopurinol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Allopurinol sits in 5 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Allopurinol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Allopurinol through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Allopurinol through this category.

Allopurinol (Zyloprim) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Allopurinol through this category.

Antigout Drugs 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Allopurinol through this category.

About Allopurinol

Allopurinol is a uric acid-lowering medicine used to treat gout, manage high uric acid levels caused by cancer treatment, and reduce recurrent calcium oxalate kidney stones.

Generic name: Allopurinol  ·  Brand names: Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric.

See the full Allopurinol drug information
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Take a Supplement Product? Check the Whole Bottle Against Allopurinol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Allopurinol.

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Pharmacist Counseling Corner

Allopurinol & Supplements: Common Questions

What supplements interact with Allopurinol?
More than you might expect — 60 in total, though they are far from equal: 5 are rated major, 45 moderate, and 10 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Allopurinol supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer, Wine and Asarabacca. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Allopurinol?
Usually yes — most people on Allopurinol can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Zyloprim have the same supplement interactions as Allopurinol?
Yes — Zyloprim, Caplenal, Cosuric, Rimapurinol, Zyloric all contain Allopurinol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Allopurinol and my other medications?
This page covers Allopurinol against supplements and herbal ingredients. Checking Allopurinol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Allopurinol drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.